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List of works by Jan J. Brosens

2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells

scientific article published on June 2010

4-D Assessment of Endometrial Vascularity Using Spatiotemporal Image Correlation: A Study Comparing Spherical Sampling and Whole-Tissue Analysis.

scientific article published on 13 August 2015

A role for uric acid and the Nalp3 inflammasome in antiphospholipid antibody-induced IL-1β production by human first trimester trophoblast.

scientific article

Activation of SGK1 in Endometrial Epithelial Cells in Response to PI3K/AKT Inhibition Impairs Embryo Implantation

scientific article published on 31 October 2016

An altered endometrial CD8 tissue resident memory T cell population in recurrent miscarriage

scientific article published on 23 January 2017

Analysis of chromatin accessibility in decidualizing human endometrial stromal cells

scientific article published on 19 December 2017

Androgen signaling in decidualizing human endometrial stromal cells enhances resistance to oxidative stress

scientific article published on 10 November 2011

Androgens modulate the morphological characteristics of human endometrial stromal cells decidualized in vitro.

scientific article published on 24 July 2013

Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway

scientific article published on August 2009

Antiphospholipid antibodies limit trophoblast migration by reducing IL-6 production and STAT3 activity

scientific article published on 03 February 2010

Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8.

scientific article published on 29 March 2016

Aromatase P450 messenger RNA expression in eutopic endometrium is not a specific marker for pelvic endometriosis

scientific article published in October 2002

Aspirin and heparin effect on basal and antiphospholipid antibody modulation of trophoblast function.

scientific article

Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium

scientific article published on 11 December 2017

Composition, Development, and Function of Uterine Innate Lymphoid Cells

scientific article

Convergence of interferon-gamma and progesterone signaling pathways in human endometrium: role of PIASy (protein inhibitor of activated signal transducer and activator of transcription-y).

scientific article

Covalent Attachment of Fibronectin onto Emulsion-Templated Porous Polymer Scaffolds Enhances Human Endometrial Stromal Cell Adhesion, Infiltration, and Function

scientific article published on 13 December 2018

Cyclic AMP and progesterone receptor cross-talk in human endometrium: a decidualizing affair.

scientific article

Cyclic AMP-induced forkhead transcription factor, FKHR, cooperates with CCAAT/enhancer-binding protein beta in differentiating human endometrial stromal cells

scientific article

Cyclic decidualization of the human endometrium in reproductive health and failure.

scientific article

Decidualization

article

Decidualization induces a secretome switch in perivascular niche cells of the human endometrium

scientific article published on 13 August 2014

Deficiency in clonogenic endometrial mesenchymal stem cells in obese women with reproductive failure--a pilot study

scientific article

Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer

scientific article

Deregulation of the endometrial stromal cell secretome precedes embryo implantation failure.

scientific article published in August 2017

Deregulation of the endometrial stromal cell secretome precedes embryo implantation failure.

scientific article published on 10 April 2017

Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure

scientific article

Differential effects of urinary and recombinant chorionic gonadotropin on oxidative stress responses in decidualizing human endometrial stromal cells

scientific article published on 08 June 2011

Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization

scientific article

Disordered IL-33/ST2 activation in decidualizing stromal cells prolongs uterine receptivity in women with recurrent pregnancy loss

scientific article

Down-regulation of the histone methyltransferase EZH2 contributes to the epigenetic programming of decidualizing human endometrial stromal cells

scientific article

Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells

scientific article published in March 2008

Effect of a dienogest for an experimental three-dimensional endometrial culture model for endometriosis

scientific article published on 20 October 2013

Effect of hydroxychloroquine on antiphospholipid antibody-induced changes in first trimester trophoblast function

scientific article published on 11 December 2013

Elevated periimplantation uterine natural killer cell density in human endometrium is associated with impaired corticosteroid signaling in decidualizing stromal cells

scientific article

Elevated serum thyroid-stimulating hormone is associated with decreased anti-Müllerian hormone in infertile women of reproductive age.

scientific article

Endometrial androgen signaling and decidualization regulate trophoblast expansion and invasion in co-culture: A time-lapse study.

scientific article published on 13 September 2016

Endometrial spatio-temporal image correlation (STIC) and prediction of outcome following assisted reproductive treatment

scientific article

Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos

scientific article (publication date: 2012)

Endometriosis is a risk factor for spontaneous hemoperitoneum during pregnancy

scientific article published on 12 May 2009

Endometriosis is associated with a decreased risk of pre-eclampsia

scientific article published on 23 April 2007

Enhanced Differentiation Potential of Primary Human Endometrial Cells Cultured on 3D Scaffolds

scientific article published on 10 July 2018

Expression of adhesion and extracellular matrix genes in human blastocysts upon attachment in a 2D co-culture system

scientific article published on 01 July 2018

Expression of epigenetic effectors in decidualizing human endometrial stromal cells

scientific article published on 7 May 2012

FOXO and FOXM1 in Cancer: The FOXO-FOXM1 Axis Shapes the Outcome of Cancer Chemotherapy

scientific article published on 01 August 2011

FOXO transcription factors and their role in disorders of the female reproductive tract.

scientific article published in August 2011

FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer.

scientific article

Forkhead box proteins: tuning forks for transcriptional harmony.

scientific article published on July 2013

FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism.

scientific article

FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

scientific article (publication date: 12 December 2003)

Functional association of PR and CCAAT/enhancer-binding protein beta isoforms: promoter-dependent cooperation between PR-B and liver-enriched inhibitory protein, or liver-enriched activatory protein and PR-A in human endometrial stromal cells

scientific article published in January 2002

Heparin prevents programmed cell death in human trophoblast

scientific article published on 23 March 2006

Human chorionic gonadotropin confers resistance to oxidative stress-induced apoptosis in decidualizing human endometrial stromal cells

scientific article published on 7 July 2010

Human endometrial fibroblasts immortalized by simian virus 40 large T antigen differentiate in response to a decidualization stimulus

scientific article published on June 1996

Human homologs of the putative G protein-coupled membrane progestin receptors (mPRalpha, beta, and gamma) localize to the endoplasmic reticulum and are not activated by progesterone.

scientific article published on 7 September 2006

Impaired expression of endometrial differentiation markers and complement regulatory proteins in patients with recurrent pregnancy loss associated with antiphospholipid syndrome.

scientific article

Increased ovarian follicle atresia in obese Zucker rats is associated with enhanced expression of the forkhead transcription factor FOXO1

scientific article published on 24 December 2009

Induction of 11β-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells

scientific article

Induction of microRNA resistance and secretion in differentiating human endometrial stromal cells

scientific article published on 25 October 2012

Inflammation and sex steroid receptors: a motif for change

scientific article published in February 2006

Inhibition of steroid sulfatase activity in endometriotic implants by STX64 (667Coumate): a potential new therapy

scientific article published on 25 December 2008

Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE: a potential new therapy

scientific article published on 02 December 2007

Insufficient histone-3 lysine-9 deacetylation in human oocytes matured in vitro is associated with aberrant meiosis

scientific article published on 17 November 2011

Integration of GPCR Signaling and Sorting from Very Early Endosomes via Opposing APPL1 Mechanisms

scientific article published in December 2017

Interactions between inflammatory signals and the progesterone receptor in regulating gene expression in pregnant human uterine myocytes

scientific article published on October 2012

Interferon-gamma modulates prolactin and tissue factor expression in differentiating human endometrial stromal cells

scientific article

Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer

scientific article published on 30 December 2010

Interventions to improve reproductive outcomes in women with elevated natural killer cells undergoing assisted reproduction techniques: a systematic review of literature.

scientific article

LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry

scientific article published on 11 December 2017

LEFTYA Activates the Epithelial Na+ Channel (ENaC) in Endometrial Cells via Serum and Glucocorticoid Inducible Kinase SGK1.

scientific article published on 8 September 2016

LRH-1: orphaned, adopted and needed for pregnancy

scientific article

LeftyA sensitive cytosolic pH regulation and glycolytic flux in Ishikawa human endometrial cancer cells

scientific article

Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium

scientific article published on 10 April 2017

Loss of Endometrial Plasticity in Recurrent Pregnancy Loss.

scientific article published on 29 September 2015

Loss of Endometrial Sodium Glucose Cotransporter SGLT1 is Detrimental to Embryo Survival and Fetal Growth in Pregnancy.

scientific article published on 3 October 2017

Loss of miR-542-3p enhances IGFBP-1 expression in decidualizing human endometrial stromal cells

scientific article published on 04 January 2017

Meaningful menstruation: cyclic renewal of the endometrium is key to reproductive success

scientific article published on 01 May 2013

Mechanism and functional consequences of loss of FOXO1 expression in endometrioid endometrial cancer cells.

scientific article

Mechanisms of endometrial progesterone resistance

scientific article

Modulation of trophoblast angiogenic factor secretion by antiphospholipid antibodies is not reversed by heparin

scientific article published on 4 May 2011

Molecular aspects of implantation failure

scientific article

NADPH oxidase-derived reactive oxygen species mediate decidualization of human endometrial stromal cells in response to cyclic AMP signaling.

scientific article

NICE guidance on ectopic pregnancy and miscarriage restricts access and choice and may be clinically unsafe

scientific article published in the British Medical Journal

Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation

scientific article

Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss

scientific article

New insights into the mechanisms underlying recurrent pregnancy loss

scientific article published on 16 October 2018

Non-genomic progesterone actions in female reproduction.

scientific article published on 19 October 2008

Oestrogen receptor hijacked

scientific article published in Nature

Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt.

scientific article published on January 2006

Phosphatidylinositol 3-kinase is required for the transcriptional activation of cyclin D2 in BCR activated primary mouse B lymphocytes.

scientific article

Physical interaction and mutual transrepression between CCAAT/enhancer-binding protein beta and the p53 tumor suppressor

scientific article

Pravastatin does not prevent antiphospholipid antibody-mediated changes in human first trimester trophoblast function.

scientific article published on 11 August 2012

Progesterone acts via the nuclear glucocorticoid receptor to suppress IL-1β-induced COX-2 expression in human term myometrial cells

scientific article published in 2012

Progesterone and FOXO1 signaling: Harnessing cellular senescence for the treatment of ovarian cancer ⬇️

scientific article published on May 17, 2013

Progesterone and the Repression of Myometrial Inflammation: The Roles of MKP-1 and the AP-1 System

scientific article

Progesterone increases tissue factor gene expression, procoagulant activity, and invasion in the breast cancer cell line ZR-75-1.

scientific article

Progesterone pre-treatment potentiates EGF pathway signaling in the breast cancer cell line ZR-75.

scientific article published on November 2005

Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of protease-activated receptor-1.

scientific article published on 16 May 2012

Progesterone-Dependent Induction of Phospholipase C-Related Catalytically Inactive Protein 1 (PRIP-1) in Decidualizing Human Endometrial Stromal Cells.

scientific article published on 11 May 2016

Progestins regulate the expression and activity of the forkhead transcription factor FOXO1 in differentiating human endometrium

scientific article published on 25 August 2005

Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis

scientific article

Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window

scientific article published on 21 January 2020

Regulated expression of putative membrane progestin receptor homologues in human endometrium and gestational tissues.

scientific article

Regulated expression of signal transducer and activator of transcription, Stat5, and its enhancement of PRL expression in human endometrial stromal cells in vitro

scientific article published in June 2002

Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone

scientific article

Reprint of: Uterine plasticity and reproductive fitness

scientific article published on 12 October 2013

Reprogramming of the retinoic acid pathway in decidualizing human endometrial stromal cells

scientific article

Resveratrol inhibits decidualization by accelerating downregulation of the CRABP2-RAR pathway in differentiating human endometrial stromal cells

scientific article published on 20 March 2019

Role and Regulation of the Serum- and Glucocorticoid-Regulated Kinase 1 in Fertile and Infertile Human Endometrium

article

Role of maternal glucocorticoid inducible kinase SGK1 in fetal programming of blood pressure in response to prenatal diet

scientific article published on 26 March 2008

SGK1-dependent salt appetite in pregnant mice

scientific article published on 18 March 2011

SUMOylation inhibits FOXM1 activity and delays mitotic transition.

scientific article

Self-assessment of the cervical pupil sign as a new fertility-awareness method

scientific article published on 15 February 2008

Sense and sensitivity: FOXO and ROS in cancer development and treatment

scientific article published on 20 October 2010

Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals

scientific article

Something new about early pregnancy: decidual biosensoring and natural embryo selection

scientific article published in July 2010

Spatial and Temporal Analyses of FGF9 Expression During Early Pregnancy.

scientific article published on 17 August 2017

Steroid hormone-dependent myometrial zonal differentiation in the non-pregnant human uterus

scientific article published on 01 December 1998

Steroid receptor action

scientific article published on April 2004

Success after failure: the role of endometrial stem cells in recurrent miscarriage

scientific article

TBX22 missense mutations found in patients with X-linked cleft palate affect DNA binding, sumoylation, and transcriptional repression

scientific article

TGFβ1 and SGK1-sensitive store-operated Ca2+ entry and Orai1 expression in endometrial Ishikawa cells

scientific article published on 16 September 2013

TGFβ1 attenuates expression of prolactin and IGFBP-1 in decidualized endometrial stromal cells by both SMAD-dependent and SMAD-independent pathways

scientific article

The Glycosyltransferase EOGT Regulates Adropin Expression in Decidualizing Human Endometrium

scientific article

The SUMO E3‐ligase PIAS1 couples reactive oxygen species‐dependent JNK activation to oxidative cell death ⬇️

scientific article published on June 15, 2011

The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium

scientific article

The clock protein period 2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells

scientific article published on 8 January 2015

The diversity of sex steroid action: the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer

scientific article published on 07 March 2011

The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression

scientific article published on 21 July 2008

The human endometrium as a sensor of embryo quality

scientific article published on 03 September 2014

The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy

scientific article

The molecular basis of recurrent pregnancy loss: impaired natural embryo selection

scientific article published on 16 September 2010

The motile and invasive capacity of human endometrial stromal cells: implications for normal and impaired reproductive function.

scientific article published on 04 July 2013

The mutational landscape of normal human endometrial epithelium

scientific article published on 22 April 2020

The oestrogen metabolite 2-methoxyoestradiol alone or in combination with tumour necrosis factor-related apoptosis-inducing ligand mediates apoptosis in cancerous but not healthy cells of the human endometrium

scientific article

The poly(c)-binding protein-1 regulates expression of the androgen receptor

scientific article

The role of FOXO1 in the decidual transformation of the endometrium and early pregnancy

scientific article published on 05 February 2013

The uterine junctional zone.

scientific article

The uterus under hormonal control--cycling for life

scientific article published on 02 March 2012

Tissue factor is regulated by epidermal growth factor in normal and malignant human endometrial epithelial cells

scientific article

Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells

scientific article published on 3 July 2007

Translational co-regulation of a ligand and inhibitor by a conserved RNA element.

scientific article

Ultrasound assessment of the peri-implantation uterus: a review

scientific article published on June 2012

Uterine plasticity and reproductive fitness

scientific article published on 11 July 2013

Uterine selection of human embryos at implantation

scientific article (publication date: 6 February 2014)

Uterine stretch and progesterone action

scientific article published on 30 March 2011

Vitamin D reverses aPL-induced inflammation and LMWH-induced sFlt-1 release by human trophoblast.

scientific article

What exactly do we mean by 'recurrent implantation failure'? A systematic review and opinion.

scientific article

Wild-type p53 protein is up-regulated upon cyclic adenosine monophosphate-induced differentiation of human endometrial stromal cells

scientific article published in October 2004

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