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List of works by Javier Martinez-Picado

3'-Azido-2',3'-dideoxythymidine (zidovudine) uptake mechanisms in T lymphocytes.

scientific article published on January 2006

A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replication

scientific article published in January 2013

A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control

scientific article published on 29 October 2013

A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A.

scientific article published on 30 January 2013

A minor population of macrophage-tropic HIV-1 variants is identified in recrudescing viremia following analytic treatment interruption

scientific article published on 16 April 2020

A non-infectious cell-based phenotypic assay for the assessment of HIV-1 susceptibility to protease inhibitors

scientific article published on 12 October 2011

A novel TaqMan real-time PCR assay to estimate ex vivo human immunodeficiency virus type 1 fitness in the era of multi-target (pol and env) antiretroviral therapy

scientific article published in August 2003

A therapeutic dendritic cell-based vaccine for HIV-1 infection

scientific article published on 13 January 2011

A376S in the connection subdomain of HIV-1 reverse transcriptase confers increased risk of virological failure to nevirapine therapy.

scientific article

AM3 modulates dendritic cell pathogen recognition capabilities by targeting DC-SIGN.

scientific article

Actin-binding protein drebrin regulates HIV-1-triggered actin polymerization and viral infection

scientific article

Alternation of antiretroviral drug regimens for HIV infection. A randomized, controlled trial

scientific article

Alternation of antiretroviral drug regimens for HIV infection. Efficacy, safety and tolerability at week 96 of the Swatch Study

scientific article published in December 2004

Amprenavir-resistant HIV-1 exhibits lopinavir cross-resistance and reduced replication capacity

scientific article published in May 2002

An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults

scientific article published on 18 November 2021

Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral entry

scientific article published on 03 June 2019

Antiretroviral resistance during successful therapy of HIV type 1 infection.

scientific article

Antiretroviral therapy interruption guided by CD4 cell counts and plasma HIV-1 RNA levels in chronically HIV-1-infected patients

scientific article published in January 2007

Assessing main death pathways in T lymphocytes from HIV infected individuals.

scientific article

Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls

scientific article

Attacking the HIV Reservoir from the Immune and Viral Perspective ⬇️

scientific article published on March 1, 2013

Author Correction: Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection

scientific article published on 04 May 2020

Auto-antibodies against type I IFNs in patients with life-threatening COVID-19

scientific article published on 24 September 2020

Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs

scientific article published on 29 March 2013

CCR5 Δ32 homozygous cord blood allogeneic transplantation in a patient with HIV: a case report

scientific article

Cancer immunotherapy of patients with HIV infection

scientific article published on 17 November 2018

Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway

scientific article

Capture of cell-derived microvesicles (exosomes and apoptotic bodies) by human plasmacytoid dendritic cells

scientific article published on 08 February 2012

Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy

scientific article published on 13 August 2012

Combined Antiretroviral Therapy and Immune Pressure Lead to In Vivo HIV-1 Recombination With Ancestral Viral Genomes

article

Common genetic variation and the control of HIV-1 in humans

scientific article published in December 2009

Comparative analysis of HIV type 1 genotypic resistance across antiretroviral trial treatment regimens

scientific article published on September 2000

Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque

scientific article

Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus

scientific article

Contribution of immunological and virological factors to extremely severe primary HIV type 1 infection

scientific article

Copy number variation of KIR genes influences HIV-1 control

scientific article

Deep molecular characterization of HIV-1 dynamics under suppressive HAART

scientific article

Definition of the viral targets of protective HIV-1-specific T cell responses

scientific article published on 7 December 2011

Dendritic Cells From the Cervical Mucosa Capture and Transfer HIV-1 via Siglec-1

article

Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages

article

Different plasma markers of inflammation are influenced by immune recovery and cART composition or intensification in treated HIV infected individuals

scientific article

Differential Immunodominance Hierarchy of CD8+ T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection

scientific article published on 22 November 2017

Dihydrosphingomyelin Impairs HIV-1 Infection by Rigidifying Liquid-Ordered Membrane Domains

article

Does rapid HIV disease progression prior to combination antiretroviral therapy hinder optimal CD4+ T-cell recovery once HIV-1 suppression is achieved?

scientific article published in November 2015

Drug uptake transporters in antiretroviral therapy

scientific article published on 23 July 2011

Drug-Resistance Mutations Number and K70R or T215Y/F Substitutions Predict Treatment Resumption during Guided Treatment Interruptions

scientific article published on 01 May 2008

Dynamic escape of pre-existing raltegravir-resistant HIV-1 from raltegravir selection pressure

scientific article published on 29 September 2010

Dynamic imaging of cell-free and cell-associated viral capture in mature dendritic cells.

scientific article published on 10 October 2011

Dynamics of CD8 T-cell activation after discontinuation of HIV treatment intensification

scientific article published in June 2013

Early but limited effects of raltegravir intensification on CD4 T cell reconstitution in HIV-infected patients with an immunodiscordant response to antiretroviral therapy.

scientific article published on 14 May 2013

Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial

scientific article published on 17 October 2022

Effect of lithium on HIV-1 expression and proviral reservoir size in the CD4+ T cells of antiretroviral therapy suppressed patients

scientific article published on September 2014

Effect of maraviroc intensification on HIV-1-specific T cell immunity in recently HIV-1-infected individuals

scientific article published on 27 January 2014

Effect of maraviroc on non-R5 tropic HIV-1: refined analysis of subjects from the phase IIb study A4001029.

scientific article

Effect of the human immunodeficiency virus type 1 reverse transcriptase polymorphism Leu-214 on replication capacity and drug susceptibility.

scientific article published on 20 May 2009

Efficacy of low-dose subcutaneous interleukin-2 to treat advanced human immunodeficiency virus type 1 in persons with </=250/microL CD4 T cells and undetectable plasma virus load

scientific article published in July 1999

Enhancement of Antiviral CD8+ T-Cell Responses and Complete Remission of Metastatic Melanoma in an HIV-1-Infected Subject Treated with Pembrolizumab

scientific article published on 01 December 2019

Episomal HIV-1 DNA and its relationship to other markers of HIV-1 persistence

scientific article published on 30 January 2018

Epstein-Barr viral loads and serum free light chains levels are potential follow-up markers of HIV-related lymphomas

scientific article

Establishment and Replenishment of the Viral Reservoir in Perinatally HIV-1-infected Children Initiating Very Early Antiretroviral Therapy

scientific article

Evaluation of the immunogenicity and impact on the latent HIV-1 reservoir of a conserved region vaccine, MVA.HIVconsv, in antiretroviral therapy-treated subjects

scientific article published on May 2017

Evidence for preferential genotyping of a minority human immunodeficiency virus population due to primer-template mismatching during PCR-based amplification

scientific article

Ex vivo production of autologous whole inactivated HIV-1 for clinical use in therapeutic vaccines

article

Exosomes and retroviruses: the chicken or the egg?

scientific article

Expression and functionality of anti-human immunodeficiency virus and anticancer drug uptake transporters in immune cells

scientific article published on 27 November 2007

Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1

scientific article

Fitness of human immunodeficiency virus type 1 protease inhibitor-selected single mutants

scientific article published in September 2000

Fitness variations and their impact on the evolution of antiretroviral drug resistance.

scientific article published on December 2003

Functional consequences of human immunodeficiency virus escape from an HLA-B*13-restricted CD8+ T-cell epitope in p1 Gag protein.

scientific article published on 22 October 2008

Gag-protease coevolution analyses define novel structural surfaces in the HIV-1 matrix and capsid involved in resistance to Protease Inhibitors

scientific article

Genetic evolution of gp41 reveals a highly exclusive relationship between codons 36, 38 and 43 in gp41 under long-term enfuvirtide-containing salvage regimen

HIV and mature dendritic cells: Trojan exosomes riding the Trojan horse?

scientific article

HIV dynamics and T-cell immunity after three structured treatment interruptions in chronic HIV-1 infection

article

HIV evolution: CTL escape mutation and reversion after transmission

scientific article published on 8 February 2004

HIV integrase inhibitors in ART-experienced patients

scientific article published on September 2012

HIV model parameter estimates from interruption trial data including drug efficacy and reservoir dynamics

scientific article

HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4.

scientific article

HIV type 1 fitness evolution in antiretroviral-experienced patients with sustained CD4+ T cell counts but persistent virologic failure.

scientific article published on 22 July 2005

HIV-1 Capture and Antigen Presentation by Dendritic Cells: Enhanced Viral Capture Does Not Correlate with Better T Cell Activation

article

HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids and the cellular receptor Siglec-1

scientific article published on 17 July 2014

HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells

scientific article

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

scientific article published on 05 March 2019

HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects.

scientific article published on 14 March 2010

HIV-1 reverse transcriptase inhibitor resistance mutations and fitness: a view from the clinic and ex vivo.

scientific article published on 04 March 2008

HIV-1 tropism testing in subjects achieving undetectable HIV-1 RNA: diagnostic accuracy, viral evolution and compartmentalization

scientific article

HIV-1-RNA Decay and Dolutegravir Concentrations in Semen of Patients Starting a First Antiretroviral Regimen.

scientific article

Highly pathogenic adapted HIV-1 strains limit host immunity and dictate rapid disease progression

scientific article published on June 2014

Human genetic and immunological determinants of critical COVID-19 pneumonia

scientific article published on 28 January 2022

Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for In Vivo HIV Control

scientific article published on 07 June 2017

Identification of Siglec-1 null individuals infected with HIV-1.

scientific article published on 11 August 2016

Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection

scientific article

Impact of drug resistance genotypes on CD4+ counts and plasma viremia in heavily antiretroviral-experienced HIV-infected patients

scientific article published in September 2005

Impact of intensification with raltegravir on HIV-1-infected individuals receiving monotherapy with boosted PIs.

scientific article

Impact of phenotype definition on genome-wide association signals: empirical evaluation in human immunodeficiency virus type 1 infection

scientific article published on 13 April 2011

Improved CD4 lymphocyte outgrowth in response to effective antiretroviral therapy.

scientific article

In-depth characterization of viral isolates from plasma and cells compared with plasma circulating quasispecies in early HIV-1 infection.

scientific article published on 29 February 2012

Increased antiretroviral potency by the addition of enfuvirtide to a four-drug regimen in antiretroviral-naive, HIV-infected patients

scientific article published in January 2006

Increasing Diagnostic Uncertainties in Children With In Utero HIV Infection

scientific article published on 01 August 2019

Influence of Prior Structured Treatment Interruptions on the Length of Time without Antiretroviral Treatment in Chronically HIV-Infected Subjects

article

Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers.

scientific article published on July 2010

Integrase inhibitor (INI) genotypic resistance in treatment-naive and raltegravir-experienced patients infected with diverse HIV-1 clades

scientific article

Intensification of a raltegravir-based regimen with maraviroc in early HIV-1 infection

scientific article published on January 2014

Interaction of nucleoside inhibitors of HIV-1 reverse transcriptase with the concentrative nucleoside transporter-1 (SLC28A1).

scientific article

Lack of concordance between residual viremia and viral variants driving de novo infection of CD4(+) T cells on ART.

scientific article published on 02 August 2016

Lack of longitudinal intrapatient correlation between p24 antigenemia and levels of human immunodeficiency virus (HIV) type 1 RNA in patients with chronic hiv infection during structured treatment interruptions

scientific article

Long-Term Spontaneous Control of HIV-1 Is Related to Low Frequency of Infected Cells and Inefficient Viral Reactivation

scientific article published on 27 April 2016

Long-term antiretroviral treatment initiated at primary HIV-1 infection affects the size, composition, and decay kinetics of the reservoir of HIV-1-infected CD4 T cells

scientific article

Maturation of blood-derived dendritic cells enhances human immunodeficiency virus type 1 capture and transmission

scientific article

Mechanisms That Contribute to a Profound Reduction of the HIV-1 Reservoir After Allogeneic Stem Cell Transplant

article

Mechanisms involved in the selection of HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with nucleoside analogue therapy failure

scientific article published on 23 August 2010

Mechanistic basis of zidovudine hypersusceptibility and lamivudine resistance conferred by the deletion of codon 69 in the HIV-1 reverse transcriptase coding region

scientific article published on 17 July 2008

Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control

scientific article published on 06 August 2020

Modelling HIV-1 2-LTR dynamics following raltegravir intensification.

scientific article published on 8 May 2013

Mouse Siglec-1 Mediates trans-Infection of Surface-bound Murine Leukemia Virus in a Sialic Acid N-Acyl Side Chain-dependent Manner

scientific article

Naive CD4(+) T cells and recent thymic emigrant levels in treated individuals with HIV: clinical relevance

scientific article published in September 2006

New macrocyclic amines showing activity as HIV entry inhibitors against wild type and multi-drug resistant viruses

scientific article published on 22 May 2009

Novel two-round phenotypic assay for protease inhibitor susceptibility testing of recombinant and primary HIV-1 isolates.

scientific article

Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA-methyltransferase inhibitors.

scientific article

Optimal antiviral switching to minimize resistance risk in HIV therapy

scientific article

P-glycoprotein (ABCB1) activity decreases raltegravir disposition in primary CD4+P-gphigh cells and correlates with HIV-1 viral load

scientific article published on 21 June 2016

Persistent HIV-1 replication during antiretroviral therapy

scientific article published on July 2016

Phase I clinical trial of an intranodally administered mRNA based therapeutic vaccine against HIV-1 infection

article

Phenotypic hypersusceptibility to multiple protease inhibitors and low replicative capacity in patients who are chronically infected with human immunodeficiency virus type 1.

scientific article

Plasma EBV-load as an early biomarker and prognostic factor of HIV-related lymphomas

article

Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load

scientific article

Prevalence of HIV protease mutations on failure of nelfinavir-containing HAART: a retrospective analysis of four clinical studies and two observational cohorts

scientific article

Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif.

scientific article published on 13 January 2017

Proteomics study of human cord blood reticulocyte-derived exosomes

scientific article published in Scientific Reports

Raltegravir intensification shows differing effects on CD8 and CD4 T cells in HIV-infected HAART-suppressed individuals with poor CD4 T-cell recovery

scientific article published on November 2012

Raltegravir susceptibility and fitness progression of HIV type-1 integrase in patients on long-term antiretroviral therapy.

scientific article

Random T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain

scientific article published on 5 September 2007

Rate of accumulation of thymidine analogue mutations in patients continuing to receive virologically failing regimens containing zidovudine or stavudine: implications for antiretroviral therapy programs in resource-limited settings.

scientific article published in September 2009

Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting

scientific article published on 15 March 2019

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

scientific article published on 07 September 2020

Relationship between CCR5(WT/Δ32) heterozygosity and HIV-1 reservoir size in adolescents and young adults with perinatally acquired HIV-1 infection.

scientific article

Relative fitness and replication capacity of a multinucleoside analogue-resistant clinical human immunodeficiency virus type 1 isolate with a deletion of codon 69 in the reverse transcriptase coding region

scientific article published on 21 February 2007

Relative replication fitness of multi-nucleoside analogue-resistant HIV-1 strains bearing a dipeptide insertion in the fingers subdomain of the reverse transcriptase and mutations at codons 67 and 215.

scientific article published on August 2004

Response to "Tenofovir Disoproxil Fumarate Is Not an Inhibitor of Human Organic Cation Transporter 1".

scientific article published in February 2017

Retroviruses As Myeloid Cell Riders: What Natural Human Siglec-1 "Knockouts" Tell Us About Pathogenesis

scientific article published on 21 November 2017

Risk of selecting resistance mutations during treatment interruption.

scientific article published on January 2007

Role of Human Organic Cation Transporter 1 (hOCT1) Polymorphisms in Lamivudine (3TC) Uptake and Drug-Drug Interactions.

scientific article published on 24 June 2016

Role of structured treatment interruption before a 5-drug salvage antiretroviral regimen: the Retrogene Study.

scientific article

Safety and immunogenicity of a modified vaccinia Ankara-based HIV-1 vaccine (MVA-B) in HIV-1-infected patients alone or in combination with a drug to reactivate latent HIV-1.

scientific article published on 26 February 2015

Selection of drug-resistant HIV-1 mutants in response to repeated structured treatment interruptions

scientific article published in April 2002

Sensitive quantification of the HIV-1 reservoir in gut-associated lymphoid tissue

scientific article

Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection

scientific article published on 14 April 2020

Short-term Treatment With Interferon Alfa Diminishes Expression of HIV-1 and Reduces CD4+ T-Cell Activation in Patients Coinfected With HIV and Hepatitis C Virus and Receiving Antiretroviral Therapy

scientific article published on November 2015

Sialyllactose in viral membrane gangliosides is a novel molecular recognition pattern for mature dendritic cell capture of HIV-1

scientific article

Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides

scientific article

Structured treatment interruption in chronically HIV-1 infected patients after long-term viral suppression

scientific article

TL1A-DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1-Specific T Cell Responses

scientific article published on 11 November 2020

Targeting only reverse transcriptase with zidovudine/lamivudine/abacavir plus tenofovir in HIV-1-infected patients with multidrug-resistant virus: a multicentre pilot study.

scientific article published on 15 May 2008

The HIV-1 integrase genotype strongly predicts raltegravir susceptibility but not viral fitness of primary virus isolates

scientific article published in January 2010

The Magnitude of Interferon-γ Responses to Human Cytomegalovirus Is Predictive for HIV-1 Disease Progression

article

The PDZ-adaptor protein syntenin-1 regulates HIV-1 entry

scientific article

The infectious synapse formed between mature dendritic cells and CD4(+) T cells is independent of the presence of the HIV-1 envelope glycoprotein

scientific article

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

scientific article published on 16 May 2022

Therapeutic Vaccination Refocuses T-cell Responses Towards Conserved Regions of HIV-1 in Early Treated Individuals (BCN 01 study)

scientific article published on 01 May 2019

Thymidine analogue excision and discrimination modulated by mutational complexes including single amino acid deletions of Asp-67 or Thr-69 in HIV-1 reverse transcriptase.

scientific article published on 19 April 2011

Towards an HIV cure: a global scientific strategy

scientific article

Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers

scientific article

Transient treatment exclusively containing nucleoside analogue reverse transcriptase inhibitors in highly antiretroviral-experienced patients preserves viral benefit when a fully active therapy was initiated.

scientific article published in November 2008

Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3

scientific journal article

Treatment intensification with raltegravir in subjects with sustained HIV-1 viraemia suppression: a randomized 48-week study.

scientific article published on 28 September 2011

Use of a novel assay based on intact recombinant viruses expressing green (EGFP) or red (DsRed2) fluorescent proteins to examine the contribution of pol and env genes to overall HIV-1 replicative fitness

scientific article published on 11 May 2006

Variability in the plasma concentration of efavirenz and nevirapine is associated with genotypic resistance after treatment interruption.

scientific article published on January 2008

Viral and inflammatory markers in cerebrospinal fluid of patients with HIV-1-associated neurocognitive impairment during antiretroviral treatment switch.

scientific article published on 27 February 2015

Viral dynamics during structured treatment interruptions of chronic human immunodeficiency virus type 1 infection

scientific article

Viral evolution during structured treatment interruptions in chronically human immunodeficiency virus-infected individuals

scientific article

Virological and immunological effects of treatment interruptions in HIV-1 infected patients with treatment failure

scientific article published in December 2000

Virological and immunological outcome of treatment interruption in HIV-1-infected subjects vaccinated with MVA-B.

scientific article published on 27 September 2017

Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1

scientific article published on 01 May 2020

When Dendritic Cells Go Viral: The Role of Siglec-1 in Host Defense and Dissemination of Enveloped Viruses

scientific article published on 19 December 2019

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