List of works - Asier Sáez-Cirión

Antibodies attenuate the capacity of dendritic cells to stimulate HIV-specific cytotoxic T lymphocytes

scientific article published on 11 October 2012

Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity

scientific article published on 23 April 2009

Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration

scientific article published on 17 January 2014

Both HLA-B*57 and plasma HIV RNA levels contribute to the HIV-specific CD8+ T cell response in HIV controllers

scientific article published on 16 October 2013

Cellular Determinants of HIV Persistence on Antiretroviral Therapy

article

Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection

scientific article published on 20 December 2018

Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission

scientific article

Conformational transitions of membrane-bound HIV-1 fusion peptide

scientific article published in August 2002

Dendritic Cells from HIV Controllers Have Low Susceptibility to HIV-1 Infection In Vitro but High Capacity to Capture HIV-1 Particles

scientific article

Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset

scientific article

Elevated IP10 levels are associated with immune activation and low CD4+ T-cell counts in HIV controller patients

article

Ex vivo T cell–based HIV suppression assay to evaluate HIV-specific CD8+ T-cell responses

article

First Dominique Dormont International Conference on "Host-pathogen interactions in chronic infections - viral and host determinants of HCV, HCMV, and HIV infections"

scientific article

HIV Controllers Have Low Inflammation Associated with a Strong HIV-Specific Immune Response in Blood

scientific article published on 01 May 2019

HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype

scholarly article

HIV controllers: a genetically determined or inducible phenotype?

scientific article published on July 2013

HIV controllers: how do they tame the virus?

scientific article published on 5 November 2007

HIV controllers: to treat or not to treat? Is that the right question?

scientific article published on 14 October 2019

HIV cure research: advances and prospects

scientific article

HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry

scientific article published on 01 September 2019

HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report

scientific article published on 9 December 2015

HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection

scientific article published on 6 September 2017

Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses

scientific article

High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers

scientific article

High eomesodermin expression among CD57+ CD8+ T cells identifies a CD8+ T cell subset associated with viral control during chronic human immunodeficiency virus infection

scientific article published on 6 August 2014

Immediate T-Helper 17 Polarization Upon Triggering CD11b/c on HIV-Exposed Dendritic Cells.

scientific article

Immune Responses to Retroviruses.

scientific article published on 12 January 2018

Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?

scientific article

Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency

scientific article published on 13 October 2012

Immunologic and Virologic Progression in HIV Controllers: The Role of Viral "Blips" and Immune Activation in the ANRS CO21 CODEX Study.

scientific article published on 6 July 2015

Immunometabolism and HIV-1 pathogenesis: food for thought

scientific article published on 06 August 2020

Immunovirologic control 24 months after interruption of antiretroviral therapy initiated close to HIV seroconversion

scientific article published in March 2013

Interfacial pre-transmembrane domains in viral proteins promoting membrane fusion and fission.

scientific article published on 03 January 2008

International AIDS Society global scientific strategy: towards an HIV cure 2016.

scientific article published on 11 July 2016

Kidney transplantation in an elite HIV controller: limited impact of immunosuppressive therapy on viro-immunological status

scientific article published on 6 March 2012

Ku80 participates in the targeting of retroviral transgenes to the chromatin of CHO cells.

scientific article published on 16 May 2007

Long-Term Spontaneous Control of HIV-1 Is Related to Low Frequency of Infected Cells and Inefficient Viral Reactivation

scientific article published on 27 April 2016

Long-term control of simian immunodeficiency virus (SIV) in cynomolgus macaques not associated with efficient SIV-specific CD8+ T-cell responses

scientific article

Metabolic plasticity of HIV-specific CD8+ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection

scientific article published on 12 July 2019

NKG2D expression on HIV-specific CD8+ T cells is reduced in viremic HIV-1-infected patients but maintained in HIV controllers

scientific article published in January 2013

Natural resistance to HIV infection: lessons learned from HIV‐exposed uninfected individuals.

scientific article published in November 2010

Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks

scientific article

Polyfunctional HIV-specific T cells in Post-Treatment Controllers

scientific article

Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study

scientific article

Posttreatment controllers: what do they tell us?

scientific article

Potential role for HIV-specific CD38-/HLA-DR+ CD8+ T cells in viral suppression and cytotoxicity in HIV controllers

scientific article

Pre-transmembrane sequence of Ebola glycoprotein. Interfacial hydrophobicity distribution and interaction with membranes.

scientific article published on January 2003

Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers.

scientific article

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

Quantitative real-time analysis of HIV-1 gene expression dynamics in single living primary cells

scientific article published in June 2006

Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)

article

Reply to Pauls et al.: p21 is a master regulator of HIV replication in macrophages through dNTP synthesis block

scientific article published on April 2014

Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers

scientific article

SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity

scientific article published on 24 February 2021

SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends

scientific article published on 08 June 2020

Safety of CD34 Hematopoietic Stem Cells and CD4 T Lymphocytes Transduced with LVsh5/C46 in HIV-1 Infected Patients with High-Risk Lymphoma

article

Sphingomyelin and cholesterol promote HIV-1 gp41 pretransmembrane sequence surface aggregation and membrane restructuring.

scientific article

Strong ifitm1 Expression in CD4 T Cells in HIV Controllers Is Correlated With Immune Activation

scientific article published on 19 August 2016

The Yellow Brick Road towards HIV Eradication

scientific article published on 06 May 2019

The characteristic CD8+ T cell response in HIV controllers: An objective to achieve?

article

The hydrophobic internal region of bovine prion protein shares structural and functional properties with HIV type 1 fusion peptide

scientific article

The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate

scientific article published on February 2014

The pre-transmembrane region of the human immunodeficiency virus type-1 glycoprotein: a novel fusogenic sequence

scientific article published in July 2000

The proportion of CD57+ cells among effector CD8+ T cells is lower HIV controllers compared to ART treated patients

Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents

scientific article published on 11 January 2017

Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1

scientific article published on 01 May 2020

What is the significance of posttreatment control of HIV infection vis-à-vis functional cure?

scientific article published in February 2014

Will it be possible to live without antiretroviral therapy?

scientific article published on May 2013

p21 Restricts HIV-1 in Monocyte-Derived Dendritic Cells through the Reduction of Deoxynucleoside Triphosphate Biosynthesis and Regulation of SAMHD1 Antiviral Activity

scientific article published on 20 September 2017

p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway

scientific article published on 30 September 2013

List of works by Asier Sáez-Cirión

Antibodies attenuate the capacity of dendritic cells to stimulate HIV-specific cytotoxic T lymphocytes

Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity

Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration

Both HLA-B*57 and plasma HIV RNA levels contribute to the HIV-specific CD8+ T cell response in HIV controllers

Cellular Determinants of HIV Persistence on Antiretroviral Therapy

Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection

Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission

Conformational transitions of membrane-bound HIV-1 fusion peptide

Dendritic Cells from HIV Controllers Have Low Susceptibility to HIV-1 Infection In Vitro but High Capacity to Capture HIV-1 Particles

Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset

Elevated IP10 levels are associated with immune activation and low CD4+ T-cell counts in HIV controller patients

Ex vivo T cell–based HIV suppression assay to evaluate HIV-specific CD8+ T-cell responses

First Dominique Dormont International Conference on "Host-pathogen interactions in chronic infections - viral and host determinants of HCV, HCMV, and HIV infections"

HIV Controllers Have Low Inflammation Associated with a Strong HIV-Specific Immune Response in Blood

HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype

HIV controllers: a genetically determined or inducible phenotype?

HIV controllers: how do they tame the virus?

HIV controllers: to treat or not to treat? Is that the right question?

HIV cure research: advances and prospects

HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry

HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report

HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection

Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses

High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers

High eomesodermin expression among CD57+ CD8+ T cells identifies a CD8+ T cell subset associated with viral control during chronic human immunodeficiency virus infection

Immediate T-Helper 17 Polarization Upon Triggering CD11b/c on HIV-Exposed Dendritic Cells.

Immune Responses to Retroviruses.

Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?

Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency

Immunologic and Virologic Progression in HIV Controllers: The Role of Viral "Blips" and Immune Activation in the ANRS CO21 CODEX Study.

Immunometabolism and HIV-1 pathogenesis: food for thought

Immunovirologic control 24 months after interruption of antiretroviral therapy initiated close to HIV seroconversion

Interfacial pre-transmembrane domains in viral proteins promoting membrane fusion and fission.

International AIDS Society global scientific strategy: towards an HIV cure 2016.

Kidney transplantation in an elite HIV controller: limited impact of immunosuppressive therapy on viro-immunological status

Ku80 participates in the targeting of retroviral transgenes to the chromatin of CHO cells.

Long-Term Spontaneous Control of HIV-1 Is Related to Low Frequency of Infected Cells and Inefficient Viral Reactivation

Long-term control of simian immunodeficiency virus (SIV) in cynomolgus macaques not associated with efficient SIV-specific CD8+ T-cell responses

Metabolic plasticity of HIV-specific CD8+ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection

NKG2D expression on HIV-specific CD8+ T cells is reduced in viremic HIV-1-infected patients but maintained in HIV controllers

Natural resistance to HIV infection: lessons learned from HIV‐exposed uninfected individuals.

Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks

Polyfunctional HIV-specific T cells in Post-Treatment Controllers

Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study

Posttreatment controllers: what do they tell us?

Potential role for HIV-specific CD38-/HLA-DR+ CD8+ T cells in viral suppression and cytotoxicity in HIV controllers

Pre-transmembrane sequence of Ebola glycoprotein. Interfacial hydrophobicity distribution and interaction with membranes.

Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers.

Proceedings of the Frontiers of Retrovirology Conference 2016.

Quantitative real-time analysis of HIV-1 gene expression dynamics in single living primary cells

Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)

Reply to Pauls et al.: p21 is a master regulator of HIV replication in macrophages through dNTP synthesis block

Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers

SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity

SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends

Safety of CD34 Hematopoietic Stem Cells and CD4 T Lymphocytes Transduced with LVsh5/C46 in HIV-1 Infected Patients with High-Risk Lymphoma

Sphingomyelin and cholesterol promote HIV-1 gp41 pretransmembrane sequence surface aggregation and membrane restructuring.

Strong ifitm1 Expression in CD4 T Cells in HIV Controllers Is Correlated With Immune Activation

The Yellow Brick Road towards HIV Eradication

The characteristic CD8+ T cell response in HIV controllers: An objective to achieve?

The hydrophobic internal region of bovine prion protein shares structural and functional properties with HIV type 1 fusion peptide

The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate

The pre-transmembrane region of the human immunodeficiency virus type-1 glycoprotein: a novel fusogenic sequence

The proportion of CD57+ cells among effector CD8+ T cells is lower HIV controllers compared to ART treated patients

Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents

Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1

What is the significance of posttreatment control of HIV infection vis-à-vis functional cure?

Will it be possible to live without antiretroviral therapy?

p21 Restricts HIV-1 in Monocyte-Derived Dendritic Cells through the Reduction of Deoxynucleoside Triphosphate Biosynthesis and Regulation of SAMHD1 Antiviral Activity

p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway