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List of works by Jian Yang

10 Years of GWAS Discovery: Biology, Function, and Translation

scientific article

3D graphical visualization of the genetic architectures underlying complex traits in multiple environments

scholarly article by Cheng-cheng Hu et al published April 2007 in Journal of Zhejiang University. Science. A

52 Genetic Loci Influencing Myocardial Mass

scientific article

A Commentary on ‘Common SNPs Explain a Large Proportion of the Heritability for Human Height’ by Yang et al. (2010) ⬇️

scientific article published on December 1, 2010

A plethora of pleiotropy across complex traits

scientific article published on June 2016

A resource-efficient tool for mixed model association analysis of large-scale data

A resource-efficient tool for mixed model association analysis of large-scale data

scientific article published on 25 November 2019

Across-cohort QC analyses of GWAS summary statistics from complex traits

scientific article

Additive genetic variation in schizophrenia risk is shared by populations of African and European descent

scientific article published on 15 August 2013

Advantages and pitfalls in the application of mixed-model association methods

scientific article published on February 2014

Analysis of DNA methylation associates the cystine-glutamate antiporter SLC7A11 with risk of Parkinson's disease

scientific article published on 06 March 2020

Assessing the genetic overlap between BMI and cognitive function

scientific article published on 9 February 2016

Association Between Population Density and Genetic Risk for Schizophrenia

Author Correction: Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes

scientific article published on 01 April 2019

Author reply to A commentary on Pitfalls of predicting complex traits from SNPs

scientific article published on December 2013

Autosomal genetic control of human gene expression does not differ across the sexes

scientific article published on December 2016

Biological interpretation of genome-wide association studies using predicted gene functions

scientific article published on 19 January 2015

Causal associations between risk factors and common diseases inferred from GWAS summary data

scientific article published on 15 January 2018

Childhood intelligence is heritable, highly polygenic and associated with FNBP1L

scientific article

Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model

article

Common SNPs explain a large proportion of the heritability for human height

scientific article (publication date: July 2010)

Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion.

scientific article published on 17 April 2012

Comparing apples and oranges: equating the power of case-control and quantitative trait association studies

scientific article published in April 2010

Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits

article

Concepts, estimation and interpretation of SNP-based heritability

scientific article published on August 2017

Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders

scientific article published on 12 May 2020

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

scientific article published on 18 March 2012

Constraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression

scientific article published on 9 June 2017

Correction: GWAS on family history of Alzheimer's disease.

scientific article

Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis.

scientific article published on 20 September 2017

DNA evidence for strong genetic stability and increasing heritability of intelligence from age 7 to 12 ⬇️

scientific article published on January 29, 2013

DNA evidence for strong genome-wide pleiotropy of cognitive and learning abilities

scientific article published on 23 April 2013

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Detection and quantification of inbreeding depression for complex traits from SNP data

scientific article

Dissection of genetic variation and evidence for pleiotropy in male pattern baldness

scientific article published in Nature Communications

Dominance genetic variation contributes little to the missing heritability for human complex traits

scientific article

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs.

scientific article

Estimation and partition of heritability in human populations using whole-genome analysis methods.

scientific article

Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood

scientific article

Evidence of inbreeding depression on human height

scientific article

FTO genotype is associated with phenotypic variability of body mass index

scientific article published on 16 September 2012

Fast set-based association analysis using summary data from GWAS identifies novel gene loci for human complex traits

scientific article

Five years of GWAS discovery

scientific article

From Galton to GWAS: quantitative genetics of human height

scientific article published on December 2010

GCTA-GREML accounts for linkage disequilibrium when estimating genetic variance from genome-wide SNPs

scientific article published on 25 July 2016

GCTA: a tool for genome-wide complex trait analysis

scientific article (publication date: 7 January 2011)

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

scientific article published on 21 June 2013

GWAS on family history of Alzheimer's disease.

scientific article

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

article

Genetic analyses of medication-use and implications for precision medicine

Genetic analysis of grain yield conditioned on its component traits in rice (Oryza sativa L.)

article

Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility

scientific article published on 06 February 2021

Genetic contributions to stability and change in intelligence from childhood to old age.

scientific article

Genetic control of RNA splicing and its distinct role in complex trait variation

scientific article published in 2022

Genetic correlates of social stratification in Great Britain

scientific article published on 21 October 2019

Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood

scientific article published on 7 September 2017

Genetic mechanisms of critical illness in Covid-19

scientific article published on 11 December 2020

Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome

scientific article published in Scientific Reports

Genetic signatures of high-altitude adaptation in Tibetans

scientific article

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

scientific article

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

scientific article published on 18 April 2016

Genetics of rheumatoid arthritis contributes to biology and drug discovery

scientific article

Genome partitioning of genetic variation for complex traits using common SNPs

scientific article

Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes

scientific article

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

scientific article published in Nature Communications

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

scientific article published on 26 April 2018

Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus

scientific article published on 06 January 2013

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

scientific article published on 25 July 2016

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

scientific article published on 14 January 2019

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

scientific article published on 09 January 2020

Genome-wide association studies establish that human intelligence is highly heritable and polygenic

scientific article

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

scientific article published on 02 April 2020

Genome-wide association study identifies 74 loci associated with educational attainment

scientific article published on 11 May 2016

Genome-wide association study of medication-use and associated disease in the UK Biobank

scientific article published on 23 April 2019

Genome-wide genetic homogeneity between sexes and populations for human height and body mass index

scientific article published on 22 October 2015

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Genomic inflation factors under polygenic inheritance

scientific article

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

scientific article published on 14 August 2019

Genotype-covariate interaction effects and the heritability of adult body mass index

scientific article published on 10 July 2017

Global genetic differentiation of complex traits shaped by natural selection in humans.

scientific article

Hemani et al. reply

scientific article published on October 2014

Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis

scientific article

Human fertility, molecular genetics, and natural selection in modern societies.

scientific article published on 3 June 2015

Hundreds of variants clustered in genomic loci and biological pathways affect human height

scientific article

Identification of 55,000 Replicated DNA Methylation QTL

scientific article published in Scientific Reports

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

scientific article published on 14 April 2013

Identification of miRNAs as non-invasive biomarkers for early diagnosis of lung cancers

scientific article published on 3 November 2016

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci ⬇️

scientific article published on June 9, 2013

Identifying differentially expressed genes in human acute leukemia and mouse brain microarray datasets utilizing QTModel

scientific article

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood.

scientific article published on 11 June 2018

Imprint of assortative mating on the human genome

scientific article published on 26 November 2018

Improved polygenic prediction by Bayesian multiple regression on summary statistics

scientific article published on 08 November 2019

Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations

scientific article

Improving genetic prediction by leveraging genetic correlations among human diseases and traits.

scientific article published on 7 March 2018

Inference in Psychiatry via 2-Sample Mendelian Randomization-From Association to Causal Pathway?

scientific article published in November 2017

Inference of the genetic architecture underlying BMI and height with the use of 20,240 sibling pairs

scientific article published on 31 October 2013

Influence of outliers on QTL mapping for complex traits

scientific article published on December 2008

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

scientific article

Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

scientific article published on 2 March 2018

Is Schizophrenia a Risk Factor for Breast Cancer?—Evidence From Genetic Data

scientific article published on 01 October 2019

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

scientific article published on 2 February 2015

Leveraging GWAS for complex traits to detect signatures of natural selection in humans

scientific article published on 16 June 2018

Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding

scientific article

Mapping interspecific genetic architecture in a host-parasite interaction system

scientific article published on February 2008

Mapping the genetic architecture of complex traits in experimental populations

scientific article published on 25 April 2007

Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease

scientific article published on 27 March 2019

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article

Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism

scientific article

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

scientific article published on 26 March 2021

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry

article by Sara Pulit et al published 1 January 2019 in Human Molecular Genetics

Methods for predicting superior genotypes under multiple environments based on QTL effects

Mixed model with correction for case-control ascertainment increases association power

scientific article published on 16 April 2015

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

scientific article

Multiple associated variants increase the heritability explained for plasma lipids and coronary artery disease

scientific article

Narrow-sense heritability estimation of complex traits using identity-by-descent information

scientific article published on 28 March 2018

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

scientific article published on February 2016

Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans

scientific article

Partitioning Phenotypic Variance Due to Parent-of-Origin Effects Using Genomic Relatedness Matrices

scientific article published on 2 November 2017

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture

scientific article published in October 2013

Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals

scientific article

Pitfalls of predicting complex traits from SNPs

scientific article

Population genetic differentiation of height and body mass index across Europe

scientific article

Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits

scientific article

Predictive accuracy of combined genetic and environmental risk scores

scientific article published on 26 November 2017

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

scientific article published on 28 April 2020

QTLNetwork: mapping and visualizing genetic architecture of complex traits in experimental populations

scholarly article by Jian Yang et al published 17 January 2008 in Bioinformatics

QTLNetworkR: an interactive R package for QTL visualization

scientific article

Quantifying the mapping precision of genome-wide association studies using whole-genome sequencing data

scientific article

RETRACTED ARTICLE: Detection and replication of epistasis influencing transcription in humans

retracted scholarly article

Replicability and robustness of genome-wide-association studies for behavioral traits

scientific article

Reply to Kardos et al.: Estimation of inbreeding depression from SNP data

article published in the Proceedings of the National Academy of Sciences of the United States of America

Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes

scientific article published on 14 January 2019

Response to 'Predicting the diagnosis of autism spectrum disorder using gene pathway analysis'.

scientific article published on 22 October 2013

Response to Browning and Browning

scientific article published in July 2011

Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture

scientific article published on 23 September 2020

Seventy-five genetic loci influencing the human red blood cell

scientific article published on 5 December 2012

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

scientific article

Signatures of negative selection in the genetic architecture of human complex traits

scientific article published on 16 April 2018

Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis

scientific article published on 27 February 2020

Sporadic cases are the norm for complex disease

scientific article

Statistical power to detect genetic (co)variance of complex traits using SNP data in unrelated samples.

scientific article

The Genetic Architecture of Gene Expression in Peripheral Blood

scientific article published on 24 December 2016

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

The effect of X-linked dosage compensation on complex trait variation

scientific article published on 08 July 2019

The genetic architecture of pediatric cognitive abilities in the Philadelphia Neurodevelopmental Cohort

scientific article

The genetic interpretation of area under the ROC curve in genomic profiling

scientific article

The transcriptional landscape of age in human peripheral blood

scientific article

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

scientific article published on 31 July 2020

Transformation of Summary Statistics from Linear Mixed Model Association on All-or-None Traits to Odds Ratio

scientific article published on 2 February 2018

Tumor mutational burden is polygenic and genetically associated with complex traits and diseases

scientific article published on 08 January 2021

Ubiquitous polygenicity of human complex traits: genome-wide analysis of 49 traits in Koreans

scientific article

Uncovering genetic regulatory network divergence between duplicate genes using yeast eQTL landscape

scientific article

Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in Chinese.

scientific article published on 17 November 2017

Widespread signatures of natural selection across human complex traits and functional genomic categories

scientific article published in 2021

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