List of works - Angela Simpson

17q12-21 and asthma: interactions with early-life environmental exposures

scientific article published on 6 March 2013

17q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom

scientific article

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

scientific article

A protocol for a systematic review to identify allergenic tree nuts and the molecules responsible for their allergenic properties

scientific article published on 05 June 2017

Air pollution and respiratory infections during early childhood: an analysis of 10 European birth cohorts within the ESCAPE Project

scientific article published on 22 October 2013

Air pollution exposure and lung function in children: the ESCAPE project

scientific article published on 27 September 2013

Allergen avoidance in the primary prevention of asthma

scientific article published on February 2004

Allergen avoidance in the secondary and tertiary prevention of allergic diseases: does it work?

scientific article

Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood

scientific article published on 13 April 2011

Allergy is an important factor in asthma exacerbation: A Pro/Con Debate

scientific article published on 27 August 2010

Allergy or tolerance in children sensitized to peanut: Prevalence and differentiation using component-resolved diagnostics

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.

scientific article published in August 2018

Animal Allergens

Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study

scientific article published on 14 May 2014

Associations between particulate matter elements and early-life pneumonia in seven birth cohorts: results from the ESCAPE and TRANSPHORM projects

scientific article published on 29 May 2014

Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood

scientific article

Asthma severity, polymorphisms in 20p13 and their interaction with tobacco smoke exposure

scientific article published in February 2013

Atopic wheezing and early life antibiotic exposure: a nested case-control study

scientific article published in May 2006

Behavior problems antecede the development of wheeze in childhood: a birth cohort study

scientific article published on 19 November 2004

Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study

scientific article

Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop

scientific article

Body mass index in young children and allergic disease: gender differences in a longitudinal study

scientific article published on 16 August 2010

Challenges in identifying asthma subgroups using unsupervised statistical learning techniques

scientific article published on December 2013

Challenges in interpreting allergen microarrays in relation to clinical symptoms: a machine learning approach

scientific article

Characterizing wheeze phenotypes to identify endotypes of childhood asthma, and the implications for future management

scientific article published on October 2013

Current mite, cat, and dog allergen exposure, pet ownership, and sensitization to inhalant allergens in adults

scientific article

Day-care attendance, position in sibship, and early childhood wheezing: a population-based birth cohort study

scientific article published in September 2008

Developmental profiles of eczema, wheeze, and rhinitis: two population-based birth cohort studies

scientific article

Dietary antioxidant intake, allergic sensitization and allergic diseases in young children

scientific article published in October 2009

Different definitions of atopic dermatitis: impact on prevalence estimates and associated risk factors

scientific article published on 26 June 2019

Differing associations of BMI and body fat with asthma and lung function in children

scientific article

Dimensions of respiratory symptoms in preschool children: population-based birth cohort study

scientific article published on 20 March 2008

Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma

scientific article published on 12 April 2017

Domestic allergen and endotoxin exposure and allergic sensitization in Cyprus.

scientific article

Dust mite allergen avoidance as a preventive and therapeutic strategy

scientific article published on November 2006

Dust mite allergens are carried on not only large particles

scientific article published on 01 November 1999

Early life environmental control: effect on symptoms, sensitization, and lung function at age 3 years

scientific article

Early pet exposure: friend or foe?

scientific article

Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies

scientific article

Effects of long-term exposure to PM10 and NO2 on asthma and wheeze in a prospective birth cohort

scientific article published on 2 September 2013

Elemental composition of particulate matter and the association with lung function

scientific article published in September 2014

Endotoxin Exposure, CD14, and Allergic Disease

article

Environmental allergen exposure, sensitisation and asthma: from whole populations to individuals at risk

scientific article published in October 2004

Environmental exposures, genetic predisposition and allergic diseases: one size never fits all.

scientific article published in April 2006

European birth cohort studies on asthma and atopic diseases: I. Comparison of study designs -- a GALEN initiative.

scientific article

European birth cohort studies on asthma and atopic diseases: II. Comparison of outcomes and exposures--a GA2LEN initiative

scientific article published on September 2006

Evolution of IgE responses to multiple allergen components throughout childhood

scientific article published on 8 February 2018

Exhaled Breath Condensate pH and Childhood Asthma

Food protein–induced enterocolitis syndrome can occur in adults

article

Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants

scientific article

Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure

scientific article published in June 2008

Gene-environment interactions in the development of asthma and atopy

scientific article published on June 2012

Genetic variation in vascular endothelial growth factor-a and lung function

scientific article

Genome-wide association study to identify genetic determinants of severe asthma.

scientific article

Housing characteristics and mite allergen levels: to humidity and beyond

scientific article published on 01 June 2001

IgE antibody quantification and the probability of wheeze in preschool children

scientific article

Immune System Modeling with Infer.NET

Impact of rhinitis on asthma severity in school-age children

scientific article

Increased serum-soluble interleukin-5 receptor alpha level precedes the development of eczema in children.

scientific article

Insoluble and soluble roasted walnut proteins retain antibody reactivity.

scientific article published on 3 September 2015

Interaction between glutathione S-transferase variants, maternal smoking and childhood wheezing changes with age.

scientific article published on 3 June 2013

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing

scientific article published on 29 July 2013

Long-term exposure to PM10 and NO2 in association with lung volume and airway resistance in the MAAS birth cohort

scientific article published on 18 June 2013

Lung function at age 3 years: effect of pet ownership and exposure to indoor allergens

scientific article published in October 2004

Manchester cohort

Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts

article

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

scientific article

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

scientific article

Methylation of IL-2 promoter at birth alters the risk of asthma exacerbations during childhood.

scientific article

Modelling air pollution for epidemiologic research--Part I: A novel approach combining land use regression and air dispersion.

scientific article

Modelling air pollution for epidemiologic research--part II: predicting temporal variation through land use regression.

scientific article

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

scientific article published on 22 December 2017

Multiple atopy phenotypes and their associations with asthma: similar findings from two birth cohorts

scientific article published on 29 April 2013

NAC Manchester Asthma and Allergy Study (NACMAAS): risk factors for asthma and allergic disorders in adults

scientific article published on March 2001

Neurturin regulates the lung-resident macrophage inflammatory response to viral infection

scientific article published on 05 October 2020

Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years

scientific article

Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations

scientific article

Pediatric asthma and development of atopy

scientific article published on April 2013

Performance of a microenviromental model for estimating personal NO2 exposure in children

article

Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function

scientific article (publication date: July 2005)

Polymorphisms of endotoxin pathway and endotoxin exposure:in vitroIgE synthesis and replication in a birth cohort

scientific article published on 20 September 2014

Predicting phenotypes of asthma and eczema with machine learning

scientific article

Preventing Severe Asthma Exacerbations in Children. A Randomized Trial of Mite-Impermeable Bedcovers

scientific article published on 10 March 2017

Prevention of allergic sensitization by environmental control

scientific article published on September 2009

Quantification of atopy and the probability of rhinitis in preschool children: a population-based birth cohort study

scientific article published on 05 September 2007

Quantification of specific IgE to whole peanut extract and peanut components in prediction of peanut allergy

Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4

scientific article published on 16 November 2021

Response

Rhinoconjunctivitis in 5-year-old children: a population-based birth cohort study.

scientific article published on April 2007

Skin test reactivity to natural and recombinant Blomia and Dermatophagoides spp. allergens among mite allergic patients in the UK.

scientific article published on January 2003

Staphylococcus aureus sensitization and allergic disease in early childhood: Population-based birth cohort study

article published in 2007

The effect of air filtration on airborne dog allergen

scientific article published on 01 May 1999

The role of allergen avoidance in primary and secondary prevention

The role of lipopolysaccharide in the development of atopy in humans

scientific article

Trajectories of childhood immune development and respiratory health relevant to asthma and allergy

scientific article published on 15 October 2018

Trajectories of lung function during childhood

scientific article

Vacuum cleaners and airborne dog allergen

scientific article published on 01 April 1999

What are we learning from genetic cohort studies?

scientific article published on 5 June 2006

Wheeze phenotypes and lung function in preschool children

scientific article published on 22 October 2004

List of works by Angela Simpson

17q12-21 and asthma: interactions with early-life environmental exposures

17q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

A protocol for a systematic review to identify allergenic tree nuts and the molecules responsible for their allergenic properties

Air pollution and respiratory infections during early childhood: an analysis of 10 European birth cohorts within the ESCAPE Project

Air pollution exposure and lung function in children: the ESCAPE project

Allergen avoidance in the primary prevention of asthma

Allergen avoidance in the secondary and tertiary prevention of allergic diseases: does it work?

Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood

Allergy is an important factor in asthma exacerbation: A Pro/Con Debate

Allergy or tolerance in children sensitized to peanut: Prevalence and differentiation using component-resolved diagnostics

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.

Animal Allergens

Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study

Associations between particulate matter elements and early-life pneumonia in seven birth cohorts: results from the ESCAPE and TRANSPHORM projects

Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood

Asthma severity, polymorphisms in 20p13 and their interaction with tobacco smoke exposure

Atopic wheezing and early life antibiotic exposure: a nested case-control study

Behavior problems antecede the development of wheeze in childhood: a birth cohort study

Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study

Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop

Body mass index in young children and allergic disease: gender differences in a longitudinal study

Challenges in identifying asthma subgroups using unsupervised statistical learning techniques

Challenges in interpreting allergen microarrays in relation to clinical symptoms: a machine learning approach

Characterizing wheeze phenotypes to identify endotypes of childhood asthma, and the implications for future management

Current mite, cat, and dog allergen exposure, pet ownership, and sensitization to inhalant allergens in adults

Day-care attendance, position in sibship, and early childhood wheezing: a population-based birth cohort study

Developmental profiles of eczema, wheeze, and rhinitis: two population-based birth cohort studies

Dietary antioxidant intake, allergic sensitization and allergic diseases in young children

Different definitions of atopic dermatitis: impact on prevalence estimates and associated risk factors

Differing associations of BMI and body fat with asthma and lung function in children

Dimensions of respiratory symptoms in preschool children: population-based birth cohort study

Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma

Domestic allergen and endotoxin exposure and allergic sensitization in Cyprus.

Dust mite allergen avoidance as a preventive and therapeutic strategy

Dust mite allergens are carried on not only large particles

Early life environmental control: effect on symptoms, sensitization, and lung function at age 3 years

Early pet exposure: friend or foe?

Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies

Effects of long-term exposure to PM10 and NO2 on asthma and wheeze in a prospective birth cohort

Elemental composition of particulate matter and the association with lung function

Endotoxin Exposure, CD14, and Allergic Disease

Environmental allergen exposure, sensitisation and asthma: from whole populations to individuals at risk

Environmental exposures, genetic predisposition and allergic diseases: one size never fits all.

European birth cohort studies on asthma and atopic diseases: I. Comparison of study designs -- a GALEN initiative.

European birth cohort studies on asthma and atopic diseases: II. Comparison of outcomes and exposures--a GA2LEN initiative

Evolution of IgE responses to multiple allergen components throughout childhood

Exhaled Breath Condensate pH and Childhood Asthma

Food protein–induced enterocolitis syndrome can occur in adults

Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants

Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure

Gene-environment interactions in the development of asthma and atopy

Genetic variation in vascular endothelial growth factor-a and lung function

Genome-wide association study to identify genetic determinants of severe asthma.

Housing characteristics and mite allergen levels: to humidity and beyond

IgE antibody quantification and the probability of wheeze in preschool children

Immune System Modeling with Infer.NET

Impact of rhinitis on asthma severity in school-age children

Increased serum-soluble interleukin-5 receptor alpha level precedes the development of eczema in children.

Insoluble and soluble roasted walnut proteins retain antibody reactivity.

Interaction between glutathione S-transferase variants, maternal smoking and childhood wheezing changes with age.

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing

Long-term exposure to PM10 and NO2 in association with lung volume and airway resistance in the MAAS birth cohort

Lung function at age 3 years: effect of pet ownership and exposure to indoor allergens

Manchester cohort

Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

Methylation of IL-2 promoter at birth alters the risk of asthma exacerbations during childhood.

Modelling air pollution for epidemiologic research--Part I: A novel approach combining land use regression and air dispersion.

Modelling air pollution for epidemiologic research--part II: predicting temporal variation through land use regression.

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Multiple atopy phenotypes and their associations with asthma: similar findings from two birth cohorts

NAC Manchester Asthma and Allergy Study (NACMAAS): risk factors for asthma and allergic disorders in adults

Neurturin regulates the lung-resident macrophage inflammatory response to viral infection

Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years

Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations

Pediatric asthma and development of atopy

Performance of a microenviromental model for estimating personal NO2 exposure in children