List of works - Xavier Darzacq

A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains ⬇️

scientific article

A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs.

scientific article

A dynamic interplay of enhancer elements regulates Klf4 expression in naïve pluripotency

scientific article published in September 2017

A dynamic mode of mitotic bookmarking by transcription factors

scientific article published on 18 November 2016

A new class of disordered elements controls DNA replication through initiator self-assembly

scientific article published on 27 September 2019

A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting

scientific article

A stable mode of bookmarking by TBP recruits RNA polymerase II to mitotic chromosomes

scientific article published on 25 June 2018

A transgenic mouse for in vivo detection of endogenous labeled mRNA.

scientific article

Accessing the third dimension in localization-based super-resolution microscopy

scientific article

Architectural Features of 3D Genome Organization Revealed by Counting CTCF and Cohesin Molecules

scholarly article published 17 July 2018

Assessing the localization of centrosomal proteins by PALM/STORM nanoscopy

scientific article published on 18 October 2011

CTCF and cohesin regulate chromatin loop stability with distinct dynamics

scientific article

CTCF sites display cell cycle-dependent dynamics in factor binding and nucleosome positioning

scientific article published on 17 January 2019

Caffeine prevents transcription inhibition and P-TEFb/7SK dissociation following UV-induced DNA damage

scientific article

Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs

scientific article

Cohesin residency determines chromatin loop patterns

scientific article published on 10 November 2020

Correction: Caffeine Prevents Transcription Inhibition and P-TEFb/7SK Dissociation Following UV-Induced DNA Damage

scientific article published in PLoS ONE

Cotranscriptional recognition of human intronic box H/ACA snoRNAs occurs in a splicing-independent manner.

scientific article published in April 2006

Dense Bicoid hubs accentuate binding along the morphogen gradient

scientific article published in September 2017

Determining cellular CTCF and cohesin abundances to constrain 3D genome models

scientific article published on 17 June 2019

Dynamic association and localization of human H/ACA RNP proteins

scientific article

Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos

Dynamic multifactor hubs interact transiently with sites of active transcription in embryos

scientific article published on 27 December 2018

Dynamic sorting of nuclear components into distinct nucleolar caps during transcriptional inhibition

scientific article

Dynamics of single mRNPs in nuclei of living cells.

scientific article

Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

scientific article published on 07 May 2019

FISH-quant: automatic counting of transcripts in 3D FISH images

scientific article published on 01 April 2013

Fast multicolor 3D imaging using aberration-corrected multifocus microscopy.

scientific article

Gene expression within a dynamic nuclear landscape

scientific article

Geometry of the nucleus: a perspective on gene expression regulation

scientific article

Guided nuclear exploration increases CTCF target search efficiency

scientific article published on 02 December 2019

High-frequency promoter firing links THO complex function to heavy chromatin formation

scientific article published on 7 November 2013

Imaging Transcription: Past, Present, and Future

scientific article

Imaging dynamic and selective low-complexity domain interactions that control gene transcription

scientific article published in Science

Imaging gene expression in single living cells.

scientific article

Imaging transcription in living cells.

scientific article published on January 2009

In vivo dynamics of RNA polymerase II transcription.

scientific article published on 05 August 2007

Intra-nuclear mobility and target search mechanisms of transcription factors: a single-molecule perspective on gene expression

scientific article published on 10 February 2012

Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9

scientific article

Master regulators in primary skin fibroblast fate reprogramming in a human ex vivo model of chronic wounds.

scientific article published on 9 December 2015

Mitochondria-associated yeast mRNAs and the biogenesis of molecular complexes.

scientific article

Modification of Sm small nuclear RNAs occurs in the nucleoplasmic Cajal body following import from the cytoplasm

scientific article

Multifocus microscopy with precise color multi-phase diffractive optics applied in functional neuronal imaging

scientific article

Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism

scientific article

Nucleolar factors direct the 2'-O-ribose methylation and pseudouridylation of U6 spliceosomal RNA

scientific article

PSF shaping using adaptive optics for three-dimensional single-molecule super-resolution imaging and tracking

scientific article published in February 2012

Probing the target search of DNA-binding proteins in mammalian cells using TetR as model searcher

scientific article

Processing of intron-encoded box C/D small nucleolar RNAs lacking a 5',3'-terminal stem structure

scientific article

Protein motion in the nucleus: from anomalous diffusion to weak interactions

scientific article published on 31 July 2018

Quantitative nanoscopy of inhibitory synapses: counting gephyrin molecules and receptor binding sites

scientific article published in July 2013

RNA asymmetric distribution and daughter/mother differentiation in yeast

scientific article published on December 2003

RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization

Real-time dynamics of RNA polymerase II clustering in live human cells

scientific article published on 4 July 2013

Recent evidence that TADs and chromatin loops are dynamic structures

scientific article

Robust model-based analysis of single-particle tracking experiments with Spot-On.

scientific article published on 4 January 2018

Role of the DHH1 gene in the regulation of monocarboxylic acids transporters expression in Saccharomyces cerevisiae

scientific article

Short exposure to the DNA intercalator DRAQ5 dislocates the transcription machinery and induces cell death.

scientific article

Single cell correlation fractal dimension of chromatin: a framework to interpret 3D single molecule super-resolution

scientific article published on January 2014

Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

scientific article

Splicing-independent recruitment of U1 snRNP to a transcription unit in living cells.

scientific article

Spot-On: robust model-based analysis of single-particle tracking experiments

Stable assembly of HIV-1 export complexes occurs cotranscriptionally.

scientific article published on 19 November 2013

Stepwise RNP assembly at the site of H/ACA RNA transcription in human cells

scientific article

Structure of the human SAGA coactivator complex

scientific article published on 22 November 2021

Super-resolution dynamic imaging of dendritic spines using a low-affinity photoconvertible actin probe

scientific article

Switch-like Arp2/3 activation upon WASP and WIP recruitment to an apparent threshold level by multivalent linker proteins in vivo

scientific article published on 16 August 2017

The SNARE Sec22b has a non-fusogenic function in plasma membrane expansion

scientific article published on 6 April 2014

The dynamic range of transcription

scientific article published on June 2008

The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing

scientific article published in 2011

Transcription activation depends on the length of the RNA polymerase II C-terminal domain

scientific article published on 08 February 2021

Transcription factors modulate c-Fos transcriptional bursts

scientific article

[Imaging of single molecules in live cells].

scientific article published on 25 May 2011

List of works by Xavier Darzacq

A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains ⬇️

A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs.

A dynamic interplay of enhancer elements regulates Klf4 expression in naïve pluripotency

A dynamic mode of mitotic bookmarking by transcription factors

A new class of disordered elements controls DNA replication through initiator self-assembly

A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting

A stable mode of bookmarking by TBP recruits RNA polymerase II to mitotic chromosomes

A transgenic mouse for in vivo detection of endogenous labeled mRNA.

Accessing the third dimension in localization-based super-resolution microscopy

Architectural Features of 3D Genome Organization Revealed by Counting CTCF and Cohesin Molecules

Assessing the localization of centrosomal proteins by PALM/STORM nanoscopy

CTCF and cohesin regulate chromatin loop stability with distinct dynamics

CTCF sites display cell cycle-dependent dynamics in factor binding and nucleosome positioning

Caffeine prevents transcription inhibition and P-TEFb/7SK dissociation following UV-induced DNA damage

Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs

Cohesin residency determines chromatin loop patterns

Correction: Caffeine Prevents Transcription Inhibition and P-TEFb/7SK Dissociation Following UV-Induced DNA Damage

Cotranscriptional recognition of human intronic box H/ACA snoRNAs occurs in a splicing-independent manner.

Dense Bicoid hubs accentuate binding along the morphogen gradient

Determining cellular CTCF and cohesin abundances to constrain 3D genome models

Dynamic association and localization of human H/ACA RNP proteins

Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos

Dynamic multifactor hubs interact transiently with sites of active transcription in embryos

Dynamic sorting of nuclear components into distinct nucleolar caps during transcriptional inhibition

Dynamics of single mRNPs in nuclei of living cells.

Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

FISH-quant: automatic counting of transcripts in 3D FISH images

Fast multicolor 3D imaging using aberration-corrected multifocus microscopy.

Gene expression within a dynamic nuclear landscape

Geometry of the nucleus: a perspective on gene expression regulation

Guided nuclear exploration increases CTCF target search efficiency

High-frequency promoter firing links THO complex function to heavy chromatin formation

Imaging Transcription: Past, Present, and Future

Imaging dynamic and selective low-complexity domain interactions that control gene transcription

Imaging gene expression in single living cells.

Imaging transcription in living cells.

In vivo dynamics of RNA polymerase II transcription.

Intra-nuclear mobility and target search mechanisms of transcription factors: a single-molecule perspective on gene expression

Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9

Master regulators in primary skin fibroblast fate reprogramming in a human ex vivo model of chronic wounds.

Mitochondria-associated yeast mRNAs and the biogenesis of molecular complexes.

Modification of Sm small nuclear RNAs occurs in the nucleoplasmic Cajal body following import from the cytoplasm

Multifocus microscopy with precise color multi-phase diffractive optics applied in functional neuronal imaging

Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism

Nucleolar factors direct the 2'-O-ribose methylation and pseudouridylation of U6 spliceosomal RNA

PSF shaping using adaptive optics for three-dimensional single-molecule super-resolution imaging and tracking

Probing the target search of DNA-binding proteins in mammalian cells using TetR as model searcher

Processing of intron-encoded box C/D small nucleolar RNAs lacking a 5',3'-terminal stem structure

Protein motion in the nucleus: from anomalous diffusion to weak interactions

Quantitative nanoscopy of inhibitory synapses: counting gephyrin molecules and receptor binding sites

RNA asymmetric distribution and daughter/mother differentiation in yeast

RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization

Real-time dynamics of RNA polymerase II clustering in live human cells

Recent evidence that TADs and chromatin loops are dynamic structures

Robust model-based analysis of single-particle tracking experiments with Spot-On.

Role of the DHH1 gene in the regulation of monocarboxylic acids transporters expression in Saccharomyces cerevisiae

Short exposure to the DNA intercalator DRAQ5 dislocates the transcription machinery and induces cell death.

Single cell correlation fractal dimension of chromatin: a framework to interpret 3D single molecule super-resolution

Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

Splicing-independent recruitment of U1 snRNP to a transcription unit in living cells.

Spot-On: robust model-based analysis of single-particle tracking experiments

Stable assembly of HIV-1 export complexes occurs cotranscriptionally.

Stepwise RNP assembly at the site of H/ACA RNA transcription in human cells

Structure of the human SAGA coactivator complex

Super-resolution dynamic imaging of dendritic spines using a low-affinity photoconvertible actin probe

Switch-like Arp2/3 activation upon WASP and WIP recruitment to an apparent threshold level by multivalent linker proteins in vivo

The SNARE Sec22b has a non-fusogenic function in plasma membrane expansion

The dynamic range of transcription

The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing

Transcription activation depends on the length of the RNA polymerase II C-terminal domain

Transcription factors modulate c-Fos transcriptional bursts

[Imaging of single molecules in live cells].