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List of works by Darrell N Kotton

A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells

scientific article published on 23 June 2020

A novel stem-cell population in adult liver with potent hematopoietic-reconstitution activity

scientific article published on 3 May 2005

A shift from cell cultures to creatures: in vivo imaging of small animals in experimental regenerative medicine.

scientific article

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

scientific article published on 19 November 2020

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

scientific article published on 01 January 2021

Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages

scientific article

Another notch in stem cell biology: Drosophila intestinal stem cells and the specification of cell fates.

scientific article published on February 2008

Are embryonic stem and induced pluripotent stem cells the same or different? Implications for their potential therapeutic use.

scientific article published in January 2012

Bone marrow-derived cells as progenitors of lung alveolar epithelium

scientific article published on 01 December 2001

Case records of the Massachusetts General Hospital. Case 2-2012. A 63-year-old woman with dyspnea and rapidly progressive respiratory failure

scientific article published on 01 January 2012

Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010

scientific article

Common genetic variation in humans impacts in vitro susceptibility to SARS-CoV-2 infection

scientific article published on 21 September 2020

Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells

scientific article published on 19 October 2020

Derivation of Endodermal Progenitors From Pluripotent Stem Cells

scientific article

Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells

scientific article published on 04 May 2018

Derivation of lung epithelium from bone marrow cells.

scientific article

Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells

scientific article published on 15 November 2019

Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells.

scientific article

Dual-promoter lentiviral system allows inducible expression of noxious proteins in macrophages.

scientific article

Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation.

scientific article

Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling.

scientific article published on 22 March 2017

Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells

scientific article published on April 2012

Enhanced reprogramming and cardiac differentiation of human keratinocytes derived from plucked hair follicles, using a single excisable lentivirus.

scientific article

Epigenetic mechanisms modulate thyroid transcription factor 1-mediated transcription of the surfactant protein B gene

scientific article

Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration

scientific article published on 19 October 2020

Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector

scientific article

Exogenous control of mammalian gene expression via modulation of translational termination

scientific article published on 6 August 2006

Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease

scientific article published on 23 July 2020

FOXO1 modulates osteoblast differentiation ⬇️

scientific article published on January 28, 2011

Failure of bone marrow to reconstitute lung epithelium

scientific article

Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood Using the STEMCCA Lentiviral Vector ⬇️

scientific article published on October 31, 2012

Generation of human induced pluripotent stem cells from peripheral blood using the STEMCCA lentiviral vector

scientific article published on 10 May 2013

Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells

scientific article published on 10 January 2020

Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.

scientific article published on October 2010

Human distal airways contain a multipotent secretory cell that can regenerate alveoli

Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors

scientific article published on 04 June 2020

Induced pluripotent stem cell generation using a single lentiviral stem cell cassette

scientific article published on March 2009

Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis.

scientific article published on 31 October 2013

Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics

scientific article published on January 2013

Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo.

scientific article

KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.

scientific article published on June 2013

Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors

scientific article published in 2013

Lung stem cells: new paradigms.

scientific article published on April 2004

Maintenance and repair of the lung endothelium does not involve contributions from marrow-derived endothelial precursor cells.

scientific article

Modeling pulmonary alveolar proteinosis with induced pluripotent stem cells

Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells.

scientific article published on 22 August 2012

Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19

scientific article published on 10 June 2020

Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes

scientific article published on 2 May 2011

Mouse ESC Differentiation to Nkx2.1+ Lung and Thyroid Progenitors

scientific article published on November 2012

Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells

scientific article published on 22 August 2020

Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification

scientific article

Programmatic change: lung disease research in the era of induced pluripotency

scientific article published on 7 October 2011

Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells.

scientific article

Pulmonary alveolar proteinosis: a bench-to-bedside story of granulocyte-macrophage colony-stimulating factor dysfunction.

scientific article published on August 2009

Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors

scientific article published on 30 January 2020

Reconstructing SARS-CoV-2 response signaling and regulatory networks

scientific article published on 13 October 2020

Regeneration and orthotopic transplantation of a bioartificial lung

article by Harald C Ott et al published 13 July 2010 in Nature Medicine

Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells

scientific article

Regenerative therapy for hypothyroidism: Mechanisms and possibilities

scientific article published on 19 November 2016

Residual expression of reprogramming factors affects the transcriptional program and epigenetic signatures of induced pluripotent stem cells

scientific article

Role of Nanog in the maintenance of marrow stromal stem cells during post natal bone regeneration.

scientific article published on 28 November 2011

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

scientific article published on 18 September 2020

SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

scientific article published on 30 June 2020

SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway

scientific article published on 28 October 2020

SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes

scientific article published on 25 September 2020

Self-Renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells ⬇️

scientific article published on April 6, 2012

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors

scientific article published on 17 November 2021

Side population cells and Bcrp1 expression in lung.

scientific article published on 7 March 2003

Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium.

scientific article published on 12 April 2018

Specific mesoderm subset derived from human pluripotent stem cells ameliorates microvascular pathology in type 2 diabetic mice

scientific article published on 04 March 2022

Stem cell antigen-1 expression in the pulmonary vascular endothelium

scientific article published on 28 February 2003

Sustained expression of alpha1-antitrypsin after transplantation of manipulated hematopoietic stem cells.

scientific article

Targeted correction and restored function of the CFTR gene in cystic fibrosis induced pluripotent stem cells.

scientific article

Telomere dysfunction induces metabolic and mitochondrial compromise.

scientific article

The 2012 Nobel Prize in physiology or medicine: democratizing pluripotency for lung researchers.

scientific article published in December 2012

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future

scientific article published on 01 April 2020

The Transcription Factors Grainyhead-like 2 and NK2-Homeobox 1 Form a Regulatory Loop That Coordinates Lung Epithelial Cell Morphogenesis and Differentiation ⬇️

scientific article published on September 6, 2012

The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation.

scientific article

The in vivo genetic program of murine primordial lung epithelial progenitors

scientific article published on 31 January 2020

Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1.

scientific article published on 25 January 2017

Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes

scientific article

Translational physiology: origin and phenotype of lung side population cells.

scientific article published on 26 March 2004

miR-129 regulates cell proliferation by downregulating Cdk6 expression

scientific article

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