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List of works by Gerard D. Wright

A Forward Chemical Screen Identifies Antibiotic Adjuvants in Escherichia coli ⬇️

scientific article published on June 22, 2012

A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene

scientific article

A macrophage-stimulating compound from a screen of microbial natural products.

scientific article

A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria.

scientific article

A small molecule discrimination map of the antibiotic resistance kinome

scientific article

A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor.

scientific article published on 11 April 2010

Accessorizing natural products: adding to nature's toolbox.

scientific article

Active site labeling of the gentamicin resistance enzyme AAC(6')-APH(2") by the lipid kinase inhibitor wortmannin

scientific article

Allostery trumps antibiotic resistance.

scientific article published in August 2005

Aminoglycoside antibiotic phosphotransferases are also serine protein kinases

scientific article

Aminoglycoside-modifying enzymes

scientific article

An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens

scientific article

An ecological perspective of microbial secondary metabolism

scientific article published on 15 April 2011

An in vitro screen of bacterial lipopolysaccharide biosynthetic enzymes identifies an inhibitor of ADP-heptose biosynthesis.

scientific article

An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria

scientific article

Analysis of the pi-pi stacking interactions between the aminoglycoside antibiotic kinase APH(3')-IIIa and its nucleotide ligands

scientific article

Antibiotic adjuvants: multicomponent anti-infective strategies.

scientific article published on 23 February 2011

Antibiotic resistance by enzyme inactivation: from mechanisms to solutions.

scientific article

Antibiotic resistance in the environment: a link to the clinic? ⬇️

scientific article published on September 16, 2010

Antibiotic resistance is ancient

scientific article

Antibiotic resistance is ancient: implications for drug discovery

scientific article published on 25 January 2012

Antibiotic resistance is prevalent in an isolated cave microbiome

scientific article published in 2012

Antibiotic resistance-mediated isolation of scaffold-specific natural product producers

scientific article published on 29 May 2014

Antibiotic resistance-the need for global solutions

scientific article

Antibiotics: A New Hope ⬇️

scientific article published on January 27, 2012

Antibiotics: An irresistible newcomer.

scientific article

Antibiotics: inactive but not inert

scientific article published in February 2010

Antimicrobials

scientific article published on 3 September 2009

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

scientific article

Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009 ⬇️

scientific article

Back to the future: a new 'old' lead for tuberculosis.

scientific article

Bacterial inactivation of the anticancer drug doxorubicin.

scientific article published on October 2012

Bacterial resistance to aminoglycoside antibiotics

scientific article published on June 1997

Biochemistry. A new target for antibiotic development

scientific article published on March 2007

Bioinformatics of antimicrobial resistance in the age of molecular epidemiology

scientific article published on 31 July 2015

Biosynthesis of sulfated glycopeptide antibiotics by using the sulfotransferase StaL.

scientific article published in February 2006

Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA-Specified Leu-tRNA(UUA) Molecule

scientific article

Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes

scientific article

Catalytic mechanism of fungal homoserine transacetylase

scientific article published on October 2005

Characterization of a Rifampin-Inactivating Glycosyltransferase from a Screen of Environmental Actinomycetes ⬇️

scientific article published on July 16, 2012

Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance

scientific article

Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.

scientific article

Chemical biology of tetracycline antibioticsThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.

scientific article (publication date: April 2008)

Chimeric streptogramin-tyrocidine antibiotics that overcome streptogramin resistance.

scientific article

Christopher Walsh: Pioneer and innovator in antibiotic and natural product chemical biology

scientific article published in January 2014

Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium

scientific article

ClpP inhibitors are produced by a widespread family of bacterial gene clusters ⬇️

scientific article published on 4 March 2022

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole

scientific article

Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of alpha/beta-hydrolases

scientific article

Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases

scientific article

Crystallization and preliminary X-ray crystallographic analysis of the tetracycline-degrading monooxygenase TetX2 from Bacteroides thetaiotaomicron.

scientific article published on 30 April 2010

Cystathionine beta-lyase is important for virulence of Salmonella enterica serovar Typhimurium

scientific article

D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB

scientific article

Designing analogs of ticlopidine, a wall teichoic acid inhibitor, to avoid formation of its oxidative metabolites.

scientific article

Determining the mode of action of bioactive compounds.

scientific article

Diversity of Integron- and Culture-Associated Antibiotic Resistance Genes in Freshwater Floc ⬇️

scientific article published on March 30, 2012

Diversity-oriented synthesis and preliminary biological screening of highly substituted five-membered lactones and lactams originating from an allyboration of aldehydes and imines

scientific article

Domain-domain interactions in the aminoglycoside antibiotic resistance enzyme AAC(6')-APH(2'').

scientific article

Drug combinations: a strategy to extend the life of antibiotics in the 21st century

scientific article published on 25 January 2019

Enzyme-Assisted Suicide

article published in 2003

Establishing the principles of recognition in the adenine-binding region of an aminoglycoside antibiotic kinase [APH(3')-IIIa].

scientific article

Expanding the soil antibiotic resistome: exploring environmental diversity

scientific article

Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites.

scientific article published on 25 October 2017

First JA medal goes to a paper on decalpenic acid

scientific article published in December 2012

Forces shaping the antibiotic resistome.

scientific article

Functionally important amino acids in Saccharomyces cerevisiae aspartate kinase

scientific article published in November 2003

GPAHex-A synthetic biology platform for Type IV-V glycopeptide antibiotic production and discovery ⬇️

scientific article published on 16 October 2020

Glycopeptide antibiotic biosynthesis

scientific article

Glycopeptide antibiotic resistance.

scientific article

Glycopeptide sulfation evades resistance.

scientific article published on 26 October 2012

Harnessing the synthetic capabilities of glycopeptide antibiotic tailoring enzymes: characterization of the UK-68,597 biosynthetic cluster

scientific article published on 26 September 2014

Heterologous expression-facilitated natural products’ discovery in actinomycetes

scientific article published on 16 November 2018

Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics

scientific article published on 09 September 2019

Homoserine dehydrogenase from Saccharomyces cerevisiae: kinetic mechanism and stereochemistry of hydride transfer

scientific article

Identification and Characterization of New Inhibitors of Fungal Homoserine Kinase ⬇️

scientific article published on April 28, 2011

Identifying producers of antibacterial compounds by screening for antibiotic resistance.

scientific article

Inactivation of the lipopeptide antibiotic daptomycin by hydrolytic mechanisms

scientific article published on 14 November 2011

Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1

article

Influence of humans on evolution and mobilization of environmental antibiotic resistome

scientific article published on July 2013

Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams.

scientific article published on 19 October 2012

Inhibition of aminoglycoside antibiotic resistance enzymes by protein kinase inhibitors

scientific article

Inhibition of the ANT(2")-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones

scientific article

Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function

scientific article

Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions

scientific article published on 13 March 2013

Introduction to the Special Issue: "Natural Product Discovery and Development in the Genomic Era".

scientific article published on 11 December 2015

Introduction: antibiotic resistance

scientific article published in February 2005

Iron and citrate export by a major facilitator superfamily pump regulates metabolism and stress resistance in Salmonella Typhimurium

scientific article published on 02 July 2013

Isolation of flavonoids from the heartwood and resin of Prunus avium and some preliminary biological investigations

scientific article published on 01 December 2009

Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6')-Ii from Enterococcus faecium: evidence of dimer subunit cooperativity

scientific article published in June 2003

Making Sense of Antisense in Antibiotic Drug Discovery

scientific article published on 01 September 2009

Mechanism and Diversity of the Erythromycin Esterase Family of Enzymes

scientific article published on 10 February 2012

Mechanism of aminoglycoside 3'-phosphotransferase type IIIa: His188 is not a phosphate-accepting residue

scientific article published on 01 September 1996

Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop

scientific article (publication date: 4 June 2002)

Mechanisms of resistance to antibiotics

scientific article published on 01 October 2003

Metal-induced isomerization yields an intracellular chelator that disrupts bacterial iron homeostasis.

scientific article

Minimum Information about a Biosynthetic Gene cluster.

scientific article published on August 2015

Molecular Mechanism of VanHst, an α-Ketoacid Dehydrogenase Required for Glycopeptide Antibiotic Resistance from a Glycopeptide Producing Organism†

scientific article published on 01 June 1999

Molecular mechanism of the enterococcal aminoglycoside 6'-N-acetyltransferase': role of GNAT-conserved residues in the chemistry of antibiotic inactivation

scientific article

Molecular mechanisms of antibiotic resistance

scientific article published on 01 February 2011

New phenolic inhibitors of yeast homoserine dehydrogenase

scientific article

Non-sterol structural probes of the lanosterol 14α-demethylase from Saccharomyces cerevisiae

scientific article published on 01 August 1990

Noncanonical vancomycin resistance cluster from Desulfitobacterium hafniense Y51.

scientific article published on 4 May 2009

Nucleotide selectivity of antibiotic kinases

scientific article published on 15 March 2010

On the road to bacterial cell death.

scientific article published in September 2007

One-pot chemoenzymatic preparation of coenzyme A analogues

scientific article

Opportunities for natural products in 21st century antibiotic discovery

scientific article published on June 2017

Opportunities for synthetic biology in antibiotics: expanding glycopeptide chemical diversity

scientific article published on 28 December 2012

Outbreak of vancomycin-susceptible Enterococcus faecium containing the wild-type vanA gene

scientific article published on 12 February 2014

Palmitoyl-DL-carnitine is a multitarget inhibitor of Pseudomonas aeruginosa biofilm development.

scientific article

Perspective: Synthetic biology revives antibiotics

scientific article published on May 2014

Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance

scientific article published on 12 August 2019

Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.

scientific article

Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning.

scientific article published on 23 December 2015

Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7.

scientific article published in November 2017

Prodigious substrate specificity of AAC(6')-APH(2"), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci

scientific article published on February 1999

Purification and Characterization of Two Haloperoxidases from the Glycopeptide Antibiotic Producer Streptomyces toyocaensis NRRL 15009

scientific article published on 01 February 1996

Q&A: Antibiotic resistance: where does it come from and what can we do about it?

scientific article

Q&A: Antibiotic resistance: what more do we know and what more can we do? ⬇️

scientific article published on May 17, 2013

Receptor domains of two-component signal transduction systems.

scientific article published on 24 February 2011

Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity

scientific article published on 07 November 2020

Resisting resistance: new chemical strategies for battling superbugs

scientific article

Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr

scientific article

Role of PBPD1 in stimulation of Listeria monocytogenes biofilm formation by subminimal inhibitory β-lactam concentrations

scientific article published on 18 August 2014

Role of homoserine transacetylase as a new target for antifungal agents

scientific article

Sampling the antibiotic resistome

scientific article

Self resistance to the atypical cationic antimicrobial peptide edeine of Brevibacillus brevis Vm4 by the N-acetyltransferase EdeQ.

scientific article published on 25 July 2013

Simultaneous In Vitro Assay of the First Four Enzymes in the Fungal Aspartate Pathway Identifies a New Class of Aspartate Kinase Inhibitor ⬇️

scientific article published on October 1, 2003

Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine

scientific article published in February 2004

Small-molecule modulators of Listeria monocytogenes biofilm development

scientific article

Solution Studies of Isepamicin and Conformational Comparisons between Isepamicin and Butirosin A When Bound to an Aminoglycoside 6‘-N-Acetyltransferase Determined by NMR Spectroscopy

scientific article published on 01 March 1998

Something old, something new: revisiting natural products in antibiotic drug discovery

scientific article

Spectinomycin kinase from Legionella pneumophila. Characterization of substrate specificity and identification of catalytically important residues

scientific article published on June 1998

StoPK-1, a serine/threonine protein kinase from the glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009, affects oxidative stress response

scientific article published in April 2002

Streptogramin antibiotics: mode of action and resistance.

scientific article

Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis.

scientific article

Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases lnu(A) and lnu(D).

scientific article published on 18 April 2015

Structural and kinetic characterization of the LPS biosynthetic enzyme D-alpha,beta-D-heptose-1,7-bisphosphate phosphatase (GmhB) from Escherichia coli

scientific article

Structural and molecular basis for resistance to aminoglycoside antibiotics by the adenylyltransferase ANT(2″)-Ia

scientific article

Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyase

scientific article

Structure and Function of APH(4)-Ia, a Hygromycin B Resistance Enzyme

scientific article

Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme.

scientific article published in December 2011

Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants

scientific article

Structure and mechanism of the lincosamide antibiotic adenylyltransferase LinB

scientific article

Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance

scientific article

Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis.

scientific article published on 9 April 2018

Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold

scientific article

Synthesis and Structure−Activity Relationships of Truncated Bisubstrate Inhibitors of Aminoglycoside 6‘-N-Acetyltransferases

scientific article published on 01 August 2006

Synthesis and inhibitory action on HMG-CoA synthase of racemic and optically active oxetan-2-ones (β-Lactones)

scientific article published on 01 August 1998

TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics

scientific article published on 27 September 2004

The COOH Terminus of Aminoglycoside Phosphotransferase (3′)-IIIa Is Critical for Antibiotic Recognition and Resistance

scientific article published in Journal of Biological Chemistry

The Genomic Enzymology of Antibiotic Resistance ⬇️

scientific article published on January 1, 2010

The Wall Teichoic Acid Polymerase TagF Efficiently Synthesizes Poly(glycerol phosphate) on the TagB Product Lipid III

scientific article published on 01 June 2008

The antibiotic resistance "mobilome": searching for the link between environment and clinic.

scientific article published on 30 May 2013

The antibiotic resistome ⬇️

scientific article published on June 17, 2010

The antibiotic resistome: the nexus of chemical and genetic diversity

scientific article (publication date: March 2007)

The antibiotic resistome: what's new?

scientific article published on 30 September 2014

The comprehensive antibiotic resistance database.

scientific article published on 06 May 2013

The glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009 has both D-alanyl-D-alanine and D-alanyl-D-lactate ligases ⬇️

scientific article published on 01 December 1997

The molecular basis of the expansive substrate specificity of the antibiotic resistance enzyme aminoglycoside acetyltransferase-6'-aminoglycoside phosphotransferase-2". The role of ASP-99 as an active site base important for acetyl transfer

scientific article

The tetracycline resistome

scientific article published on 28 October 2009

Tigecycline is modified by the flavin-dependent monooxygenase TetX.

scientific article published in September 2005

Total Synthesis and Activity of the Metallo-β-lactamase Inhibitor Aspergillomarasmine A.

scientific article published on 28 December 2015

Transformation of the Anticancer Drug Doxorubicin in the Human Gut Microbiome

scientific article

Vancomycin-variable enterococci can give rise to constitutive resistance during antibiotic therapy

scientific article published on 15 December 2014

Winners of the 2013 JA Medals for excellence

scientific article published on 01 May 2014

Winners of the 2014 JA Medals for excellence

scientific article published in January 2015

β-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents

scientific article published on 27 April 2011

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