List of works - John Svaren

A Loss of Insulin-like Growth Factor-2 Imprinting Is Modulated by CCCTC-binding Factor Down-regulation at Senescence in Human Epithelial Cells

scientific article published in Journal of Biological Chemistry

A methyl-deficient diet modifies histone methylation and alters Igf2 and H19 repression in the prostate

scientific article published in August 2008

A mutation in the Tubb4a gene leads to microtubule accumulation with hypomyelination and demyelination

scientific article

A mutation in the canine gene encoding folliculin-interacting protein 2 (FNIP2) associated with a unique disruption in spinal cord myelination

scientific article

A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene.

scientific article published on March 2000

A novel pathway links oxidative stress to loss of insulin growth factor-2 (IGF2) imprinting through NF-κB activation

scientific article

Activation of luteinizing hormone beta gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1.

scientific article published on May 1999

Active gene repression by the Egr2.NAB complex during peripheral nerve myelination

scientific journal article

Aging and cancer-related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate

scientific article

Associations between early life stress and gene methylation in children

scientific article

Bach2 regulates homeostasis of Foxp3+ regulatory T cells and protects against fatal lung disease in mice.

scientific article published on 23 December 2013

Cell transplantation strategies for acquired and inherited disorders of peripheral myelin

scientific article published on 22 January 2018

Comparison of nucleosome remodeling by the yeast transcription factor Pho4 and the glucocorticoid receptor

scientific article published in March 2000

DNA denatures upon drying after ethanol precipitation

scientific article

Developmental regulation of microRNA expression in Schwann cells

scientific article published on 7 November 2011

Differential Sox10 genomic occupancy in myelinating glia

scientific article

Differential regulation of NAB corepressor genes in Schwann cells

scientific article

Differential requirement for Lck during primary and memory CD8+ T cell responses

scholarly article

Direct regulation of myelin protein zero expression by the Egr2 transactivator

scientific article published on 22 December 2005

Distal enhancers upstream of the Charcot-Marie-Tooth type 1A disease gene PMP22

scientific article published on 15 December 2011

Dual specificity phosphatase 15 regulates Erk activation in Schwann cells

scientific article

Dynamic regulation of Schwann cell enhancers after peripheral nerve injury

scientific article

EGR1 target genes in prostate carcinoma cells identified by microarray analysis.

scientific article published on December 2000

EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression.

scientific article published on May 2001

Early growth response 1 (Egr1) regulates cholesterol biosynthetic gene expression

scientific article

Egr2-dependent microRNA-138 is dispensable for peripheral nerve myelination

scientific article published on 28 February 2018

Epigenetic Control of Schwann Cells

scientific article

Epigenetic susceptibility factors for prostate cancer with aging.

scientific article

Epigenomic Regulation of Schwann Cell Reprogramming in Peripheral Nerve Injury

scientific article published on August 2016

Epigenomic reprogramming in peripheral nerve injury

scientific article published on December 2016

Expression of immune response genes in the stifle joint of dogs with oligoarthritis and degenerative cranial cruciate ligament rupture

article

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

scientific article published on 21 January 2021

Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies.

scientific article

Functional dissection of the Oct6 Schwann cell enhancer reveals an essential role for dimeric Sox10 binding

scientific article

Genome editing-enabled HTS assays expand drug target pathways for Charcot-Marie-tooth disease

scientific article

Genome-Edited Cell Lines for High-Throughput Screening

scientific article published on 01 January 2018

Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve

scientific article

H3K27 demethylases are dispensable for activation of Polycomb-regulated injury response genes in peripheral nerve

scientific article published on 04 June 2021

HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination

scientific article

Haplotype-specific modulation of a SOX10/CREB response element at the Charcot-Marie-Tooth disease type 4C locus SH3TC2.

scientific article published on 15 May 2014

Histones, nucleosomes and transcription

scientific article published on April 1993

Identification of drug modulators targeting gene-dosage disease CMT1A.

scientific article

Identification of equine P-selectin glycoprotein ligand-1 (CD162).

scientific article

In silico pooling of ChIP-seq control experiments

scientific article

In vivo detection of Egr2 binding to target genes during peripheral nerve myelination

scientific article published on September 2006

Induction of myelin protein zero by early growth response 2 through upstream and intragenic elements

scientific article published on June 2009

Interactions of Sox10 and Egr2 in myelin gene regulation

scientific article

Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes

scientific article published on 4 November 2010

MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes

scientific article published on 13 August 2013

MicroRNA and transcriptional crosstalk in myelinating glia

scientific article published on 27 June 2014

Modifier Gene Candidates in Charcot-Marie-Tooth Disease Type 1A: A Case-Only Genome-Wide Association Study

article

Multivalent recognition of histone tails by the PHD fingers of CHD5

scientific article

Myelin protein zero mutations and the unfolded protein response in Charcot Marie Tooth disease type 1B.

scientific article published on 10 March 2018

NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex

scientific article

Nab proteins are essential for peripheral nervous system myelination

scientific journal article

Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy

scientific article published on 01 April 2019

Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1.

scientific article

Neuropathy-Associated Egr2 Mutants Disrupt Cooperative Activation of Myelin Protein Zero by Egr2 and Sox10

scientific article (publication date: 26 February 2007)

Novel mutants of NAB corepressors enhance activation by Egr transactivators

scientific article

PMP22 antisense oligonucleotides reverse Charcot-Marie-Tooth disease type 1A features in rodent models

scientific article published on 4 December 2017

Polycomb repression regulates Schwann cell proliferation and axon regeneration after nerve injury

article

Regulating PMP22 expression as a dosage sensitive neuropathy gene

scientific article published on 03 October 2019

Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2

scientific article published on June 2015

Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination

scientific article

Regulation of gene expression by nucleosomes

scientific article published on April 1996

Regulation of memory CD8 T-cell differentiation by cyclin-dependent kinase inhibitor p27Kip1

scientific article

Regulation of the PMP22 gene through an intronic enhancer

scientific article

Regulation of the neuropathy-associated Pmp22 gene by a distal super-enhancer

article

Role of cell cycle regulator E2F1 in regulating CD8 T cell responses during acute and chronic viral infection

scientific article published in July 2004

Role of cell cycle regulator p19ARF in regulating T cell responses

article

SOX10 directly modulates ERBB3 transcription via an intronic neural crest enhancer

scientific article

SOX10 regulates an alternative promoter at the Charcot-Marie-Tooth disease locus MTMR2.

scientific article

SOX10 regulates expression of the SH3-domain kinase binding protein 1 (Sh3kbp1) locus in Schwann cells via an alternative promoter

scientific article published on 19 October 2011

Schwann cell transcript biomarkers for hereditary neuropathy skin biopsies

scientific article published on 22 April 2019

Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies

scientific article

Specification of Macroglia by Transcription Factors

article

Stringent comparative sequence analysis reveals SOX10 as a putative inhibitor of glial cell differentiation

scientific article

Tead1 regulates the expression of Peripheral Myelin Protein 22 during Schwann cell development

scientific article published on 10 June 2016

The Ddx20/DP103 dead box protein represses transcriptional activation by Egr2/Krox-20.

scientific article published on 29 December 2003

The Nab2 and Stat6 genes share a common transcription termination region.

scientific article

The Transcriptional Corepressor NAB2 Blocks Egr-1-Mediated Growth Factor Activation and Angiogenesis

article

The molecular machinery of myelin gene transcription in Schwann cells

scientific article

The nucleosome remodeling and deacetylase chromatin remodeling (NuRD) complex is required for peripheral nerve myelination

scientific article published on February 2012

The structure and assembly of active chromatin

scientific article published on February 1990

The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells

scientific article

Transcription factor early growth response-1 induction mediates inflammatory gene expression and brain damage following transient focal ischemia

scientific article published on 16 January 2008

Transcription factors vs nucleosomes: regulation of the PHO5 promoter in yeast

scientific article published on March 1997

Transmembrane protease serine 5: a novel Schwann cell plasma marker for CMT1A

scientific article published on 12 December 2019

Use of real-time reverse transcriptase polymerase chain reaction assay and cell culture methods for detection of swine influenza A viruses.

scientific article published on January 2005

Variation in SIPA1L2 is correlated with phenotype modification in Charcot- Marie- Tooth disease type 1A

scientific article published on 01 March 2019

YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells

scientific article

Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination

scientific article

[8] In Vivo Analysis of nucleosome structure and transcription factor binding in Saccharomyces cerevisiae

article

List of works by John Svaren

A Loss of Insulin-like Growth Factor-2 Imprinting Is Modulated by CCCTC-binding Factor Down-regulation at Senescence in Human Epithelial Cells

A methyl-deficient diet modifies histone methylation and alters Igf2 and H19 repression in the prostate

A mutation in the Tubb4a gene leads to microtubule accumulation with hypomyelination and demyelination

A mutation in the canine gene encoding folliculin-interacting protein 2 (FNIP2) associated with a unique disruption in spinal cord myelination

A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene.

A novel pathway links oxidative stress to loss of insulin growth factor-2 (IGF2) imprinting through NF-κB activation

Activation of luteinizing hormone beta gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1.

Active gene repression by the Egr2.NAB complex during peripheral nerve myelination

Aging and cancer-related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate

Associations between early life stress and gene methylation in children

Bach2 regulates homeostasis of Foxp3+ regulatory T cells and protects against fatal lung disease in mice.

Cell transplantation strategies for acquired and inherited disorders of peripheral myelin

Comparison of nucleosome remodeling by the yeast transcription factor Pho4 and the glucocorticoid receptor

DNA denatures upon drying after ethanol precipitation

Developmental regulation of microRNA expression in Schwann cells

Differential Sox10 genomic occupancy in myelinating glia

Differential regulation of NAB corepressor genes in Schwann cells

Differential requirement for Lck during primary and memory CD8+ T cell responses

Direct regulation of myelin protein zero expression by the Egr2 transactivator

Distal enhancers upstream of the Charcot-Marie-Tooth type 1A disease gene PMP22

Dual specificity phosphatase 15 regulates Erk activation in Schwann cells

Dynamic regulation of Schwann cell enhancers after peripheral nerve injury

EGR1 target genes in prostate carcinoma cells identified by microarray analysis.

EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression.

Early growth response 1 (Egr1) regulates cholesterol biosynthetic gene expression

Egr2-dependent microRNA-138 is dispensable for peripheral nerve myelination

Epigenetic Control of Schwann Cells

Epigenetic susceptibility factors for prostate cancer with aging.

Epigenomic Regulation of Schwann Cell Reprogramming in Peripheral Nerve Injury

Epigenomic reprogramming in peripheral nerve injury

Expression of immune response genes in the stifle joint of dogs with oligoarthritis and degenerative cranial cruciate ligament rupture

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies.

Functional dissection of the Oct6 Schwann cell enhancer reveals an essential role for dimeric Sox10 binding

Genome editing-enabled HTS assays expand drug target pathways for Charcot-Marie-tooth disease

Genome-Edited Cell Lines for High-Throughput Screening

Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve

H3K27 demethylases are dispensable for activation of Polycomb-regulated injury response genes in peripheral nerve

HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination

Haplotype-specific modulation of a SOX10/CREB response element at the Charcot-Marie-Tooth disease type 4C locus SH3TC2.

Histones, nucleosomes and transcription

Identification of drug modulators targeting gene-dosage disease CMT1A.

Identification of equine P-selectin glycoprotein ligand-1 (CD162).

In silico pooling of ChIP-seq control experiments

In vivo detection of Egr2 binding to target genes during peripheral nerve myelination

Induction of myelin protein zero by early growth response 2 through upstream and intragenic elements

Interactions of Sox10 and Egr2 in myelin gene regulation

Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes

MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes

MicroRNA and transcriptional crosstalk in myelinating glia

Modifier Gene Candidates in Charcot-Marie-Tooth Disease Type 1A: A Case-Only Genome-Wide Association Study

Multivalent recognition of histone tails by the PHD fingers of CHD5

Myelin protein zero mutations and the unfolded protein response in Charcot Marie Tooth disease type 1B.

NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex

Nab proteins are essential for peripheral nervous system myelination

Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy

Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1.

Neuropathy-Associated Egr2 Mutants Disrupt Cooperative Activation of Myelin Protein Zero by Egr2 and Sox10

Novel mutants of NAB corepressors enhance activation by Egr transactivators

PMP22 antisense oligonucleotides reverse Charcot-Marie-Tooth disease type 1A features in rodent models

Polycomb repression regulates Schwann cell proliferation and axon regeneration after nerve injury

Regulating PMP22 expression as a dosage sensitive neuropathy gene

Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2

Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination

Regulation of gene expression by nucleosomes

Regulation of memory CD8 T-cell differentiation by cyclin-dependent kinase inhibitor p27Kip1

Regulation of the PMP22 gene through an intronic enhancer

Regulation of the neuropathy-associated Pmp22 gene by a distal super-enhancer

Role of cell cycle regulator E2F1 in regulating CD8 T cell responses during acute and chronic viral infection

Role of cell cycle regulator p19ARF in regulating T cell responses

SOX10 directly modulates ERBB3 transcription via an intronic neural crest enhancer

SOX10 regulates an alternative promoter at the Charcot-Marie-Tooth disease locus MTMR2.

SOX10 regulates expression of the SH3-domain kinase binding protein 1 (Sh3kbp1) locus in Schwann cells via an alternative promoter

Schwann cell transcript biomarkers for hereditary neuropathy skin biopsies

Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies

Specification of Macroglia by Transcription Factors

Stringent comparative sequence analysis reveals SOX10 as a putative inhibitor of glial cell differentiation

Tead1 regulates the expression of Peripheral Myelin Protein 22 during Schwann cell development

The Ddx20/DP103 dead box protein represses transcriptional activation by Egr2/Krox-20.