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List of works by Benhur Lee

2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

scientific article published on 04 September 2020

A broad-spectrum antiviral targeting entry of enveloped viruses

scientific article

A catalytically and genetically optimized beta-lactamase-matrix based assay for sensitive, specific, and higher throughput analysis of native henipavirus entry characteristics

scientific article published on 31 July 2009

A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations

scientific article published on 20 April 2013

A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model

scientific article

A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus

scientific article published on 20 December 2019

A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion

scientific article published in 2013

A novel receptor-induced activation site in the Nipah virus attachment glycoprotein (G) involved in triggering the fusion glycoprotein (F)

scientific article published on 19 November 2008

A quantitative affinity-profiling system that reveals distinct CD4/CCR5 usage patterns among human immunodeficiency virus type 1 and simian immunodeficiency virus strains

scientific article published on 19 August 2009

A quantitative and kinetic fusion protein-triggering assay can discern distinct steps in the nipah virus membrane fusion cascade

scientific article

A structural basis for antibody-mediated neutralization of Nipah virus reveals a site of vulnerability at the fusion glycoprotein apex

scientific article published on 25 November 2019

Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4.

scientific article

Affinofile profiling: how efficiency of CD4/CCR5 usage impacts the biological and pathogenic phenotype of HIV

scientific article

An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes

scientific article

Anthrax oedema toxin induces anthrax toxin receptor expression in monocyte-derived cells

scientific article published in July 2006

Association of RNase mitochondrial RNA processing enzyme with ribonuclease P in higher ordered structures in the nucleolus: a possible coordinate role in ribosome biogenesis

scientific article published on October 1996

Binding and transfer of human immunodeficiency virus by DC-SIGN+ cells in human rectal mucosa.

scientific article

Breast milk and in utero transmission of HIV-1 select for envelope variants with unique molecular signatures

scientific article published on 26 January 2017

Broad-spectrum antivirals against viral fusion

scientific article

CCR5 HIV-1 coreceptor activity. Role of cooperativity between residues in N-terminal extracellular and intracellular domains

scientific journal article

CCR5 and CXCR4 expression correlated with X4 and R5 HIV-1 infection yet not sustained replication in Th1 and Th2 cells

scientific article

CD4-independent use of Rhesus CCR5 by human immunodeficiency virus Type 2 implicates an electrostatic interaction between the CCR5 N terminus and the gp120 C4 domain

scientific article

CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain

scientific article published on December 1997

CRISPR/Cas9 allows efficient and complete knock-in of a destabilization domain-tagged essential protein in a human cell line, allowing rapid knockdown of protein function

scientific article (publication date: 2014)

Combined chloroquine and ribavirin treatment does not prevent death in a hamster model of Nipah and Hendra virus infection

scientific article

Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design

scientific article published on 24 April 2013

Constrained use of CCR5 on CD4+ lymphocytes by R5X4 HIV-1: efficiency of Env-CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated entry

scientific article

Constraints on the Genetic and Antigenic Variability of Measles Virus

scientific article

Containing the contagion: treating the virus that inspired the film

scientific article

Cross-Reactive and Cross-Neutralizing Activity of Human Mumps Antibodies Against a Novel Mumps Virus From Bats

scientific article

Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly

scientific article (publication date: December 2015)

Cysteines in the stalk of the nipah virus G glycoprotein are located in a distinct subdomain critical for fusion activation

scientific article

DC-SIGN binds to HIV-1 glycoprotein 120 in a distinct but overlapping fashion compared with ICAM-2 and ICAM-3.

scientific article published on 16 February 2004

DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus

scientific article

DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans

scientific article

Development of a neutralization assay for Nipah virus using pseudotype particles

scientific article published on 9 March 2009

Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia

scientific article published on April 1999

Distinct HIV-1 entry phenotypes are associated with transmission, subtype specificity, and resistance to broadly neutralizing antibodies

scientific article

Dose-response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodies

scientific article

Effects of singlet oxygen generated by a broad-spectrum viral fusion inhibitor on membrane nanoarchitecture

scientific article published on 17 March 2015

Efficient construction of an inverted minimal H1 promoter driven siRNA expression cassette: facilitation of promoter and siRNA sequence exchange

scientific article

Efficient reverse genetics reveals genetic determinants of budding and fusogenic differences between Nipah and Hendra viruses and enables real-time monitoring of viral spread in small animal models of henipavirus infection.

scientific article

Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics

scientific article

Emerging Paramyxoviruses: Receptor Tropism and Zoonotic Potential

scientific article

Emerging paramyxoviruses: molecular mechanisms and antiviral strategies

scientific article published on 24 February 2011

Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formation

scientific article published in 2010

Envelope-receptor interactions in Nipah virus pathobiology

scientific article published on April 2007

EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus

scientific article

Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function

scientific article published on April 1999

Escape From Monoclonal Antibody Neutralization Affects Henipavirus Fitness In Vitro and In Vivo

scientific article

Evidence for henipavirus spillover into human populations in Africa

scientific article

Evidence for ubiquitin-regulated nuclear and subnuclear trafficking among Paramyxovirinae matrix proteins

scientific article

Evil versus 'eph-ective' use of ephrin-B2

Evolution of Codon Usage Bias in Henipaviruses Is Governed by Natural Selection and Is Host-Specific

article

Expression and coreceptor function of APJ for primate immunodeficiency viruses

scientific article

Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity

scientific article

Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity

scientific article

Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc

scientific article

Functional rectification of the newly described African henipavirus fusion glycoprotein (Gh-M74a).

scientific article published on 12 February 2014

Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and protein kinase C signaling

scientific article published on 27 July 2009

Galectin-1 regulates tissue exit of specific dendritic cell populations

scientific article

Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry

scientific article

Genome-wide transposon mutagenesis of paramyxoviruses reveals constraints on genomic plasticity

scientific article published on 09 October 2020

HIV provides ample PAMPs for innate immune sensing

scientific article

HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropism

scientific article

HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry

scientific article published on 7 November 2011

HIV-1 resistance to CCR5 antagonists associated with highly efficient use of CCR5 and altered tropism on primary CD4+ T cells

scientific article

Human immunodeficiency virus envelope (gp120) binding to DC-SIGN and primary dendritic cells is carbohydrate dependent but does not involve 2G12 or cyanovirin binding sites: implications for structural analyses of gp120-DC-SIGN binding

scientific article published on December 2002

Human milk oligosaccharides reduce HIV-1-gp120 binding to dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN).

scientific article

IL-15 regulates susceptibility of CD4 T cells to HIV infection

article published in the Proceedings of the National Academy of Sciences of the United States of America

ISG15 deficiency and increased viral resistance in humans but not mice

scientific article

Identification of the optimal DC-SIGN binding site on human immunodeficiency virus type 1 gp120.

scientific article published on 23 May 2007

Idiosyncratic Mòjiāng virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses

scientific article published on 12 July 2017

Individual N-glycans added at intervals along the stalk of the Nipah virus G protein prevent fusion but do not block the interaction with the homologous F protein

scientific article published on 2 January 2013

Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities

scientific article published on 20 March 2009

Inhibition of an Aquatic Rhabdovirus Demonstrates Promise of a Broad-Spectrum Antiviral for Use in Aquaculture

scientific article published on 30 November 2016

Interactions of human complement with virus particles containing the Nipah virus glycoproteins

scientific article published on 30 March 2011

Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol

scientific article

Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection

scientific article published on 13 February 2005

Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Naïve Subjects with Progressive HIV-1 Subtype C Infection.

scientific article

Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5

scientific article

Measles and Nipah virus assembly: Specific lipid binding drives matrix polymerization

scientific article published on 20 July 2022

MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation

scientific article

Microbe-Host Interactions are Positively and Negatively Regulated by Galectin-Glycan Interactions

scientific article published on 18 June 2014

Modes of paramyxovirus fusion: a Henipavirus perspective

scientific article

Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus

scientific article published on 30 March 2015

Molecular structure and function of autoantigens in systemic sclerosis.

scientific article published on January 1995

Mutational Analysis of Measles Virus Suggests Constraints on Antigenic Variation of the Glycoproteins

scientific article published on 21 May 2015

N-Glycans on the Nipah virus attachment glycoprotein modulate fusion and viral entry as they protect against antibody neutralization

scientific article

N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry

scientific article published on May 2006

Nipah Virus C Protein Recruits Tsg101 to Promote the Efficient Release of Virus in an ESCRT-Dependent Pathway

scientific article

Nipah Virus Envelope-Pseudotyped Lentiviruses Efficiently Target ephrinB2-Positive Stem Cell Populations In Vitro and Bypass the Liver Sink When Administered In Vivo.

scientific article published in April 2013

Nipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo

scientific article published on 28 November 2012

Nipah virus matrix protein: expert hacker of cellular machines.

scientific article

Nipah@20: Lessons Learned from Another Virus with Pandemic Potential

scientific article published on 08 July 2020

Optimized P2A for reporter gene insertion into Nipah virus results in efficient ribosomal skipping and wild-type lethality

scientific article published on 18 January 2016

Palmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways

scientific article

Pathobiology of henipavirus entry: insights into therapeutic strategies

Placental expression of DC-SIGN may mediate intrauterine vertical transmission of HIV

article

Polybasic KKR motif in the cytoplasmic tail of Nipah virus fusion protein modulates membrane fusion by inside-out signaling

scientific article published on 14 February 2007

Positive reinforcement for viruses

scientific article published on October 2010

Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages

scientific article

Quantification of entry phenotypes of macrophage-tropic HIV-1 across a wide range of CD4 densities

scientific article published on 04 December 2013

Quantifying CD4/CCR5 Usage Efficiency of HIV-1 Env Using the Affinofile System

scientific article published on January 2016

Quantifying Neutralizing Antibodies in Patients with COVID-19 by a Two-Variable Generalized Additive Model

scientific article published on 02 February 2022

Quantifying absolute neutralization titers against SARS-CoV-2 by a standardized virus neutralization assay allows for cross-cohort comparisons of COVID-19 sera

scientific article published on 15 August 2020

Quantifying the Sensitivity of HIV-1 Viral Entry to Receptor and Coreceptor Expression

scientific article published on 3 May 2016

Redirecting lentiviral vectors pseudotyped with Sindbis virus-derived envelope proteins to DC-SIGN by modification of N-linked glycans of envelope proteins

scientific article

Regulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin-related modifiers

scientific article published on 28 December 2011

Rho GTPase activity modulates paramyxovirus fusion protein-mediated cell–cell fusion

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

scientific article published on 29 December 2020

Sendai virus, an RNA virus with no risk of genomic integration, delivers CRISPR/Cas9 for efficient gene editing

scientific article published on 24 August 2016

Single amino acid changes in the Nipah and Hendra virus attachment glycoproteins distinguish ephrinB2 from ephrinB3 usage

scientific article published on 25 July 2007

Singlet oxygen effects on lipid membranes: implications for the mechanism of action of broad-spectrum viral fusion inhibitors

scientific article

Specific interaction of feline immunodeficiency virus surface glycoprotein with human DC-SIGN.

scientific article published on March 2004

Targeted transduction via CD4 by a lentiviral vector uses a clathrin-mediated entry pathway

scientific article published on 30 September 2009

Taxonomy of the order Mononegavirales: second update 2018

scientific article published on 01 April 2019

Taxonomy of the order Mononegavirales: update 2017.

scientific article

Taxonomy of the order Mononegavirales: update 2018.

scientific article published on 11 April 2018

Taxonomy of the order Mononegavirales: update 2019

scientific article published on 01 July 2019

The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response

scientific article

The Microtubule Inhibitor Podofilox Inhibits an Early Entry Step of Human Cytomegalovirus

scientific article published on 24 October 2016

The Viral Polymerase Complex Mediates the Interaction of Viral Ribonucleoprotein Complexes with Recycling Endosomes during Sendai Virus Assembly

scientific article published on 25 August 2020

The greasy response to virus infections

scientific article published on April 2013

The magnitude of HIV-1 resistance to the CCR5 antagonist maraviroc may impart a differential alteration in HIV-1 tropism for macrophages and T-cell subsets

scientific article published on 17 April 2013

The quest for good explanations

scientific article published on 8 March 2018

The rigid amphipathic fusion inhibitor dUY11 acts through photosensitization of viruses

scientific article

The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry ⬇️

scientific article

Timing of galectin-1 exposure differentially modulates Nipah virus entry and syncytium formation in endothelial cells

scientific article

Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5.

scientific article published on 26 December 2012

Triggering of the newcastle disease virus fusion protein by a chimeric attachment protein that binds to Nipah virus receptors

scientific article

Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus

scientific article

Ubiquitin-regulated nuclear-cytoplasmic trafficking of the Nipah virus matrix protein is important for viral budding

scientific article

Use of GPR1, GPR15, and STRL33 as coreceptors by diverse human immunodeficiency virus type 1 and simian immunodeficiency virus envelope proteins

scientific article published in September 1998

cis Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor

scientific article

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