List of works - Krzysztof Pyrć

A New Network for the Advancement of Marine Biotechnology in Europe and Beyond

scientific article published on 12 May 2020

A novel pancoronavirus RT-PCR assay: frequent detection of human coronavirus NL63 in children hospitalized with respiratory tract infections in Belgium

scientific article

APOBEC3-mediated restriction of RNA virus replication

scientific article

Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and related conditions

scientific article published on 21 May 2020

Angiotensin converting enzyme: A review on expression profile and its association with human disorders with special focus on SARS-CoV-2 infection

scientific article published on 11 May 2020

Anti-SARS-CoV-2 activity of cyanopeptolins produced by Nostoc edaphicum CCNP1411

scientific article published in 2023

Attachment factor and receptor engagement of SARS coronavirus and human coronavirus NL63.

scientific article published on January 2006

Bacterial Infections During Hospital Stay and Their Impact on Mortality After Lung Transplantation: A Single-Center Study

scientific article published on 13 March 2018

Bacterial proteases in disease - role in intracellular survival, evasion of coagulation/ fibrinolysis innate defenses, toxicoses and viral infections

scientific article published on January 2013

Battle at the entrance gate: CIITA as a weapon to prevent the internalization of SARS-CoV-2 and Ebola viruses

scientific article published on 24 November 2020

Berberine Hampers Influenza A Replication through Inhibition of MAPK/ERK Pathway

scientific article published on 21 March 2020

Biopolymeric nano/microspheres for selective and reversible adsorption of coronaviruses

scientific article published on 6 March 2017

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

scientific article

CRISPR-Cas Systems in Prokaryotes

scientific article

Canine Respiratory Coronavirus, Bovine Coronavirus, and Human Coronavirus OC43: Receptors and Attachment Factors

scientific article published on 5 April 2019

Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells.

scientific article published on 3 July 2018

Cat flu: Broad spectrum polymeric antivirals

scientific article published on 17 July 2019

Citrullination alters immunomodulatory function of LL-37 essential for prevention of endotoxin-induced sepsis.

scientific article

Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) RNAs in the Porphyromonas gingivalis CRISPR-Cas I-C System.

scientific article published on 11 September 2017

Croup is associated with the novel coronavirus NL63

scientific article

Culturing the unculturable: human coronavirus HKU1 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell cultures

scientific article

Detection of legal highs in the urine of methadone-treated patient by LC-MS

scientific article published on 26 June 2019

Detection of new viruses by VIDISCA. Virus discovery based on cDNA-amplified fragment length polymorphism

scientific article published in January 2008

Development of loop-mediated isothermal amplification assay for detection of human coronavirus-NL63

article

Early events during human coronavirus OC43 entry to the cell

scientific article

Effects of host genetic variations on response to, susceptibility and severity of respiratory infections

scientific article published on 29 May 2020

Efficacy of antiviral drugs against the omicron variant of SARS-CoV-2

scientific article published on 23 December 2021

Electrochemical Immunosensors Based on Screen-Printed Gold and Glassy Carbon Electrodes: Comparison of Performance for Respiratory Syncytial Virus Detection

scientific article published on 13 November 2020

Entry of human coronavirus NL63 to the cell.

scientific article published on 15 November 2017

Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021

scientific article published on 30 September 2021

Functional Analysis of Porphyromonas gingivalis W83 CRISPR-Cas Systems.

scientific article published on 26 May 2015

Genome structure and transcriptional regulation of human coronavirus NL63

scientific article

Gingipains: Critical Factors in the Development of Aspiration Pneumonia Caused by Porphyromonas gingivalis

scientific article published on 28 November 2015

HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoV

scientific article published on 20 November 2020

HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 and MERS-CoV

scientific article published on 01 April 2020

HTCC: Broad Range Inhibitor of Coronavirus Entry

scientific article

HexaPrime: a novel method for detection of coronaviruses

scientific article published on 7 December 2012

Highly Effective and Safe Polymeric Inhibitors of Herpes Simplex Virus in Vitro and in Vivo

scientific article published on 19 July 2019

Human Coronavirus HKU1 Spike Protein Uses O-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme

scientific article published on 29 April 2015

Human Coronavirus NL63 Infection is Associated with Croup

Human coronavirus 229E encodes a single ORF4 protein between the spike and the envelope genes

scientific article published on 28 December 2006

Human coronavirus NL63 and 229E seroconversion in children

scientific article published on 21 May 2008

Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry

scientific article

Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells

scientific article

Human coronavirus NL63, a new respiratory virus

scientific article published on September 2006

Human parechovirus type 1, 3, 4, 5, and 6 detection in picornavirus cultures

scientific article published on 12 December 2007

Identification of Cellular Factors Required for SARS-CoV-2 Replication

scholarly article by Aleksandra Synowiec published in November 2021

Identification of cell lines permissive for human coronavirus NL63.

scientific article published on 7 September 2006

Identification of new human coronaviruses

scientific article published on April 2007

Immunosuppressive Treatment and Its Effect on the Occurrence of Pneumocystis jiroveci, Mycoplasma pneumoniae, Chlamydophila pnemoniae, and Legionella pneumophila Infections/Colonizations Among Lung Transplant Recipients

scientific article published on 13 March 2018

In Vitro Inhibition of Zika Virus Replication with Poly(Sodium 4-Styrenesulfonate)

scientific article published on 23 August 2020

In vitro testing the potential of a novel chimeric IgG variant for inhibiting collagen fibrils formation in recurrent hereditary gingival fibromatosis: chimeric antibody in a gingival model

scientific article published on 01 August 2014

Inactivation of epidermal growth factor by Porphyromonas gingivalis as a potential mechanism for periodontal tissue damage

scientific article published on 22 October 2012

Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells

scientific article

Inhibition of Herpes Simplex Viruses by Cationic Dextran Derivatives.

scientific article published on 28 September 2017

Inhibition of human coronavirus NL63 infection at early stages of the replication cycle

scientific article published on June 2006

Interaction Between the Spike Protein of Human Coronavirus NL63 and its Cellular Receptor ACE2

Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1

scientific article published on 24 November 2020

Kallikrein 13: a new player in coronaviral infections

scientific article (preprint)

MASS SPECTROMETRY IN VIROLOGICAL SCIENCES

scientific article published on 25 December 2019

Mass Spectrometry versus Conventional Techniques of Protein Detection: Zika Virus NS3 Protease Activity towards Cellular Proteins

scientific article published on 18 June 2021

Membrane Protein of Human Coronavirus NL63 Is Responsible for Interaction with the Adhesion Receptor

scientific article published on 12 September 2019

Mosaic structure of human coronavirus NL63, one thousand years of evolution ⬇️

scientific article published on 3 October 2006

Nonstructural proteins of human coronavirus NL63.

scientific article published in January 2006

Novel Polyanions Inhibiting Replication of Influenza Viruses

scientific article published on 4 January 2016

Novel coronavirus-like particles targeting cells lining the respiratory tract

scientific article published in PLoS ONE

Novel peptidyl α-aminoalkylphosphonates as inhibitors of hepatitis C virus NS3/4A protease.

scientific article published on 30 June 2017

Novel polymeric inhibitors of HCoV-NL63.

scientific article published on 29 November 2012

One Step Beyond: Design of Substrates Spanning Primed Positions of Zika Virus NS2B-NS3 Protease

scholarly article by Natalia Gruba et al published 11 October 2018 in ACS Medicinal Chemistry Letters

Ozone Treatment Is Insufficient to Inactivate SARS-CoV-2 Surrogate under Field Conditions

scientific article published on 16 September 2021

Phosphonate inhibitors of West Nile virus NS2B/NS3 protease

scientific article published on 01 December 2019

Porphyromonas gingivalis enzymes enhance infection with human metapneumovirus in vitro

scientific article published on 29 June 2011

Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD)

scientific article published in September 2013

Recent antiviral strategies against human coronavirus-related respiratory illnesses

scientific article published on May 2008

Replication of SARS-CoV-2 in human respiratory epithelium

scientific article (preprint)

Replication of SARS-CoV-2 in human respiratory epithelium

scientific article published on 20 May 2020

Replication-dependent downregulation of cellular angiotensin-converting enzyme 2 protein expression by human coronavirus NL63.

scientific article

Seleno-Functionalization of Quercetin Improves the Non-Covalent Inhibition of M and Its Antiviral Activity in Cells against SARS-CoV-2

scientific article published on 30 June 2021

Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors

scientific article published on 28 January 2022

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic Infection

article published in 2021

Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.

scientific article published on 7 August 2017

Stability of infectious human coronavirus NL63.

scientific article published on 18 April 2014

Staphylococcus aureus proteases degrade lung surfactant protein A potentially impairing innate immunity of the lung

scientific article published on 11 December 2012

Structural Characterization of Human Coronavirus NL63 N Protein

scientific article published on 22 March 2017

Substrate profiling of Zika virus NS2B-NS3 protease.

scientific article published on 7 October 2016

Synthetic sulfonated derivatives of poly(allylamine hydrochloride) as inhibitors of human metapneumovirus

scientific article published on 28 March 2019

The SARS-CoV-2 ORF10 is not essential in vitro or in vivo in humans

scientific article published on 10 December 2020

The SARS-CoV-2 ORF10 is not essential in vitro or in vivo in humans

The inhibitory effect of secretory leukocyte protease inhibitor (SLPI) on formation of neutrophil extracellular traps

scientific article published on 27 April 2015

The novel human coronaviruses NL63 and HKU1.

scientific article published on November 2006

The nucleocapsid protein of human coronavirus NL63

scientific article

Tuning the Surface Properties of Poly(Allylamine Hydrochloride)-Based Multilayer Films

scientific article published in May 2021

Type III CRISPR complexes from Thermus thermophilus

scientific article published on 14 June 2016

Use of sensitive, broad-spectrum molecular assays and human airway epithelium cultures for detection of respiratory pathogens

scientific article

Virus Like Particles as Immunogens and Universal Nanocarriers

scientific article

Visualizing Coronavirus Entry into Cells

scientific article published on 01 January 2020

Zika virus NS3 protease and its cellular substrates

scientific article published on 20 September 2020

Zika virus: mapping and reprogramming the entry

scientific article published on 03 May 2019

l-Arginine Improves Solubility and ANTI SARS-CoV-2 Mpro Activity of Rutin but Not the Antiviral Activity in Cells

scientific article published on 7 October 2021

List of works by Krzysztof Pyrć

A New Network for the Advancement of Marine Biotechnology in Europe and Beyond

A novel pancoronavirus RT-PCR assay: frequent detection of human coronavirus NL63 in children hospitalized with respiratory tract infections in Belgium

APOBEC3-mediated restriction of RNA virus replication

Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and related conditions

Angiotensin converting enzyme: A review on expression profile and its association with human disorders with special focus on SARS-CoV-2 infection

Anti-SARS-CoV-2 activity of cyanopeptolins produced by Nostoc edaphicum CCNP1411

Attachment factor and receptor engagement of SARS coronavirus and human coronavirus NL63.

Bacterial Infections During Hospital Stay and Their Impact on Mortality After Lung Transplantation: A Single-Center Study

Bacterial proteases in disease - role in intracellular survival, evasion of coagulation/ fibrinolysis innate defenses, toxicoses and viral infections

Battle at the entrance gate: CIITA as a weapon to prevent the internalization of SARS-CoV-2 and Ebola viruses

Berberine Hampers Influenza A Replication through Inhibition of MAPK/ERK Pathway

Biopolymeric nano/microspheres for selective and reversible adsorption of coronaviruses

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

CRISPR-Cas Systems in Prokaryotes

Canine Respiratory Coronavirus, Bovine Coronavirus, and Human Coronavirus OC43: Receptors and Attachment Factors

Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells.

Cat flu: Broad spectrum polymeric antivirals

Citrullination alters immunomodulatory function of LL-37 essential for prevention of endotoxin-induced sepsis.

Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) RNAs in the Porphyromonas gingivalis CRISPR-Cas I-C System.

Croup is associated with the novel coronavirus NL63

Culturing the unculturable: human coronavirus HKU1 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell cultures

Detection of legal highs in the urine of methadone-treated patient by LC-MS

Detection of new viruses by VIDISCA. Virus discovery based on cDNA-amplified fragment length polymorphism

Development of loop-mediated isothermal amplification assay for detection of human coronavirus-NL63

Early events during human coronavirus OC43 entry to the cell

Effects of host genetic variations on response to, susceptibility and severity of respiratory infections

Efficacy of antiviral drugs against the omicron variant of SARS-CoV-2

Electrochemical Immunosensors Based on Screen-Printed Gold and Glassy Carbon Electrodes: Comparison of Performance for Respiratory Syncytial Virus Detection

Entry of human coronavirus NL63 to the cell.

Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021

Functional Analysis of Porphyromonas gingivalis W83 CRISPR-Cas Systems.

Genome structure and transcriptional regulation of human coronavirus NL63

Gingipains: Critical Factors in the Development of Aspiration Pneumonia Caused by Porphyromonas gingivalis

HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoV

HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 and MERS-CoV

HTCC: Broad Range Inhibitor of Coronavirus Entry

HexaPrime: a novel method for detection of coronaviruses

Highly Effective and Safe Polymeric Inhibitors of Herpes Simplex Virus in Vitro and in Vivo

Human Coronavirus HKU1 Spike Protein Uses O-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme

Human Coronavirus NL63 Infection is Associated with Croup

Human coronavirus 229E encodes a single ORF4 protein between the spike and the envelope genes

Human coronavirus NL63 and 229E seroconversion in children

Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry

Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells

Human coronavirus NL63, a new respiratory virus

Human parechovirus type 1, 3, 4, 5, and 6 detection in picornavirus cultures

Identification of Cellular Factors Required for SARS-CoV-2 Replication

Identification of cell lines permissive for human coronavirus NL63.

Identification of new human coronaviruses

Immunosuppressive Treatment and Its Effect on the Occurrence of Pneumocystis jiroveci, Mycoplasma pneumoniae, Chlamydophila pnemoniae, and Legionella pneumophila Infections/Colonizations Among Lung Transplant Recipients

In Vitro Inhibition of Zika Virus Replication with Poly(Sodium 4-Styrenesulfonate)

In vitro testing the potential of a novel chimeric IgG variant for inhibiting collagen fibrils formation in recurrent hereditary gingival fibromatosis: chimeric antibody in a gingival model

Inactivation of epidermal growth factor by Porphyromonas gingivalis as a potential mechanism for periodontal tissue damage

Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells

Inhibition of Herpes Simplex Viruses by Cationic Dextran Derivatives.

Inhibition of human coronavirus NL63 infection at early stages of the replication cycle

Interaction Between the Spike Protein of Human Coronavirus NL63 and its Cellular Receptor ACE2

Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1

Kallikrein 13: a new player in coronaviral infections

MASS SPECTROMETRY IN VIROLOGICAL SCIENCES

Mass Spectrometry versus Conventional Techniques of Protein Detection: Zika Virus NS3 Protease Activity towards Cellular Proteins

Membrane Protein of Human Coronavirus NL63 Is Responsible for Interaction with the Adhesion Receptor

Mosaic structure of human coronavirus NL63, one thousand years of evolution ⬇️

Nonstructural proteins of human coronavirus NL63.

Novel Polyanions Inhibiting Replication of Influenza Viruses

Novel coronavirus-like particles targeting cells lining the respiratory tract

Novel peptidyl α-aminoalkylphosphonates as inhibitors of hepatitis C virus NS3/4A protease.

Novel polymeric inhibitors of HCoV-NL63.

One Step Beyond: Design of Substrates Spanning Primed Positions of Zika Virus NS2B-NS3 Protease

Ozone Treatment Is Insufficient to Inactivate SARS-CoV-2 Surrogate under Field Conditions

Phosphonate inhibitors of West Nile virus NS2B/NS3 protease

Porphyromonas gingivalis enzymes enhance infection with human metapneumovirus in vitro

Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD)

Recent antiviral strategies against human coronavirus-related respiratory illnesses

Replication of SARS-CoV-2 in human respiratory epithelium

Replication of SARS-CoV-2 in human respiratory epithelium

Replication-dependent downregulation of cellular angiotensin-converting enzyme 2 protein expression by human coronavirus NL63.

Seleno-Functionalization of Quercetin Improves the Non-Covalent Inhibition of M and Its Antiviral Activity in Cells against SARS-CoV-2

Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors