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List of works by Gernot Längst

A 'loop recapture' mechanism for ACF-dependent nucleosome remodeling

scientific article published on 17 July 2005

A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression

scientific article

A nucleosome sliding assay for chromatin remodeling factors

scientific article published in January 2004

ALY RNA-binding proteins are required for nucleo-cytosolic mRNA transport and modulate plant growth and development.

scientific article published on 14 March 2018

ARMADILLO REPEAT ONLY proteins confine Rho GTPase signalling to polar growth sites

scientific article published on 05 October 2020

Acf1, the largest subunit of CHRAC, regulates ISWI-induced nucleosome remodelling

scientific article published on July 2001

Antibody-targeted chromatin enables effective intracellular delivery and functionality of CRISPR/Cas9 expression plasmids

scientific article published on 01 June 2019

Arabidopsis DEAD-box RNA helicase UAP56 interacts with both RNA and DNA as well as with mRNA export factors

scientific article

Author Correction: ARMADILLO REPEAT ONLY proteins confine Rho GTPase signalling to polar growth sites

scientific article published on 06 January 2021

Author Correction: Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1.

scientific article published on 25 February 2020

Bioinformatic Analysis of ChIP-seq Data on the Repetitive Ribosomal RNA Gene

scientific article

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality

scientific article published on 28 August 2017

Changes in higher order structures of chromatin by RNP complexes

scientific article

Characterization of Dnmt1 Binding and DNA Methylation on Nucleosomes and Nucleosomal Arrays

scientific article published on 23 October 2015

Characterizing the nuclease accessibility of DNA in human cells to map higher order structures of chromatin.

scientific article published in February 2019

Chromatin Organization and the Mammalian Nucleolus

Chromatin Remodelers: From Function to Dysfunction

scientific article published on 12 June 2015

Chromatin Remodeling and Nucleosome Positioning

Chromatin higher order structure: opening up chromatin for transcription

scientific article published on February 2004

Chromatin organization of active ribosomal RNA genes

scientific journal article

Chromatin targeting signals, nucleosome positioning mechanism and non-coding RNA-mediated regulation of the chromatin remodeling complex NoRC.

scientific article

Chromatin-specific regulation of mammalian rDNA transcription by clustered TTF-I binding sites

scientific article

CpG domains downstream of TSSs promote high levels of gene expression

scientific article published on 09 January 2014

Critical role for the histone H4 N terminus in nucleosome remodeling by ISWI.

scientific article published on February 2001

DNA sequence encoded repression of rRNA gene transcription in chromatin

scientific article published on 25 April 2010

DNA sequence- and conformation-directed positioning of nucleosomes by chromatin-remodeling complexes

scholarly article

DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells

scientific article

Deep sequencing of small chromatin-associated RNA: bioinformatic analysis

scientific article published on January 2014

Deep sequencing of small chromatin-associated RNA: isolation and library preparation

scientific article

Defects in 18 S or 28 S rRNA processing activate the p53 pathway

scientific article

Df31 Protein and snoRNAs Maintain Accessible Higher-Order Structures of Chromatin

scientific article (publication date: November 2012)

Differential enrichment of TTF-I and Tip5 in the T-like promoter structures of the rDNA contribute to the epigenetic response of Cyprinus carpio during environmental adaptation

scientific article published on 13 April 2016

Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain

scientific article

Elucidation of the functional roles of the Q and I motifs in the human chromatin-remodeling enzyme BRG1

scientific article published on 15 January 2019

Epigenetic control of RNA polymerase I transcription in mammalian cells

scientific article

Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells

scientific article published on 13 March 2007

Epigenetic regulation of TTF-I-mediated promoter-terminator interactions of rRNA genes

scientific article published on 20 March 2008

Fluorescence anisotropy assays for analysis of ISWI-DNA and ISWI-nucleosome interactions.

scientific article published on January 2004

Genome organization in and around the nucleolus

scientific article published on 04 February 2011

High mobility group 1 protein is not stably associated with the chromosomes of somatic cells.

scientific article

Histone 2B monoubiquitination complex integrates transcript elongation with RNA processing at circadian clock and flowering regulators

scientific article published on 28 March 2019

Histone H2A C-terminus regulates chromatin dynamics, remodeling, and histone H1 binding

scientific article

Human ISWI chromatin-remodeling complexes sample nucleosomes via transient binding reactions and become immobilized at active sites

scientific article

ISWI Induces Nucleosome Sliding on Nicked DNA ⬇️

scientific article published on November 1, 2001

ISWI Is an ATP-Dependent Nucleosome Remodeling Factor

article

Initial genomics of the human nucleolus

scientific article published in March 2010

Large-scale organization of ribosomal DNA chromatin is regulated by Tip5.

scientific article published on 10 April 2013

Mapping of replication initiation sites in the mouse ribosomal gene cluster

scientific article published on April 1996

Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1.

scientific article published on 21 January 2020

Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1.

scientific article published on 8 May 2013

MicroScale Thermophoresis: A Rapid and Precise Method to Quantify Protein-Nucleic Acid Interactions in Solution

scientific article

Microscale thermophoresis as a sensitive method to quantify protein: nucleic acid interactions in solution

scientific article

Myb-binding protein 1a (Mybbp1a) regulates levels and processing of pre-ribosomal RNA.

scientific article published on 29 May 2012

Nanoarchaeal origin of histone H3?

scientific article

NoRC-dependent nucleosome positioning silences rRNA genes

scientific article published on 30 November 2006

Nucleosome movement by CHRAC and ISWI without disruption or trans-displacement of the histone octamer.

scientific article

Nucleosome remodeling: one mechanism, many phenomena?

scientific article published on March 2004

Nucleosome stability at the yeast PHO5 and PHO8 promoters correlates with differential cofactor requirements for chromatin opening

scientific article published on December 2005

Nucleosomes Stabilize ssRNA-dsDNA Triple Helices in Human Cells

scientific article published on 12 February 2019

Nucleosomes protect DNA from DNA methylation in vivo and in vitro.

scientific article

Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology

scientific article published on 21 May 2021

Overexpression of UHRF1 promotes silencing of tumor suppressor genes and predicts outcome in hepatoblastoma

scientific article published on 2 March 2018

Plasmodium falciparum Nucleosomes Exhibit Reduced Stability and Lost Sequence Dependent Nucleosome Positioning

scientific article

Preparation of Chromatin Templates to Study RNA Polymerase I Transcription In Vitro

scientific article published in January 2016

Purine- and pyrimidine-triple helix forming oligonucleotides recognize qualitatively different target sites at the ribosomal DNA locus

scientific article

RNA polymerase I transcription fidelity, speed and processivity depend on the interplay of its lobe binding subunits

Ran binds to chromatin by two distinct mechanisms.

scientific article

Recruitment of the nucleolar remodeling complex NoRC establishes ribosomal DNA silencing in chromatin

scientific article published on February 2004

Sequence and functional differences in the ATPase domains of CHD3 & SNF2H promise potential for selective regulability and drugability

scientific article published on 05 January 2021

Splicing of many human genes involves sites embedded within introns

scientific article published on 20 April 2015

Structural analysis of mouse rDNA: coincidence between nuclease hypersensitive sites, DNA curvature and regulatory elements in the intergenic spacer

scientific article published on February 1997

Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling.

scientific article

TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning

scientific article

TTF-I determines the chromatin architecture of the active rDNA promoter

scientific article

Targeting chromatin remodelers: signals and search mechanisms.

scientific article published on 16 June 2011

The Arabidopsis Histone Chaperone FACT: Role of the HMG-Box Domain of SSRP1

scientific article

The Arabidopsis THO/TREX component TEX1 functionally interacts with MOS11 and modulates mRNA export and alternative splicing events

scientific article published on 21 December 2016

The Composition of the Arabidopsis RNA Polymerase II Transcript Elongation Complex Reveals the Interplay between Elongation and mRNA Processing Factors

scientific article published on 28 March 2017

The DNA chaperone HMGB1 facilitates ACF/CHRAC-dependent nucleosome sliding

scientific article published on December 2002

The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation

scientific article

The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize

scientific article published in 2023

The UAP56-Interacting Export Factors UIEF1 and UIEF2 Function in mRNA Export

scientific article published on 30 January 2019

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

scientific article

The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo

scientific article

The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization

scientific article published on May 2002

The extended AT-hook is a novel RNA binding motif.

scientific article published on 9 July 2015

The impact of intragenic CpG content on gene expression

scientific article

The intracellular domain of β-dystroglycan mediates the nucleolar stress response by suppressing UBF transcriptional activity

scientific article published on 27 February 2019

The monoclonal S9.6 antibody exhibits highly variable binding affinities towards different R-loop sequences

scientific article

Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner.

scientific article

dCHD3, a novel ATP-dependent chromatin remodeler associated with sites of active transcription

scientific article published on 4 February 2008

dMi-2 and ISWI chromatin remodelling factors have distinct nucleosome binding and mobilization properties

scientific article

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