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List of works by Ignacio A. Romero

3D Reconstruction of the Neurovascular Unit Reveals Differential Loss of Cholinergic Innervation in the Cortex and Hippocampus of the Adult Mouse Brain

scientific article published on 04 July 2019

A multi-system approach assessing the interaction of anticonvulsants with P-gp

scientific article

A novel vascular targeting strategy for brain-derived endothelial cells using a TCR mimic antibody.

scientific article

A recombinant inhibitory isoform of vascular endothelial growth factor164/165 aggravates ischemic brain damage in a mouse model of focal cerebral ischemia

scientific article published on 30 July 2013

A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions.

scientific article published on 17 November 2015

ABC and SLC transporter expression and proton oligopeptide transporter (POT) mediated permeation across the human blood--brain barrier cell line, hCMEC/D3 [corrected]

scientific article

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers.

scientific article published on 27 October 2017

Action of transcription factors in the control of transferrin receptor expression in human brain endothelium

scientific article published on 26 October 2006

Adenosine receptors regulate gap junction coupling of the human cerebral microvascular endothelial cells hCMEC/D3 by Ca2+ influx through cyclic nucleotide-gated channels

scientific article published on 11 January 2017

Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier

scientific article published on 25 June 2019

Age-associated changes in the blood-brain barrier: comparative studies in human and mouse

scientific article published on 28 April 2017

Alteration of blood-brain barrier integrity by retroviral infection

scientific article published in November 2008

Amyloid-beta-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation.

scientific article published on 2 April 2009

Anin VitroStudy ofm-Dinitrobenzene Toxicity on the Cellular Components of the Blood–Brain Barrier, Astrocytes and Endothelial Cells

article

Assessment of electrophile damage in a human brain endothelial cell line utilizing a clickable alkyne analog of 2-chlorohexadecanal.

scientific article published on 11 November 2015

BBB on chip: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function.

scientific article published on February 2013

Blood-brain barrier-specific properties of a human adult brain endothelial cell line

scientific article published on September 2005

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation

scientific article

CCL2 binding is CCR2 independent in primary adult human astrocytes

scientific article published on 4 December 2011

CCL2 disrupts the adherens junction: implications for neuroinflammation ⬇️

scientific article published on May 28, 2012

CXCL1/CXCL8 (GROα/IL-8) in human diabetic ketoacidosis plasma facilitates leukocyte recruitment to cerebrovascular endothelium in vitro

article

Cannabidiol Enhances the Passage of Lipid Nanocapsules across the Blood-Brain Barrier Both in Vitro and in Vivo

scientific article published on 22 March 2019

Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging

scientific article

Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice

scientific article published on 15 November 2018

Cerebrospinal fluid dynamics modulation by diet and cytokines in rats

scientific article published on 10 February 2020

Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells

scientific article published on June 2003

Characterizing the pathotype of neonatal meningitis causing Escherichia coli (NMEC).

scientific article published on 14 October 2015

Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation.

scientific article

Chemokine transport across human vascular endothelial cells.

scientific article

Chemokines control fat accumulation and leptin secretion by cultured human adipocytes

scientific article published on 01 April 2001

Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation.

scientific article

Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.

scientific article published on 7 November 2017

Cytokine-induced changes in the gene expression profile of a human cerebral microvascular endothelial cell-line, hCMEC/D3

scientific article published on 19 September 2013

Development of a three-dimensional, all-human in vitro model of the blood-brain barrier using mono-, co-, and tri-cultivation Transwell models

scientific article published on 14 May 2011

Differences in amyloid-β clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling.

scientific article published on 24 January 2014

Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier

scientific article published on 7 February 2008

Differential permissivity of human cerebrovascular endothelial cells to enterovirus infection and specificities of serotype EV-A71 in crossing an in vitro model of the human blood-brain barrier

scientific article

Drug-induced trafficking of p-glycoprotein in human brain capillary endothelial cells as demonstrated by exposure to mitomycin C

scientific article (publication date: 2014)

Early alterations of Hedgehog signaling pathway in vascular endothelial cells after peripheral nerve injury elicit blood-nerve barrier disruption, nerve inflammation, and neuropathic pain development.

scientific article published on 26 November 2015

Early metabolic changes during m-dinitrobenzene neurotoxicity and the possible role of oxidative stress

scientific article published on 01 February 1995

Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown

scientific article

Expression and localization of claudins-3 and -12 in transformed human brain endothelium

scientific article

Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells.

scientific article

Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment

scientific article published on 25 March 2009

Expression of chemokines and their receptors by human brain endothelium: implications for multiple sclerosis.

scientific article

Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway.

scientific article published on 31 December 2008

Ezrin and moesin co-localise with ICAM-1 in brain endothelial cells but are not directly associated

scientific article published on September 2002

F-actin cytoskeleton and sucrose permeability of immortalised rat brain microvascular endothelial cell monolayers: effects of cyclic AMP and astrocytic factors

scientific article

Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro

scientific article published on 23 November 2011

Glucose-coated gold nanoparticles transfer across human brain endothelium and enter astrocytes in vitro

scientific article

Hepatitis C virus infects the endothelial cells of the blood-brain barrier

scientific article published on December 2011

Human brain endothelial cells are responsive to adenosine receptor activation ⬇️

scientific article published on February 17, 2011

Hyperosmotic stress induces Axl activation and cleavage in cerebral endothelial cells

scientific article

Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications

scientific article

Identification of peptide ligands for targeting to the blood-brain barrier

scientific article

Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies

scientific article

Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain barrier

scientific article published on 13 October 2012

Inflammatory response of endothelial cells to a human endogenous retrovirus associated with multiple sclerosis is mediated by TLR4.

scientific article

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

scientific article

In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use.

scientific article published on 11 February 2016

Lamotrigine is a substrate for OCT1 in brain endothelial cells

scientific article published on 29 December 2011

Localization and mobility of glucose-coated gold nanoparticles within the brain.

scientific article

Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis

scientific article published on 22 November 2017

Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium.

scientific article

Metabolic and permeability changes caused by thiamine deficiency in immortalized rat brain microvessel endothelial cells

scientific article published on May 1997

Methamphetamine disrupts blood-brain barrier function by induction of oxidative stress in brain endothelial cells

scientific article

Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells

scientific article published on 4 July 2016

MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium

scientific article published on 30 March 2017

MicroRNA-155 contributes to shear-resistant leukocyte adhesion to human brain endothelium in vitro

scientific article

MicroRNA-155 negatively affects blood–brain barrier function during neuroinflammation

scientific article published on 06 March 2014

MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis.

scientific article published on April 2013

Microparticles in multiple sclerosis and clinically isolated syndrome: effect on endothelial barrier function

scientific article

Modulation of blood-brain barrier permeability by neutrophils: in vitro and in vivo studies

scientific article

Molecular cytogenetic characterization of the human cerebral microvessel endothelial cell line hCMEC/D3.

scientific article published on 26 October 2009

Nanoparticle formulation improves the anticonvulsant effect of clonazepam on the pentylenetetrazole-induced seizures: behavior and electroencephalogram.

scientific article

Oxidative stress affects the junctional integrity of retinal pigment epithelial cells.

scientific article published on February 2004

P-glycoprotein and breast cancer resistance protein restrict apical-to-basolateral permeability of human brain endothelium to amyloid-beta

scientific article published on 15 April 2009

PPARγ agonist-loaded PLGA-PEG nanocarriers as a potential treatment for Alzheimer's disease: in vitro and in vivo studies

scientific article published on 20 September 2018

Paracrine signalling of inflammatory cytokines from an in vitro blood brain barrier model upon exposure to polymeric nanoparticles

scientific article published on 5 November 2013

Peripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line

scientific article

Permeability of PEGylated immunoarsonoliposomes through in vitro blood brain barrier-medulloblastoma co-culture models for brain tumor therapy

scientific article published on 19 September 2014

Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123.

scientific article

Prolonged Morphine Exposure Induces Increased Firm Adhesion in an in Vitro Model of the Blood-Brain Barrier

scientific article published on 09 June 2016

Protective effect of the multitarget compound DPH-4 on human SSAO/VAP-1-expressing hCMEC/D3 cells under oxygen-glucose deprivation conditions: an in vitro experimental model of cerebral ischaemia.

scientific article published on 12 September 2015

Purine receptors and Ca(2+) signalling in the human blood-brain barrier endothelial cell line hCMEC/D3

scientific article published on 29 September 2011

Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling

scientific article

Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation

scientific article published on 26 April 2016

Regulation of cerebral endothelial cell morphology by extracellular calcium

scientific article published on 02 October 2007

Role of KCNMA1 gene in breast cancer invasion and metastasis to brain

scientific article published on 29 July 2009

Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells

scientific article published on 15 August 2012

Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability.

scientific article

Serotype O18 avian pathogenic and neonatal meningitis Escherichia coli strains employ similar pathogenic strategies for the onset of meningitis.

scientific article published on 25 September 2015

Signaling mechanism of extracellular RNA in endothelial cells

scientific article

Solid lipid nanoparticles as a vehicle for brain-targeted drug delivery: two new strategies of functionalization with apolipoprotein E.

scientific article published on 17 November 2015

Somatostatin preserved blood brain barrier against cytokine induced alterations: possible role in multiple sclerosis

scientific article published on 13 June 2013

Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS.

scientific article published on January 2013

Temporal profile of matrix metalloproteinases and their inhibitors in a human endothelial cell culture model of cerebral ischemia

scientific article published on 25 June 2013

The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases in vitro drug delivery across blood-brain barrier cells.

scientific article

The blood-brain barrier in multiple sclerosis: microRNAs as key regulators.

scientific article

The hCMEC/D3 cell line as a model of the human blood brain barrier

scientific article published on 26 March 2013

The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies

scientific article

The involvement of a Na⁺- and Cl⁻-dependent transporter in the brain uptake of amantadine and rimantadine

scientific article published in March 2012

The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the SLC22 family

scientific article published on 26 August 2014

The role of perivascular innervation and neurally mediated vasoreactivity in the pathophysiology of Alzheimer's disease.

scientific article published on June 2017

The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood-brain barrier: evidence for involvement of breast cancer resistance protein

scientific article

Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and beta-alanine

scientific article

Transcellular targeting of fiber- and hexon-modified adenovirus vectors across the brain microvascular endothelial cells in vitro

scientific article

Transcriptional control of occludin expression in vascular endothelia: regulation by Sp3 and YY1.

scientific article

Transcriptional control of the multi-drug transporter ABCB1 by transcription factor Sp3 in different human tissues

scientific article

Transendothelial permeability changes induced by free radicals in an in vitro model of the blood-brain barrier

scientific article published on September 1999

Transport of Gold Nanoparticles by Vascular Endothelium from Different Human Tissues

scientific article (publication date: 2016)

Transporting therapeutics across the blood-brain barrier

scientific article published on March 1996

Transthyretin participates in beta-amyloid transport from the brain to the liver--involvement of the low-density lipoprotein receptor-related protein 1?

scientific article published on 3 February 2016

Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium ⬇️

scientific article published on December 18, 2010

Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line

scientific article

Uptake and permeability studies of BBB-targeting immunoliposomes using the hCMEC/D3 cell line

scientific article published on 29 November 2010

[EXPRESS] Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury?

scientific article published on January 2017

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