List of works - Nic E. Savaskan

A new functional classification system (FGA/B) with prognostic value for glioma patients.

scientific article

A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting

scientific journal article

A versatile ex vivo technique for assaying tumor angiogenesis and microglia in the brain

scientific article published on 10 December 2015

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

scientific article published on 29 May 2017

Adaptive Immune Response to and Survival Effect of Temozolomide- and Valproic Acid-induced Autophagy in Glioblastoma

scientific article published on March 2016

Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma

scientific article published in January 2007

Biochemical analysis of selenoprotein expression in brain cell lines and in distinct brain regions

scientific article

Brain miffed by macrophage migration inhibitory factor

scientific article published on 03 September 2012

Cabazitaxel operates anti-metastatic and cytotoxic via apoptosis induction and stalls brain tumor angiogenesis

scientific article

Cellular characterization of the peritumoral edema zone in malignant brain tumors.

scientific article published on 24 July 2009

Chemotherapeutic xCT inhibitors sorafenib and erastin unraveled with the synaptic optogenetic function analysis tool

scientific article

Cholecystokinin expression after hippocampal deafferentiation: molecular evidence revealed by differential display-reverse transcription-polymerase chain reaction

scientific article published in January 2003

Comparative analysis of selenocysteine machinery and selenoproteome gene expression in mouse brain identifies neurons as key functional sites of selenium in mammals

scientific article published on 21 November 2007

Corrigendum: Identification of two novel Chlorotoxin derivatives CA4 and CTX-23 with chemotherapeutic and anti-angiogenic potential

scientific article published on 25 May 2016

Cytotoxic profiling of artesunic and betulinic acids and their synthetic hybrid compound on neurons and gliomas

scientific article published on 7 June 2017

Dexamethasone alleviates tumor-associated brain damage and angiogenesis

scientific article

Dissection of mitogenic and neurodegenerative actions of cystine and glutamate in malignant gliomas

scientific article published on 30 August 2010

Entorhinal cortex lesion studied with the novel dye Fluoro-Jade

article

Epigenetics in Brain Tumors: HDACs Take Center Stage

scientific article

Erratum: Identification of two novel Chlorotoxin derivatives CA4 and CTX-23 with chemotherapeutic and anti-angiogenic potential

scientific article published on March 2016

Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275.

scientific article

Ferroptosis and Cell Death Analysis by Flow Cytometry

scientific article published on January 2017

Glioblastoma cells induce differential glutamatergic gene expressions in human tumor-associated microglia/macrophages and monocyte-derived macrophages.

scientific article published on 5 June 2015

Hidden association of Cowden syndrome, PTEN mutation and meningioma frequency

scientific article

High resolution neurochemical gold staining method for myelin in peripheral and central nervous system at the light- and electron-microscopic level

scientific article

Histone deacetylases inhibition by SAHA/Vorinostat normalizes the glioma microenvironment via xCT equilibration

scientific article published on 17 September 2014

Homeostatic regulation of NCAM polysialylation is critical for correct synaptic targeting

scientific article published on 9 November 2011

IG-molecule Kilon shows differential expression pattern from LAMP in the developing and adult rat hippocampus

scientific article

Identification of macrophage/microglia activation factor (MAF) associated with late endosomes/lysosomes in microglial cells

scientific article published on April 2004

Identification of neuronal cell death in a model of degeneration in the hippocampus

scientific article published on March 2003

Identification of two novel Chlorotoxin derivatives CA4 and CTX-23 with chemotherapeutic and anti-angiogenic potential

scientific article published on 2 February 2016

Impaired postnatal development of hippocampal neurons and axon projections in the Emx2-/- mutants

scientific article published in December 2002

Improved outcome of facial nerve repair in rats is associated with enhanced regenerative response of motoneurons and augmented neocortical plasticity

scientific article published in October 2006

Improving the extent of malignant glioma resection by dual intraoperative visualization approach

scientific article published in 2012

Intraoperative vascular DIVA surgery reveals angiogenic hotspots in tumor zones of malignant gliomas

scientific article

MCT4 Promotes Tumor Malignancy in F98 Glioma Cells

scientific article published in 2021

MIF-CD74 signaling impedes microglial M1 polarization and facilitates brain tumorigenesis

scientific article published on 9 May 2016

Molecular actions of selenium in the brain: neuroprotective mechanisms of an essential trace element.

scientific article published on January 2004

Molecular and functional analysis of hyperpolarization-activated pacemaker channels in the hippocampus after entorhinal cortex lesion.

scientific article published in December 2001

Molecular biology of glutathione peroxidase 4: from genomic structure to developmental expression and neural function.

scientific article

Molecules involved in reactive sprouting in the hippocampus.

scientific article

Myelin does not influence the choice behaviour of entorhinal axons but strongly inhibits their outgrowth length in vitro

scientific article published in January 1999

Myelination in the hippocampus during development and following lesion

scientific article published in May 2004

Neurodegeneration and the Brain Tumor Microenvironment. [corrected]

scientific article

Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion

scientific article

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

scientific article published on 14 August 2017

Outgrowth-promoting molecules in the adult hippocampus after perforant path lesion

scientific article published in March 2000

PRG3 induces Ras-dependent oncogenic cooperation in gliomas

scientific article published on 5 April 2016

Perforant path lesion induces up-regulation of stathmin messenger RNA, but not SCG10 messenger RNA, in the adult rat hippocampus.

scientific article

Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury.

scientific article published on 15 October 2016

Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics.

scientific article published on 14 September 2010

Regulation of expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene. Tissue-specific expression pattern and identification of functional cis- and trans-regulatory elements.

scientific article

Role for glutathione peroxidase-4 in brain development and neuronal apoptosis: specific induction of enzyme expression in reactive astrocytes following brain injury

scientific article published on 10 April 2007

Selenium action in neuro-oncology

scientific article

Selenium and brain function: a poorly recognized liaison

article

Sema3C and netrin-1 differentially affect axon growth in the hippocampal formation

scientific article published in February 2000

Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema.

scientific article

Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo

scientific article

Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema

scientific article published on 8 April 2016

Sunitinib impedes brain tumor progression and reduces tumor-induced neurodegeneration in the microenvironment

scientific article

Supra-complete surgery via dual intraoperative visualization approach (DiVA) prolongs patient survival in glioblastoma

scientific article published on 25 March 2016

Surgical resection of malignant gliomas-role in optimizing patient outcome.

scientific article

Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.

scientific article

Target- and maturation-specific membrane-associated molecules determine the ingrowth of entorhinal fibers into the hippocampus

scientific article

Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis

scientific article

The impact of dietary isoflavonoids on malignant brain tumors

scientific article

The oxido-metabolic driver ATF4 enhances temozolamide chemo-resistance in human gliomas

scientific article published on 9 May 2017

The role of phospholipid hydroperoxide glutathione peroxidase isoforms in murine embryogenesis

scientific article

The role of selenite on microglial migration

scientific article published on January 2007

The x(c)(-) cystine/glutamate antiporter (xCT) as a potential target for therapy of cancer: yet another cytotoxic anticancer approach?

scientific article published in August 2009

xCT modulation in gliomas: relevance to energy metabolism and tumor microenvironment normalization

scientific article published on 05 August 2010

List of works by Nic E. Savaskan

A new functional classification system (FGA/B) with prognostic value for glioma patients.

A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting

A versatile ex vivo technique for assaying tumor angiogenesis and microglia in the brain

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

Adaptive Immune Response to and Survival Effect of Temozolomide- and Valproic Acid-induced Autophagy in Glioblastoma

Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma

Biochemical analysis of selenoprotein expression in brain cell lines and in distinct brain regions

Brain miffed by macrophage migration inhibitory factor

Cabazitaxel operates anti-metastatic and cytotoxic via apoptosis induction and stalls brain tumor angiogenesis

Cellular characterization of the peritumoral edema zone in malignant brain tumors.

Chemotherapeutic xCT inhibitors sorafenib and erastin unraveled with the synaptic optogenetic function analysis tool

Cholecystokinin expression after hippocampal deafferentiation: molecular evidence revealed by differential display-reverse transcription-polymerase chain reaction

Comparative analysis of selenocysteine machinery and selenoproteome gene expression in mouse brain identifies neurons as key functional sites of selenium in mammals

Corrigendum: Identification of two novel Chlorotoxin derivatives CA4 and CTX-23 with chemotherapeutic and anti-angiogenic potential

Cytotoxic profiling of artesunic and betulinic acids and their synthetic hybrid compound on neurons and gliomas

Dexamethasone alleviates tumor-associated brain damage and angiogenesis

Dissection of mitogenic and neurodegenerative actions of cystine and glutamate in malignant gliomas

Entorhinal cortex lesion studied with the novel dye Fluoro-Jade

Epigenetics in Brain Tumors: HDACs Take Center Stage

Erratum: Identification of two novel Chlorotoxin derivatives CA4 and CTX-23 with chemotherapeutic and anti-angiogenic potential

Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275.

Ferroptosis and Cell Death Analysis by Flow Cytometry

Glioblastoma cells induce differential glutamatergic gene expressions in human tumor-associated microglia/macrophages and monocyte-derived macrophages.

Hidden association of Cowden syndrome, PTEN mutation and meningioma frequency

High resolution neurochemical gold staining method for myelin in peripheral and central nervous system at the light- and electron-microscopic level

Histone deacetylases inhibition by SAHA/Vorinostat normalizes the glioma microenvironment via xCT equilibration

Homeostatic regulation of NCAM polysialylation is critical for correct synaptic targeting

IG-molecule Kilon shows differential expression pattern from LAMP in the developing and adult rat hippocampus

Identification of macrophage/microglia activation factor (MAF) associated with late endosomes/lysosomes in microglial cells

Identification of neuronal cell death in a model of degeneration in the hippocampus

Identification of two novel Chlorotoxin derivatives CA4 and CTX-23 with chemotherapeutic and anti-angiogenic potential

Impaired postnatal development of hippocampal neurons and axon projections in the Emx2-/- mutants

Improved outcome of facial nerve repair in rats is associated with enhanced regenerative response of motoneurons and augmented neocortical plasticity

Improving the extent of malignant glioma resection by dual intraoperative visualization approach

Intraoperative vascular DIVA surgery reveals angiogenic hotspots in tumor zones of malignant gliomas

MCT4 Promotes Tumor Malignancy in F98 Glioma Cells

MIF-CD74 signaling impedes microglial M1 polarization and facilitates brain tumorigenesis

Molecular actions of selenium in the brain: neuroprotective mechanisms of an essential trace element.

Molecular and functional analysis of hyperpolarization-activated pacemaker channels in the hippocampus after entorhinal cortex lesion.

Molecular biology of glutathione peroxidase 4: from genomic structure to developmental expression and neural function.

Molecules involved in reactive sprouting in the hippocampus.

Myelin does not influence the choice behaviour of entorhinal axons but strongly inhibits their outgrowth length in vitro

Myelination in the hippocampus during development and following lesion

Neurodegeneration and the Brain Tumor Microenvironment. [corrected]

Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

Outgrowth-promoting molecules in the adult hippocampus after perforant path lesion

PRG3 induces Ras-dependent oncogenic cooperation in gliomas

Perforant path lesion induces up-regulation of stathmin messenger RNA, but not SCG10 messenger RNA, in the adult rat hippocampus.

Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury.

Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics.

Regulation of expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene. Tissue-specific expression pattern and identification of functional cis- and trans-regulatory elements.

Role for glutathione peroxidase-4 in brain development and neuronal apoptosis: specific induction of enzyme expression in reactive astrocytes following brain injury

Selenium action in neuro-oncology

Selenium and brain function: a poorly recognized liaison

Sema3C and netrin-1 differentially affect axon growth in the hippocampal formation

Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema.

Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo

Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema

Sunitinib impedes brain tumor progression and reduces tumor-induced neurodegeneration in the microenvironment

Supra-complete surgery via dual intraoperative visualization approach (DiVA) prolongs patient survival in glioblastoma

Surgical resection of malignant gliomas-role in optimizing patient outcome.

Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.

Target- and maturation-specific membrane-associated molecules determine the ingrowth of entorhinal fibers into the hippocampus

Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis

The impact of dietary isoflavonoids on malignant brain tumors

The oxido-metabolic driver ATF4 enhances temozolamide chemo-resistance in human gliomas

The role of phospholipid hydroperoxide glutathione peroxidase isoforms in murine embryogenesis

The role of selenite on microglial migration

The x(c)(-) cystine/glutamate antiporter (xCT) as a potential target for therapy of cancer: yet another cytotoxic anticancer approach?

xCT modulation in gliomas: relevance to energy metabolism and tumor microenvironment normalization