List of works - Mario Chiariello

Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy

scientific article published on 5 October 2018

Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.

scientific article

Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex

scientific article published in July 1999

Alterations of autophagy in the peripheral neuropathy Charcot-Marie-Tooth type 2B.

scientific article published on 13 November 2017

Aptamer Functionalization of Nanosystems for Glioblastoma Targeting through the Blood-Brain Barrier

scientific article

Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells

scientific article published on 10 October 2015

Cloning and expression analysis of the murine Rab7 cDNA.

scientific article published on December 1995

Context-dependent miR-204 and miR-211 affect the biological properties of amelanotic and melanotic melanoma cells

scientific article published on April 2017

Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693.

scientific article

EGFR-Targeted Magnetic Nanovectors Recognize, in Vivo, Head and Neck Squamous Cells Carcinoma-Derived Tumors.

scientific article

Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor α (ERRα) cellular localization and inhibits its transcriptional activity.

scientific article

Genetic mapping of the mouse Rab7 gene and pseudogene and of the human RAB7 homolog.

scientific article

Growth factor transduction pathways: paradigm of anti-neoplastic targeted therapy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction

scientific article published on 20 March 2020

Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma

scientific article published on 19 December 2016

Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery

scientific article published on 22 February 2016

Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1).

scientific article

MAPK15 is part of the ULK complex and controls its activity to regulate early phases of the autophagic process

scientific article published in Journal of Biological Chemistry

MAPK15 mediates BCR-ABL1-induced autophagy and regulates oncogene-dependent cell proliferation and tumor formation

scientific article published on 20 August 2015

MAPK15 upregulation promotes cell proliferation and prevents DNA damage in male germ cell tumors.

scientific article published on 14 March 2016

MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins ⬇️

scientific article published on September 4, 2012

Molecular cloning and expression analysis of the human Rab7 GTP-ase complementary deoxyribonucleic acid

scientific journal article

Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions

scientific article published on 21 December 2015

Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

scientific article

NCOA4 Deficiency Impairs Systemic Iron Homeostasis

scientific article published on 12 January 2016

One drug for two targets: Biological evaluation of antiretroviral agents endowed with antiproliferative activity

scientific article

Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4-d]pyrimidines for Targeting Hepatocellular Carcinoma

scientific article published on 07 May 2018

Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model.

scientific article

Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: Preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line.

scientific article

Rab5a is a common component of the apical and basolateral endocytic machinery in polarized epithelial cells

scientific journal article

Regulation of c-myc expression by PDGF through Rho GTPases.

scientific article published on June 2001

Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.

scientific article

Regulation of mitogen-activated protein kinases by G-protein-coupled receptors

scientific article published on January 2002

Role of the small GTPase Rab7 in the late endocytic pathway.

scientific article published on February 1997

Selective transcription and cellular proliferation induced by PDGF require histone deacetylase activity

scientific article published on 13 March 2006

Straightforward synthesis of a novel ring-fused pyrazole-lactam and in vitro cytotoxic activity on cancer cell lines.

scientific article published on 05 April 2016

Structure prediction and validation of the ERK8 kinase domain

scientific article published on 11 January 2013

Surface chemistry and entrapment of magnesium nanoparticles into polymeric micelles: a highly biocompatible tool for photothermal therapy

scientific article published on 01 July 2014

The platelet-derived growth factor controls c-myc expression through a JNK- and AP-1-dependent signaling pathway.

scientific article published on 30 September 2003

The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis.

scientific article published on April 2004

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

scientific article (publication date: 30 June 1995)

List of works by Mario Chiariello

Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy

Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.

Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex

Alterations of autophagy in the peripheral neuropathy Charcot-Marie-Tooth type 2B.

Aptamer Functionalization of Nanosystems for Glioblastoma Targeting through the Blood-Brain Barrier

Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells

Cloning and expression analysis of the murine Rab7 cDNA.

Context-dependent miR-204 and miR-211 affect the biological properties of amelanotic and melanotic melanoma cells

Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693.

EGFR-Targeted Magnetic Nanovectors Recognize, in Vivo, Head and Neck Squamous Cells Carcinoma-Derived Tumors.

Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor α (ERRα) cellular localization and inhibits its transcriptional activity.

Genetic mapping of the mouse Rab7 gene and pseudogene and of the human RAB7 homolog.

Growth factor transduction pathways: paradigm of anti-neoplastic targeted therapy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction

Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma

Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery

Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1).

MAPK15 is part of the ULK complex and controls its activity to regulate early phases of the autophagic process

MAPK15 mediates BCR-ABL1-induced autophagy and regulates oncogene-dependent cell proliferation and tumor formation

MAPK15 upregulation promotes cell proliferation and prevents DNA damage in male germ cell tumors.

MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins ⬇️

Molecular cloning and expression analysis of the human Rab7 GTP-ase complementary deoxyribonucleic acid

Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions

Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

NCOA4 Deficiency Impairs Systemic Iron Homeostasis

One drug for two targets: Biological evaluation of antiretroviral agents endowed with antiproliferative activity

Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4-d]pyrimidines for Targeting Hepatocellular Carcinoma

Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model.

Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: Preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line.

Rab5a is a common component of the apical and basolateral endocytic machinery in polarized epithelial cells

Regulation of c-myc expression by PDGF through Rho GTPases.

Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.

Regulation of mitogen-activated protein kinases by G-protein-coupled receptors

Role of the small GTPase Rab7 in the late endocytic pathway.

Selective transcription and cellular proliferation induced by PDGF require histone deacetylase activity

Straightforward synthesis of a novel ring-fused pyrazole-lactam and in vitro cytotoxic activity on cancer cell lines.

Structure prediction and validation of the ERK8 kinase domain

Surface chemistry and entrapment of magnesium nanoparticles into polymeric micelles: a highly biocompatible tool for photothermal therapy

The platelet-derived growth factor controls c-myc expression through a JNK- and AP-1-dependent signaling pathway.

The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis.

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway