List of works - Lori L. Isom

Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel

scientific article (publication date: 8 May 1992)

Auxiliary subunits of voltage-gated ion channels

scientific article

Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif

scientific journal article

Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes

scientific article

Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier

scientific article

Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current

scientific article published in January 2005

Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture

scientific journal article

Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line

scientific article published on February 1995

A functional null mutation of SCN1B in a patient with Dravet syndrome

scientific article published on August 2009

Na+ Channel ? Subunits: Overachievers of the Ion Channel Family

scientific article published on September 28, 2011

Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism

scientific article published on 02 July 2013

Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits

scientific article

Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels

scientific article

Tenascin-R is a functional modulator of sodium channel beta subunits

scientific article published on September 1999

Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat.

scientific article published on 3 May 2004

Contactin associates with Na+ channels and increases their functional expression

scientific article (publication date: October 2001)

Cloning, localization, and functional expression of sodium channel beta1A subunits

scientific article

Structural requirements for interaction of sodium channel beta 1 subunits with ankyrin

scientific article (publication date: 19 July 2002)

Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease

scientific article published on 23 June 2010

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals

scientific article

Molecular determinants of Na+ channel function in the extracellular domain of the beta1 subunit

scientific article published in February 1998

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes

scientific journal article

A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction

scientific article

Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth

scientific article

Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain.

scientific article published in July 2006

Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin

scientific article (publication date: 16 April 2004)

Modulation of cardiac Na+ channel expression in Xenopus oocytes by beta 1 subunits

scientific article published in October 1995

Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo

scientific journal article

Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes

scientific article published on 20 July 2011

Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1

scientific article (publication date: 15 December 2002)

A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit.

scientific article

Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons

scientific article published on 27 September 2004

Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion molecules

scientific article

Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome

scientific article published in 2013

Upregulation of the Voltage-Gated Sodium Channel 2 Subunit in Neuropathic Pain Models: Characterization of Expression in Injured and Non-Injured Primary Sensory Neurons

article

Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets

scientific article published in September 2008

Therapeutic potential for phenytoin: targeting Na(v)1.5 sodium channels to reduce migration and invasion in metastatic breast cancer.

scientific article

Identification of the cysteine residue responsible for disulfide linkage of Na+ channel α and β2 subunits

scientific article

The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels.

scientific article published on January 2014

The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels.

scientific article

Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy

scientific article published on October 2011

The intracellular segment of the sodium channel beta 1 subunit is required for its efficient association with the channel alpha subunit

scientific article published in March 2001

Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents

scientific article published on June 2010

Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts

scientific article published on 17 September 2014

Conduction block in PMP22 deficiency.

scientific article published on January 2010

Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability.

scientific article published on 31 December 2012

More than a pore: ion channel signaling complexes

scientific article

Na+ channel Scn1b gene regulates dorsal root ganglion nociceptor excitability in vivo

scientific article

The voltage-gated Na+ channel beta3 subunit does not mediate trans homophilic cell adhesion or associate with the cell adhesion molecule contactin

scientific article published on 17 July 2009

Cardiac arrhythmia in a mouse model of sodium channel SCN8A epileptic encephalopathy

scientific article published on 26 October 2016

List of works by Lori L. Isom

Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel

Auxiliary subunits of voltage-gated ion channels

Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif

Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes

Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier

Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current

Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture

Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line

A functional null mutation of SCN1B in a patient with Dravet syndrome

Na+ Channel ? Subunits: Overachievers of the Ion Channel Family

Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism

Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits

Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels

Tenascin-R is a functional modulator of sodium channel beta subunits

Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat.

Contactin associates with Na+ channels and increases their functional expression

Cloning, localization, and functional expression of sodium channel beta1A subunits

Structural requirements for interaction of sodium channel beta 1 subunits with ankyrin

Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals

Molecular determinants of Na+ channel function in the extracellular domain of the beta1 subunit

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes

A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction

Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth

Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain.

Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin

Modulation of cardiac Na+ channel expression in Xenopus oocytes by beta 1 subunits

Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo

Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes

Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1

A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit.

Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons

Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion molecules

Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome

Upregulation of the Voltage-Gated Sodium Channel 2 Subunit in Neuropathic Pain Models: Characterization of Expression in Injured and Non-Injured Primary Sensory Neurons

Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets

Therapeutic potential for phenytoin: targeting Na(v)1.5 sodium channels to reduce migration and invasion in metastatic breast cancer.

Identification of the cysteine residue responsible for disulfide linkage of Na+ channel α and β2 subunits

The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels.

The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels.

Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy

The intracellular segment of the sodium channel beta 1 subunit is required for its efficient association with the channel alpha subunit

Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents

Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts

Conduction block in PMP22 deficiency.

Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability.

More than a pore: ion channel signaling complexes

Na+ channel Scn1b gene regulates dorsal root ganglion nociceptor excitability in vivo

The voltage-gated Na+ channel beta3 subunit does not mediate trans homophilic cell adhesion or associate with the cell adhesion molecule contactin

Cardiac arrhythmia in a mouse model of sodium channel SCN8A epileptic encephalopathy