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List of works by Lori L. Isom

A functional null mutation of SCN1B in a patient with Dravet syndrome

scientific article published on August 2009

A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit.

scientific article

A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction

scientific article

Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability.

scientific article published on 31 December 2012

Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome

scientific article published in 2013

Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome

scientific article published on 01 August 2020

Auxiliary subunits of voltage-gated ion channels

scientific article

Cannabinoid-induced depression of synaptic transmission is switched to stimulation when dopaminergic tone is increased in the globus pallidus of the rodent

scientific article published on 6 August 2016

Cardiac arrhythmia in a mouse model of sodium channel SCN8A epileptic encephalopathy

scientific article published on 26 October 2016

Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes

Cloning and expression of a zebrafish SCN1B ortholog and identification of a species-specific splice variant

scientific article

Cloning, localization, and functional expression of sodium channel beta1A subunits

scientific article

Conduction block in PMP22 deficiency.

scientific article published on January 2010

Contactin associates with Na+ channels and increases their functional expression

scientific article (publication date: October 2001)

Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome

article published in 2019

Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier

scientific article

Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism

scientific article published on 02 July 2013

Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat.

scientific article published on 3 May 2004

Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents

scientific article published on June 2010

Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease

scientific article published on 23 June 2010

Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52

scientific article published on 26 September 2020

Expecting the Unexpected: Lack of In Vivo Network Defects in an Scn1a Model of Dravet Syndrome

scientific article published on November 2016

Expression and regulation of voltage-gated sodium channel beta1 subunit protein in human gliosis-associated pathologies

scientific article

Floxed allele for conditional inactivation of the voltage-gated sodium channel β1 subunitScn1b

scientific article published on 01 September 2007

Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1

scientific article (publication date: 15 December 2002)

Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line

scientific article published on February 1995

Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth

scientific article

Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion molecules

scientific article

Identification of the cysteine residue responsible for disulfide linkage of Na+ channel α and β2 subunits

scientific article

Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes

scientific article

Loss of β1accessory Na+channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high-frequency firing via differential effects on persistent Na+currents

scientific article published on 27 September 2012

Mechanisms of Epilepsy and Neuronal Synchronization Gordon Research Conference Power Hour Summary

scientific article published on 07 July 2019

Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture

scientific journal article

Modulation of cardiac Na+ channel expression in Xenopus oocytes by beta 1 subunits

scientific article published in October 1995

Molecular determinants of Na+ channel function in the extracellular domain of the beta1 subunit

scientific article published in February 1998

More than a pore: ion channel signaling complexes

scientific article

Na+ Channel ? Subunits: Overachievers of the Ion Channel Family

scientific article published on September 28, 2011

Na+ channel Scn1b gene regulates dorsal root ganglion nociceptor excitability in vivo

scientific article

Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy

scientific article published on 13 February 2017

Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current

scientific article published in January 2005

PKCbeta co-localizes with the dopamine transporter in mesencephalic neurons

scientific article

Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel

scientific article (publication date: 8 May 1992)

Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits

scientific article

Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels

scientific article

SCN1B-linked early infantile developmental and epileptic encephalopathy

scientific article published on 11 November 2019

SUMOylation of Neuronal K+ Channels: A Potential Therapeutic Pathway for Epilepsy and SUDEP?

scientific article published on 01 September 2014

Scn1b deletion in adult mice results in seizures and SUDEP

scientific article published on 08 May 2019

Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts

scientific article published on 17 September 2014

Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias.

scientific article published in December 2016

Scn2b,a Voltage-Gated Sodium Channel β2 Gene on Mouse Chromosome 9

article

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals

scientific article

Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin

scientific article (publication date: 16 April 2004)

Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons

scientific article published on 27 September 2004

Sodium channel beta1-subunit expression is increased in reactive astrocytes in a rat model for mesial temporal lobe epilepsy

scientific article published in July 2002

Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain.

scientific article published in July 2006

Sodium channel β1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis

scientific article published on 05 June 2020

Structural requirements for interaction of sodium channel beta 1 subunits with ankyrin

scientific article (publication date: 19 July 2002)

Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif

scientific journal article

Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes

scientific article published on 20 July 2011

Tenascin-R is a functional modulator of sodium channel beta subunits

scientific article published on September 1999

The intracellular segment of the sodium channel beta 1 subunit is required for its efficient association with the channel alpha subunit

scientific article published in March 2001

The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels.

scientific article published on January 2014

The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels.

scientific article

The voltage-gated Na+ channel beta3 subunit does not mediate trans homophilic cell adhesion or associate with the cell adhesion molecule contactin

scientific article published on 17 July 2009

The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6.

scientific article published on 27 February 2020

Therapeutic potential for phenytoin: targeting Na(v)1.5 sodium channels to reduce migration and invasion in metastatic breast cancer.

scientific article

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes

scientific journal article

Untangling the dravet syndrome seizure network: the changing face of a rare genetic epilepsy

scientific article published on March 2014

Upregulation of the Voltage-Gated Sodium Channel 2 Subunit in Neuropathic Pain Models: Characterization of Expression in Injured and Non-Injured Primary Sensory Neurons

article

Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo

scientific journal article

Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy

scientific article published on October 2011

Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets

scientific article published in September 2008

Voltage-gated sodium channel β subunits: The power outside the pore in brain development and disease

scientific article published on 16 September 2017

deletion fails to rescue premature lethality in two models of sodium channel epilepsy

scn1bb, a zebrafish ortholog of SCN1B expressed in excitable and nonexcitable cells, affects motor neuron axon morphology and touch sensitivity

scientific article published on November 2008

β1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function

scientific article published on June 2016