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List of works by Jon H Tobias

'Sink or swim': an evaluation of the clinical characteristics of individuals with high bone mass

scientific article published on April 2011

25-Hydroxyvitamin-D3 levels are positively related to subsequent cortical bone development in childhood: findings from a large prospective cohort study

scientific article

3-Amino-1-hydroxypropylidine-1-bisphosphonate (AHPrBP) suppresses not only the induction of new, but also the persistence of existing bone-forming surfaces in rat cancellous bone

scientific article published on 01 July 1993

45-day mortality after 467,779 knee replacements for osteoarthritis from the National Joint Registry for England and Wales: an observational study

scientific article published on October 2014

5 alpha-Dihydrotestosterone partially restores cancellous bone volume in osteopenic ovariectomized rats

scientific article published on 01 December 1994

90-day mortality after 409,096 total hip replacements for osteoarthritis, from the National Joint Registry for England and Wales: a retrospective analysis

scientific article published on September 2013

A Metabolic Screen in Adolescents Reveals an Association Between Circulating Citrate and Cortical Bone Mineral Density

scientific article published on 18 March 2019

A Rare Mutation in SMAD9 Associated With High Bone Mass Identifies the SMAD-Dependent BMP Signaling Pathway as a Potential Anabolic Target for Osteoporosis

scientific article published on 14 November 2019

A comparison of bone mineral density between Caucasian, Asian and Afro-Caribbean women

scientific article

A cross-sectional study of the relationship between cortical bone and high-impact activity in young adult males and females.

scientific article

A diagnosis of knee osteoarthritis does not predict physical activity 2 years later in older adults: findings from the Hertfordshire Cohort Study

scientific article published on 29 April 2019

A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement

scientific article

A novel ACVR1 mutation in the glycine/serine-rich domain found in the most benign case of a fibrodysplasia ossificans progressiva variant reported to date

scientific article

A novel member of the SAF (scaffold attachment factor)-box protein family inhibits gene expression and induces apoptosis.

scientific article

Adiponectin and its association with bone mass accrual in childhood

scientific article

Adipose tissue stimulates bone growth in prepubertal children.

scientific article published on 18 April 2006

Age at puberty and accelerometer-measured physical activity: Findings from two independent UK cohorts

scientific article published on 07 May 2020

Aminohexane bisphosphonate suppresses bone turnover in postmenopausal women more rapidly than oestrogen-gestagen therapy

scientific article published on 01 July 1996

An atlas of genetic influences on osteoporosis in humans and mice

scientific article published on 31 December 2018

An exploration of barriers and facilitators to older adults' participation in higher impact physical activity and bone health: a qualitative study

scientific article published on 10 November 2015

An observational cohort study to produce and evaluate an improved tool to screen older women with back pain for osteoporotic vertebral fractures (Vfrac): study protocol

scientific article published on 25 January 2019

Analysis of body composition in individuals with high bone mass reveals a marked increase in fat mass in women but not men

scientific article published on 21 January 2013

Analysis of the contribution of dydrogesterone to bone turnover changes in postmenopausal women commencing hormone replacement therapy.

scientific article

Androgens contribute to the stimulation of cancellous bone formation by ovarian hormones in female rats

scientific article published on 01 March 1996

Are cathepsin k inhibitors just another class of anti-resorptives?

scientific article published on 20 September 2013

Assessing the Role of DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio in Rheumatoid Arthritis

article

Assessment of bone mineral density in women with Marfan syndrome

scientific article published on June 1995

Association Between Age at Puberty and Bone Accrual From 10 to 25 Years of Age

scientific article published on 02 August 2019

Association between bone mass and fractures in children: a prospective cohort study

scientific article published in September 2006

Association between components of body composition and scoliosis: a prospective cohort study reporting differences identifiable before the onset of scoliosis

scientific article published in August 2014

Association between physical activity and scoliosis: a prospective cohort study

scientific article published on 01 August 2019

Association of maternal vitamin D status during pregnancy with bone-mineral content in offspring: a prospective cohort study

scientific article

Associations of lifetime walking and weight bearing exercise with accelerometer-measured high impact physical activity in later life

scientific article published on 25 October 2017

Associations of size at birth and dual-energy X-ray absorptiometry measures of lean and fat mass at 9 to 10 y of age.

scientific article published in October 2006

Birth weight is positively related to bone size in adolescents but inversely related to cortical bone mineral density: findings from a large prospective cohort study

scientific article

Bone Mineral Density Is Positively Related to Carotid Intima-Media Thickness: Findings From a Population-Based Study in Adolescents and Premenopausal Women

scientific article published on 30 June 2016

Bone fragility contributes to the risk of fracture in children, even after moderate and severe trauma

scientific article published on February 2008

Breech presentation is associated with lower adolescent tibial bone strength

scientific article published on 24 April 2019

Can 11β-Hydroxysteroid Dehydrogenase Activity Predict the Sensitivity of Bone to Therapeutic Glucocorticoids in Inflammatory Bowel Disease?

scientific article published on 22 June 2011

Capturing remote disease activity - results of a 12-month clinical pilot of a smartphone app in NHS rheumatology clinics in Bristol

scientific article published on 07 February 2020

Changes in rheumatology out-patient workload over 12 years in the South West of England.

scientific article

Characterisation of the temporal sequence of osteoblast gene expression during estrogen-induced osteogenesis in female mice

scientific article

Characteristics of early Paget's disease in SQSTM1 mutation carriers: Baseline analysis of the ZiPP study cohort

scientific article published on 16 March 2020

Characterization of Vertical Accelerations Experienced by Older People Attending an Aerobics Class Designed to Produce High Impacts

scientific article published on 30 September 2015

Childhood fractures do not predict future fractures: results from the European Prospective Osteoporosis Study

scientific article

Children with low muscle strength are at an increased risk of fracture with exposure to exercise

scientific article published on 01 June 2011

Chronic Fatigue Syndrome and Chronic Widespread Pain in Adolescence: Population Birth Cohort Study

scientific article

Common variants in the region around Osterix are associated with bone mineral density and growth in childhood

scientific article published on 30 January 2009

Comparison of Muscle Function, Bone Mineral Density and Body Composition of Early Starting and Later Starting Older Masters Athletes

scientific article published on 27 August 2019

Correlates of high-impact physical activity measured objectively in older British adults

scientific article published on 11 December 2017

Cyclical etidronate prevents spinal bone loss in early post-menopausal women

scientific article published on 01 May 1997

DMPA and bone density

scientific article published in August 1991

DNA methylation patterns in cord blood DNA and body size in childhood

scientific article (publication date: 2012)

DXA-derived hip shape is related to osteoarthritis: findings from in the MrOS cohort.

scientific article published on 20 September 2017

Day-to-day physical activity producing low gravitational impacts is associated with faster visual processing speed at age 69: cross-sectional study

scientific article published on 25 June 2019

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

scientific article published on 26 August 2021

Deriving alpha angle from anterior-posterior dual-energy x-ray absorptiometry scans: an automated and validated approach

scientific article published on 19 July 2022

Deriving alpha angle from anterior-posterior dual-energy x-ray absorptiometry scans: an automated and validated approach

scientific article published in 2021

Describing the application of statistical shape modelling to DXA images to quantify the shape of the proximal femur at ages 14 and 18 years in the Avon Longitudinal Study of Parents and Children

scientific article published on 27 August 2019

Determinants of fracture risk in a UK-population-based cohort of older women: a cross-sectional analysis of the Cohort for Skeletal Health in Bristol and Avon (COSHIBA).

scientific article published on 21 November 2011

Distinct effects of ovarian transplantation and exogenous 17 beta-oestradiol on cancellous bone of osteopenic ovariectomized rats

scientific article published on 01 October 1995

Distinct relationships of intramuscular and subcutaneous fat with cortical bone: findings from a cross-sectional study of young adult males and females.

scientific article published on 26 March 2013

Do subjective memory complaints predict falls, fractures and healthcare utilization? A two-year prospective study based on a cohort of older women recruited from primary care

scientific article published on 18 July 2016

Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of β-C-telopeptides of type I collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT.

scientific article

Does estrogen stimulate osteoblast function in postmenopausal women?

scientific article published on 01 February 1999

Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo-Controlled Trial

scientific article published on 07 March 2019

Effect of an Estrogen Receptor-α Intron 4 Polymorphism on Fat Mass in 11-Year-Old Children

scientific article published on 03 April 2007

Effects of combination therapy with PTH and 17beta-estradiol on long bones of female mice

scientific article published in September 2001

Effects of high-dose estrogen on murine hematopoietic bone marrow precede those on osteogenesis

scientific article published on 01 November 2000

Elevated circulating Sclerostin concentrations in individuals with high bone mass, with and without LRP5 mutations.

scientific article

Epidemiology of generalized joint laxity (hypermobility) in fourteen-year-old children from the UK: a population-based evaluation

scientific article

Estimated maternal ultraviolet B exposure levels in pregnancy influence skeletal development of the child

scientific article

Estrogen Receptor α Regulates Area-Adjusted Bone Mineral Content in Late Pubertal Girls

scientific article published on 14 November 2006

Estrogen maintains trabecular bone volume in rats not only by suppression of bone resorption but also by stimulation of bone formation.

scientific article published on January 1992

Estrogen receptor-alpha dependency of estrogen's stimulatory action on cancellous bone formation in male mice

scientific article published in May 2003

Estrogen-induced osteogenesis in intact female mice lacking ERbeta

scientific article published in October 2002

Estrogen-induced osteogenesis in mice is associated with the appearance of Cbfa1-expressing bone marrow cells

scientific article published in January 2002

Fat mass exerts a greater effect on cortical bone mass in girls than boys.

scientific article

Fat mass is a positive predictor of bone mass in adolescents

scientific article published in March 2011

Feasibility and acceptability of using jumping mechanography to detect early components of sarcopenia in community-dwelling older women

scientific article published on September 2017

Friend or foe: high bone mineral density on routine bone density scanning, a review of causes and management

scientific article

Genetic Studies of Endophenotypes From Spine CT Scans Provide Novel Insights Into the Contribution of Mechanosensory Pathways to Vertebral Fractures and Spinal Curvature

scientific article published on 21 November 2016

Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure

scientific article

Genetic variants in adult bone mineral density and fracture risk genes are associated with the rate of bone mineral density acquisition in adolescence

scientific article published on 4 May 2015

Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone

scientific article

Genome-wide association study of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes

scientific article published in September 2018

Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances

scientific article published on 23 May 2013

Grand Challenges in Bone Endocrinology ⬇️

scientific article published on December 10, 2010

Group G β-haemolytic streptococcal vertebral osteomyelitis

scientific article published on 01 July 1992

Growth hormone deficiency during puberty reduces adult bone mineral density ⬇️

scientific article published on December 1, 1992

Habitual levels of high, but not moderate or low, impact activity are positively related to hip BMD and geometry: results from a population-based study of adolescents

scientific article

Habitual levels of higher, but not medium or low, impact physical activity are positively related to lower limb bone strength in older women: findings from a population-based study using accelerometers to classify impact magnitude.

scientific article published on 13 December 2016

Habitual levels of physical activity influence bone mass in 11-year-old children from the United Kingdom: findings from a large population-based cohort

scientific article published in January 2007

Habitual levels of vigorous, but not moderate or light, physical activity is positively related to cortical bone mass in adolescents ⬇️

scientific article

Health-related quality of life in older people with osteoporotic vertebral fractures: a systematic review and meta-analysis.

scientific article published on 4 June 2016

High Bone Mass is associated with bone-forming features of osteoarthritis in non-weight bearing joints independent of body mass index.

scientific article published on 07 January 2017

High bone mass is associated with an increased prevalence of joint replacement: a case-control study

scientific article published on 28 January 2013

High impact activity is related to lean but not fat mass: findings from a population-based study in adolescents

scientific article

High-Dose Estrogen Induces De Novo Medullary Bone Formation in Female Mice

scientific article published on 01 February 1999

High-dose estrogen-induced osteogenesis in the mouse is partially suppressed by indomethacin

scientific article published on 01 December 1999

Hip and spine bone mineral density are greater in master sprinters, but not endurance runners compared with non-athletic controls

scientific article published on 03 July 2018

Hormone replacement for osteoporosis

scientific article published in June 1990

How do bisphosphonates prevent fractures? ⬇️

scientific article published on September 1, 1997

IL-6 may modulate the skeletal response to glucocorticoids during exacerbations of inflammatory bowel disease

scientific article published on 14 March 2010

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis.

scientific article published on 4 September 2017

Identifying scoliosis in population-based cohorts: development and validation of a novel method based on total-body dual-energy x-ray absorptiometric scans

scientific article published on 28 February 2013

Impact of mild and moderate/severe vertebral fractures on physical activity: a prospective study of older women in the UK

scientific article published on 07 September 2018

Impaired growth plate function in bmp-6 null mice

scientific article

Increased bone morphogenetic protein-6 expression in mouse long bones after estrogen administration

scientific article

Individuals with high bone mass have an increased prevalence of radiographic knee osteoarthritis

scientific article

Insights into the programming of bone development from the Avon Longitudinal Study of Parents and Children (ALSPAC).

scientific article

Intermittent retinoic acid in combination with continuous oestradiol-17 beta increases cancellous bone volume in osteopaenic ovariectomized rats

scientific article published on 01 July 1994

Intervertebral Disc Degeneration Can Lead to “Stress-Shielding” of the Anterior Vertebral Body

scientific article published on 01 April 2004

Intervertebral Disc Degeneration Can Predispose to Anterior Vertebral Fractures in the Thoracolumbar Spine

scientific article published on 01 September 2006

Investigation of sex differences in hip structure in peripubertal children

scientific article

Investigation of the Relationship Between Susceptibility Loci for Hip Osteoarthritis and Dual X‐Ray Absorptiometry–Derived Hip Shape in a Population‐Based Cohort of Perimenopausal Women

scientific article published on 27 October 2018

Is high-dose estrogen-induced osteogenesis in the mouse mediated by an estrogen receptor?

scientific article published on 01 July 2000

Joint hypermobility is a risk factor for musculoskeletal pain during adolescence: findings of a prospective cohort study

scientific article published in April 2013

Jump power and force have distinct associations with cortical bone parameters: findings from a population enriched by individuals with high bone mass

scientific article

LRP5 regulates human body fat distribution by modulating adipose progenitor biology in a dose- and depot-specific fashion.

scientific article

Lean mass and lower limb muscle function in relation to hip strength, geometry and fracture risk indices in community-dwelling older women

scientific article published on 14 December 2018

Life-course determinants of bone mass in young adults from a transitional rural community in India: the Andhra Pradesh Children and Parents Study (APCAPS)

scientific article published on 2 April 2014

Management of steroid-induced osteoporosis: what is the current state of play?

scientific article published on 01 March 1999

Maternal Preeclampsia Is Associated With Reduced Adolescent Offspring Hip BMD in a UK Population-Based Birth Cohort

scientific article published in September 2015

Maternal vitamin D status during pregnancy and bone-mineral content in offspring - Authors' reply

scientific article

Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures

scientific article published on 02 August 2019

Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women

scientific article published on March 2013

Metabolomics analysis in adults with high bone mass identifies a relationship between bone resorption and circulating citrate which replicates in the general population

scientific article published on 20 November 2019

Meta‐Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry

scientific article published on 19 March 2019

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with spinal BMD in 9-year-old children

scientific article published on January 2009

Mice Rendered Severely Deficient in Megakaryocytes through Targeted Gene Deletion of the Thrombopoietin Receptor c-Mpl Have a Normal Skeletal Phenotype

article

Motor Competence in Early Childhood Is Positively Associated With Bone Strength in Late Adolescence

scientific article published on 29 December 2015

Mutations in Known Monogenic High Bone Mass Loci Only Explain a Small Proportion of High Bone Mass Cases

scientific article published on 8 September 2015

NOGG guideline should be implemented

scientific article published in the British Medical Journal

Natural history, reasons for, and impact of low/non-adherence to medications for osteoporosis in a cohort of community-dwelling older women already established on medication: a 2-year follow-up study

scientific article published on 19 August 2015

Neridronate Preferentially Suppresses the Urinary Excretion of Peptide-Bound Deoxypyridinoline in Postmenopausal Women

scientific article published on 01 November 1996

OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.

scientific article

Obesity is a risk factor for musculoskeletal pain in adolescents: findings from a population-based cohort

scientific article published on 16 July 2012

Opposite effects of insulin-like growth factor-I on the formation of trabecular and cortical bone in adult female rats

scientific article published in November 1992

Osteoarthritis and bone mineral density: are strong bones bad for joints?

scientific article published on 21 January 2015

Osteophytes, enthesophytes, and high bone mass: a bone-forming triad with potential relevance in osteoarthritis

scientific article

PTH/PTHrP activity and the programming of skeletal development in utero

scientific article published on 16 December 2003

PTHR1 Polymorphisms Influence BMD Variation through Effects on the Growing Skeleton

article

Parental smoking during pregnancy and offspring bone mass at age 10 years: findings from a prospective birth cohort.

scientific article

Physical Activity Producing Low, but Not Medium or Higher, Vertical Impacts Is Inversely Related to BMI in Older Adults: Findings From a Multicohort Study

scientific article

Physical Activity and Bone: May the Force be with You.

scientific article published on 03 March 2014

Placental Size Is Associated Differentially With Postnatal Bone Size and Density

scientific article

Postural Stability During Standing Balance and Sit-to-Stand in Master Athlete Runners Compared With Nonathletic Old and Young Adults

Potential use of an estrogen-glucocorticoid receptor chimera as a drug screen for tissue selective estrogenic activity

scientific article

Predicting ambient ultraviolet from routine meteorological data; its potential use as an instrumental variable for vitamin D status in pregnancy in a longitudinal birth cohort in the UK.

scientific article

Prenatal concentrations of perfluoroalkyl substances and bone health in British girls at age 17

article

Prevalence of radiographic hip osteoarthritis is increased in high bone mass

scientific article

Prolonged intermittent but not continuous administration of oestradiol-17 beta increases bone volume in the rat

scientific article published on 01 November 1993

Quantifying Habitual Levels of Physical Activity According to Impact in Older People: Accelerometry Protocol for the VIBE Study

scientific article published on 15 September 2015

Randomized controlled trial of a primary care-based screening program to identify older women with prevalent osteoporotic vertebral fractures: Cohort for Skeletal Health in Bristol and Avon (COSHIBA).

scientific article

Rapid hip bone loss in active Crohn's disease patients receiving short-term corticosteroid therapy

scientific article published in November 2004

Relation of maternal prepregnancy body mass index with offspring bone mass in childhood: is there evidence for an intrauterine effect?

scientific article

Response to: Effects of Alendronic Acid on Fracture Healing

scientific article published on 06 November 2019

Reversal of gold-induced neutropenia with granulocyte colony-stimulating factor (G-CSF)

scientific article published on 01 June 1993

Role of endothelial nitric oxide synthase in estrogen-induced osteogenesis.

scientific article published in July 2001

Sarcopenia Is Negatively Related to High Gravitational Impacts Achieved From Day-to-day Physical Activity

scientific article published on 22 November 2017

Self-reported everyday physical activities in older people with osteoporotic vertebral fractures: a systematic review and meta-analysis.

scientific article published on 3 November 2017

Sex differences in proximal femur shape: findings from a population-based study in adolescents

scientific article published on 12 March 2020

Social position affects bone mass in childhood through opposing actions on height and weight

scientific article published on 8 August 2005

Supplementation with a low–moderate dose of n-3 long-chain PUFA has no short-term effect on bone resorption in human adults

scientific article published on 06 December 2010

Symptoms of oestrogen deficiency in women with oestradiol implants.

scientific article published in September 1989

Tamoxifen stimulates cancellous bone formation in long bones of female mice

scientific article published on 2 December 2004

The Effect of Plasma Lipids and Lipid-Lowering Interventions on Bone Mineral Density: A Mendelian Randomization Study

scientific article published on 12 March 2020

The Impact of Small Spinal Curves in Adolescents Who Have Not Presented to Secondary Care: A Population-Based Cohort Study

scientific article

The association between insulin levels and cortical bone: findings from a cross-sectional analysis of pQCT parameters in adolescents

scientific article

The association between primary tooth emergence and anthropometric measures in young adults: findings from a large prospective cohort study.

scientific article

The association of fasting insulin, glucose, and lipids with bone mass in adolescents: findings from a cross-sectional study

scientific article

The development of worry throughout childhood: Avon Longitudinal Study of Parents and Children data

scientific article published on 13 December 2015

The effect of LRP5 polymorphisms on bone mineral density is apparent in childhood.

scientific article

The effect of pubertal timing, as reflected by height tempo, on proximal femur shape: Findings from a population-based study in adolescents

scientific article published on 30 November 2019

The effect of vigorous physical activity and body composition on cortical bone mass in adolescence

scientific article published in March 2015

The effects of ovarian transplantation on bone loss in ovariectomized rats

scientific article published on 01 July 1994

The estrogen antagonist ICI 182,780 reduces cancellous bone volume in female rats

scientific article published on 01 December 1993

The high bone mass phenotype is characterised by a combined cortical and trabecular bone phenotype: findings from a pQCT case-control study

scientific article

The role of pain-related anxiety in adolescents' disability and social impairment: ALSPAC data.

scientific article

The social patterning of fat and lean mass in a contemporary cohort of children

scientific article published in January 2006

Transcriptional regulation of a BMP-6 promoter by estrogen receptor alpha

scientific article published on 22 December 2003

Transient reduction in trabecular bone formation after discontinuation of administration of oestradiol-17 beta to ovariectomized rats

scientific article published on 01 June 1993

Urban-Rural Differences in Bone Mineral Density: A Cross Sectional Analysis Based on the Hyderabad Indian Migration Study

scientific article published on 20 October 2015

Use of Mendelian Randomization to Examine Causal Inference in Osteoporosis

scientific article published on 21 November 2019

Use of clinical risk factors to identify postmenopausal women with vertebral fractures

scientific article published on 02 September 2006

Use of risedronate to prevent bone loss following a single course of glucocorticoids: findings from a proof-of-concept study in inflammatory bowel disease.

scientific article published on 30 May 2009

Using SITAR (SuperImposition by Translation and Rotation) to estimate age at peak height velocity in Avon Longitudinal Study of Parents and Children

article

Using multiple genetic variants as instrumental variables for modifiable risk factors ⬇️

scientific article published on January 7, 2011

Vertebral fracture assessment (VFA) by lateral DXA scanning may be cost-effective when used as part of fracture liaison services or primary care screening

scientific article published on 29 November 2013

Vigorous physical activity increases fracture risk in children irrespective of bone mass: a prospective study of the independent risk factors for fractures in healthy children

scientific article published on July 2008

WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk

scientific article published in July 2012

Zoledronate in the prevention of Paget's (ZiPP): protocol for a randomised trial of genetic testing and targeted zoledronic acid therapy to prevent SQSTM1-mediated Paget's disease of bone

scientific article published on 4 September 2019

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