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List of works by Christian H. Ottensmeier

A phase I clinical trial of irinotecan and carboplatin in patients with extensive stage small cell lung cancer.

scientific article published on 15 August 2012

A phase I/II, multiple-dose, dose-escalation study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with advanced solid tumors

scientific article published on 21 February 2014

A plant-expressed conjugate vaccine breaks CD4(+) tolerance and induces potent immunity against metastatic Her2(+) breast cancer

scientific article published on 22 April 2016

A randomised, phase II study of intetumumab, an anti-αv-integrin mAb, alone and with dacarbazine in stage IV melanoma ⬇️

scientific article published on July 12, 2011

Absence of constitutive EGF receptor activation in ovarian cancer cell lines.

scientific article

Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma

scientific article

Actively personalized vaccination trial for newly diagnosed glioblastoma

scientific article published on 19 December 2018

Afatinib use in non-small cell lung cancer previously sensitive to epidermal growth factor receptor inhibitors: the United Kingdom Named Patient Programme.

scientific article published on 10 April 2014

An optimised tissue disaggregation and data processing pipeline for characterising fibroblast phenotypes using single-cell RNA sequencing

scientific article published on 03 July 2019

Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression.

scientific article published in June 1998

Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.

scientific article published on September 2014

Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α

scientific article published on 24 February 2020

Anti-idiotype vaccines

scientific article published on December 2003

Assessment of neuronal autoantibodies in patients with small cell lung cancer treated with chemotherapy with or without ipilimumab.

scientific article published on 27 November 2017

Autophagy inhibition-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis

scientific article published on 07 August 2019

BILATERAL METASTATIC CUTANEOUS MELANOMA TO RETINA AND VITREOUS AFTER IPILIMUMAB TREATED WITH PARS PLANA VITRECTOMY AND RADIOTHERAPY

scientific article published on 01 June 2018

Binding of ovarian cancer cells to peritoneal mesothelium in vitro is partly mediated by CD44H

scientific article published on 01 August 1993

CONFIRM: a double-blind, placebo-controlled phase III clinical trial investigating the effect of nivolumab in patients with relapsed mesothelioma: study protocol for a randomised controlled trial.

scientific article published on 18 April 2018

CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer

scientific article published on 13 October 2020

Cancer Vaccines

scientific article published in 2007

Cancer classification using the Immunoscore: a worldwide task force

scientific article

Case Report: CD103+CD8+ lymphocytes characterize the immune infiltration in a case with pseudoprogression in SqNSCLC.

scientific article

Clinical activity and safety of Pembrolizumab in Ipilimumab pre-treated patients with uveal melanoma.

scientific article published on 18 February 2016

Clinical and Biological Effects of an Agonist Anti-CD40 Antibody: A Cancer Research UK Phase I Study

scientific article published on 14 January 2015

Clinical and immunological responses in metastatic melanoma patients vaccinated with a high-dose poly-epitope vaccine

article

Correlation of HPV16 Gene Status and Gene Expression With Antibody Seropositivity and TIL Status in OPSCC

scientific article published on 01 January 2020

CyTOF mass cytometry reveals phenotypically distinct human blood neutrophil populations differentially correlated with melanoma stage

scientific article published on 01 September 2020

DNA fusion gene vaccines against cancer: from the laboratory to the clinic.

scientific article published in June 2004

DNA fusion gene vaccines induce cytotoxic T-cell attack on naturally processed peptides of human prostate-specific membrane antigen.

scientific article published on 4 July 2011

DNA fusion vaccines enter the clinic.

scientific article published on 05 June 2011

DNA fusion-gene vaccination in patients with prostate cancer induces high-frequency CD8(+) T-cell responses and increases PSA doubling time

scientific article published on 22 May 2012

DNA vaccination with electroporation induces increased antibody responses in patients with prostate cancer

scientific article published on November 2009

DNA vaccines against cancer come of age.

scientific article published on 19 February 2010

DNA vaccines to attack cancer

scholarly article

DNA vaccines: precision tools for activating effective immunity against cancer.

scientific article published on February 2008

DOC-MEK: a double-blind randomized phase II trial of docetaxel with or without selumetinib in wild-type BRAF advanced melanoma.

scientific article published on 24 February 2014

Data analysis as a source of variability of the HLA-peptide multimer assay: from manual gating to automated recognition of cell clusters

scientific article

Defining the critical hurdles in cancer immunotherapy

scientific article published on 14 December 2011

Determining mutational status of immunoglobulin v genes in chronic lymphocytic leukemia: a useful prognostic indicator

article

Evaluating the effect of immune cells on the outcome of patients with mesothelioma.

scientific article

Evaluation of immune infiltration in the colonic mucosa of patients with ipilimumab-related colitis

scientific article published on 15 July 2016

Evidence that recurrent Group A streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant Tfh cells

Expression and Function of β1 and αvβ3 Integrins in Ovarian Cancer

scientific article published on 01 August 1995

FOXO3 expression during colorectal cancer progression: biomarker potential reflects a tumour suppressor role.

scientific article published on 04 July 2013

First case report of Muir-Torre syndrome associated with non-small cell lung cancer

scientific article published on 16 May 2009

Fit for purpose? A case study: validation of immunological endpoint assays for the detection of cellular and humoral responses to anti-tumour DNA fusion vaccines

article

Functional heterogeneity of CD44 molecules in ovarian cancer cell lines

scientific article published on 01 March 1995

Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors.

scientific article published on 22 July 2016

HNSCC: Tumour Antigens and Their Targeting by Immunotherapy

scientific article published on 15 September 2020

HPV Epitope Processing Differences Correlate with ERAP1 Allotype and Extent of CD8+ T-cell Tumor Infiltration in OPSCC

scientific article published on 31 May 2019

HPV, tumour metabolism and novel target identification in head and neck squamous cell carcinoma

scientific article published on 17 January 2019

Harmonisation of short-term in vitro culture for the expansion of antigen-specific CD8(+) T cells with detection by ELISPOT and HLA-multimer staining

scientific article

Harmonization of immune biomarker assays for clinical studies

scientific article

Harmonization of the intracellular cytokine staining assay

scientific article published on 22 May 2012

Head and Neck Squamous Cell Carcinomas Are Characterized by a Stable Immune Signature Within the Primary Tumor Over Time and Space

scientific article

Health related quality of life outcomes for unresectable stage III or IV melanoma patients receiving ipilimumab treatment

scientific article

Histological transformation of indolent (follicular) lymphoma

scientific article

Human Papillomavirus Drives Tumor Development Throughout the Head and Neck: Improved Prognosis Is Associated With an Immune Response Largely Restricted to the Oropharynx.

scientific article

Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma

scientific article published on 02 August 2018

Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma

scientific article published on 01 June 2019

Idiotype gene rescue in follicular lymphoma

article

Idiotypic DNA vaccination for the treatment of multiple myeloma: safety and immunogenicity in a phase I clinical study

scientific article published on 16 May 2015

Ig gene diversification and selection in follicular lymphoma, diffuse large B cell lymphoma and primary central nervous system lymphoma revealed by lineage tree and mutation analyses

scientific article published on 8 November 2010

Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19

scientific article published on 05 October 2020

Immunocytochemical assessment of bone marrow aspirates for monitoring response to chemotherapy in small-cell lung cancer patients

scientific article published on December 1999

Immunoglobulin heavy chain locus events and expression of activation-induced cytidine deaminase in epithelial breast cancer cell lines

scientific article published on April 2006

Immunosuppression for ipilimumab-related toxicity can cause pneumocystis pneumonia but spare antitumor immune control.

scientific article published on 27 May 2015

Implications of Tuberculosis Reactivation after Immune Checkpoint Inhibition

Importance of the immune system in head and neck cancer

scientific article published on 28 February 2019

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

scientific article (publication date: 19 August 2010)

Incidence of potential glycosylation sites in immunoglobulin variable regions distinguishes between subsets of Burkitt's lymphoma and mucosa-associated lymphoid tissue lymphoma

scientific article published on 01 January 2003

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis

scientific article published on 15 December 2016

Infliximab for IPILIMUMAB-Related Colitis--Letter

scientific article published on 01 December 2015

Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genes

scientific article

Interleukin-2 followed by fluorouracil and folinic acid in refractory colorectal cancer--results of a clinical phase II study

scientific article

Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy

scientific article published on 24 June 2021

Ipilimumab in the real world: the UK expanded access programme experience in previously treated advanced melanoma patients

scientific article

Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model.

scientific article published on 12 January 2018

Linked CD4 T Cell Help: Broadening Immune Attack Against Cancer by Vaccination

scientific article published on 5 October 2016

M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer

scientific article published on 01 July 2020

Melanoma sentinel node biopsy and prediction models for relapse and overall survival

scientific article

Mucosal-Associated Invariant T (MAIT) Cells Are Impaired in Th17 Associated Primary and Secondary Immunodeficiencies

scientific article

Multicenter, Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Pravastatin Added to First-Line Standard Chemotherapy in Small-Cell Lung Cancer (LUNGSTAR).

scientific article published on 27 February 2017

NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors

scientific article published on 02 March 2020

NY-ESO-1 specific antibody and cellular responses in melanoma patients primed with NY-ESO-1 protein in ISCOMATRIX and boosted with recombinant NY-ESO-1 fowlpox virus

scientific article published on 14 August 2014

Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis.

scientific article

Novel Approaches for Vaccination Against HPV-Induced Cancers

scientific article published on 4 March 2015

Origins of the malignant clone in typical Waldenstrom's macroglobulinemia

scientific article published in April 2003

Outcome and Biomarker Analysis from a Multicenter Phase 2 Study of Ipilimumab in Combination with Carboplatin and Etoposide as First-Line Therapy for Extensive-Stage SCLC.

scientific article published on 10 June 2016

Paracrine signalling during ZEB1-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in lung fibrosis.

scientific article published on 26 July 2018

Patient selection for anti-PD-1/PD-L1 therapy in advanced non-small-cell lung cancer: implications for clinical practice

scientific article published on 06 July 2018

Percutaneous hepatic perfusion with melphalan in uveal melanoma: A safe and effective treatment modality in an orphan disease

scientific article published on 28 December 2017

Phase II study of first-line bortezomib and cisplatin in malignant pleural mesothelioma and prospective validation of progression free survival rate as a primary end-point for mesothelioma clinical trials (European Organisation for Research and Trea

scientific article

Plant virus particles carrying tumour antigen activate TLR7 and Induce high levels of protective antibody

scientific article

Primary central nervous system lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development

scientific article published on 18 December 2008

Publisher Correction: Actively personalized vaccination trial for newly diagnosed glioblastoma

scientific article published on 01 February 2019

Randomized double-blind placebo-controlled trial of thalidomide in combination with gemcitabine and Carboplatin in advanced non-small-cell lung cancer

scientific article published on 21 September 2009

Randomized trial of erlotinib plus whole-brain radiotherapy for NSCLC patients with multiple brain metastases

scientific article

Recent advances in the molecular landscape of lung neuroendocrine tumors

scientific article published on 27 March 2019

Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells.

scientific article published in February 2019

Remarkable selective glycosylation of the immunoglobulin variable region in follicular lymphoma

scientific article published on 19 November 2007

Response definition criteria for ELISPOT assays revisited

scientific article

Results of a randomized, double-blind phase II clinical trial of NY-ESO-1 vaccine with ISCOMATRIX adjuvant versus ISCOMATRIX alone in participants with high-risk resected melanoma

scientific article published on 01 April 2020

Serum cytokine levels as predictive biomarkers of benefit from ipilimumab in small cell lung cancer

scientific article published on 27 March 2019

Serum is not required for ex vivo IFN-gamma ELISPOT: a collaborative study of different protocols from the European CIMT Immunoguiding Program.

scientific article

Serum-free freezing media support high cell quality and excellent ELISPOT assay performance across a wide variety of different assay protocols.

scientific article published on 9 November 2012

Single-Cell Transcriptomic Analysis of SARS-CoV-2 Reactive CD4 + T Cells

scientific article published on 07 July 2020

Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4 + T cells

scientific article published on 13 June 2020

Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer

scientific article published on 21 June 2019

Sorafenib and dacarbazine as first-line therapy for advanced melanoma: phase I and open-label phase II studies

scientific article

Staging and treatment of oropharyngeal cancer in the human papillomavirus era.

scientific article published on 12 July 2014

Suppression of Hedgehog signalling promotes pro-tumourigenic integrin expression and function.

scientific article published on 29 April 2014

Synthesis and In Vivo Evaluation of 4-Deoxy-4,4-difluoro-KRN7000

scientific article published in 2008

Synthesis and in vitro evaluation of alpha-GalCer epimers

scientific article published in July 2008

Systematic review and meta-analysis of immunohistochemical prognostic biomarkers in resected oesophageal adenocarcinoma

scientific article

Systematic review and meta-analysis of immunohistochemical prognostic biomarkers in resected oesophageal adenocarcinoma

scientific article published in December 2015

T Cell Assays and MIATA: The Essential Minimum for Maximum Impact

TG4010 immunotherapy and first-line chemotherapy for advanced non-small-cell lung cancer (TIME): results from the phase 2b part of a randomised, double-blind, placebo-controlled, phase 2b/3 trial

scientific article published on 22 December 2015

TG4010 immunotherapy plus chemotherapy as first-line treatment of advanced non small cell lung cancer (NSCLC): Phase IIb results of the TIME trial.

scientific article published on 4 November 2015

TG4010: a vaccine with a therapeutic role in cancer

scientific article published on May 2016

Taking Electroporation-Based Delivery of DNA Vaccination into Humans: A Generic Clinical Protocol

scientific article published on 01 January 2008

Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes.

scientific article published on 18 April 2016

Targeting gp100 and TRP-2 with a DNA vaccine: Incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial.

scientific article published on 22 February 2018

Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4.

scientific article

The CIMT-monitoring panel: a two-step approach to harmonize the enumeration of antigen-specific CD8+ T lymphocytes by structural and functional assays

scientific article published on 25 August 2007

The Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy

scientific article published in 2024

The adaptive immune response to colorectal cancer: from the laboratory to clinical practice.

scientific article published on 19 June 2012

The classification of lymphomas and leukemias

scientific article published in June 2001

The development of standard samples with a defined number of antigen-specific T cells to harmonize T cell assays: a proof-of-principle study

scientific article

The effect of neoadjuvant chemotherapy on physical fitness and survival in patients undergoing oesophagogastric cancer surgery.

scientific article

The immune response in HPV(+) oropharyngeal cancer

scientific article published on January 2014

The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000.

scientific article

Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer.

scientific article published on 19 June 2017

Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study

scientific article published on 4 January 2016

Towards personalised medicine in lung and thymus neuroendocrine tumours.

scientific article published on 23 October 2017

Treatment of advanced chronic lymphocytic leukemia by fludarabine

scientific article published on 01 July 1991

Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma

scientific article published on 28 March 2016

Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer.

scientific article published on 29 October 2013

Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events

scientific article published on 01 August 2002

Universal N-glycosylation sites introduced into the B-cell receptor of follicular lymphoma by somatic mutation: a second tumorigenic event?

scientific article published on 01 March 2006

Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma.

scientific article published on 20 May 2016

Uveal Melanoma UK National Guidelines

scientific article (publication date: November 2015)

Vaccination Expands Antigen-Specific CD4+ Memory T Cells and Mobilizes Bystander Central Memory T Cells

scientific article published on 2 September 2015

Vaccine therapy in NHL: future promises and current limitations

scientific article published on January 2003

Validation of immunomonitoring methods for application in clinical studies: The HLA-peptide multimer staining assay

scientific article published on July 2016

Vascular cell adhesion molecule-1 expressed by peritoneal mesothelium partly mediates the binding of activated human T lymphocytes.

scientific article published on September 1994

Wilms’ tumour antigen 1 Immunity via DNA fusion gene vaccination in haematological malignancies by intramuscular injection followed by intramuscular electroporation: a Phase II non-randomised clinical trial (WIN)

scientific article

Withdrawal: Identification of tumor antigens among the HLA peptidomes of glioblastoma tumors and plasma

scientific article published on 01 June 2019

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