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List of works by Helge Grosshans

A branched heterochronic pathway directs juvenile-to-adult transition through two LIN-29 isoforms

scientific article published on 30 March 2020

A conserved chronobiological complex times C. elegans development

scientific article published on 9 May 2024

A folder mechanism ensures size uniformity among C. elegans individuals by coupling growth and development

scientific article published on 25 March 2021

A genetic interactome of the let-7 microRNA in C. elegans

scientific article

A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans

scientific article

Active turnover modulates mature microRNA activity in Caenorhabditis elegans

scientific article

An interplay of miRNA abundance and target site architecture determines miRNA activity and specificity.

scientific article

Bayesian prediction of RNA translation from ribosome profiling

scientific article

Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export.

scientific article

C. elegans molting requires rhythmic accumulation of the Grainyhead/ LSF transcription factor GRH ‐1

scientific article published on 23 January 2023

Convergence of multiple RNA-silencing pathways on GW182/TNRC6

scientific article published in July 2023

Coupling of growth rate and developmental tempo reduces body size heterogeneity in C. elegans

scientific article published on 6 June 2022

Developmental function and state transitions of a gene expression oscillator in C. elegans

scientific article published on 5 September 2019

Developmental function and state transitions of a gene expression oscillator in Caenorhabditis elegans

scientific article published on 01 July 2020

Developmental function and state transitions of a gene expression oscillator in Caenorhabditis elegans

scientific article published in October 2020

Dynamics of miRNA accumulation during C. elegans larval development

scientific article published on 22 May 2024

Engineering of a conditional allele reveals multiple roles of XRN2 in Caenorhabditis elegans development and substrate specificity in microRNA turnover

scientific article published on 20 January 2014

Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition.

scientific article published on 19 April 2018

Extensive oscillatory gene expression during C. elegans larval development

scientific article published on 16 January 2014

Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p

scientific article

Gene therapy--when a simple concept meets a complex reality. Review on gene therapy.

scientific article

H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity

scientific article published on 04 November 2021

Interplay of target site architecture and miRNA abundance determine miRNA activity and specificity

scientific article published on 21 November 2017

LIN-41/TRIM71: emancipation of a miRNA target

scientific article published on March 2013

LIN41 Post-transcriptionally Silences mRNAs by Two Distinct and Position-Dependent Mechanisms

scientific article published on 5 January 2017

Massively parallel quantification of substrate turnover defines protease subsite cooperativity

scientific article published on 17 November 2023

Micro-RNAs: small is plentiful

scientific article

MicroRNA biogenesis takes another single hit from microsatellite instability

scientific article published on 01 October 2010

MicroRNA turnover: when, how, and why.

scientific article published on 23 August 2012

MicroRNAs in C. elegans Development

scientific article published in October 2010

MicroRNases and the Regulated Degradation of Mature Animal miRNAs ⬇️

scientific article published on January 1, 2011

PAXT-1 promotes XRN2 activity by stabilizing it through a conserved domain

scientific article published in January 2014

Potent degradation of neuronal miRNAs induced by highly complementary targets.

scientific article

Protease-mediated processing of Argonaute proteins controls small RNA association

scientific article published on 9 December 2020

Proteomics joins the search for microRNA targets

scientific article published on 01 August 2008

Pus1p-dependent tRNA pseudouridinylation becomes essential when tRNA biogenesis is compromised in yeast.

scientific article published on 24 September 2001

RAS is regulated by the let-7 microRNA family

scientific article (publication date: 11 March 2005)

Regulating the regulators: mechanisms controlling the maturation of microRNAs.

scientific article

Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins

scientific article published on 08 January 2009

Structural basis and function of XRN2 binding by XTB domains

scientific article published on 18 January 2016

Target-mediated protection of endogenous microRNAs in C. elegans

scientific article published in March 2011

Targeted heritable mutation and gene conversion by Cas9-CRISPR in Caenorhabditis elegans

scientific article published on 26 August 2013

The BLMP-1 transcription factor promotes oscillatory gene expression to achieve timely molting

scientific article published on 5 July 2021

The Grainyhead/LSF transcription factor GRH-1 is rhythmically required for molting

scientific article published on 4 March 2022

The Liver-Specific MicroRNA miR-122: Biology and Therapeutic Potential

scientific article published on 3 September 2010

The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1

scientific article published on 01 August 2019

The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans

scientific article

The expanding world of small RNAs

scientific article published in Nature

The intracellular location of two aminoacyl-tRNA synthetases depends on complex formation with Arc1p

scientific article

The let-7 microRNA directs vulval development through a single target

scientific article published in February 2015

The let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiation

scientific article

The multifunctional RNase XRN2.

scientific article published on August 2013

The nuclear export receptor XPO-1 supports primary miRNA processing in C. elegans and Drosophila

scientific article

The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling

scientific article

The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans

scientific article (publication date: March 2005)

The type II poly(A)-binding protein PABP-2 genetically interacts with the let-7 miRNA and elicits heterochronic phenotypes in Caenorhabditis elegans

scientific article

Timing mechanism of sexually dimorphic nervous system differentiation

scientific article published on 01 January 2019

Transcriptome-wide measurement of ribosomal occupancy by ribosome profiling

scientific article published on 20 June 2015

Translational control of endogenous microRNA target genes in C. elegans

scientific article published on January 2010

Two distinct transcription termination modes dictated by promoters

scientific article published on 11 October 2017

Two parallel arms of the heterochronic pathway direct coordinated juvenile-to-adult transition through distinct LIN-29 isoforms

scientific article published on 26 September 2019

XRN2 Autoregulation and Control of Polycistronic Gene Expresssion in Caenorhabditis elegans

scientific article (publication date: September 2016)

coordinates the transition to adulthood through a single primary and four secondary targets

scientific article published on 25 March 2019

let-7 microRNAs in development, stem cells and cancer

scientific article

miRNA, piRNA, siRNA -- Kleine Wiener Ribonukleinsäuren

scientific article published on 01 September 2007

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