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List of works by Christopher J Lord

A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events.

scientific article

A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.

scientific article

A compendium of co-regulated protein complexes in breast cancer reveals collateral loss events

scholarly article published 26 June 2017

A genetic screen using the PiggyBac transposon in haploid cells identifies Parp1 as a mediator of olaparib toxicity

scientific article

A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines

scientific article

A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity

scientific article published on 15 October 2008

A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer

scientific article published on 12 August 2013

A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer

scientific article published on 27 August 2010

A modified method for whole exome resequencing from minimal amounts of starting DNA

scientific article

A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors

scientific article published in Scientific Reports

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

scientific article published on 03 April 2008

A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers

scientific article published on 23 February 2012

APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer

scientific article

ATR Is a Therapeutic Target in Synovial Sarcoma.

scientific article published on 16 October 2017

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.

scientific article published on 13 December 2016

Abstract 2931: Cancer cells deficient in DNA mismatch repair (MMR) are selectively sensitive to inhibition of the DNA dependent protein kinase (DNA-PK)

scientific article published on 30 September 2014

Abstract 3417: An in vivo functional screen to identify metastasis suppressor genes

article

Abstract 3917: EMSY amplification and overexpression is not associated with defective homologous recombination and does not predict sensitivity to cisplatin or PARP inhibitors

article by Paul Wilkerson et al published 15 April 2011 in Cancer Research

Abstract 4829: Massively parallel RNA sequencing analysis of micropapillary carcinomas of the breast

article by Rachael Natrajan et al published 15 April 2011 in Cancer Research

Abstract 4987: Identification of novel genes and pathways involved in resistance to HER2-targeting agents in breast cancer

article

Abstract 5076: Integrative genomic and transcriptomic analysis of metaplastic carcinomas of the breast

article by Alan G. Mackay et al published 15 April 2012 in Cancer Research

Abstract A09: Induced aggravation of oxidative DNA damage as a targeted synthetic lethal approach in mismatch repair-deficient tumors

article by Y. Fontebasso et al published 1 May 2013 in Molecular Cancer Therapeutics

Abstract A36: A transposon-based genetic screen in haploid mouse embryonic stem cells identifies Parp1 as a major mediator of olaparib toxicity

article

Abstracts

article by L. Bie et al published 1 April 2013 in Neuro-Oncology

Abstracts from the 2011 BNOS Conference, June 29 - July 1, 2011, Homerton College, Cambridge

article by S. Ammoun et al published 21 September 2011 in Neuro-Oncology

An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence

scientific article

An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor

scientific article published on 11 February 2014

An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers

scientific article published on 18 August 2009

Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors

scientific article published on 27 April 2017

Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition

scientific article

BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency.

scientific article

BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency

scientific article published on September 2005

BRCAness revisited

scientific article

Biology-driven cancer drug development: back to the future

scientific article

Bringing DNA repair in tumors into focus

scientific article

CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

scientific article

CRK7 modifies the MAPK pathway and influences the response to endocrine therapy

scientific article

CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer

scientific article published on 11 July 2017

CancerGD: a resource for identifying and interpreting genetic dependencies in cancer

scholarly article published 26 October 2016

Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast

scientific article

Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness

scientific article published on 13 July 2018

Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition.

scientific article published on 27 April 2017

Clinical BRCA1/2 reversion analysis identifies hotspot mutations and predicted neoantigens associated with therapy resistance

scientific article published on 22 July 2020

Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity

scientific article

Comprehensive genomic analysis of a BRCA2 deficient human pancreatic cancer

scientific article

Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation

scientific article published in November 2009

Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1

article

Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping

scientific article

Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

scientific article published on 20 April 2017

Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

scientific article published on 18 April 2016

Correction: Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

scientific article published in PLoS ONE

Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets.

scientific article

Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib

scientific article

Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells

scientific article published on 16 February 2021

Cytosine-based nucleoside analogs are selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress

scientific article

DAISY: picking synthetic lethals from cancer genomes

scientific article published in September 2014

DIFFERENTIAL GLYCOSYLATION OF INTERLEUKIN 2, THE MOLECULAR BASIS FOR THE NOD Idd3 TYPE 1 DIABETES GENE?

article

DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1

scientific article

DNA repair deficiency as a therapeutic target in cancer

scientific article published on February 2008

DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade

scientific article published on 15 February 2018

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer ⬇️

scientific article

DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells

scientific journal article

De Novo Truncating Mutations in the Last and Penultimate Exons of PPM1D Cause an Intellectual Disability Syndrome

scientific article published on 18 March 2017

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

article by Nuala McCabe et al published 15 August 2006 in Cancer Research

Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors

article

Directing the use of DDR kinase inhibitors in cancer treatment.

scientific article

Dissecting resistance to endocrine therapy in breast cancer

scientific article

Driver Oncogenes but Not as We Know Them: Targetable Fusion Genes in Breast Cancer

article

Dsh homolog DVL3 mediates resistance to IGFIR inhibition by regulating IGF-RAS signaling

scientific article published on 28 August 2014

Dysregulated TRK signalling is a therapeutic target in CYLD defective tumours

scientific article published on 09 May 2011

E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.

scientific article published in April 2018

Efficacy of chemotherapy in BRCA1/2 mutation carrier ovarian cancer in the setting of PARP inhibitor resistance: a multi-institutional study

scientific article published on 06 August 2013

Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells

scientific article

Establishment and characterisation of a new breast cancer xenograft obtained from a woman carrying a germline BRCA2 mutation

scientific article

Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer.

scientific article published on 13 November 2017

Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways.

scientific article

Functional analysis of Drosophila melanogaster BRCA2 in DNA repair

scientific article published on 5 September 2007

Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

scientific article published in July 2021

Functional characterization of EMSY gene amplification in human cancers

scientific article published on 7 July 2011

Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance

scientific article published in 2022

Functional viability profiles of breast cancer

scientific article

Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma

scientific article published on 23 June 2017

Genetic Interactions in Cancer Progression and Treatment

scientific article published on 01 April 2011

Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation

scientific article

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.

scientific article published on 10 May 2018

Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

scientific article

Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells

scientific article

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress

scientific article published on 13 May 2014

Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen

scientific article published on 11 April 2011

Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity

scientific article

Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers

scientific article published on 13 March 2015

Genomic characterisation of acral melanoma cell lines

scientific article published on July 2012

Genomic instability and the selection of treatments for cancer

scientific article published on January 2010

Germline mutations in RAD51D confer susceptibility to ovarian cancer

scientific article (publication date: 7 August 2011)

HG-97PAEDIATRIC GBM AND DIPG SUBCLONES CO-OPERATE TO PROMOTE TUMORIGENESIS.

scientific article published on 30 May 2016

HGG-07. MUTATIONS IN ATRX INCREASE GENETIC INSTABILITY AND SENSITIVITY TO PARP INHIBITORS IN PAEDIATRIC GLIOBLASTOMA CELLS.

scientific article published on 31 May 2017

HLA-B*5603: sequence of a novel hybrid allele comprising B*56 and B*4601 segments

scientific article published in May 1997

High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing

scientific article

High-throughput RNAi screening reveals novel regulators of telomerase

scientific article

Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN.

scientific article published on May 2013

Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer

scientific article

Identification of a Structurally Distinct CD101 Molecule Encoded in the 950-kb Idd10 Region of NOD Mice

scientific article published on 01 June 2003

Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma

scientific article

Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer

scientific article published on 18 June 2018

Identification of miRNA modulators to PARP inhibitor response

scientific article published on 6 April 2013

Identification of novel determinants of resistance to lapatinib in ERBB2-amplified cancers

scientific article

Identifying Genetic Dependencies in Cancer by Analyzing siRNA Screens in Tumor Cell Line Panels

scientific article published in January 2018

Identifying Modifiers of Tamoxifen Sensitivity Using High-Throughput Genetic and Chemical Screens

scholarly article

Integrated functional, gene expression and genomic analysis for the identification of cancer targets

scientific article

Integrative molecular and functional profiling of ERBB2-amplified breast cancers identifies new genetic dependencies

scientific article published on 21 January 2013

Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment

scientific article published on February 2006

Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma

scientific article

Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines

scientific article published on 2 March 2016

MESH: Phase II trial of methotrexate as a synthetic lethal therapy for metastatic MSH2-deficient colorectal and other tumors

article by M. Hewish et al published 20 May 2010 in Journal of Clinical Oncology

Mapping by Genetic Interaction: High-Resolution Congenic Mapping of the Type 1 Diabetes Loci Idd10 and Idd18 in the NOD Mouse

scientific article published on 01 November 2001

Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer

scientific article

Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene.

scientific article

Mapping the diabetes polygene Idd3 on mouse chromosome 3 by use of novel congenic strains

scientific article

Mechanisms of resistance to therapies targeting BRCA-mutant cancers

scientific article published on 07 October 2013

Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2

scientific article

Mismatch repair deficient colorectal cancer in the era of personalized treatment

scientific article published on 23 February 2010

Modeling Therapy Resistance in BRCA1/2-Mutant Cancers

scientific article published on 15 June 2017

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

scientific article

NLK is a novel therapeutic target for PTEN deficient tumour cells

scientific article published on 29 October 2012

Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway

scientific article published on May 2015

Optimised ARID1A immunohistochemistry is an accurate predictor of ARID1A mutational status in gynaecological cancers.

scientific article published on 16 April 2018

Overexpression of MYB drives proliferation of CYLD-defective cylindroma cells

scientific article published on 11 March 2016

PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer

article by Roman M Chabanon et al published 1 March 2019 in Journal of Clinical Investigation

PARP inhibitor combination therapy

scientific article published on 31 October 2016

PARP inhibitors: Synthetic lethality in the clinic

scientific article published on 16 March 2017

PD-0017 * DRUGGABLE GENETIC DEPENDENCIES FOR MOLECULARLY DEFINED SUBGROUPS OF OESOPHAGEAL CANCER IDENTIFIED FROM HIGH-THROUGHPUT FUNCTIONAL PROFILING

scientific article published in June 2014

PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study

scientific article published on 11 June 2010

PPM1D is a potential therapeutic target in ovarian clear cell carcinomas

scientific article published on 17 March 2009

PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors

scientific article published on October 2010

Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization

scientific article

Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair-deficient cancers

scientific article published on 17 January 2011

Phenotypic effects of heterozygosity for a BRCA2 mutation

scientific article published on 19 August 2003

Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes

scientific article

Poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of advanced germline BRCA2 mutant prostate cancer

scientific article published on 22 March 2013

Preclinical evaluation of PARP inhibition as a treatment for endometrioid endometrial carcinomas

article by K. J. Dedes et al published 20 May 2010 in Journal of Clinical Oncology

RAD51, BRCA2 and DNA repair: a partial resolution

scientific article published on 01 June 2007

RNA interference screening demystified

scientific article

Regulator of G-protein signalling 2 mRNA is differentially expressed in mammary epithelial subpopulations and over-expressed in the majority of breast cancers

scientific article

Resistance to therapy caused by intragenic deletion in BRCA2

scientific article

Searching for synthetic lethality in cancer

scientific article published on 20 January 2011

Secondary mutations inBRCA2associated with clinical resistance to a PARP inhibitor

article by Louise J Barber et al published 25 January 2013 in Journal of Pathology

Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer

scientific article

Sequential interactions with Sec23 control the direction of vesicle traffic

scientific article

Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits

scientific article

Statistical modeling of interlocus interactions in a complex disease: rejection of the multiplicative model of epistasis in type 1 diabetes

scientific article

Structural basis for allosteric PARP-1 retention on DNA breaks

scientific article

Structural basis for recruitment of BRCA2 by PALB2

scientific article

Structural basis for recruitment of BRCA2 by PALB2.

scientific article published on July 2017

Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma

scientific article

Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib

scientific article

Synthetic Lethality and Cancer - Penetrance as the Major Barrier

article by Colm J. Ryan et al published October 2018 in Trends in cancer

Synthetic lethal approaches to breast cancer therapy

scientific article published on 19 October 2010

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

scientific article

Synthetic lethal targeting of PTEN-deficient cancer cells using selective disruption of polynucleotide kinase/phosphatase

scientific article published on 24 July 2013

Synthetic lethal therapies for cancer: what's next after PARP inhibitors?

article by Alan Ashworth et al published September 2018 in Nature Reviews Clinical Oncology

Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors

scientific article

Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells

scientific article

Synthetic lethality: the road to novel therapies for breast cancer

scientific article

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family

scientific article published on December 2012

Targeted therapy for cancer using PARP inhibitors

scientific article published on August 2008

Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer.

scientific article

Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers

scientific article

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

scientific article (publication date: 14 April 2005)

Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer

scientific article published in January 2018

Targeting the double-strand DNA break repair pathway as a therapeutic strategy

scientific article published on August 2006

The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.

scientific article published in May 2018

The DNA damage response and cancer therapy

scientific article published on 18 January 2012

The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137.

scientific article

The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling

scientific article published on December 2014

The derivation of highly germline-competent embryonic stem cells containing NOD-derived genome

scientific article published on January 2003

The genomic landscape of oesophagogastric junctional adenocarcinoma

scientific article

The genomic profile of HER2-amplified breast cancers: the influence of ER status

scientific article

The murine type 1 diabetes loci, Idd1, Idd3, Idd5, Idd9, and Idd17/10/18, do not control thymic CD4 − CD8 − /TCRαβ + deficiency in the nonobese diabetic mouse

scientific article published on 01 February 2001

The potential of exploiting DNA-repair defects for optimizing lung cancer treatment

scientific article published on 14 February 2012

The promise of combining inhibition of PI3K and PARP as cancer therapy.

scientific article

The proteasome is involved in determining differential utilization of double-strand break repair pathways

article by K Gudmundsdottir et al published 29 November 2007 in Oncogene

The shieldin complex mediates 53BP1-dependent DNA repair

scientific article published in Nature

The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module

scientific article

Therapeutic targeting of the DNA mismatch repair pathway

scientific article published on 07 September 2010

Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model

scientific article published on 11 August 2016

Tiling path genomic profiling of grade 3 invasive ductal breast cancers

scientific article published on 24 March 2009

Transition from cylindroma to spiradenoma in CYLD-defective tumours is associated with reduced DKK2 expression

scientific article published on 19 May 2011

Utilizing RNA interference to enhance cancer drug discovery

scientific article published on July 2007

Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor

scientific article published on 26 April 2012

Whole genome sequencing of matched primary and metastatic acral melanomas

scientific article

Whole-exome DNA sequence analysis of Brca2- and Trp53-deficient mouse mammary gland tumours

scientific article published on 2 April 2015

p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene

scientific article published on February 2006

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