List of works by Manuel C. Peitsch

3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product

scientific article published on 7 July 2016

3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow - application in systems toxicology

scientific article published on 22 August 2019

A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes.

scientific article published on 12 March 2014

A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors

scientific article

A 6-month systems toxicology inhalation study in ApoE-/- mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared with cigarette smoke

scientific article published on 24 January 2020

A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product

scientific article published on 02 April 2015

A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clin

scientific article published on 11 April 2018

A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology asses

scientific article published on 13 March 2018

A Meta-Analysis of the Performance of a Blood-Based Exposure Response Gene Signature Across Clinical Studies on the Tobacco Heating System 2.2 (THS 2.2)

article

A Pathogen-specific Epitope Inserted into Recombinant Secretory Immunoglobulin A Is Immunogenic by the Oral Route

scientific article published in Journal of Biological Chemistry

A Systems Toxicology Approach to Investigating the Cardiovascular Effects of Cigarette Smoke and Environmental Pollutants in ApoE-Deficient Mice

A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue

scientific article

A crowd-sourcing approach for the construction of species-specific cell signaling networks

scientific article

A decade of Systems Biology: where are we and where are we going to?

scientific article

A framework for in vitro systems toxicology assessment of e-liquids

scientific article published on 26 April 2016

A genome-based approach for the identification of essential bacterial genes.

scientific article published in September 1998

A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment

scientific article published on 05 March 2019

A lung/liver-on-a-chip platform for acute and chronic toxicity studies

scientific article published on 01 December 2018

A meta-analysis of microRNAs expressed in human aerodigestive epithelial cultures and their role as potential biomarkers of exposure response to nicotine-containing products

scientific article published on 12 September 2020

A modular cell-type focused inflammatory process network model for non-diseased pulmonary tissue

scientific article published on 20 June 2013

A network-based approach to quantifying the impact of biologically active substances

scientific article published on 02 December 2011

A new function for an old enzyme: the role of DNase I in apoptosis.

scientific article published on January 1995

A protein conformational search space defined by secondary structure contacts

scientific article

A prototypic modified risk tobacco product exhibits reduced effects on chemotaxis and transendothelial migration of monocytes compared with a reference cigarette.

scientific article

A purification method for apolipoprotein A-I and A-II

scientific article published on 01 May 1989

A rapid and efficient method for the purification of the complement subcomponents C1r and C1s in zymogen form using fast protein chromatography

scientific article published on 01 April 1988

A six-month systems toxicology inhalation/cessation study in ApoE-/- mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes

scientific article published on 12 February 2019

A systems biology approach reveals the dose- and time-dependent effect of primary human airway epithelium tissue culture after exposure to cigarette smoke in vitro

scientific article published on 9 March 2015

A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures

scientific article published on 16 November 2016

A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability.

scientific article

About the involvement of deoxyribonuclease I in apoptosis.

scientific article published in July 1994

About the use of protein models

scientific article published on 01 July 2002

Advancing Risk Assessment through the Application of Systems Toxicology

scientific article published on 31 January 2016

Aerosol Flow in the Vitrocell 24/48 Exposure System: Flow Mixing and Aerosol Coalescence

Aerosol from Tobacco Heating System 2.2 has reduced impact on mouse heart gene expression compared with cigarette smoke

scientific article published on 19 January 2017

Aerosol from a candidate modified risk tobacco product has reduced effects on chemotaxis and transendothelial migration compared to combustion of conventional cigarettes

scientific article published on 30 September 2015

Alterations in Serum Polyunsaturated Fatty Acids and Eicosanoids in Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD)

scientific article published on 20 September 2016

Alterations in the sputum proteome and transcriptome in smokers and early-stage COPD subjects

scientific article published on 22 August 2015

Alternatives to Animal Use in Risk Assessment of Mixtures

scientific article published on 18 February 2020

Amino acid sequence of the alpha subunit and computer modelling of the alpha and beta subunits of echicetin from the venom of Echis carinatus (saw-scaled viper).

scientific article published on April 1997

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes.

scientific article

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe−/−Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes

scientific article published on 01 June 2016

An Intestine-on-a-Chip Model of Plug-and-Play Modularity to Study Inflammatory Processes

scientific article published on 24 June 2020

An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors

scientific article published on 19 December 2019

Analysis of Proteomic Data for Toxicological Applications

Analysis of chemical deposits on tooth enamel exposed to total particulate matter from cigarette smoke and tobacco heating system 2.2 aerosol by novel GC-MS deconvolution procedures

scientific article published on 10 June 2020

Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis

scientific article published on 24 August 2020

Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate

scientific article

Antibody-independent activation of C1. II. Evidence for two classes of nonimmune activators of the classical pathway of complement.

scientific article

Antibody-independent activation of the complement system by mitochondria is mediated by cardiolipin

scientific article published on January 1988

Antiparasitic properties of leaf extracts derived from selected Nicotiana species and Nicotiana tabacum varieties

scientific article published on 03 July 2019

Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology

scientific article published on 07 September 2019

Aqueous cigarette smoke extract promotes the adhesion of monocytic cells to human coronary artery endothelial cells in direct and indirect-dependent ways

scholarly article by Carine Poussin et al published September 2014 in Toxicology Letters

Asp-49 is not an absolute prerequisite for the enzymic activity of low-M(r) phospholipases A2: purification, characterization and computer modelling of an enzymically active Ser-49 phospholipase A2, ecarpholin S, from the venom of Echis carinatus so

scientific article published on November 1996

Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products

scientific article published on 14 February 2019

Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarette smoke on gingival organotypic cultures

scientific article published on 02 January 2019

Assessment of a novel multi-array normalization method based on spike-in control probes suitable for microRNA datasets with global decreases in expression

scientific article

Assessment of mitochondrial function following short- and long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product and reference cigarettes

scientific article published on 12 February 2018

Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks

scientific article

Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens.

scientific article published on 2 March 2018

Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: a historical perspective.

scientific article

Automated modelling of the transmembrane region of G-protein coupled receptor by Swiss-model

scientific article

Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols

scientific article published on 01 November 2018

Biological impact of cigarette smoke compared to an aerosol produced from a prototypic modified risk tobacco product on normal human bronchial epithelial cells

scientific article published on 13 August 2015

Building a Corporate Chemical Database Toward Systems Biology

Building an R&D chemical registration system

scientific article published on 31 May 2012

CD40Lbase: a database of CD40L gene mutations causing X-linked hyper-IgM syndrome

article

CSEO - the Cigarette Smoke Exposure Ontology

scientific article

Case study: the role of mechanistic network models in systems toxicology

scientific article published on 09 August 2013

Causal Biological Network Model for Inflammasome Signaling Applied for Interpreting Transcriptomic Changes in Various Inflammatory States

scientific article published on 27 January 2022

Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems

scientific article

Ceramide ratios are affected by cigarette smoke but not heat-not-burn or e-vapor aerosols across four independent mouse studies

scientific article published on 12 November 2020

Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines

scientific article

Characterization of the Vitrocell® 24/48 in vitro aerosol exposure system using mainstream cigarette smoke

scientific article published on 12 November 2014

Characterization of the non-functional Fas ligand of gld mice

article

Cigarette smoke induces molecular responses in respiratory tissues of ApoE(-/-) mice that are progressively deactivated upon cessation.

scientific article published in October 2013

Cigarette-smoke-induced atherogenic lipid profiles in plasma and vascular tissue of apolipoprotein E-deficient mice are attenuated by smoking cessation.

scientific article published on 22 April 2013

Clinical spectrum of X-linked hyper-IgM syndrome

scientific article published on 01 July 1997

Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3

scientific article

Clusterin (complement lysis inhibitor) forms a high density lipoprotein complex with apolipoprotein A-I in human plasma.

scientific article published in June 1991

Community-Reviewed Biological Network Models for Toxicology and Drug Discovery Applications

scientific article published on 12 July 2016

Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment.

scientific article published in March 2018

Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach

article

Comparative molecular modelling of the Fas-ligand and other members of the TNF family

article

Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study.

scientific article published on 23 December 2016

Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case

scientific article published on 12 September 2020

Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products

scientific article published on 13 November 2019

Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures

scientific article published on 18 November 2020

Competitive intelligence and patent analysis in drug discovery

scientific article published on January 2005

Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice

scientific article

Computational Epigenomics: From Fundamental Research to Disease Prediction and Risk Assessment

Computational Structural Biology

Computer-assisted reading in drug discovery

scientific article

Confero: an integrated contrast data and gene set platform for computational analysis and biological interpretation of omics data

scientific article

Construction of a computable cell proliferation network focused on non-diseased lung cells

scientific article

Construction of a computable network model for DNA damage, autophagy, cell death, and senescence

scientific article published on 07 March 2013

Construction of biological networks from unstructured information based on a semi-automated curation workflow

scientific article published on 17 June 2015

Corrigendum to "The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product" published in Toxicology in Vitro, Volume 50, August 2018, Pages 95-108

scientific article published on 25 January 2019

Covalent homodimers of murine secretory component induced by epitope substitution unravel the capacity of the polymeric Ig receptor to dimerize noncovalently in the absence of IgA ligand.

scientific article

Crowd-Sourced Verification of Computational Methods and Data in Systems Toxicology: A Case Study with a Heat-Not-Burn Candidate Modified Risk Tobacco Product

scientific article

Defining the Regions of Human Interleukin-5 Important in Receptor Binding and Cellular Activation

scientific article published on 01 October 1996

Design of a tobacco exon array with application to investigate the differential cadmium accumulation property in two tobacco varieties

scientific article

Discovery of Emphysema Relevant Molecular Networks from an A/J Mouse Inhalation Study Using Reverse Engineering and Forward Simulation (REFS™).

scientific article published on 19 February 2014

Distribution of deoxyribonuclease I in rat tissues and its correlation to cellular turnover and apoptosis (programmed cell death).

scientific article

E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE-/- mouse model

scientific article published on 14 May 2020

Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe-/- Mice-An Integrative Systems Toxicology Analysis

scientific article

Effects of cigarette smoke and tobacco heating aerosol on color stability of dental enamel, dentin, and composite resin restorations

scientific article published on 18 December 2018

Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe -/- mice--a systems toxicology analysis

scientific article

Effects of cigarette smoking on color stability of dental resin composites

scientific article published in December 2017

Effects of different discoloration challenges and whitening treatments on dental hard tissues and composite resin restorations

scientific article published on 17 August 2019

Enhancement of COPD biological networks using a web-based collaboration interface.

scientific article

Evaluation of the Tobacco Heating System 2.2 (THS2.2). Part 5: microRNA expression from a 90-day rat inhalation study indicates that exposure to THS2.2 aerosol causes reduced effects on lung tissue compared with cigarette smoke

scientific article published on 17 November 2016

Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the system and the scientific assessment program

scientific article

Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke

scientific article published on 25 October 2016

Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke

scientific article published on 3 November 2016

Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke

scientific article published on 3 November 2016

Evaluation of the tobacco heating system 2.2. Part 9: Application of systems pharmacology to identify exposure response markers in peripheral blood of smokers switching to THS2.2.

scientific article published on 11 November 2016

Evaluation of toxicity of aerosols from flavored e-liquids in Sprague-Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis

scientific article published on 05 May 2020

From proteomics to systems biology of bacterial pathogens: Approaches, tools, and applications

scientific article published on 01 March 2007

Functional characterisation of serum DNase I in MRL-lprlpr mice

scientific article published on 01 July 1992

GladiaTOX: GLobal Assessment of Dose-IndicAtor in TOXicology

scientific article published on 01 October 2019

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC).

scientific article published on 10 May 2016

How complex should an in vitro model be? Evaluation of complex 3D alveolar model with transcriptomic data and computational biological network models

scientific article published on 12 February 2019

Human CD40 ligand: molecular cloning, cellular distribution and regulation of IgE synthesis

scientific article published on March 1994

Human aspects of the management of drug discovery knowledge

scientific article published on 01 January 2005

Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers

scientific article published on 25 January 2013

Hydrophobic C-terminal amino acids in the beta-subunit are involved in assembly with the alpha-subunit of Na,K-ATPase

scientific article published in December 1993

Identification of gene expression signature for cigarette smoke exposure response--from man to mouse

scientific article published on December 2015

Identification of key charged residues of human interleukin-5 in receptor binding and cellular activation.

scientific article

Identification of mutations in cystatin B, the gene responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy (EPM1)

scientific article

Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts

scientific article

Impact assessment of repeated exposure of organotypic 3D bronchial and nasal tissue culture models to whole cigarette smoke

scientific article published on 12 February 2015

In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air-Liquid Interface Cultures

scientific article published on 23 January 2020

In Vitro Systems Toxicology Assessment of a Candidate Modified Risk Tobacco Product Shows Reduced Toxicity Compared to That of a Conventional Cigarette.

scientific article published on 10 December 2015

In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures

scientific article

In vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP 1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells

scientific article published on 17 July 2018

Increased p34cdc2-dependent kinase activity during apoptosis: a possible activation mechanism of DNase I leading to DNA breakdown.

scientific article published on February 1996

Industrial methodology for process verification in research (IMPROVER): toward systems biology verification

scientific article

Inflammatory Bowel Disease-Associated Changes in the Gut: Focus on Kazan Patients

scientific article published on 07 August 2020

Interaction of peptides derived from the Fas ligand with the Fyn-SH3 domain

scientific article

Interrogating the microbiome: experimental and computational considerations in support of study reproducibility

scientific article published on 08 June 2018

Large scale protein modelling and model repository.

scientific article published in January 1997

Large-scale protein modelling and integration with the SWISS-PROT and SWISS-2DPAGE databases: the example of Escherichia coli.

scientific article

Lung transcriptomic clock predicts premature aging in cigarette smoke-exposed mice

scientific article published on 09 April 2020

MDB: a database system utilizing automatic construction of modules and STAR-derived universal language

scientific article

Mapping regions of Gαqinteracting with PLCβ1 using multiple overlapping synthetic peptides

scientific article published on 01 May 1995

Mechanism of an indirect effect of aqueous cigarette smoke extract on the adhesion of monocytic cells to endothelial cells in an in vitro assay revealed by transcriptomics analysis

scientific article published on 18 April 2014

Mechanistic Evaluation of the Impact of Smoking and Chronic Obstructive Pulmonary Disease on the Nasal Epithelium

scientific article

Mitochondria as a possible target for nicotine action

scientific article published on 13 June 2019

Modulation of atherogenic lipidome by cigarette smoke in apolipoprotein E-deficient mice

scientific article published on 10 October 2012

Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke

scientific article published on 25 April 2020

Multicomponent aerosol particle deposition in a realistic cast of the human upper respiratory tract

scientific article published on February 2017

Mutational analysis of polymeric immunoglobulin receptor/ligand interactions. Evidence for the involvement of multiple complementarity determining region (CDR)-like loops in receptor domain I

scientific article (publication date: 16 December 1994)

Mutations in the putative lipid-interaction domain of complement C9 result in defective secretion of the functional protein

scientific article published on January 1993

NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks

scientific article published on 03 September 2019

Neurobehavioral effects of selected tobacco constituents in rodents following subchronic administration

scientific article published on 15 November 2019

New insulin-like proteins with atypical disulfide bond pattern characterized in Caenorhabditis elegans by comparative sequence analysis and homology modeling.

scientific article published in April 1998

Novel approaches to develop community-built biological network models for potential drug discovery

scientific article published on 06 June 2017

On Crowd-verification of Biological Networks

scientific article (publication date: October 2013)

Overexpression of deoxyribonuclease I (DNase I) transfected into COS-cells: its distribution during apoptotic cell death

scientific article published on December 1993

PEOPLE WATCH

Perforin and granzymes: crucial effector molecules in cytolytic T lymphocyte and natural killer cell-mediated cytotoxicity.

scientific article published on January 1995

Physiological and biological characterization of smokers with and without COPD.

scientific article published on 13 June 2017

Pre-malignant processes of smoking-induced lung adenocarcinoma development: A conceptual biological model

Probing the structure and function of the tachykinin neurokinin-2 receptor through biosynthetic incorporation of fluorescent amino acids at specific sites

scientific article

Propidium iodide staining correlates with the extent of DNA degradation in isolated nuclei

scientific article published on 01 March 1992

Protein Homology Modeling

Protein Homology Modelling

Protein Tertiary Structure Modeling

scientific article published on 01 May 2001

Protein modelling for all

article

Protein structure computing in the genomic era.

scientific article

Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification

scientific article published on 15 September 2018

Proteomics for systems toxicology

scientific article

Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models

scientific article

Quantifying the Biological Impact of Active Substances Using Causal Network Models

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models

scientific article

Quantitative proteomics analysis using 2D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modified risk tobacco product on the lung proteome in C57BL/6 mice

scientific article

Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol from a Heated Tobacco Product Compared with Cigarette Smoke

scientific article published on 11 August 2020

Reduced impact of a prototypic modified risk tobacco product compared with conventional cigarette smoke on exposed human and rat primary normal bronchial epithelial cells

scholarly article by Carole Mathis et al published September 2014 in Toxicology Letters

Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana tomentosiformis

scientific article published on 17 June 2013

Reputation-based collaborative network biology

scientific article published on January 2015

Respirable aerosol exposures of nicotine dry powder formulations to in vitro, ex vivo, and in vivo pre-clinical models demonstrate consistency of pharmacokinetic profiles

scientific article published on 01 May 2019

Respiratory effects of exposure to aerosol from the candidate modified-risk tobacco product THS 2.2 in an 18-month systems toxicology study with A/J mice

scientific article published on 11 August 2020

Role of a hydrophobic pocket of the human Y1 neuropeptide Y receptor in ligand binding

scientific article published on 01 August 1995

SWISS-MODEL: An automated protein homology-modeling server

scientific article

Selectivity and antagonism of chemokine receptors

scientific article published on January 1996

Semi-Automated Curation Allows Causal Network Model Building for the Quantification of Age-Dependent Plaque Progression in ApoE-/- Mouse

scientific article

Sequence similarity of phospholipase A2 activating protein and the G protein beta-subunits: a new concept of effector protein activation in signal transduction?

scientific article

Spatial Orientation of the α and βcReceptor Chain Binding Sites on Monomeric Human Interleukin-5 Constructs

scientific article published in Journal of Biological Chemistry

Strengths and limitations of microarray-based phenotype prediction: lessons learned from the IMPROVER Diagnostic Signature Challenge

scientific article published on 20 August 2013

Structural analysis of TCR-ligand interactions studied on H-2Kd-restricted cloned CTL specific for a photoreactive peptide derivative

article

Structural and functional characterization of complement c8γ, a member of the lipocalin protein family ⬇️

scientific article published on January 1, 1991

Structural, functional, and molecular impact on the cardiovascular system in ApoE-/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smo

scientific article published on 06 November 2019

Structure and bioactivity of recombinant human CTAP-III and NAP-2.

scientific article

Supporting evidence-based analysis for modified risk tobacco products through a toxicology data-sharing infrastructure.

scientific article published on 5 January 2017

Systematic verification of upstream regulators of a computable cellular proliferation network model on non-diseased lung cells using a dedicated dataset

scientific article published on 23 July 2013

Systems Biology Approaches for Compound Testing

Systems Biology Research into Cardiovascular Disease: Contributions of Lipidomics-based Approaches to Biomarker Discovery.

scientific article published on 02 July 2015

Systems Biology Reveals Cigarette Smoke-Induced Concentration-Dependent Direct and Indirect Mechanisms That Promote Monocyte-Endothelial Cell Adhesion

scientific article

Systems Toxicology

Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures.

scientific article published on 5 August 2016

Systems Toxicology: Real World Applications and Opportunities.

scientific article

Systems approaches evaluating the perturbation of xenobiotic metabolism in response to cigarette smoke exposure in nasal and bronchial tissues

scientific article published on 3 October 2013

Systems biology approach for evaluating the biological impact of environmental toxicants in vitro

scientific article published on 30 January 2014

Systems biology approach reveals a dose-dependent recovery of primary human airway epithelium culture after exposure to cigarette smoke

article

Systems toxicology approach for testing chemical cardiotoxicity in larval zebrafish

scientific article published on 08 July 2020

Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model

scientific article published on June 2014

Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells

scientific article published on 25 November 2019

Systems toxicology meta-analysis of assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract

article

Systems toxicology-based assessment of the candidate modified risk tobacco product THS2.2 for the adhesion of monocytic cells to human coronary arterial endothelial cells.

scientific article published on 2 December 2015

Systems toxicology: from basic research to risk assessment

scientific article published on 21 January 2014

Systems-toxicology approach to evaluate the biological impact of a subset of harmful/potentially harmful constituents of tobacco smoke

article by Ignacio Gonzalez-Suarez et al published August 2013 in Toxicology Letters

Tandem mass spectrometry protein identification on a PC grid

scientific article published on January 2007

Text mining for biology - the way forward: opinions from leading scientists

scientific article (publication date: 2008)

The Apoe(-/-) mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

scientific article

The Apoe-/- Mouse PhysioLab® Platform: A Validated Physiologically-based Mathematical Model of Atherosclerotic Plaque Progression in the Apoe-/- Mouse

The BEL information extraction workflow (BELIEF): evaluation in the BioCreative V BEL and IAT track

scientific article published on 2 October 2016

The Molecular Basis of the Chemokine/Chemokine Receptor Interaction—Scope for Design of Chemokine Antagonists

scientific article published on 01 August 1996

The Swiss-3DImage collection and PDB-Browser on the World-Wide Web

article

The SwissBioGrid Project: Objectivse, Preliminary Results and Lessons Learned

article

The apoptosis endonucleases: cleaning up after cell death?

scientific article published on 01 February 1994

The application of systems biology to drug discovery

scientific article published on 5 July 2006

The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product.

scientific article published on 7 March 2018

The carboxy-terminal region of human interleukin-5 is essential for maintenance of tertiary structure but not for dimerization.

scientific article

The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases.

scientific article

The heparin binding domain of S-protein/vitronectin binds to complement components C7, C8, and C9 and perforin from cytolytic T-cells and inhibits their lytic activities

scientific article published on 01 May 1988

The molecular basis of selectivity between CC and CXC chemokines: the possibility of chemokine antagonists as anti-inflammatory agents

scientific article published on October 1996

The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts

scientific article published on 02 March 2020

The response of human nasal and bronchial organotypic tissue cultures to repeated whole cigarette smoke exposure.

scientific article published on 8 October 2014

The sbv IMPROVER Systems Toxicology Computational Challenge: Identification of Human and Species-Independent Blood Response Markers as Predictors of Smoking Exposure and Cessation Status

scientific article published on 14 July 2017

The species translation challenge-a systems biology perspective on human and rat bronchial epithelial cells

scientific article

The systems toxicology challenge

The tobacco genome sequence and its comparison with those of tomato and potato

scientific article

Tobacco Heating System 2.2 has a limited impact on DNA methylation of candidate enhancers in mouse lung compared with cigarette smoke

scientific article published on 09 November 2018

Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague-Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology

scientific article published on 21 August 2015

Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints

scientific article published on 4 September 2017

Toxicological assessment of Tobacco Heating System 2.2: Findings from an independent peer review

scientific article published on 14 March 2019

Toxicopanomics: Applications of Genomics, Transcriptomics, Proteomics, and Lipidomics in Predictive Mechanistic Toxicology

Training and evaluation corpora for the extraction of causal relationships encoded in biological expression language (BEL).

scientific article published on 23 August 2016

Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains

scientific article published on 12 May 2015

Translational systems biology understanding the limits of animal models as predictors of human biology

Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge

scientific article

Verification of systems biology research in the age of collaborative competition

scientific article

Where are we at regarding species translation? A review of the sbv IMPROVER challenge

scientific article published on 31 January 2015

Whole genome profiling physical map and ancestral annotation of tobacco Hicks Broadleaf

scientific article published on 26 June 2013

[5] Granzyme B

scientific article published on 01 January 1994

alpha 1 but not alpha 2 or alpha 3 isoforms of Na,K-ATPase are efficiently phosphorylated in a novel protein kinase C motif

scientific article published in November 1996

sbv IMPROVER Diagnostic Signature Challenge

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