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List of works by Darren Hargrave

'I have to live with the decisions I make': laying a foundation for decision making for children with life-limiting conditions and life-threatening illnesses

scientific article

18F-fluoroethylcholine (18F-Cho) PET/MRI functional parameters in pediatric astrocytic brain tumors

scientific article published in January 2015

A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation-Positive Solid Tumors

scientific article published on 10 September 2019

A cell-based MAPK reporter assay reveals synergistic MAPK pathway activity suppression by MAPK inhibitor combination in BRAF-driven pediatric low-grade glioma cells

scientific article published on 25 May 2020

A distinct spectrum of copy number aberrations in pediatric high-grade gliomas

scientific article published on 22 June 2010

A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.

scientific article published on 3 December 2014

A phase 1 study of oral ridaforolimus in pediatric patients with advanced solid tumors

scientific article

A phase I trial of AT9283 (a selective inhibitor of aurora kinases) in children and adolescents with solid tumors: a Cancer Research UK study

scientific article

A phase II single-arm study of irinotecan in combination with temozolomide (TEMIRI) in children with newly diagnosed high grade glioma: a joint ITCC and SIOPE-brain tumour study

scientific article published on 04 March 2013

A population pharmacokinetic model of AT9283 in adults and children to predict the maximum tolerated dose in children with leukaemia

scientific article published on 8 February 2017

Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation

scientific article published on 11 August 2021

Case of interstitial 12q deletion in association with Wilms tumor

Central nervous system tumours in adolescents.

scientific article published on December 2003

Challenges to curing primary brain tumours

scientific article published on 01 August 2019

Challenges with defining response to antitumor agents in pediatric neuro-oncology: A report from the response assessment in pediatric neuro-oncology (RAPNO) working group

article

Childhood brain tumour information on the Internet in the Chinese language

scientific article published on 10 November 2005

Clinical presentation and prognostic indicators in 100 adults and children with neurofibromatosis 1 associated non-optic pathway brain gliomas

scientific article published on 7 June 2017

Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries.

scientific article

Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease

scientific article published on 12 January 2015

Commentary on "Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes".

scientific article

Consensus and perspectives on treatment strategies in childhood craniopharyngioma: results of a meeting of the Craniopharyngioma Study Group (SIOP), Genova, 2004

scientific article published on 01 April 2006

Conventional MRI cannot predict survival in childhood diffuse intrinsic pontine glioma

scientific article

Delineation of the visual pathway in paediatric optic pathway glioma patients using probabilistic tractography, and correlations with visual acuity

scientific article published on 11 October 2017

Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease

scientific article published on 21 January 2017

Diagnostic and therapeutic challenges owing to concurrent pontine glioma and acute lymphoblastic leukemia.

scientific article

Diffuse brainstem glioma in children: critical review of clinical trials

scientific article

Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy--results of a United Kingdom phase II trial (CNS 2007 04).

scientific article published on 04 September 2013

EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines

scientific article published on 08 September 2009

Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation-Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study

scientific article published on 01 December 2019

Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRα/β.

scientific article

European paediatric hematology/oncology subspecialty training

scientific article published on 01 October 2004

Evaluation of the Implementation of the Response Assessment in Neuro-Oncology Criteria in the HERBY Trial of Pediatric Patients with Newly Diagnosed High-Grade Gliomas

scientific article published on 28 February 2019

Evaluation of treatment response using integrated 18F-labeled choline positron emission tomography/magnetic resonance imaging in adolescents with intracranial non-germinomatous germ cell tumours

scientific article published on 8 April 2015

Extent of resection in medulloblastoma: time to reconsider?

scientific article

Gender as a disease modifier in neurofibromatosis type 1 optic pathway glioma

scientific article published on 14 May 2014

Genetic heterogeneity for SMARCB1, H3F3A and BRAF in a malignant childhood brain tumour: genetic-pathological correlation

scientific article published on 18 June 2015

Germinoma with synchronous lesions in the pineal and suprasellar regions

scientific article published on 13 October 2006

HG-75CLINICAL, RADIOLOGICAL, AND HISTO-GENETIC CHARACTERISTICS OF LONG-TERM SURVIVORS OF DIFFUSE INTRINSIC PONTINE GLIOMA: A COLLABORATIVE REPORT FROM THE INTERNATIONAL AND SIOP-E DIPG REGISTRIES.

scientific article published on 30 May 2016

Hereditary leiomyomatosis and renal cell carcinoma: very early diagnosis of renal cancer in a paediatric patient

scientific article published on 01 June 2010

Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma

scientific article published in June 2011

Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN.

scientific article published on May 2013

Hypofractionation vs conventional radiation therapy for newly diagnosed diffuse intrinsic pontine glioma: a matched-cohort analysis

scientific article published on 9 June 2012

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

scientific article published on 01 April 2020

Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors

scientific article

Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease

scientific article

MEK inhibition appears to improve symptom control in primary NRAS-driven CNS melanoma in children

scientific article

MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature

scientific article published on 8 October 2010

MRI-based radiomics for prognosis of pediatric diffuse intrinsic pontine glioma: an international study

scientific article published on 01 January 2021

Microsatellite instability in pediatric high grade glioma is associated with genomic profile and differential target gene inactivation

scientific article

Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development

scientific article

Movement disorders in association with herpes simplex virus encephalitis in children: a review.

scientific article published in September 1998

Mutations of the BRAF gene in human cancer

scientific article (publication date: 27 June 2002)

Natural history and outcome of optic pathway gliomas in children

scientific article published on December 2009

New drugs for children and adolescents with cancer: the need for novel development pathways.

scientific article published on 20 February 2013

Nocturnal oxygen saturation and painful sickle cell crises in children

scientific article published on 12 September 2002

On-treatment relapse of medulloblastoma as prolonged pyrexia of unknown origin

scientific article published in May 2007

Paediatric and adult malignant glioma: close relatives or distant cousins?

scientific article published on 29 May 2012

Paediatric high and low grade glioma: the impact of tumour biology on current and future therapy

scientific article published on August 2009

Palliative and end-of-life care for children with diffuse intrinsic pontine glioma: results from a London cohort study and international survey

scientific article published on 11 October 2015

Parents' responses to prognostic disclosure at diagnosis of a child with a high-risk brain tumor: Analysis of clinician-parent interactions and implications for clinical practice

scientific article published on 23 November 2020

Pattern of recurrence in paediatric malignant glioma: an institutional experience

scientific article

Pediatric CNS tumors: current treatment and future directions.

scientific article published on August 2007

Pediatric Low-Grade Gliomas: Next Biologically Driven Steps

scientific article published on 2 August 2017

Pediatric diffuse intrinsic pontine glioma: can optimism replace pessimism?

scientific article

Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity

scientific article published on 28 August 2020

Phase I study of fotemustine in pediatric patients with refractory brain tumors

scientific article

Phase II study of irinotecan in combination with temozolomide (TEMIRI) in children with recurrent or refractory medulloblastoma: a joint ITCC and SIOPE brain tumor study

scientific article

Phase II study of weekly vinblastine in recurrent or refractory pediatric low-grade glioma

scientific article published on 5 March 2012

Pontine glioma. To biopsy or not to biopsy: that is the question

scientific article published in October 2008

Pre-existing neurodevelopmental and neuropsychiatric difficulties in children with brain tumours: implications for future outcome studies

scientific article published on 18 November 2010

Preclinical drug development for childhood cancer

scientific article published on 24 November 2010

Primary Pericardial Synovial Sarcoma Confirmed by Molecular Genetic Studies

scientific article published on 01 July 2007

Prognostic factors of overall survival in children and adolescents enrolled in dose-finding trials in Europe: An Innovative Therapies for Children with Cancer study.

scientific article published on 20 September 2016

Progressive reduction in treatment-related deaths in Medical Research Council childhood lymphoblastic leukaemia trials from 1980 to 1997 (UKALL VIII, X and XI)

scientific article published on 01 February 2001

Quality of health information on the Internet in pediatric neuro-oncology

scientific article

Quantitative MRI demonstrates abnormalities of the third ventricle subventricular zone in neurofibromatosis type-1 and sporadic paediatric optic pathway glioma

scientific article published on 28 September 2020

Radiological Evaluation of Newly Diagnosed Non-Brainstem Pediatric High-Grade Glioma in the HERBY Phase II Trial

scientific article published on 10 January 2020

Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

scientific article (publication date: May 2014)

Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'

scientific article published on 01 August 2019

Response Assessment in Pediatric Neuro-Oncology: Implementation and Expansion of the RANO Criteria in a Randomized Phase II Trial of Pediatric Patients with Newly Diagnosed High-Grade Gliomas.

scientific article published on 28 April 2016

Response to low dose temozolomide in radiation induced gliomatosis cerebri

scientific article published in December 2003

Safety and pharmacokinetics of temozolomide using a dose-escalation, metronomic schedule in recurrent paediatric brain tumours

scientific article

State of affairs in use of steroids in diffuse intrinsic pontine glioma: an international survey and a review of the literature

scientific article

Surveillance imaging of grade 1 astrocytomas in children: can duration and frequency of follow-up imaging and the use of contrast agents be reduced?

scientific article published on 25 November 2020

Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria

scientific article

The addition of high-dose tamoxifen to standard radiotherapy does not improve the survival of patients with diffuse intrinsic pontine glioma

scientific article published on 19 March 2010

The value of magnetic resonance spectroscopy in tumour imaging

scientific article published on 07 May 2008

Tobacco smoke exposure in children and adolescents with diabetes mellitus

scientific article published on 01 January 1999

Toxicity and outcome of children and adolescents participating in phase I/II trials of novel anticancer drugs: the Royal Marsden experience.

scientific article published in April 2014

Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target

scientific article published on 14 March 2018

Vincristine and carboplatin chemotherapy for unresectable and/or recurrent low-grade astrocytoma of the brainstem

scientific article published on September 2010

Visual outcomes in children with neurofibromatosis type 1-associated optic pathway glioma following chemotherapy: a multicenter retrospective analysis

scientific article

What are the experiences of the child with a brain tumour and their parents?

scientific article

[Analysis of paediatric neuro-oncological information on the Internet in German language]

scientific article published in November 2003

[Quality of childhood brain tumour information on the Internet in French language].

scientific article published in July 2003

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