List of works - Norman Maitland

A Detailed Analysis of Gene Expression in Human Basal, Luminal, and Stromal Cell Populations from Benign Prostatic Hyperplasia Tissues and Comparisons with Cultured Basal Cells ⬇️

scientific article

A Transductionally Retargeted Adenoviral Vector for Virotherapy of Her2/neu-Expressing Prostate Cancer ⬇️

scientific article published on October 12, 2011

A fusion at the root of prostate cancer

scientific article published on 10 June 2013

A microdissection approach to detect molecular markers during progression of prostate cancer

scientific article published on October 1995

A polymerase chain reaction (PCR) investigation of oral verrucae which contain HPV types 2 and 57 by in situ hybridization

scientific article

A preclinical xenograft model of prostate cancer using human tumors

scientific article published on 4 April 2013

Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures

scientific article

Adenovirus-derived vectors for prostate cancer gene therapy

scientific article published on July 2010

Advanced prostate cancer--a case for adjuvant differentiation therapy

scientific article published on 14 August 2012

Allelic imbalance within the E-cadherin gene is an infrequent event in prostate carcinogenesis.

scientific article published in January 2000

Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer

scientific article

Alternative splicing of the human PTEN/MMAC1/TEP1 gene

scientific article

An internal polyadenylation signal substantially increases expression levels of lentivirus-delivered transgenes but has the potential to reduce viral titer in a promoter-dependent manner

scientific article

Analysis of prostate tissue DNA for the presence of human papillomavirus by polymerase chain reaction, cloning, and automated sequencing

scientific article published on May 1997

Androgen receptor localisation and turnover in human prostate epithelium treated with the antiandrogen, casodex.

scientific article

Androgen receptor signalling in prostate: effects of stromal factors on normal and cancer stem cells.

scientific article published on 02 March 2008

Androgens are not a direct requirement for the proliferation of human prostatic epithelium in vitro

scientific article

BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas. MPT Collaborators, St George's Hospital Collaborators

scientific article published on July 1999

Baculoviruses as Vectors for Gene Therapy against Human Prostate Cancer

scientific article

Baculoviruses as gene therapy vectors for human prostate cancer.

scientific article published on July 2011

CD133, a novel marker for human prostatic epithelial stem cells.

scientific article

Cancer stem cells - A therapeutic target?

scientific article published on December 2010

Cancer stem cells, models of study and implications of therapy resistance mechanisms

scientific article published on January 2011

Carcinoma-derived exosomes modify microenvironment

scientific article published in January 2015

Characterization of human papillomavirus type 16 E2 protein and subdomains expressed in insect cells.

scientific article

Characterization of the interactions of human papillomavirus type 16 E6 with p53 and E6-associated protein in insect and human cells

scientific article published in March 1998

Clinical adenoviral gene therapy for prostate cancer

scientific article published on July 2010

Clusterin overexpression in both malignant and nonmalignant prostate epithelial cells induces cell cycle arrest and apoptosis

scientific article published on November 2004

Co-ordinated changes in expression of cell adhesion molecules in prostate cancer

scientific article published on 01 February 1997

Coculture of prostate cancer cells

scientific article published on 01 January 2004

Conserved two-step regulatory mechanism of human epithelial differentiation ⬇️

scientific article published on 6 February 2014

Constitutive expression of FGF2/bFGF in non-tumorigenic human prostatic epithelial cells results in the acquisition of a partial neoplastic phenotype

scientific article published on July 1997

DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation.

scientific article published on 24 January 2014

Detection of Epstein-Barr virus in oral scrapes in HIV infection, in hairy leukoplakia, and in healthy non-HIV-infected people

scientific article published in November 1998

Detection of cytomegalovirus and Epstein-Barr virus in labial salivary glands in Sjogren's syndrome and non-specific sialadenitis

scientific article

Development and limitations of lentivirus vectors as tools for tracking differentiation in prostate epithelial cells.

scientific article published on 19 August 2010

Development and preliminary evaluation of VISLAN, a surgical planning and guidance system using intra-operative video imaging

scientific article

Differences in serological IgA responses to recombinant baculovirus-derived human papillomavirus E2 protein in the natural history of cervical neoplasia

scientific article

Differential cytotoxic activity of a novel palladium-based compound on prostate cell lines, primary prostate epithelial cells and prostate stem cells

scientific article

Differential expression of neutral endopeptidase-24.11 (neprilysin) and endothelin-converting enzyme in human prostate cancer cell lines

scientific article published on August 2002

Differential regulation of TROP2 release by PKC isoforms through vesicles and ADAM17.

scientific article

Differentiation of prostate epithelial cell cultures by matrigel/ stromal cell glandular reconstruction.

scientific article published on September 2006

Dimerization of the human papillomavirus type 16 E2 N terminus results in DNA looping within the upstream regulatory region

scientific article

Enhanced expression of vimentin in motile prostate cell lines and in poorly differentiated and metastatic prostate carcinoma.

scientific article

Evaluating baculovirus as a vector for human prostate cancer gene therapy

scientific article (publication date: 2013)

Experimental prostate epithelial morphogenesis in response to stroma and three-dimensional matrigel culture

scientific article

Exploitation of prostate gene expression to develop targeted therapies

article

Expression and localization of endothelin-converting enzyme-1 in human prostate cancer.

scientific article published on June 2006

Expression of a model gene in prostate cancer cells lentivirally transduced in vitro and in vivo.

scientific article published on January 2003

Expression patterns of the human papillomavirus type 16 transcription factor E2 in low- and high-grade cervical intraepithelial neoplasia

scientific article published on November 1998

Expression, crystallization and preliminary X-ray analysis of the E2 transactivation domain from papillomavirus type 16

scientific article published on 01 November 1998

FGF7/KGF triggers cell transformation and invasion on immortalised human prostatic epithelial PNT1A cells.

scientific article published on July 1999

Functional expression of sv40 in normal human prostatic epithelial and fibroblastic cells - differentiation pattern of nontumorigenic cell-lines.

scientific article published on February 1995

Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions.

scientific article published on 20 May 2008

Gene transfer vectors targeted to human prostate cancer: do we need better preclinical testing systems?

scientific article published on July 2010

HDAC inhibitor confers radiosensitivity to prostate stem-like cells

scientific article published on 12 November 2013

Human epithelial basal cells are cells of origin of prostate cancer, independent of CD133 status.

scientific article

Human papillomavirus DNA and TP53 mutations in lung cancers from butchers

scientific article published on August 1995

Human papillomavirus type 16 E2-specific T-helper lymphocyte responses in patients with cervical intraepithelial neoplasia

article

Human prostate cell lines from normal and tumourigenic epithelia differ in the pattern and control of choline lipid headgroups released into the medium on stimulation of protein kinase C.

scientific article published on 25 January 2011

Identification and isolation of human prostate epithelial stem cells based on alpha(2)beta(1)-integrin expression.

scientific article

Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues

scientific article published in June 2005

Immortalization of human prostate cells with the human papillomavirus type 16 E6 gene.

scientific article published on January 2004

In vitro modelling of epithelial and stromal interactions in non-malignant and malignant prostates.

scientific article

In vitro models to study cellular differentiation and function in human prostate cancers

scientific article

In vitro primary cell culture as a physiologically relevant method for preclinical testing of human oncolytic adenovirus

scientific article

Inflammation as the primary aetiological agent of human prostate cancer: a stem cell connection?

scientific article

Inverse relationship between the expression of the human papillomavirus type 16 transcription factor E2 and virus DNA copy number during the progression of cervical intraepithelial neoplasia

scientific article published on July 2000

JAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cells

scientific article published on 3 July 2013

Kinetic and equilibrium binding studies of the human papillomavirus type-16 transcription regulatory protein E2 interacting with core enhancer elements

scientific article published on November 1994

Low temperature plasma: a novel focal therapy for localized prostate cancer?

scientific article

Low-temperature plasma treatment induces DNA damage leading to necrotic cell death in primary prostate epithelial cells

scientific article

Macrophages in gene therapy: cellular delivery vehicles and in vivo targets.

scientific article

Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy

scientific article published on March 2015

Metastasis-associated Mts1 (S100A4) Protein Modulates Protein Kinase C Phosphorylation of the Heavy Chain of Nonmuscle Myosin

scientific article published in Journal of Biological Chemistry

MicroRNA Expression Profile of Primary Prostate Cancer Stem Cells as a Source of Biomarkers and Therapeutic Targets

scientific article published on 16 September 2014

Molecular analysis of the interaction between HPV type 16 E6 and human E6-associated protein

scientific article

Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cells

scientific article published in January 2013

Mutations of the BRAF gene in human cancer

scientific article (publication date: 27 June 2002)

Nonviral and viral gene transfer into different subsets of human dendritic cells yield comparable efficiency of transfection

scientific article published in November 2002

Optimization of a synthetic beta-catenin-dependent promoter for tumor-specific cancer gene therapy

scientific article published on July 2004

Phenotypic effects of HPV-16 E2 protein expression in human keratinocytes

scientific article published on 27 March 2010

Phenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells

scientific article published on October 2000

Phorbol ester stimulates ethanolamine release from the metastatic basal prostate cancer cell line PC3 but not from prostate epithelial cell lines LNCaP and P4E6.

scientific article published on 19 August 2014

Pre-clinical safety assessment of Ad[I/PPT-E1A], a novel oncolytic adenovirus for prostate cancer

scientific article published on 18 February 2014

Precise microdissection of human prostate cancers reveals genotypic heterogeneity ⬇️

scientific article published on January 1, 1998

Preclinical evaluation of innate immunity to baculovirus gene therapy vectors in whole human blood

scientific article published on 08 August 2009

Preclinical safety assessment of Ad[I/PPT-E1A], a novel oncolytic adenovirus for prostate cancer

scientific article published on March 2014

Predisposing gene for early-onset prostate cancer, localized on chromosome 1q42.2-43

scientific article

Primary prostate stromal cells modulate the morphology and migration of primary prostate epithelial cells in type 1 collagen gels

scientific article published on 01 January 2002

Prominin-1 (CD133) Expression in the Prostate and Prostate Cancer: A Marker for Quiescent Stem Cells.

scientific article published on January 2013

Prostate cancer stem cells.

scientific article

Prostate cancer stem cells: a new target for therapy

scientific article

Prostate cancer stem cells: a target for new therapies

scientific article published on 01 January 2006

Prostate cancer stem cells: are they androgen-responsive?

scientific article published on 23 July 2011

Prostate cancer stem cells: do they have a basal or luminal phenotype?

scientific article

Re: Yves Allorya, Willemien Beukers, Ana Sagrera, et al. Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome. Eur Urol 2014;65:360-6: telomeras

scientific article published on 25 February 2014

Recombinant adenovirus vector activates and protects human monocyte-derived dendritic cells from apoptosis

scientific article published in September 2002

Regeneration of interest in the prostate

scientific article published on 01 April 2009

Regulation of protein kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines

scientific article published on 7 June 2006

Regulation of the stem cell marker CD133 is independent of promoter hypermethylation in human epithelial differentiation and cancer.

scientific article

Retinoic acid and androgen receptors combine to achieve tissue specific control of human prostatic transglutaminase expression: a novel regulatory network with broader significance. ⬇️

scientific article

Retinoic acid represses invasion and stem cell phenotype by induction of the metastasis suppressors RARRES1 and LXN.

scientific article published on 15 April 2013

Seeding drug discovery: integrating telomerase cancer biology and cellular senescence to uncover new therapeutic opportunities in targeting cancer stem cells.

scientific article published on 27 July 2007

Stem cells and the role of ETS transcription factors in the differentiation hierarchy of normal and malignant prostate epithelium

scientific article published on 13 May 2016

Stromal-epithelial interactions influence prostate cancer cell invasion by altering the balance of metallopeptidase expression

scientific article published on April 2004

Targeting gene therapy for prostate cancer.

scientific article published on January 2004

The calcium sensor STIM1 is regulated by androgens in prostate stromal cells

scientific article

The dimerization interface of the metastasis-associated protein S100A4 (Mts1): in vivo and in vitro studies

scientific article (publication date: 29 June 2001)

The molecular and cellular origin of human prostate cancer.

scientific article published on 24 February 2016

The three-dimensional structure of human S100A12

scientific article

Use of macrophages to target therapeutic adenovirus to human prostate tumors

scientific article published on 13 January 2011

Use of the PSA enhancer core element to modulate the expression of prostate- and non-prostate-specific basal promoters in a lentiviral vector context

scientific article published on 2 June 2006

Words of wisdom: re: prognostic value of blood mRNA expression signatures in castration-resistant prostate cancer: a prospective, two-stage study

scientific article published in August 2013

miR-25 Modulates Invasiveness and Dissemination of Human Prostate Cancer Cells via Regulation of αv- and α6-Integrin Expression.

scientific article

List of works by Norman Maitland

A Detailed Analysis of Gene Expression in Human Basal, Luminal, and Stromal Cell Populations from Benign Prostatic Hyperplasia Tissues and Comparisons with Cultured Basal Cells ⬇️

A Transductionally Retargeted Adenoviral Vector for Virotherapy of Her2/neu-Expressing Prostate Cancer ⬇️

A fusion at the root of prostate cancer

A microdissection approach to detect molecular markers during progression of prostate cancer

A polymerase chain reaction (PCR) investigation of oral verrucae which contain HPV types 2 and 57 by in situ hybridization

A preclinical xenograft model of prostate cancer using human tumors

Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures

Adenovirus-derived vectors for prostate cancer gene therapy

Advanced prostate cancer--a case for adjuvant differentiation therapy

Allelic imbalance within the E-cadherin gene is an infrequent event in prostate carcinogenesis.

Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer

Alternative splicing of the human PTEN/MMAC1/TEP1 gene

An internal polyadenylation signal substantially increases expression levels of lentivirus-delivered transgenes but has the potential to reduce viral titer in a promoter-dependent manner

Analysis of prostate tissue DNA for the presence of human papillomavirus by polymerase chain reaction, cloning, and automated sequencing

Androgen receptor localisation and turnover in human prostate epithelium treated with the antiandrogen, casodex.

Androgen receptor signalling in prostate: effects of stromal factors on normal and cancer stem cells.

Androgens are not a direct requirement for the proliferation of human prostatic epithelium in vitro

BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas. MPT Collaborators, St George's Hospital Collaborators

Baculoviruses as Vectors for Gene Therapy against Human Prostate Cancer

Baculoviruses as gene therapy vectors for human prostate cancer.

CD133, a novel marker for human prostatic epithelial stem cells.

Cancer stem cells - A therapeutic target?

Cancer stem cells, models of study and implications of therapy resistance mechanisms

Carcinoma-derived exosomes modify microenvironment

Characterization of human papillomavirus type 16 E2 protein and subdomains expressed in insect cells.

Characterization of the interactions of human papillomavirus type 16 E6 with p53 and E6-associated protein in insect and human cells

Clinical adenoviral gene therapy for prostate cancer

Clusterin overexpression in both malignant and nonmalignant prostate epithelial cells induces cell cycle arrest and apoptosis

Co-ordinated changes in expression of cell adhesion molecules in prostate cancer

Coculture of prostate cancer cells

Conserved two-step regulatory mechanism of human epithelial differentiation ⬇️

Constitutive expression of FGF2/bFGF in non-tumorigenic human prostatic epithelial cells results in the acquisition of a partial neoplastic phenotype

DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation.

Detection of Epstein-Barr virus in oral scrapes in HIV infection, in hairy leukoplakia, and in healthy non-HIV-infected people

Detection of cytomegalovirus and Epstein-Barr virus in labial salivary glands in Sjogren's syndrome and non-specific sialadenitis

Development and limitations of lentivirus vectors as tools for tracking differentiation in prostate epithelial cells.

Development and preliminary evaluation of VISLAN, a surgical planning and guidance system using intra-operative video imaging

Differences in serological IgA responses to recombinant baculovirus-derived human papillomavirus E2 protein in the natural history of cervical neoplasia

Differential cytotoxic activity of a novel palladium-based compound on prostate cell lines, primary prostate epithelial cells and prostate stem cells

Differential expression of neutral endopeptidase-24.11 (neprilysin) and endothelin-converting enzyme in human prostate cancer cell lines

Differential regulation of TROP2 release by PKC isoforms through vesicles and ADAM17.

Differentiation of prostate epithelial cell cultures by matrigel/ stromal cell glandular reconstruction.

Dimerization of the human papillomavirus type 16 E2 N terminus results in DNA looping within the upstream regulatory region

Enhanced expression of vimentin in motile prostate cell lines and in poorly differentiated and metastatic prostate carcinoma.

Evaluating baculovirus as a vector for human prostate cancer gene therapy

Experimental prostate epithelial morphogenesis in response to stroma and three-dimensional matrigel culture

Exploitation of prostate gene expression to develop targeted therapies

Expression and localization of endothelin-converting enzyme-1 in human prostate cancer.

Expression of a model gene in prostate cancer cells lentivirally transduced in vitro and in vivo.

Expression patterns of the human papillomavirus type 16 transcription factor E2 in low- and high-grade cervical intraepithelial neoplasia

Expression, crystallization and preliminary X-ray analysis of the E2 transactivation domain from papillomavirus type 16

FGF7/KGF triggers cell transformation and invasion on immortalised human prostatic epithelial PNT1A cells.

Functional expression of sv40 in normal human prostatic epithelial and fibroblastic cells - differentiation pattern of nontumorigenic cell-lines.

Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions.

Gene transfer vectors targeted to human prostate cancer: do we need better preclinical testing systems?

HDAC inhibitor confers radiosensitivity to prostate stem-like cells

Human epithelial basal cells are cells of origin of prostate cancer, independent of CD133 status.

Human papillomavirus DNA and TP53 mutations in lung cancers from butchers

Human papillomavirus type 16 E2-specific T-helper lymphocyte responses in patients with cervical intraepithelial neoplasia

Human prostate cell lines from normal and tumourigenic epithelia differ in the pattern and control of choline lipid headgroups released into the medium on stimulation of protein kinase C.

Identification and isolation of human prostate epithelial stem cells based on alpha(2)beta(1)-integrin expression.

Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues

Immortalization of human prostate cells with the human papillomavirus type 16 E6 gene.

In vitro modelling of epithelial and stromal interactions in non-malignant and malignant prostates.

In vitro models to study cellular differentiation and function in human prostate cancers

In vitro primary cell culture as a physiologically relevant method for preclinical testing of human oncolytic adenovirus

Inflammation as the primary aetiological agent of human prostate cancer: a stem cell connection?

Inverse relationship between the expression of the human papillomavirus type 16 transcription factor E2 and virus DNA copy number during the progression of cervical intraepithelial neoplasia

JAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cells

Kinetic and equilibrium binding studies of the human papillomavirus type-16 transcription regulatory protein E2 interacting with core enhancer elements

Low temperature plasma: a novel focal therapy for localized prostate cancer?

Low-temperature plasma treatment induces DNA damage leading to necrotic cell death in primary prostate epithelial cells

Macrophages in gene therapy: cellular delivery vehicles and in vivo targets.

Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy

Metastasis-associated Mts1 (S100A4) Protein Modulates Protein Kinase C Phosphorylation of the Heavy Chain of Nonmuscle Myosin

MicroRNA Expression Profile of Primary Prostate Cancer Stem Cells as a Source of Biomarkers and Therapeutic Targets

Molecular analysis of the interaction between HPV type 16 E6 and human E6-associated protein

Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cells

Mutations of the BRAF gene in human cancer