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List of works by Kate Schroder

A novel flow cytometric method to assess inflammasome formation

scientific article

A rescue strategy for multimapping short sequence tags refines surveys of transcriptional activity by CAGE.

scientific article

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

scientific article

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC.

scientific article published on 03 May 2013

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

scientific article published on 17 January 2017

Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors.

scientific article published on October 2001

Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction

scientific article

Alternate transcription of the Toll-like receptor signaling cascade

scientific article published on 17 February 2006

An antioxidant role for catecholate siderophores in Salmonella.

scientific article published on September 2013

Antimicrobial functions of inflammasomes ⬇️

scientific article published on 04 March 2013

Assessment of Inflammasome Formation by Flow Cytometry.

scientific article published in August 2016

Author Correction: Mitochondrial DNA synthesis fuels NLRP3 inflammasome

scholarly article by Rebecca Coll published in December 2018

Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations

scientific article published on 01 January 2018

Burn the house, save the day: pyroptosis in pathogen restriction

scholarly article published 1 January 2016

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity.

scientific article published on 6 February 2018

Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages

scientific article

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

scientific article

Corrigendum: Tiny RNAs associated with transcription start sites in animals

scholarly article published in Nature Genetics

Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion

scientific article published on 16 April 2018

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB

scientific article

Data-driven normalization strategies for high-throughput quantitative RT-PCR.

scientific article

Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice

scientific article published on 26 June 2015

Development of a DNA barcode tagging method for monitoring dynamic changes in gene expression by using an ultra high-throughput sequencer

scientific article

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS.

scientific article published on 3 March 2010

Differential expression of NLRP3 among hematopoietic cells

scientific article published on 21 January 2011

Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome

scientific article published on 06 December 2018

Expression analysis of G Protein-Coupled Receptors in mouse macrophages

scientific article

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation. ⬇️

scientific article

G-protein-coupled receptor expression, function, and signaling in macrophages

scientific article published on 24 April 2007

Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes

article

Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages

scientific article

Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment

article

IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection

scientific article published on 10 January 2018

IL-1 Contributes to the Anti-Cancer Efficacy of Ingenol Mebutate

scientific article

In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis.

scientific article published on 28 June 2017

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

scientific article published on 01 October 2018

Inflammasome signaling and regulation of interleukin-1 family cytokines

scientific article published on 01 January 2020

Inflammasomes and Inflammation

Innate immunity, the constant gardener of antimicrobial defense ⬇️

scientific article published on July 20, 2013

Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome

scientific article published in March 2009

Interferon-γ: an overview of signals, mechanisms and functions ⬇️

scientific article (publication date: February 2004)

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

scientific article published on 01 August 2018

K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

scientific article

LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action

scientific article

LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression

scientific article published on July 2006

Lipopolysaccharide promotes Drp1-dependent mitochondrial fission and associated inflammatory responses in macrophages

scientific article published on 20 July 2020

Liver repercussions of defective gut surveillance

scientific article published on 01 September 2012

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

scientific article published on 13 May 2019

MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice.

scientific article published on 5 June 2018

Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis

scientific article

Mechanisms and Consequences of Inflammasome Activation

scientific article published on 13 December 2017

Mechanisms of unconventional secretion of IL-1 family cytokines

scientific article published on 25 April 2015

Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling

scientific article published on 30 April 2015

Mitochondrial DNA synthesis fuels NLRP3 inflammasome

scientific article published on 01 November 2018

Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis.

scientific article published in January 2018

NLRC3 Restrains Responses to a T

scientific article published on 01 December 2018

NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells

scientific article

NLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS- or infection-induced NF-κB or ERK signalling

scientific article published on 23 October 2015

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.

scientific article published on 14 July 2015

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.

scientific article published on 3 February 2017

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

scientific article published on 01 August 2018

Novel insights into the innate immune response to non-tuberculous Mycobacteria

article

Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo

scientific article published in July 2008

PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages

scientific article

Pattern recognition receptor function in neutrophils

scientific article published on 26 March 2013

Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion ⬇️

scientific article

Probing the S100 protein family through genomic and functional analysis

scientific article published in July 2004

Quantifying Caspase-1 Activity in Murine Macrophages

scientific article published in January 2018

Questions and controversies in innate immune research: what is the physiological role of NLRP3?

scientific article

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

scientific article

Role of the NLRP3 inflammasome in a model of acute burn-induced pain

scientific article

Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages

scientific article published on 2 February 2016

Salmonella-induced inflammasome activation in humans

scientific article published on 11 December 2016

Signal integration between IFNgamma and TLR signalling pathways in macrophages

scientific article published on 5 July 2006

Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages

scientific journal article

Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals

scientific article

Strain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli

scientific article

Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors.

scientific article

TRAF6 is a nexus for TLR-STAT1 crosstalk

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

scientific article

The E3 ubiquitin ligase RNF144B is LPS-inducible in human, but not mouse, macrophages and promotes inducible IL-1β expression

scientific article published on 27 January 2016

The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments

scientific article

The NLRP3 inflammasome: a sensor for metabolic danger?

scientific article

The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses

article

The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells

scientific article published on 22 June 2010

The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade

scientific article

The inflammasomes

scientific article

The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans

scientific journal article

The mammalian PYHIN gene family: phylogeny, evolution and expression

scientific article (publication date: 7 August 2012)

The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists

scientific article published on February 2016

The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge

scientific article published on 17 July 2014

The rOX-stars of inflammation: links between the inflammasome and mitochondrial meltdown

scientific article published on 10 February 2020

The regulated retrotransposon transcriptome of mammalian cells

scientific article (publication date: May 2009)

The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized

scientific article

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.

scientific article

Tiny RNAs associated with transcription start sites in animals

scientific article published on 19 April 2009

Update of the FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation

scientific article published on 12 November 2010

XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.

scientific article published on July 2017

Zebrafish earns its stripes for in vivo ASC speck dynamics

scientific article published on 15 August 2017

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