Search filters

List of works by Martin Noble

4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.

scientific article published on January 2003

8-Substituted O(6)-cyclohexylmethylguanine CDK2 inhibitors: using structure-based inhibitor design to optimize an alternative binding mode

scientific article

A new crystal form of Lys48-linked diubiquitin

scientific article

A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain

scientific article

Active and inactive protein kinases: structural basis for regulation

scientific article (publication date: 19 April 1996)

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects

scientific article published in January 2003

An inhibitor's-eye view of the ATP-binding site of CDKs in different regulatory states.

scientific article

Analysis of chemical shift changes reveals the binding modes of isoindolinone inhibitors of the MDM2-p53 interaction

scientific article published in November 2008

Analysis of the structure of Pseudomonas glumae lipase

article

Announcing mandatory submission of PDBx/mmCIF format files for crystallographic depositions to the Protein Data Bank (PDB)

scientific article published on 08 April 2019

Arylamine N-acetyltransferases in mycobacteria

scientific article published on July 2008

Aurora A regulates expression of AR-V7 in models of castrate resistant prostate cancer

scientific article published on 16 February 2017

Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.

scientific article

Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis.

scientific article published in March 2005

CCP4i2: the new graphical user interface to the CCP4 program suite.

scientific article published in February 2018

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.

scientific article published on 13 April 2015

Catalysis and regulation

article

Catalytic mechanism of phosphorylase kinase probed by mutational studies

scientific article

Chemical inhibitors of cyclin-dependent kinases: insights into design from X-ray crystallographic studies.

scientific article

Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity

scientific article

Comparison of the refined crystal structures of liganded and unliganded chicken, yeast and trypanosomal triosephosphate isomerase

scientific article published on April 1992

Computational analyses of the surface properties of protein-protein interfaces.

scientific article published on 13 December 2006

Could Omega 3 Supplements Play a Role in the Prevention of Neurocognitive Impairment in Cancer Patients?

scientific article published on 07 October 2016

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

scientific article published on 07 October 2020

Crystallographic binding studies with triosephosphate isomerases: Conformational changes induced by substrate and substrate-analogues ⬇️

scientific article published on July 27, 1992

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.

scientific article published on 22 December 2016

Cyclin-Dependent Kinase Inhibition by New C-2 Alkynylated Purine Derivatives and Molecular Structure of a CDK2−Inhibitor Complex

scientific article published on 01 April 2000

Cyclin-dependent kinases: inhibition and substrate recognition.

scientific article

Developments in the CCP4 molecular-graphics project

scientific article (publication date: December 2004)

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition

scientific article published on 21 November 2018

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System.

scientific article published in October 2017

Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivity

scientific article

Distinctive properties of the hyaluronan-binding domain in the lymphatic endothelial receptor Lyve-1 and their implications for receptor function

scientific article

Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase

scientific article

Dynamite extended: two new services to simplify protein dynamic analysis

scientific article published on 26 April 2005

Dynamite: a simple way to gain insight into protein motions

scientific article published on 26 November 2004

Exploiting structural principles to design cyclin-dependent kinase inhibitors.

scientific article

Expression, Purification and Crystallisation of Phosphorylase Kinase Catalytic Domain

scientific article published on 01 February 1995

Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase

scientific journal article

FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation

scientific article published on 26 March 2019

Generation of protein lattices by fusing proteins with matching rotational symmetry

scientific article

How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A.

scientific article published on 9 November 2006

Identification and Characterization of an Irreversible Inhibitor of CDK2.

scientific article published on 27 August 2015

Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach.

scientific article published on 22 February 2018

Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4

scientific article published on 25 May 2019

Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate

scientific article published in May 2001

Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines

scientific article published on August 2005

Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency

scientific article published on 11 February 2011

MDM2-p53 protein-protein interaction inhibitors: a-ring substituted isoindolinones.

scientific article

Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain

scientific article published on September 2005

Modular mutagenesis of a TIM-barrel enzyme: the crystal structure of a chimeric E. coli TIM having the eighth beta alpha-unit replaced by the equivalent unit of chicken TIM

scientific article

Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3

scientific article

Molecular cloning, characterisation and ligand-bound structure of an azoreductase from Pseudomonas aeruginosa

scientific article

Molecular motions of human cyclin-dependent kinase 2.

scientific article published on 28 January 2005

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor

scientific article

Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain

scientific article

N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2

scientific article

Overexpression of trypanosomal triosephosphate isomerase in Escherichia coli and characterisation of a dimer-interface mutant

scientific article published on 01 February 1993

Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors

scientific article published on 13 March 2020

Plasticity of the TSG-6 HA-binding loop and mobility in the TSG-6-HA complex revealed by NMR and X-ray crystallography

scientific article

Presenting your structures: the CCP4mg molecular-graphics software

scientific article (publication date: April 2011)

Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives

scientific article

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site

scientific article

Protein kinase inhibitors: insights into drug design from structure.

scientific article published on March 2004

Purification, characterization, and crystallization of an N-hydroxyarylamine O-acetyltransferase from Salmonella typhimurium

scientific article published in April 1998

Recent developments in cyclin-dependent kinase biochemical and structural studies.

scientific article published on 12 October 2009

Replacing the (beta alpha)-unit 8 of E.coli TIM with its chicken homologue leads to a stable and active hybrid enzyme.

scientific article

Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4

scientific article

Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination

scientific article published on 01 May 2006

Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A

scientific article

Structural Analysis of the Interactions Between Paxillin LD Motifs and α-Parvin

scientific article

Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation

scientific article

Structural characterization of the cyclin-dependent protein kinase family ⬇️

scientific article published on August 1, 2013

Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH).

scientific article published on 6 November 2017

Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase.

scientific article

Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2.

scientific article

Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis

scientific article

Structure of Mesorhizobium loti arylamine N-acetyltransferase 1.

scientific article published on 24 December 2004

Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12

scientific article

Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44.

scientific article published in February 2004

Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2

scientific article published on 23 April 2007

Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2

scientific article

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

scientific article

Structure-based design of cyclin-dependent kinase inhibitors

scientific article

Structure-based discovery of cyclin-dependent protein kinase inhibitors.

scientific article published on 8 November 2017

Structures of P. falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition

scientific article

Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design

scientific article

Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction

scientific article

Structures of the Dsk2 UBL and UBA domains and their complex

scientific article

Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities

scientific article

The CCP4 molecular-graphics project

scientific article (publication date: November 2002)

The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508

scientific article

The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b

scientific article

The Eleventh Datta Lecture. The structural basis for substrate recognition and control by protein kinases

scientific article published in June 1998

The crystal structure of triacylglycerol lipase from Pseudomonas glumae reveals a partially redundant catalytic aspartate

scientific article

The cyclin box fold: protein recognition in cell-cycle and transcription control

scientific article published on December 1997

The role of structure in kinase-targeted inhibitor design.

scientific article published in July 2004

The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases

scientific article

The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition

scientific article

The structural basis for control of eukaryotic protein kinases

scientific article published on 05 April 2012

The structural basis of localization and signaling by the focal adhesion targeting domain

scientific article

The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant

scientific article

The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis--an enzyme which inactivates the anti-tubercular drug, isoniazid

scientific article

Tuning the Binding Affinity and Selectivity of Perfluoroaryl-Stapled Peptides by Cysteine-Editing

scientific article published on 27 November 2018

Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product

scientific article

Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy

scientific article published on March 2011

Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.

scientific article

Xenopus phospho-CDK7/cyclin H expressed in baculoviral-infected insect cells

scientific article

Paulina is supported by:

About Paulina

Help