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List of works by John M. Lachin

A Diabetes Outcome Progression Trial (ADOPT): baseline characteristics of Type 2 diabetic patients in North America and Europe

scientific article published in December 2006

A comparison of the baseline metabolic profiles between Diabetes Prevention Trial-Type 1 and TrialNet Natural History Study participants

scientific article

A composite design for transition from a preliminary to a full-scale study

scientific article published on 01 November 2007

A diabetes outcome progression trial (ADOPT): an international multicenter study of the comparative efficacy of rosiglitazone, glyburide, and metformin in recently diagnosed type 2 diabetes

scientific article published in October 2002

A flexible stochastic curtailing procedure for the log-rank test.

scientific article

A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose

scientific article

A review of methods for futility stopping based on conditional power

scientific article

A risk score for type 1 diabetes derived from autoantibody-positive participants in the diabetes prevention trial-type 1.

scientific article published on 13 November 2007

An Observational Study of the Equivalence of Age and Duration of Diabetes to Glycemic Control Relative to the Risk of Complications in the Combined Cohorts of the DCCT/EDIC Study

scientific article published on 11 August 2020

Aortic distensibility in type 1 diabetes

scientific article published on 08 March 2013

Application of robust estimating equations to the analysis of quantitative longitudinal data.

scientific article

Application of the Wei-Lachin multivariate one-directional test to multiple event-time outcomes

scientific article

Applications of the Wei-Lachin multivariate one-sided test for multiple outcomes on possibly different scales

scientific article

Assessment of stratum-covariate interactions in Cox's proportional hazards regression model

article

Association between 7 years of intensive treatment of type 1 diabetes and long-term mortality

scientific article

Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort

scientific article published on 17 December 2020

Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial

scientific article published on 12 April 2017

Association of Insulin Dose, Cardiometabolic Risk Factors, and Cardiovascular Disease in Type 1 Diabetes During 30 Years of Follow-up in the DCCT/EDIC Study

scientific article published on 06 February 2019

Association of diet with glycated hemoglobin during intensive treatment of type 1 diabetes in the Diabetes Control and Complications Trial

scientific article published on 23 December 2008

Biological variation in HbA1c predicts risk of retinopathy and nephropathy in type 1 diabetes: response to McCarter et al.

scientific article published in January 2005

Biomarkers of tubulointerstitial damage and function in type 1 diabetes

scientific article

C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001.

scientific article published in January 2004

Cardiovascular outcome trials in type 2 diabetes and the sulphonylurea controversy: rationale for the active-comparator CAROLINA trial

scientific article published on 28 February 2013

Causes of Death in a Contemporary Cohort of Patients With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease: Insights From the TECOS Trial.

scientific article

Central laboratory quality control in the National Cooperative Gallstone Study

scientific article published in June 1983

Circulating vitamin D metabolites and kidney disease in type 1 diabetes

scientific article

Circulating vitamin D metabolites and subclinical atherosclerosis in type 1 diabetes

scientific article published on 25 March 2013

Closed testing of each group versus the others combined in a multiple group analysis

scientific article published on 24 October 2019

Closed testing using surrogate hypotheses with restricted alternatives

scientific article published on 12 July 2019

Comment on Miller and Orchard: Understanding Metabolic Memory: A Tale of Two Studies. Diabetes 2020;69:291-299

scientific article published on 01 July 2020

Comment on Novodvorsky et al. Diurnal Differences in Risk of Cardiac Arrhythmias During Spontaneous Hypoglycemia in Young People With Type 1 Diabetes. Diabetes Care 2017;40:655-662

scientific article published on 01 April 2018

Comparison of urinary albumin-creatinine ratio and albumin excretion rate in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study

scientific article

Conflicts of interest in data monitoring of industry versus publicly financed clinical trials

scientific article

Costs associated with the primary prevention of type 2 diabetes mellitus in the diabetes prevention program

scientific article

DCCT and EDIC studies in type 1 diabetes: lessons for diabetic neuropathy regarding metabolic memory and natural history

scientific article published on August 2010

Data sharing is desirable, but benefits should not be exaggerated

scientific article

Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA®)

scientific article

Design and methodological considerations in the National Cooperative Gallstone Study: A multicenter clinical trial

article

Determining Stability of Stored Samples Retrospectively: The Validation of Glycated Albumin

scientific article published on 28 October 2010

Development and progression of renal insufficiency with and without albuminuria in adults with type 1 diabetes in the diabetes control and complications trial and the epidemiology of diabetes interventions and complications study ⬇️

scientific article

Diabetes Care Editors’ Expert Forum 2018: Managing Big Data for Diabetes Research and Care

scientific article published on 01 June 2019

Diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: advances and contributions

scientific article published on December 2013

Differences in A1C by race and ethnicity among patients with impaired glucose tolerance in the Diabetes Prevention Program

scientific article published on 29 May 2007

Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes

scientific article

Effect of glycemic exposure on the risk of microvascular complications in the diabetes control and complications trial--revisited

scientific article published on 25 January 2008

Effect of intensive diabetes therapy on the progression of diabetic retinopathy in patients with type 1 diabetes: 18 years of follow-up in the DCCT/EDIC

scientific article

Effect of intensive diabetes treatment on albuminuria in type 1 diabetes: long-term follow-up of the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications study

scientific article

Effect of intensive glycemic therapy on erectile function in men with type 1 diabetes

scientific article published on 21 March 2011

Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during the Epidemiology of Diabetes Interventions and Complications (EDIC) Study

scientific article

Effect of rituximab on human in vivo antibody immune responses ⬇️

scientific article published on September 9, 2011

Effect of rosiglitazone, metformin, and glyburide on bone biomarkers in patients with type 2 diabetes

scientific article published on 29 October 2009

Effect of weight loss with lifestyle intervention on risk of diabetes

scientific article published on September 2006

Effects of dose relative to body weight in the National Cooperative Gallstone Study: a fixed-dose trial

scientific article published in June 1983

Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 diabetes mellitus: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC).

scientific article published on 26 May 2009

Effects of prior intensive versus conventional therapy and history of glycemia on cardiac function in type 1 diabetes in the DCCT/EDIC.

scientific article published on 21 March 2013

Effects of rosiglitazone, glyburide, and metformin on β-cell function and insulin sensitivity in ADOPT.

scientific article published on 17 March 2011

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes

scientific article published on 14 June 2016

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

scientific article

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

scientific article published on 01 March 2016

Erratum

scholarly article published in Diabetes

Erratum to: Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes

scientific article published on 9 October 2015

Evaluating the role of epigenetic histone modifications in the metabolic memory of type 1 diabetes.

scientific article published on 23 January 2014

External monitoring of a data coordinating center: experience of the National Cooperative Gallstone Study.

scientific article

Factors affecting the decline in incidence of diabetes in the Diabetes Prevention Program Outcomes Study (DPPOS)

scientific article

Factors associated with diabetes onset during metformin versus placebo therapy in the diabetes prevention program

scientific article published on April 2007

Failure to preserve beta-cell function with mycophenolate mofetil and daclizumab combined therapy in patients with new- onset type 1 diabetes

scientific article

Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite Type 1 Diabetes TrialNet data

scientific article

Fallacies of last observation carried forward analyses

scientific article published on 22 September 2015

Feasibility of low-dose and intermittent chenodeoxycholic acid therapy of gallstones

article

Futility interim monitoring with control of type I and II error probabilities using the interim Z-value or confidence limit

scientific article

Gaps in the Glycation Gap Hypothesis

scientific article published on 02 December 2010

Group sequential large sample T2-like chi2 tests for multivariate observations

scientific article published in November 2003

Haptoglobin 2-2 genotype and the risk of coronary artery disease in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC).

scientific article published on 25 July 2016

Haptoglobin genotype and the rate of renal function decline in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study

scientific article published on 12 June 2013

Hearing Impairment and Type 1 Diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Cohort

scientific article published on 25 September 2018

Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial

scientific article

High levels of oxidized LDL in circulating immune complexes are associated with increased odds of developing abnormal albuminuria in Type 1 diabetes

scientific article

How Does Empagliflozin Reduce Cardiovascular Mortality? Insights From a Mediation Analysis of the EMPA-REG OUTCOME Trial

scientific article published on 4 December 2017

Identifying change points in a covariate effect on time-to-event analysis with reduced isotonic regression

scientific article

Immune Complexes and the Risk of CVD in Type 1 Diabetes

scientific article published on 19 June 2019

Impact of C-peptide preservation on metabolic and clinical outcomes in the Diabetes Control and Complications Trial

scientific article

Increased Risk of Severe Hypoglycemic Events Before and After Cardiovascular Outcomes in TECOS Suggests an At-Risk Type 2 Diabetes Frail Patient Phenotype

scientific article

Increased T cell proliferative responses to islet antigens identify clinical responders to anti-CD20 monoclonal antibody (rituximab) therapy in type 1 diabetes

scientific article

Insulin secretion measured by stimulated C-peptide in long-established Type 1 diabetes in the Diabetes Control and Complications Trial (DCCT)/ Epidemiology of Diabetes Interventions and Complications (EDIC) cohort: a pilot study

scientific article

Insulin therapy, hyperglycemia, and hypertension in type 1 diabetes mellitus

scientific article published on September 2008

Intensive Diabetes Therapy and Glomerular Filtration Rate in Type 1 Diabetes ⬇️

scientific article published on November 12, 2011

Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes

scientific article

Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus

scientific article published on June 2003

Intensive diabetes therapy and ocular surgery in type 1 diabetes

scientific article published on April 2015

Introduction to sample size determination and power analysis for clinical trials

scientific article published in June 1981

Large sample inference for a win ratio analysis of a composite outcome based on prioritized components

scientific article

Levels of oxidized LDL and advanced glycation end products-modified LDL in circulating immune complexes are strongly associated with increased levels of carotid intima-media thickness and its progression in type 1 diabetes

scientific article

Link-Based Models for Survival Data with Interval and Continuous Time Censoring

article

Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: an analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort

scientific article

Longitudinal changes in estimated and measured GFR in type 1 diabetes

scientific article published on 05 December 2013

Major issues in the organization and implementation of the National Cooperative Gallstone Study (NCGS).

scientific article published on March 1984

Martingales without tears

scientific article published in January 1995

Maximum information designs

Measurement of electroencephalic evoked response: comparison of univariate and multivariate

scientific article published in May 1976

Mediation of the Effect of Glycemia on the Risk of CVD Outcomes in Type 1 Diabetes: The DCCT/EDIC Study

scientific article published on 20 March 2019

Methods for a longitudinal quantitative outcome with a multivariate Gaussian distribution multi-dimensionally censored by therapeutic intervention

scientific article

Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes

scientific article published on 15 July 2008

Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complicat

scientific article published on 03 October 2007

Myocardial structure, function, and scar in patients with type 1 diabetes mellitus

scientific article published on 26 September 2011

Newborn offspring of a schizophrenic parent: cardiac reactivity to auditory stimuli

scientific article published in September 1975

Obesity is a major determinant of the association of C-reactive protein levels and the metabolic syndrome in type 2 diabetes

scientific article published in August 2006

On stepwise discriminant analyses applied to physiologic data.

scientific article published on November 1974

Operating characteristics of sample size re-estimation with futility stopping based on conditional power

scientific article published in October 2006

Over-ruling a group sequential boundary--a stopping rule versus a guideline

scientific article published on November 2003

Oxidized LDL immune complexes and coronary artery calcification in type 1 diabetes

scientific article

Parametric survival models for interval-censored data with time-dependent covariates

scientific article

Pilot genome-wide association search identifies potential loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohort

scientific article

Point: Intensive glycemic control and mortality in ACCORD--a chance finding?

scientific article published on December 2010

Power and sample size evaluation for the Cochran–Mantel–Haenszel mean score (Wilcoxon rank sum) test and the Cochran–Armitage test for trend ⬇️

scientific article published on August 25, 2011

Power and sample size evaluation for the McNemar test with application to matched case-control studies

scientific article published on June 30, 1992

Power of the Mantel–Haenszel and other tests for discrete or grouped time‐to‐event data under a chained binomial model ⬇️

scientific article published on July 16, 2012

Probabilistic measures of cost-effectiveness

scientific article

Progression of Electrocardiographic Abnormalities in Type 1 Diabetes During 16 Years of Follow-up: The Epidemiology of Diabetes Interventions and Complications (EDIC) Study

scientific article published on 14 March 2016

Progression of carotid artery intima-media thickness during 12 years in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study

scientific article

Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial

scientific article published on December 2008

Properties of composite time to first event versus joint marginal analyses of multiple outcomes

scientific article published on 28 June 2018

Properties of permuted-block randomization in clinical trials

article

Properties of simple randomization in clinical trials

article

Properties of the urn randomization in clinical trials

scientific article published on December 1988

Randomization in clinical trials: conclusions and recommendations.

scientific article

Rationale and design of the glycemia reduction approaches in diabetes: a comparative effectiveness study (GRADE).

scientific article published on 20 May 2013

Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOME™)

scientific article

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

scientific article

Relation between carotid intima-media thickness and left ventricular mass in type 1 diabetes mellitus (from the Epidemiology of Diabetes Interventions and Complications [EDIC] Study)

scientific article

Relationship of glycated albumin to blood glucose and HbA1c values and to retinopathy, nephropathy, and cardiovascular outcomes in the DCCT/EDIC study

scientific article published on 29 August 2013

Relationship of myocardial scar with cardiovascular disease risk factors in the diabetes control and complications trial (DCCT)/epidemiology of diabetes interventions and complications (EDIC) study

Reminiscences of Jerry Cornfield ⬇️

scientific article published on April 1, 2013

Renal function in type 2 diabetes with rosiglitazone, metformin, and glyburide monotherapy

scientific article

Renal outcomes in patients with type 1 diabetes and macroalbuminuria

scientific article

Response to Comment on Lachin et al. Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial. Diabetes Care 2017;40:777-783.

scientific article

Response to Comment on: Lachin et al. (2007) The Hemoglobin Glycation Index Is Not an Independent Predictor of the Risk of Microvascular Complications in the Diabetes Control and Complications Trial: Diabetes 56:1913-1921, 2007

Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy

scientific article

Risk Factors for First and Subsequent CVD Events in Type 1 Diabetes: The DCCT/EDIC Study

scientific article published on 30 January 2020

Risk Factors for Kidney Disease in Type 1 Diabetes

article

Risk Factors for Retinopathy in Type 1 Diabetes: The DCCT/EDIC Study

scientific article published on 04 March 2019

Risk of Severe Hypoglycemia in Type 1 Diabetes Over 30 Years of Follow-up in the DCCT/EDIC Study

scientific article published on 26 May 2017

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

article

Rosiglitazone decreases C-reactive protein to a greater extent relative to glyburide and metformin over 4 years despite greater weight gain: observations from a Diabetes Outcome Progression Trial (ADOPT)

scientific article

Rosiglitazone-associated fractures in type 2 diabetes: an Analysis from A Diabetes Outcome Progression Trial (ADOPT).

scientific article

Sample size and power for a logrank test and Cox proportional hazards model with multiple groups and strata, or a quantitative covariate with multiple strata ⬇️

scientific article published on May 13, 2013

Sample size evaluation for a multiply matched case-control study using the score test from a conditional logistic (discrete Cox PH) regression model

scientific article published on June 2008

Sample size evaluation for a multiply matched case-control study using the score test from a conditional logistic (discrete Cox PH) regression model

scientific article published on 31 January 2018

Sample size requirements for studies of treatment effects on beta-cell function in newly diagnosed type 1 diabetes

scientific article

Sequential monitoring of survival data with the Wilcoxon statistic.

scientific article published on September 1995

Severe hypoglycaemia in Diabetes Control and Complications Trial

scientific article published in The Lancet

Significance of Epicardial and Intrathoracic Adipose Tissue Volume among Type 1 Diabetes Patients in the DCCT/EDIC: A Pilot Study

scientific article

Skin advanced glycation end products glucosepane and methylglyoxal hydroimidazolone are independently associated with long-term microvascular complication progression of type 1 diabetes

scientific article

Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes

scientific article

Skin collagen fluorophore LW-1 versus skin fluorescence as markers for the long-term progression of subclinical macrovascular disease in type 1 diabetes

scientific article published on 11 February 2016

Some large-sample distribution-free estimators and tests for multivariate partially incomplete data from two populations.

scientific article

Statistical considerations in the intent-to-treat principle

scientific article (publication date: June 2000)

Statistical properties of randomization in clinical trials

scientific article

Termination of a clinical trial with no treatment group difference: the Lupus Nephritis Collaborative Study

scientific article

The Department of Statistics at The George Washington University

The Hemoglobin Glycation Index Is Not an Independent Predictor of the Risk of Microvascular Complications in the Diabetes Control and Complications Trial

scientific article published on 14 March 2007

The Society for Clinical Trials supports United States legislation mandating trials registration. Position paper

scientific article

The TrialNet Natural History Study of the Development of Type 1 Diabetes: objectives, design, and initial results

scientific article published on 24 September 2008

The association between skin collagen glucosepane and past progression of microvascular and neuropathic complications in type 1 diabetes

scientific article published on 12 November 2012

The effect of intensive diabetes treatment on resting heart rate in type 1 diabetes: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study

scientific article published on 27 April 2007

The effect of intensive glycemic treatment on coronary artery calcification in type 1 diabetic participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study

scientific article published on December 2006

The minimum intensity of a mixed exposure that increases the risk of an outcome

scientific article published on 03 September 2020

The predictive role of markers of Inflammation and endothelial dysfunction on the course of diabetic retinopathy in type 1 diabetes

scientific article published on 20 August 2014

The role of measurement reliability in clinical trials

scientific article published on January 2004

The use of response-adaptive designs in clinical trials

scientific article

Type 1 Diabetes TrialNet--an international collaborative clinical trials network

scientific article

Uncertainty, Variability, and Sensitivity Analysis in Physiological Pharmacokinetic Models

scientific article published on 01 November 1995

Update on cardiovascular outcomes at 30 years of the diabetes control and complications trial/epidemiology of diabetes interventions and complications study

scientific article published on January 2014

Use of spending functions for occasional or continuous monitoring of data in clinical trials.

scientific article published on December 1993

Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes.

scientific article published on 12 August 2009

Validity of self-report in type 1 diabetic subjects for laser treatment of retinopathy

scientific article

Worst-rank score analysis with informatively missing observations in clinical trials

scientific article

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