List of works - Mitsutoshi Yoneyama

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

scientific article

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

scientific article (publication date: 4 May 2006)

Cell type-specific involvement of RIG-I in antiviral response

scientific article (publication date: July 2005)

Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I

scientific article

Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300

scientific article published on February 16, 1998

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

scientific article

Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses

scientific article

RNA recognition and signal transduction by RIG-I-like receptors

scientific article published on January 2009

Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection

scientific article

Induction of IRF-3/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathways

scientific article published in April 2001

Viral Infections Activate Types I and III Interferon Genes through a Common Mechanism

scientific article published in Journal of Biological Chemistry

Function of RIG-I-like receptors in antiviral innate immunity

scientific article published on 29 March 2007

Viral RNA detection by RIG-I-like receptors

scientific article

Recognition of viral nucleic acids in innate immunity

scientific article published on January 2010

Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity

scientific article

Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation

scientific article published on 31 December 2003

The alpha/beta interferon response controls tissue tropism and pathogenicity of poliovirus

scientific article

IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc

scientific article published on July 1992

Structural mechanism of RNA recognition by the RIG-I-like receptors

scientific article

Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon

scientific article

Control of IRF-3 activation by phosphorylation

scientific article (publication date: 2002)

Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria

scientific article published on 28 August 2014

Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors

scientific article

Antiviral innate immunity and stress granule responses

scientific article

Identification of loss of function mutations in human genes encoding RIG-I and MDA5: implications for resistance to type I diabetes

scientific article published on 26 March 2009

RIG-I family RNA helicases: cytoplasmic sensor for antiviral innate immunity

scientific article published on August 2007

Virus-infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1

scientific article

Encephalomyocarditis virus disrupts stress granules, the critical platform for triggering antiviral innate immune responses

scientific article published on 19 June 2013

Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity

scientific article

Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex

scientific article published on 8 April 2002

DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation

scientific article

Retinoic acid-inducible gene-I-like receptors

scientific article published on 15 October 2010

Triggering antiviral response by RIG-I-related RNA helicases

scientific article published on 20 February 2007

The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment

scientific article

Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes

scientific article published on January 1989

A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection

scientific article

Retinoic acid-inducible gene I-inducible miR-23b inhibits infections by minor group rhinoviruses through down-regulation of the very low density lipoprotein receptor

scientific article

Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change

scientific article

Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response

scientific article published on December 2007

Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules

scientific article published on 10 February 2016

PACT, a double-stranded RNA binding protein acts as a positive regulator for type I interferon gene induced by Newcastle disease virus.

scientific article published in March 2001

Involvement of TIRAP/MAL in signaling for the activation of interferon regulatory factor 3 by lipopolysaccharide

scientific article

Cytoplasmic recognition of RNA.

scientific article published on 31 December 2007

Role of the alpha/beta interferon response in the acquisition of susceptibility to poliovirus by kidney cells in culture

scientific article

Functional characterization of domains of IPS-1 using an inducible oligomerization system

scientific article

55 Amino acid linker between helicase and carboxyl terminal domains of RIG-I functions as a critical repression domain and determines inter-domain conformation

scientific article

Impairment of interferon regulatory factor-3 activation by hepatitis C virus core protein basic amino acid region 1.

scientific article published on 30 October 2012

Regulation of antiviral innate immune signaling by stress-induced RNA granules

scientific article

The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response

scientific article

List of works by Mitsutoshi Yoneyama

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Cell type-specific involvement of RIG-I in antiviral response

Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I

Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses

RNA recognition and signal transduction by RIG-I-like receptors

Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection

Induction of IRF-3/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathways

Viral Infections Activate Types I and III Interferon Genes through a Common Mechanism

Function of RIG-I-like receptors in antiviral innate immunity

Viral RNA detection by RIG-I-like receptors

Recognition of viral nucleic acids in innate immunity

Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity

Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation

The alpha/beta interferon response controls tissue tropism and pathogenicity of poliovirus

IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc

Structural mechanism of RNA recognition by the RIG-I-like receptors

Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon

Control of IRF-3 activation by phosphorylation

Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria

Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors

Antiviral innate immunity and stress granule responses

Identification of loss of function mutations in human genes encoding RIG-I and MDA5: implications for resistance to type I diabetes

RIG-I family RNA helicases: cytoplasmic sensor for antiviral innate immunity

Virus-infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1

Encephalomyocarditis virus disrupts stress granules, the critical platform for triggering antiviral innate immune responses

Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity

Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex

DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation

Retinoic acid-inducible gene-I-like receptors

Triggering antiviral response by RIG-I-related RNA helicases

The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment

Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes

A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection

Retinoic acid-inducible gene I-inducible miR-23b inhibits infections by minor group rhinoviruses through down-regulation of the very low density lipoprotein receptor

Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change

Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response

Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules

PACT, a double-stranded RNA binding protein acts as a positive regulator for type I interferon gene induced by Newcastle disease virus.

Involvement of TIRAP/MAL in signaling for the activation of interferon regulatory factor 3 by lipopolysaccharide

Cytoplasmic recognition of RNA.

Role of the alpha/beta interferon response in the acquisition of susceptibility to poliovirus by kidney cells in culture

Functional characterization of domains of IPS-1 using an inducible oligomerization system

55 Amino acid linker between helicase and carboxyl terminal domains of RIG-I functions as a critical repression domain and determines inter-domain conformation

Impairment of interferon regulatory factor-3 activation by hepatitis C virus core protein basic amino acid region 1.

Regulation of antiviral innate immune signaling by stress-induced RNA granules

The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response

Cytoplasmic double-stranded DNA sensor