List of works - Simon C Lovell

Ab initio construction of polypeptide fragments: efficient generation of accurate, representative ensembles

scientific article published in April 2003

Abrogation of HMX1 function causes rare oculoauricular syndrome associated with congenital cataract, anterior segment dysgenesis, and retinal dystrophy

scientific article published on 8 January 2015

Agnathia-otocephaly complex and asymmetric velopharyngeal insufficiency due to an in-frame duplication in OTX2.

scientific article published on 15 January 2015

All duplicates are not equal: the difference between small-scale and genome duplication

scientific article published in January 2007

Alternative splicing and protein interaction data sets

scientific article published in April 2013

An algorithm for predicting protein-protein interaction sites: Abnormally exposed amino acid residues and secondary structure elements

scientific article published in May 2006

An exploration of alternative visualisations of the basic helix-loop-helix protein interaction network

scientific article

An integrated view of molecular coevolution in protein-protein interactions

scientific article published on 14 June 2010

Analysis of genetic interaction networks shows that alternatively spliced genes are highly versatile

scientific article

Analysis of synthetic lethality reveals genetic interactions between the GTPase Snu114p and snRNAs in the catalytic core of the Saccharomyces cerevisiae spliceosome

scientific article published on 20 July 2009

Andante: reducing side-chain rotamer search space during comparative modeling using environment-specific substitution probabilities

scientific article published on 6 March 2007

Are non‐functional, unfolded proteins (‘junk proteins’) common in the genome? ⬇️

scientific article published on November 20, 2003

Artefacts and biases affecting the evaluation of scoring functions on decoy sets for protein structure prediction.

scientific article

Binding interface change and cryptic variation in the evolution of protein-protein interactions.

scientific article published on 18 February 2016

Bioinformatics: from molecules to systems. A discussion meeting held at The Royal Society on 4 and 5 April 2005.

scientific article published on September 2005

CHORAL: a differential geometry approach to the prediction of the cores of protein structures

scientific article published on 26 July 2005

Characterization and prediction of haploinsufficiency using systems-level gene properties in yeast

scientific article published on 6 November 2013

Characterization of protein-protein interaction interfaces from a single species

scientific article

Constraints from protein structure and intra-molecular coevolution influence the fitness of HIV-1 recombinants.

scientific article

Constraints on HIV-1 diversity from protein structure

scientific article

Cooperativity in Bacillus stearothermophilus pyruvate kinase

Correlation of microsynteny conservation and disease gene distribution in mammalian genomes

scientific article

Covariation Is a Poor Measure of Molecular Coevolution.

scientific article

Crystal structures of engrailed homeodomain mutants: implications for stability and dynamics

scientific article

Cyclic AMP potentiates receptor-stimulated phosphoinositide hydrolysis in human neuroepithelioma cells

scientific article published on August 1992

Determining the evolutionary history of gene families

scientific article published on 28 October 2011

Distinguishing structural and functional restraints in evolution in order to identify interaction sites

scientific article published in October 2004

Diversification at transcription factor binding sites within a species and the implications for environmental adaptation

scientific article published on 20 June 2011

DupliPHY-Web: a web server for DupliPHY and DupliPHY-ML.

scientific article published on 7 October 2014

ERp57 is essential for efficient folding of glycoproteins sharing common structural domains

scientific article

Ebolavirus is evolving but not changing: No evidence for functional change in EBOV from 1976 to the 2014 outbreak.

scientific article

Erbb2 is required for cardiac atrial electrical activity during development

scientific article

Evolution in protein interaction networks: co-evolution, rewiring and the role of duplication

scientific article published on August 2009

Evolvability of Yeast Protein–Protein Interaction Interfaces

scientific article published on 01 April 2012

Gene duplication and environmental adaptation within yeast populations

scientific article published on 21 July 2010

Generating, Maintaining, and Exploiting Diversity in a Memetic Algorithm for Protein Structure Prediction.

scientific article

Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site

scientific article

Inferring gene family histories in yeast identifies lineage specific expansions

scientific article

Interactions between Kar2p and its nucleotide exchange factors Sil1p and Lhs1p are mechanistically distinct

scientific article published on 29 April 2010

Modular biological function is most effectively captured by combining molecular interaction data types

scientific article

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

scientific article

Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus

scientific article

Mutations in non-acid patch residues disrupt H2A.Z's association with chromatin through multiple mechanisms.

scientific article

Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability

scientific article published in 2013

Properties of polyproline II, a secondary structure element implicated in protein-protein interactions

scientific article published in March 2005

Protein interactions from complexes: a structural perspective

scientific article published on 20 December 2006

Protein-protein interaction networks and biology--what's the connection?

scientific article published in January 2008

Quantitative analysis and prediction of curvature in leucine-rich repeat proteins

scientific article

Rapid functional and evolutionary changes follow gene duplication in yeast

scientific article

Secondary structure assignment that accurately reflects physical and evolutionary characteristics.

scientific article published in December 2005

Sequence-structure homology recognition by iterative alignment refinement and comparative modeling.

scientific article

Sequencing and characterisation of rearrangements in three S. pastorianus strains reveals the presence of chimeric genes and gives evidence of breakpoint reuse

scientific article

Specificity in protein interactions and its relationship with sequence diversity and coevolution

scholarly article

Structure validation by Calpha geometry: phi,psi and Cbeta deviation

scientific article (publication date: 15 February 2003)

Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature

scientific article

The dual role of fragments in fragment-assembly methods for de novo protein structure prediction

scientific article

The effect of sequence evolution on protein structural divergence.

scientific article

The leucine-rich repeat structure.

scientific article

The origins of the evolutionary signal used to predict protein-protein interactions

scientific article

The role of protein interactions in mediating essentiality and synthetic lethality

scientific article

The role of small in-frame insertions/deletions in inherited eye disorders and how structural modelling can help estimate their pathogenicity.

scientific article

Toward a detailed understanding of search trajectories in fragment assembly approaches to protein structure prediction

scientific article

Using knowledge of protein structural constraints to predict the evolution of HIV-1.

scientific article

List of works by Simon C Lovell

Ab initio construction of polypeptide fragments: efficient generation of accurate, representative ensembles

Abrogation of HMX1 function causes rare oculoauricular syndrome associated with congenital cataract, anterior segment dysgenesis, and retinal dystrophy

Agnathia-otocephaly complex and asymmetric velopharyngeal insufficiency due to an in-frame duplication in OTX2.

All duplicates are not equal: the difference between small-scale and genome duplication

Alternative splicing and protein interaction data sets

An algorithm for predicting protein-protein interaction sites: Abnormally exposed amino acid residues and secondary structure elements

An exploration of alternative visualisations of the basic helix-loop-helix protein interaction network

An integrated view of molecular coevolution in protein-protein interactions

Analysis of genetic interaction networks shows that alternatively spliced genes are highly versatile

Analysis of synthetic lethality reveals genetic interactions between the GTPase Snu114p and snRNAs in the catalytic core of the Saccharomyces cerevisiae spliceosome

Andante: reducing side-chain rotamer search space during comparative modeling using environment-specific substitution probabilities

Are non‐functional, unfolded proteins (‘junk proteins’) common in the genome? ⬇️

Artefacts and biases affecting the evaluation of scoring functions on decoy sets for protein structure prediction.

Binding interface change and cryptic variation in the evolution of protein-protein interactions.

Bioinformatics: from molecules to systems. A discussion meeting held at The Royal Society on 4 and 5 April 2005.

CHORAL: a differential geometry approach to the prediction of the cores of protein structures

Characterization and prediction of haploinsufficiency using systems-level gene properties in yeast

Characterization of protein-protein interaction interfaces from a single species

Constraints from protein structure and intra-molecular coevolution influence the fitness of HIV-1 recombinants.

Constraints on HIV-1 diversity from protein structure

Cooperativity in Bacillus stearothermophilus pyruvate kinase

Correlation of microsynteny conservation and disease gene distribution in mammalian genomes

Covariation Is a Poor Measure of Molecular Coevolution.

Crystal structures of engrailed homeodomain mutants: implications for stability and dynamics

Cyclic AMP potentiates receptor-stimulated phosphoinositide hydrolysis in human neuroepithelioma cells

Determining the evolutionary history of gene families

Distinguishing structural and functional restraints in evolution in order to identify interaction sites

Diversification at transcription factor binding sites within a species and the implications for environmental adaptation

DupliPHY-Web: a web server for DupliPHY and DupliPHY-ML.

ERp57 is essential for efficient folding of glycoproteins sharing common structural domains

Ebolavirus is evolving but not changing: No evidence for functional change in EBOV from 1976 to the 2014 outbreak.

Erbb2 is required for cardiac atrial electrical activity during development

Evolution in protein interaction networks: co-evolution, rewiring and the role of duplication

Evolvability of Yeast Protein–Protein Interaction Interfaces

Gene duplication and environmental adaptation within yeast populations

Generating, Maintaining, and Exploiting Diversity in a Memetic Algorithm for Protein Structure Prediction.

Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site

Inferring gene family histories in yeast identifies lineage specific expansions

Interactions between Kar2p and its nucleotide exchange factors Sil1p and Lhs1p are mechanistically distinct

Modular biological function is most effectively captured by combining molecular interaction data types

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus

Mutations in non-acid patch residues disrupt H2A.Z's association with chromatin through multiple mechanisms.

Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability

Properties of polyproline II, a secondary structure element implicated in protein-protein interactions

Protein interactions from complexes: a structural perspective

Protein-protein interaction networks and biology--what's the connection?

Quantitative analysis and prediction of curvature in leucine-rich repeat proteins

Rapid functional and evolutionary changes follow gene duplication in yeast

Secondary structure assignment that accurately reflects physical and evolutionary characteristics.

Sequence-structure homology recognition by iterative alignment refinement and comparative modeling.

Sequencing and characterisation of rearrangements in three S. pastorianus strains reveals the presence of chimeric genes and gives evidence of breakpoint reuse

Specificity in protein interactions and its relationship with sequence diversity and coevolution

Structure validation by Calpha geometry: phi,psi and Cbeta deviation

Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature

The dual role of fragments in fragment-assembly methods for de novo protein structure prediction

The effect of sequence evolution on protein structural divergence.

The leucine-rich repeat structure.

The origins of the evolutionary signal used to predict protein-protein interactions

The role of protein interactions in mediating essentiality and synthetic lethality

The role of small in-frame insertions/deletions in inherited eye disorders and how structural modelling can help estimate their pathogenicity.

Toward a detailed understanding of search trajectories in fragment assembly approaches to protein structure prediction

Using knowledge of protein structural constraints to predict the evolution of HIV-1.