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List of works by Michael P. Murphy

(13)C-labelled microdialysis studies of cerebral metabolism in TBI patients.

scientific article

A Comparison of Oxidative Lactate Metabolism in Traumatically Injured Brain and Control Brain

scientific article published on 18 May 2018

A Multi-Omics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

scientific article

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

scientific article published on August 2010

A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury.

scholarly article

A mitochondria-targeted derivative of ascorbate: MitoC.

scientific article

A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic

scientific article published in October 2012

A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes.

scientific article published on 4 December 2013

A mitochondrial-targeted ubiquinone modulates muscle lipid profile and improves mitochondrial respiration in obesogenic diet-fed rats

scientific article

A new hypertrophic mechanism of serotonin in cardiac myocytes: receptor-independent ROS generation

scientific article published on 9 February 2005

A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms.

scientific article

A ratiometric fluorescent probe for assessing mitochondrial phospholipid peroxidation within living cells

scientific article published on 29 May 2012

A redox switch in angiotensinogen modulates angiotensin release

scientific article

A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1alpha.

scientific article

A transient increase in lipid peroxidation primes preadipocytes for delayed mitochondrial inner membrane permeabilization and ATP depletion during prolonged exposure to fatty acids.

scientific article

APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS

scientific article published on 01 January 2019

Accumulation of lipophilic dications by mitochondria and cells

scientific article published on November 2006

Accumulation of succinate controls activation of adipose tissue thermogenesis

scientific article published in Nature

Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells

scientific article

Active RNA interference in mitochondria

scientific article published on 17 August 2020

Age-related endothelial dysfunction in human skeletal muscle feed arteries: the role of free radicals derived from mitochondria in the vasculature.

scientific article published on 11 May 2017

Altered cellular redox homeostasis and redox responses under standard oxygen cell culture conditions versus physioxia

article

Amyloid β-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide

scientific article

An investigation of the effects of MitoQ on human peripheral mononuclear cells

scientific article published on 03 November 2010

Animal and human studies with the mitochondria-targeted antioxidant MitoQ.

scientific article published on July 2010

Antioxidant properties of MitoTEMPOL and its hydroxylamine.

scientific article published in January 2009

Antioxidants as therapies: can we improve on nature?

scientific article published on 18 April 2013

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease.

scientific article published on 21 June 2010

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

scientific article

Assessing the Delivery of Molecules to the Mitochondrial Matrix Using Click Chemistry

scientific article published on 28 April 2016

Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry

scientific article published on 16 December 2015

Assessment of H2S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA

scientific article

Attenuation of oxidative damage by targeting mitochondrial complex I in neonatal hypoxic-ischemic brain injury

scientific article published on 03 July 2018

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

scientific article published on 24 July 2020

Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload

scientific article

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.

scientific article

Cell-penetrating peptides do not cross mitochondrial membranes even when conjugated to a lipophilic cation: evidence against direct passage through phospholipid bilayers.

scientific article published on November 2004

Chapter 19 Measuring redox changes to mitochondrial protein thiols with redox difference gel electrophoresis (redox-DIGE).

scientific article published in January 2009

Chapter 22 The uptake and interactions of the redox cycler paraquat with mitochondria

scientific article

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults

scientific article published on 16 April 2018

Click-PEGylation - A mobility shift approach to assess the redox state of cysteines in candidate proteins

scientific article

ClickIn: a flexible protocol for quantifying mitochondrial uptake of nucleobase derivatives

scientific article published on April 2017

Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function.

scientific article published on March 2014

Complementation of coenzyme Q-deficient yeast by coenzyme Q analogues requires the isoprenoid side chain

scientific article

Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes.

scientific article published on 31 October 2016

Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy

scientific article

Complex I is the major site of mitochondrial superoxide production by paraquat

scientific article published on 26 November 2007

Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage

scientific article published on 8 July 2008

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice.

scientific article published on 23 October 2009

Construction and testing of engineered zinc-finger proteins for sequence-specific modification of mtDNA

scientific article published on 04 February 2010

Control of electron flux through the respiratory chain in mitochondria and cells

scientific article published on May 1987

Control of mitochondrial superoxide production by reverse electron transport at complex I.

scientific article

Correction to "Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator"

scientific article published on June 2016

Coupling Krebs cycle metabolites to signalling in immunity and cancer

scientific article published on 01 January 2019

Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage

scientific article

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 ⬇️

scientific article published on April 26, 2012

DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome

scientific article

Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion.

scientific article published on 19 December 2013

Delivery of antisense peptide nucleic acids (PNAs) to the cytosol by disulphide conjugation to a lipophilic cation.

scientific article published on January 2004

Delivery of bioactive molecules to mitochondria in vivo.

scientific article

Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator

scientific article

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

scientific article

Detection of changes in mitochondrial hydrogen sulfide i n vivo in the fish model Poecilia mexicana (Poeciliidae).

scientific article published on 9 May 2019

Detection of reactive oxygen species-sensitive thiol proteins by redox difference gel electrophoresis: implications for mitochondrial redox signaling

scientific article published on 24 May 2007

Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.

scientific article

Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma

scientific article

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

scientific article published in 2021

Do organellar genomes function as long-term redox damage sensors?

scientific article published on 27 May 2009

Dysregulated metabolism contributes to oncogenesis

scientific article

Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI

scientific article published on 19 November 2020

Effect of the mitochondrial antioxidant, Mito Vitamin E, on hypoxic-ischemic striatal injury in neonatal rats: a dose-response and stereological study

scientific article published on 14 February 2006

Effects of the mitochondria-targeted antioxidant mitoquinone in murine acute pancreatitis

scientific article

Evidence of severe mitochondrial oxidative stress and a protective effect of low oxygen in mouse models of inherited photoreceptor degeneration

scientific article published on 03 November 2010

Expanding the palette of phenanthridinium cations

scientific article

Exploring autoimmunity in the pathogenesis of abdominal aortic aneurysms

scientific article

Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster

scientific article published on 18 June 2015

Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster

scientific article published on 10 November 2015

Focally perfused succinate potentiates brain metabolism in head injury patients

scientific article

Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE.

scientific article

Glycolysis and the pentose phosphate pathway after human traumatic brain injury: microdialysis studies using 1,2-(13)C2 glucose.

scientific article

Glycolysis promotes caspase-3 activation in lipid rafts in T cells

scientific article published on 19 January 2018

HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth

scientific journal article

How mitochondria produce reactive oxygen species

scientific article

How should we talk about metabolism?

scientific article published on 14 May 2020

Hydrogen peroxide produced inside mitochondria takes part in cell-to-cell transmission of apoptotic signal

scientific article published in January 2006

Identification and quantification of protein S-nitrosation by nitrite in the mouse heart during ischemia.

scientific article published on 14 July 2017

Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension

scientific article

In vivo evidence of mitochondrial dysfunction and altered redox homeostasis in a genetic mouse model of propionic acidemia: Implications for the pathophysiology of this disorder.

scientific article

In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice.

scientific article published on 13 March 2014

Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species

scientific article

Incorporation of triphenylphosphonium functionality improves the inhibitory properties of phenothiazine derivatives in Mycobacterium tuberculosis

scientific article published on 07 August 2014

Induction of mitochondrial ROS production by electrophilic lipids: a new pathway of redox signaling?

scientific article published on 13 January 2006

Inhibition of complex I of the electron transport chain causes O2-. -mediated mitochondrial outgrowth.

scientific article

Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases

scientific article

Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools

scientific article (publication date: 3 June 2005)

Introduction to Special Issue on Mitochondrial Redox Signaling in Health and Disease

scientific article published on 5 August 2016

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

scientific article

Ischemic preconditioning protects against cardiac ischemia reperfusion injury without affecting succinate accumulation or oxidation

scientific article published on 15 August 2018

Isolating adverse effects of glucocorticoids on the embryonic cardiovascular system

scientific article published on 05 June 2020

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

scientific article published on 28 March 2018

KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation

scientific article

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

scientific article published on 01 August 2018

Long-distance apoptotic killing of cells is mediated by hydrogen peroxide in a mitochondrial ROS-dependent fashion.

scientific article published in November 2005

Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis

scientific article published on 15 June 2020

Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation.

scientific article

Malonylation of GAPDH is an inflammatory signal in macrophages

scientific article published in Nature Communications

Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix

scientific article published on March 2011

Measuring mitochondrial protein thiol redox state

scientific article published on 20 June 2010

Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury

scientific article published on 26 February 2019

Metabolic control of ferroptosis in cancer

scientific article published on 01 October 2018

Metabolomic Profiling in Acute ST-Segment-Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia-Reperfusion Injury.

scientific article

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages.

scientific article published on 7 July 2015

MitoNeoD: A Mitochondria-Targeted Superoxide Probe.

scientific article

MitoQ Inhibits Human Breast Cancer Cell Migration, Invasion and Clonogenicity

scientific article published on 16 March 2022

MitoQ Prevents Human Breast Cancer Recurrence and Lung Metastasis in Mice

scientific article published in 2022

MitoQ administration prevents endotoxin-induced cardiac dysfunction

scientific article published on 05 August 2009

MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload

scientific article published in February 2018

MitoQ modulates oxidative stress and decreases inflammation following hemorrhage.

scientific article published on March 2015

MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α

scientific article published on 26 May 2018

Mitochondria as a therapeutic target for common pathologies

scientific article published on 05 November 2018

Mitochondria selective S-nitrosation by mitochondria-targeted S-nitrosothiol protects against post-infarct heart failure in mouse hearts.

scientific article

Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

scientific article published on 06 July 2009

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

scientific article published in Journal of Biological Chemistry

Mitochondria-derived reactive oxygen species mediate caspase-dependent and -independent neuronal deaths

scientific article

Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice

scientific article published on 24 March 2014

Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines.

scientific article

Mitochondria-targeted antioxidant MitoQ reduced renal damage caused by ischemia-reperfusion injury in rodent kidneys: Longitudinal observations of T2 -weighted imaging and dynamic contrast-enhanced MRI.

scientific article

Mitochondria-targeted antioxidant mitoquinone deactivates human and rat hepatic stellate cells and reduces portal hypertension in cirrhotic rats.

scientific article

Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice

scientific article published on 26 October 2017

Mitochondria-targeted antioxidants do not prevent tumour necrosis factor-induced necrosis of L929 cells

scientific article published on September 2007

Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants.

scientific article published on 15 August 2003

Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons

scientific article

Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing.

scientific article

Mitochondria-targeted small molecule therapeutics and probes

scientific article published on 06 June 2011

Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis

scientific article published on July 2011

Mitochondrial 'flashes': a radical concept repHined.

scientific article published on 20 August 2012

Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans.

scientific article

Mitochondrial Diseases: Shortcuts to Therapies and Therapeutic Shortcuts

scientific article

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis.

scientific article

Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation.

scientific article

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

scientific article published on April 2016

Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization

scientific article published in May 2017

Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning

scientific article published on 20 March 2018

Mitochondrial ROS-derived PTEN oxidation activates PI3K pathway for mTOR-induced myogenic autophagy

scientific article published on 24 July 2018

Mitochondrial Respiration Is Reduced in Atherosclerosis, Promoting Necrotic Core Formation and Reducing Relative Fibrous Cap Thickness

scientific article

Mitochondrial Superoxide Contributes to Hippocampal Synaptic Dysfunction and Memory Deficits in Angelman Syndrome Model Mice

scientific article

Mitochondrial Thiols in Antioxidant Protection and Redox Signaling: Distinct Roles for Glutathionylation and Other Thiol Modifications ⬇️

scientific article published on December 20, 2011

Mitochondrial accumulation of a lipophilic cation conjugated to an ionisable group depends on membrane potential, pH gradient and pK(a): implications for the design of mitochondrial probes and therapies

scientific article published on 22 November 2012

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing.

scientific article published on 6 July 2016

Mitochondrial dysfunction indirectly elevates ROS production by the endoplasmic reticulum

scientific article

Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling.

scientific article published on 4 June 2004

Mitochondrial impairments contribute to Spinocerebellar ataxia type 1 progression and can be ameliorated by the mitochondria-targeted antioxidant MitoQ.

scientific article published on 6 July 2016

Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury

scientific article published on 02 June 2018

Mitochondrial oxidative stress and the metabolic syndrome

scientific article published on 24 July 2012

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

scientific article published on 29 March 2018

Mitochondrial pharmacology

scientific article published on 18 April 2012

Mitochondrial production of oxidants is necessary for physiological calcium oscillations

scientific article

Mitochondrial protein S-nitrosation protects against ischemia reperfusion-induced denervation at neuromuscular junction in skeletal muscle

scientific article published on 9 February 2018

Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes

scientific article published on March 2013

Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants

scientific article published on July 2005

Mitochondrial redox signalling at a glance

scientific article published on 01 February 2012

Mitochondrial redox state regulates transcription of the nuclear-encoded mitochondrial protein manganese superoxide dismutase: a proposed adaptive response to mitochondrial redox imbalance.

scientific article published on March 2005

Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells

scientific article published on 31 October 2018

Mitochondrial targeting of quinones: therapeutic implications.

scientific article published on 16 March 2007

Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels.

scientific article published on 8 January 2016

Mitochondrial uncouplers with an extraordinary dynamic range

scientific article published in October 2007

Modulating mitochondrial intracellular location as a redox signal

scientific article published on 18 September 2012

Monoamine oxidase-dependent endoplasmic reticulum-mitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes

scientific article published on 19 February 2018

Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy

scientific article published on March 2016

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

scientific article

Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise

scientific article published on 27 December 2018

Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles

scientific article published in 2024

Native chemical ligation approach to sensitively probe tissue acyl-CoA pools

scientific article published in 2022

Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN

scientific article published on 01 August 2008

Neurological deficits caused by tissue hypoxia in neuroinflammatory disease

scientific article published on 17 October 2013

Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis

scientific article published on 26 February 2014

Newly made mitochondrial DNA drives inflammation

scientific article published in Nature

Non-enzymatic N-acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S-acetylated Thiol Intermediate Sensitive to Glyoxalase II.

scientific article published in February 2017

Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

scientific article published on 09 December 2020

Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

scientific article published on 01 July 2019

Oxidative modification of hepatic mitochondria protein thiols: effect of chronic alcohol consumption

scientific article published on 11 December 2003

Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

scientific article

P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain

scientific article published on 21 February 2013

Persistent S-nitrosation of complex I and other mitochondrial membrane proteins by S-nitrosothiols but not nitric oxide or peroxynitrite: implications for the interaction of nitric oxide with mitochondria

scientific article published on 14 February 2006

Phosphorus spectroscopy in acute TBI demonstrates metabolic changes that relate to outcome in the presence of normal structural MRI

scientific article published on 18 September 2018

Placental Adaptation to Early-Onset Hypoxic Pregnancy and Mitochondria-Targeted Antioxidant Therapy in a Rodent Model

scientific article published on 22 September 2018

Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ.

scientific article

Pro-fluorescent mitochondria-targeted real-time responsive redox probes synthesised from carboxy isoindoline nitroxides: Sensitive probes of mitochondrial redox status in cells

scientific article published on 19 March 2018

Protection against renal ischemia-reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ

scientific article published on 29 April 2015

Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G

scientific article published on 20 February 2013

Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells.

scientific article published on 24 March 2017

Proteomic approaches to the characterization of protein thiol modification ⬇️

scientific article published on December 2, 2010

Proximal Cysteines that Enhance Lysine N-Acetylation of Cytosolic Proteins in Mice Are Less Conserved in Longer-Living Species

article by Andrew M James et al published 7 August 2018 in Cell Reports

Quantification and identification of mitochondrial proteins containing vicinal dithiols

scientific article published on 15 September 2010

Radiosynthesis of 11-[(18) F]fluoroundecyltriphenylphosphonium (MitoF) as a potential mitochondria-specific positron emission tomography radiotracer

scientific article published on 10 September 2013

Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury

scientific article published in 2022

Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: Implications for mitochondria-specific therapies and probes

scientific article published on 08 June 2010

Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold

article

Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism

scientific article

Reaction between peroxynitrite and triphenylphosphonium-substituted arylboronic acid isomers: identification of diagnostic marker products and biological implications

scientific article published on 09 May 2013

Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus

scientific article

Reactivity of ubiquinone and ubiquinol with superoxide and the hydroperoxyl radical: implications for in vivo antioxidant activity

scientific article published on 14 October 2008

Redox Homeostasis and Mitochondrial Dynamics.

scientific article published on 09 July 2015

Redox Modulation by Reversal of the Mitochondrial Nicotinamide Nucleotide Transhydrogenase.

scientific article published in September 2015

Reply to: In vivo quantification of mitochondrial membrane potential

scientific article published on 01 July 2020

Rerouting metabolism to activate macrophages

scientific article published on 01 September 2019

Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats.

scientific article published on 8 December 2011

Response to letter regarding article, "Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans".

scientific article published in March 2014

Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice

Reversible glutathionylation of complex I increases mitochondrial superoxide formation

scientific article published on 20 March 2003

Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo

scientific article published on 31 January 2019

Selective Mitochondrial Targeting Exerts Anxiolytic Effects In Vivo

scientific article published on 16 November 2015

Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat

scientific article published on 7 October 2015

Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore

scientific article

Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation

scientific article published on 23 December 2011

Species- and tissue-specific differences in ROS metabolism during exposure to hypoxia and hyperoxia plus recovery in marine sculpins

scientific article published on 21 November 2019

Specific targeting of a DNA-alkylating reagent to mitochondria. Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide

scientific article

Stable mitochondrial CICIII2 supercomplex interactions in reptiles compared to homeothermic vertebrates

scientific article published on 11 May 2020

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

scientific article published on 21 September 2016

Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.

scientific article

Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants

scientific journal article

Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone.

scientific article published on 12 September 2003

Suppression of reactive oxygen species generation in heart mitochondria from anoxic turtles: the role of complex I S-nitrosation.

scientific article published in March 2018

Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic. Insights into the interaction of ebselen with mitochondria.

scientific article published on 14 April 2005

Synthesis of a mitochondria-targeted spin trap using a novel Parham-type cyclization.

scientific article published on September 2009

Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants

scientific article published on November 2015

Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes.

scientific article published on 9 November 2017

Targeting antioxidants to mitochondria by conjugation to lipophilic cations.

scientific article published on January 2007

Targeting dinitrophenol to mitochondria: limitations to the development of a self-limiting mitochondrial protonophore

scientific article

Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphonium-conjugated alpha-lipoyl derivative

scientific article published on 12 March 2007

Targeting lipophilic cations to mitochondria.

scientific article published on 08 April 2008

Targeting mitochondria-derived reactive oxygen species to reduce epithelial barrier dysfunction and colitis.

scientific article

Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice

scientific article published on 16 April 2020

The 'mitoflash' probe cpYFP does not respond to superoxide

scientific article published in October 2014

The Activity of Menkes Disease Protein ATP7A Is Essential for Redox Balance in Mitochondria

scientific article published on 16 May 2016

The Causes and Consequences of Nonenzymatic Protein Acylation

scientific article published on 18 August 2018

The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.

scientific article published on 14 August 2014

The effect of succinate on brain NADH/NAD+ redox state and high energy phosphate metabolism in acute traumatic brain injury.

scientific article

The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster

scientific article published on 25 January 2006

The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model.

scientific article

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

scientific article published on 18 May 2010

The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice

scientific article published on 14 December 2011

The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients

scientific article

The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease.

scientific article published in November 2011

The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis.

scientific article published on 17 September 2008

The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys.

scientific article

The mitochondrial dicarboxylate and 2-oxoglutarate carriers do not transport glutathione

scientific article published on 28 January 2015

The mitochondrial-targeted antioxidant MitoQ ameliorates metabolic syndrome features in obesogenic diet-fed rats better than Apocynin or Allopurinol

scientific article published in October 2014

The mitochondrial-targeted antioxidant, MitoQ, increases liver mitochondrial cardiolipin content in obesogenic diet-fed rats

scientific article published on 28 May 2015

The permissive role of mitochondria in the induction of haem oxygenase-1 in endothelial cells

scientific article published on April 2009

The swan-neck lesion: proximal tubular adaptation to oxidative stress in nephropathic cystinosis

scientific article

Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency

scientific article published on 20 November 2018

Toward a control theory analysis of aging

scientific article published on January 2008

Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction

scientific article published on 19 August 2020

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development.

scientific article published on 22 August 2017

Treatment with antioxidants ameliorates oxidative damage in a mouse model of propionic acidemia

scientific article

UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction

scientific article

Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis

scientific article

Ubiquinol and plastoquinol triphenylphosphonium conjugates can carry electrons through phospholipid membranes.

scientific article

Understanding and preventing mitochondrial oxidative damage

scientific article

Unraveling the biological roles of reactive oxygen species

scientific article published on April 2011

Using chemical biology to assess and modulate mitochondria: progress and challenges

scientific article published on April 2017

Using exomarkers to assess mitochondrial reactive species in vivo

scientific article published on 30 May 2013

Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila

scientific article published on 19 April 2012

cGMP-Elevating Compounds and Ischemic Conditioning Provide Cardioprotection Against Ischemia and Reperfusion Injury via Cardiomyocyte-Specific BK Channels

scientific article published on 19 October 2017

mtDNA Mutagenesis Disrupts Pluripotent Stem Cell Function by Altering Redox Signaling

scientific article published on 28 May 2015

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