List of works - Louise Wain

A Genome-wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos.

scientific article published on 2 February 2018

A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample

scientific article

A large genome scan for rare CNVs in amyotrophic lateral sclerosis

scientific article

Adaptation of HIV-1 to its human host.

scientific article

Adjustment for index event bias in genome-wide association studies of subsequent events

article

Age at menarche and lung function: a Mendelian randomization study.

scientific article published on 17 June 2017

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

scientific article published on 01 June 2019

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

scientific article published on 29 September 2017

Causal Analyses, Statistical Efficiency And Phenotypic Precision Through Recall-By-Genotype Study Design

Chimpanzee reservoirs of pandemic and nonpandemic HIV-1

scientific article

Cohort Profile: Extended Cohort for E-health, Environment and DNA (EXCEED)

scientific article published on 01 June 2019

Common Variation in the WNK1 Gene and Blood Pressure in Childhood

article

Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium

scientific article published on 8 November 2011

Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies

scientific article

Copy number variation

scientific article published in January 2011

Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma

scientific article published on 03 January 2014

Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome).

scientific article published on May 2014

ERS International Congress 2018: highlights from best-abstract awardees

article

Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function

scientific article

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function.

scientific article

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.

scientific article published on 25 February 2016

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.

scientific article published on 19 February 2018

GSTCD and INTS12 regulation and expression in the human lung

scientific article

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scientific article published on 17 September 2018

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

scientific article published on 25 February 2019

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

scientific article

Genetic variants affecting cross-sectional lung function in adults show little or no effect on longitudinal lung function decline

scientific article published on 7 February 2017

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.

scientific article published on 20 October 2017

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

scientific article published on 6 October 2011

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

scientific article published on 01 March 2020

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

scientific article published on 6 February 2017

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

scientific article published on 30 January 2017

Genome-wide association analysis identifies six new loci associated with forced vital capacity

scientific article

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

scientific article

Genome-wide association studies in lung disease

scientific article published on 19 August 2011

Genome-wide association study identifies five loci associated with lung function

scientific article

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

scientific article

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

scientific article

Genome-wide association study of copy number variation with lung function identifies a novel signal of association near BANP for forced vital capacity

scientific article

Genome-wide association study to identify genetic determinants of severe asthma.

scientific article

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function

scientific article

Genomic copy number variation, human health, and disease

scientific article published on 15 June 2009

Haplotype estimation for biobank-scale data sets

scientific article

Human CCL3L1 copy number variation, gene expression, and the role of the CCL3L1-CCR5 axis in lung function.

scientific article published on 21 February 2018

Identification of a missense variant in SPDL1 associated with idiopathic pulmonary fibrosis

scientific article published on 23 March 2021

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

scientific article published in Nature Communications

Integrative pathway genomics of lung function and airflow obstruction

scientific article

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.

scientific article published on 12 July 2017

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function ⬇️

scientific article

Meta-analysis of exome array data identifies six novel genetic loci for lung function

scientific article published on 12 January 2018

Meta-analysis of exome array data identifies six novel genetic loci for lung function

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

scientific article published on 07 January 2019

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study

scientific article published on 11 December 2018

Molecular mechanisms underlying variations in lung function: a systems genetics analysis

scientific article published on 21 September 2015

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

scientific article published in October 2017

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

scientific article published on 25 February 2019

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

scholarly article published 12 June 2018

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

scientific article

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank

scientific article

Overlap of Genetic Risk between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis

scientific article published on 01 December 2019

Pedigree and genotyping quality analyses of over 10,000 DNA samples from the Generation Scotland: Scottish Family Health Study

scientific article

Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia

scientific article published on 7 August 2017

Proportion of Idiopathic Pulmonary Fibrosis Risk Explained by Known Common Genetic Loci in European Populations

scientific article published on 23 November 2020

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scholarly article published in Nature Genetics

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

erratum

Rare variants and cardiovascular disease

scientific article published on 26 April 2014

Recurrent mutation at the classical haptoglobin structural polymorphism

scientific article

Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post–COVID-19 Study

scientific article published in 2023

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

scientific article

Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls

scientific article

The UK10K project identifies rare variants in health and disease

scientific article

The causal relationship between gastro-oesophageal reflux disease and idiopathic pulmonary fibrosis: a bidirectional two-sample Mendelian randomisation study

scientific article published in 2023

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci ⬇️

scientific article

The vitamin D binding protein axis modifies disease severity in lymphangioleiomyomatosis

scientific article published on 01 November 2018

Topical dihydrotestosterone to treat micropenis secondary to partial androgen insensitivity syndrome (PAIS) before, during, and after puberty - a case series

scientific article

Towards genetic reclassification of idiopathic pulmonary fibrosis

scientific article published on 08 June 2018

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

scientific article published on 12 September 2016

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

scientific article published on 21 December 2018

Translational genomics and precision medicine: Moving from the lab to the clinic

scientific article

Use of FEV1 as a measure of lung health in the UK BiLEVE study - Authors' reply

scientific article published in December 2015

What can genetics tell us about the cause of fixed airflow obstruction?

scientific article published on August 2012

Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction.

scientific article

Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants

scientific article published on 14 October 2020

List of works by Louise Wain

A Genome-wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos.

A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample

A large genome scan for rare CNVs in amyotrophic lateral sclerosis

Adaptation of HIV-1 to its human host.

Adjustment for index event bias in genome-wide association studies of subsequent events

Age at menarche and lung function: a Mendelian randomization study.

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

Causal Analyses, Statistical Efficiency And Phenotypic Precision Through Recall-By-Genotype Study Design

Chimpanzee reservoirs of pandemic and nonpandemic HIV-1

Cohort Profile: Extended Cohort for E-health, Environment and DNA (EXCEED)

Common Variation in the WNK1 Gene and Blood Pressure in Childhood

Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium

Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies

Copy number variation

Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma

Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome).

ERS International Congress 2018: highlights from best-abstract awardees

Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function.

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.

GSTCD and INTS12 regulation and expression in the human lung

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

Genetic variants affecting cross-sectional lung function in adults show little or no effect on longitudinal lung function decline

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

Genome-wide association analysis identifies six new loci associated with forced vital capacity

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

Genome-wide association studies in lung disease

Genome-wide association study identifies five loci associated with lung function

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

Genome-wide association study of copy number variation with lung function identifies a novel signal of association near BANP for forced vital capacity

Genome-wide association study to identify genetic determinants of severe asthma.

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function

Genomic copy number variation, human health, and disease

Haplotype estimation for biobank-scale data sets

Human CCL3L1 copy number variation, gene expression, and the role of the CCL3L1-CCR5 axis in lung function.

Identification of a missense variant in SPDL1 associated with idiopathic pulmonary fibrosis

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

Integrative pathway genomics of lung function and airflow obstruction

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function ⬇️

Meta-analysis of exome array data identifies six novel genetic loci for lung function

Meta-analysis of exome array data identifies six novel genetic loci for lung function

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study

Molecular mechanisms underlying variations in lung function: a systems genetics analysis

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank

Overlap of Genetic Risk between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis

Pedigree and genotyping quality analyses of over 10,000 DNA samples from the Generation Scotland: Scottish Family Health Study

Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia

Proportion of Idiopathic Pulmonary Fibrosis Risk Explained by Known Common Genetic Loci in European Populations

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Rare variants and cardiovascular disease

Recurrent mutation at the classical haptoglobin structural polymorphism

Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post–COVID-19 Study

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls

The UK10K project identifies rare variants in health and disease

The causal relationship between gastro-oesophageal reflux disease and idiopathic pulmonary fibrosis: a bidirectional two-sample Mendelian randomisation study

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci ⬇️

The vitamin D binding protein axis modifies disease severity in lymphangioleiomyomatosis

Topical dihydrotestosterone to treat micropenis secondary to partial androgen insensitivity syndrome (PAIS) before, during, and after puberty - a case series

Towards genetic reclassification of idiopathic pulmonary fibrosis

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension