List of works by Francisco Jose Ortega

A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG

scientific article published on 13 December 2021

A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction

scientific article published on 21 August 2013

Adipocyte lipopolysaccharide binding protein (LBP) is linked to a specific lipidomic signature

scientific article

Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence

scientific article published on 16 November 2018

Adipose tissue TSH as a new modulator of human adipocyte mitochondrial function

scientific article published on 11 September 2018

Adipose tissue μ-crystallin is a thyroid hormone-binding protein associated with systemic insulin sensitivity

scientific article published on 24 July 2014

Ageing influences the relationship of circulating miR-33a and miR- 33b levels with insulin resistance and adiposity

scientific article published on 11 December 2018

Alarmin high-mobility group B1 (HMGB1) is regulated in human adipocytes in insulin resistance and influences insulin secretion in β-cells

article

Altered Circulating miRNA Expression Profile in Pregestational and Gestational Obesity.

scientific article published on 25 September 2015

Analysis of miRNA signatures in CSF identifies upregulation of miR-21 and miR-146a/b in patients with multiple sclerosis and active lesions

scientific article published on 14 November 2019

Association of circulating lactoferrin concentration and 2 nonsynonymous LTF gene polymorphisms with dyslipidemia in men depends on glucose-tolerance status

scientific article published on 21 December 2007

Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making

scientific article published on 20 May 2019

Bariatric surgery acutely changes the expression of inflammatory and lipogenic genes in obese adipose tissue

scientific article published on 24 August 2015

Breast cancer 1 (BrCa1) may be behind decreased lipogenesis in adipose tissue from obese subjects

scientific article

CIDEC/FSP27 and PLIN1 gene expression run in parallel to mitochondrial genes in human adipose tissue, both increasing after weight loss.

scientific article published on 12 September 2013

CISD1 in association with obesity-associated dysfunctional adipogenesis in human visceral adipose tissue.

scientific article published on January 2016

Changes in circulating microRNAs are associated with childhood obesity.

scientific article published on 8 August 2013

Characterization of herpes virus entry mediator as a factor linked to obesity

scientific article published on 13 August 2009

Circulating glucagon is associated with inflammatory mediators in metabolically compromised subjects

scientific article published on 28 July 2011

Circulating irisin levels are positively associated with metabolic risk factors in sedentary subjects

scientific article published on 21 April 2015

Circulating microRNA profile as a potential biomarker for obstructive sleep apnea diagnosis

scientific article published on 17 September 2019

Circulating omentin as a novel biomarker of endothelial dysfunction

scientific article published on 03 February 2011

Circulating osteocalcin concentrations are associated with parameters of liver fat infiltration and increase in parallel to decreased liver enzymes after weight loss

scientific article published on 4 March 2010

Circulating pigment epithelium-derived factor levels are associated with insulin resistance and decrease after weight loss

scientific article published on 14 July 2010

Circulating profiling reveals the effect of a polyunsaturated fatty acid-enriched diet on common microRNAs.

scientific article published on 30 May 2015

Circulating soluble CD36 is a novel marker of liver injury in subjects with altered glucose tolerance.

scientific article

Circulating soluble transferrin receptor concentration decreases after exercise-induced improvement of insulin sensitivity in obese individuals.

scientific article published on 2 June 2009

Circulating tryptase as a marker for subclinical atherosclerosis in obese subjects.

scientific article

Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance

scientific article

Comment on: jejunal long noncoding RNAs are associated with glycemic control via gut-brain axis after bariatric surgery in diabetic mice

scientific article published on 17 April 2018

Common genetic variants of surfactant protein-D (SP-D) are associated with type 2 diabetes

scientific article

Comparative and functional analysis of plasma membrane-derived extracellular vesicles from obese vs. nonobese women

scientific article published on 17 April 2019

Complement factor H is expressed in adipose tissue in association with insulin resistance

scientific article

Coxsackie and adenovirus receptor is increased in adipose tissue of obese subjects: a role for adenovirus infection?

scientific article published on 2 December 2014

Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function

scientific article published on 30 May 2019

Cytosolic aconitase activity sustains adipogenic capacity of adipose tissue connecting iron metabolism and adipogenesis

scientific article published on 30 December 2014

DBC1 is involved in adipocyte inflammation and is a possible marker of human adipose tissue senescence.

scientific article published on 13 February 2015

Decision Making Impairment: A Shared Vulnerability in Obesity, Gambling Disorder and Substance Use Disorders?

scientific article

Decrease in FASN expression in adipose tissue of hypertensive individuals

scientific article published on 22 October 2009

Decreased RB1 mRNA, protein, and activity reflect obesity-induced altered adipogenic capacity in human adipose tissue.

scientific article published on 11 January 2013

Decreased STAMP2 expression in association with visceral adipose tissue dysfunction

scientific article published on 17 August 2011

Decreased TLR3 in Hyperplastic Adipose Tissue, Blood and Inflamed Adipocytes is Related to Metabolic Inflammation

scientific article published on 26 November 2018

Decreased circulating lactoferrin in insulin resistance and altered glucose tolerance as a possible marker of neutrophil dysfunction in type 2 diabetes.

scientific article published on 7 July 2009

Decreased lipid metabolism but increased FA biosynthesis are coupled with changes in liver microRNAs in obese subjects with NAFLD.

scientific article

Decreased serum creatinine concentration is associated with short telomeres of adipose tissue cells

scientific article published on 24 February 2011

Deleted in breast cancer 1 plays a functional role in adipocyte differentiation.

scientific article published on 3 February 2015

Dietary intake of bioactive ingredients impacts liver and adipose tissue transcriptomes in a porcine model of prepubertal early obesity

scientific article published on 25 March 2020

Dysregulation of Placental miRNA in Maternal Obesity Is Associated With Pre- and Postnatal Growth

scientific article published on 20 March 2017

Enduring Changes in Decision Making in Patients with Full Remission from Anorexia Nervosa.

scientific article published on 31 August 2016

Environmental and genetic factors influence the relationship between circulating IL-10 and obesity phenotypes

scientific article published in October 2009

Extracellular Vesicles from Hypoxic Adipocytes and Obese Subjects Reduce Insulin-Stimulated Glucose Uptake.

scientific article published on 2 January 2018

Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer

scientific article published on 30 January 2009

Ferroportin mRNA is down-regulated in granulosa and cervical cells from infertile women

scientific article published on 11 November 2016

Fine-tuned iron availability is essential to achieve optimal adipocyte differentiation and mitochondrial biogenesis

scientific article published on 29 June 2014

Genetic variations of the bitter taste receptor TAS2R38 are associated with obesity and impact on single immune traits.

scientific article published on 27 May 2016

Gut Microbiota Interacts with Markers of Adipose Tissue Browning, Insulin Action and Plasma Acetate in Morbid Obesity.

scientific article published on 3 November 2017

HMOX1 as a marker of iron excess-induced adipose tissue dysfunction, affecting glucose uptake and respiratory capacity in human adipocytes.

scientific article

Heme Biosynthetic Pathway is Functionally Linked to Adipogenesis via Mitochondrial Respiratory Activity

scientific article published on 31 August 2017

Hepatic iron content is independently associated with serum hepcidin levels in subjects with obesity

scientific article published on 29 September 2016

Hydrogen sulfide impacts on inflammation-induced adipocyte dysfunction

scientific article published on 30 May 2019

Identification and validation of circulating miRNAs as endogenous controls in obstructive sleep apnea

scientific article published on 13 March 2019

Increased adipose tissue heme levels and exportation are associated with altered systemic glucose metabolism

scientific article

Inflammation and insulin resistance exert dual effects on adipose tissue tumor protein 53 expression

scientific article published on 03 September 2013

Inflammation in adipose tissue and fatty acid anabolism: when enough is enough!

scientific article

Inflammation in the spotlight-clinical relevance of genetic variants affecting nuclear factor κB and tumor necrosis factor receptor 1.

scientific article published on May 2017

Inflammation triggers specific microRNA profiles in human adipocytes and macrophages and in their supernatants

scientific article published on 24 April 2015

Insulin resistance is associated with decreased circulating mannan-binding lectin concentrations in women with polycystic ovary syndrome

scientific article published on 01 April 2008

Insulin resistance modulates iron-related proteins in adipose tissue

scientific article published on 04 February 2014

Interaction Between Orexin-A and Sleep Quality in Females in Extreme Weight Conditions.

scientific article

Inverse relation between FASN expression in human adipose tissue and the insulin resistance level

scientific article

Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance

scientific article published on 22 February 2013

Iron and obesity status-associated insulin resistance influence circulating fibroblast-growth factor-23 concentrations

scientific article

LIGHT is associated with hypertriglyceridemia in obese subjects and increased cytokine secretion from cultured human adipocytes

scientific article published on 29 September 2009

Lactoferrin gene knockdown leads to similar effects to iron chelation in human adipocytes

scientific article published on 26 February 2014

Lactoferrin increases (172Thr)AMPK phosphorylation and insulin-induced (p473Ser)AKT while impairing adipocyte differentiation

scientific article

Lean mass, and not fat mass, is an independent determinant of carotid intima media thickness in obese subjects

scientific article published on 9 September 2015

Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation.

scientific article published on 23 July 2015

Lipopolysaccharide-binding protein and soluble CD14 in the vitreous fluid of patients with proliferative diabetic retinopathy.

scientific article published in February 2010

Liver, but not adipose tissue PEDF gene expression is associated with insulin resistance

scientific article published on 15 January 2013

Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance.

scientific article published in December 2009

Metabolomics uncovers the role of adipose tissue PDXK in adipogenesis and systemic insulin sensitivity

scientific article published on 2 February 2016

MiRNA expression profile of human subcutaneous adipose and during adipocyte differentiation

scientific article

MicroRNA-221-3p Regulates Angiopoietin-Like 8 (ANGPTL8) Expression in Adipocytes

scientific article

Modulation of Irisin and Physical Activity on Executive Functions in Obesity and Morbid obesity

scientific article published on August 2016

Modulation of SHBG binding to testosterone and estradiol by sex and morbid obesity.

scientific article published on 11 January 2017

Morbidly obese subjects show increased serum sulfide in proportion to fat mass

scientific article published on 10 October 2020

Neuregulin 4 Is a Novel Marker of Beige Adipocyte Precursor Cells in Human Adipose Tissue

scientific article published on 31 January 2019

OCT1 Expression in adipocytes could contribute to increased metformin action in obese subjects. ⬇️

scientific article

Obesity Is Associated With Gene Expression and Imaging Markers of Iron Accumulation in Skeletal Muscle

scientific article published on 14 January 2016

Orexin and sleep quality in anorexia nervosa: Clinical relevance and influence on treatment outcome

scientific article published on 21 December 2015

PRDM16 sustains white fat gene expression profile in human adipocytes in direct relation with insulin action.

scientific article

Phosphorylated S6K1 (Thr389) is a molecular adipose tissue marker of altered glucose tolerance.

scientific article published on 15 June 2012

Proadipogenic effects of lactoferrin in human subcutaneous and visceral preadipocytes

scientific article published on 04 February 2011

Profiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization

scientific article published on 29 January 2014

Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.

scientific article published on 27 May 2019

Resistance training improves cardiovascular risk factors in obese women despite a significative decrease in serum adiponectin levels

scientific article published on 27 August 2009

Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity.

scientific article

Serum and urinary concentrations of calprotectin as markers of insulin resistance and type 2 diabetes

scientific article published on 20 July 2012

Serum lipopolysaccharide-binding protein as a marker of atherosclerosis

scientific article

Smell-taste dysfunctions in extreme weight/eating conditions: analysis of hormonal and psychological interactions.

scientific article published on 22 July 2015

Study of caveolin-1 gene expression in whole adipose tissue and its subfractions and during differentiation of human adipocytes.

scientific article

Study of circulating prohepcidin in association with insulin sensitivity and changing iron stores

scientific article

Study of lactoferrin gene expression in human and mouse adipose tissue, human preadipocytes and mouse 3T3-L1 fibroblasts. Association with adipogenic and inflammatory markers

scientific article published on 17 January 2013

Study of the proinflammatory role of human differentiated omental adipocytes.

scientific article

Subcutaneous fat shows higher thyroid hormone receptor-alpha1 gene expression than omental fat.

scientific article published on 9 April 2009

Surgery-Induced Weight Loss Is Associated With the Downregulation of Genes Targeted by MicroRNAs in Adipose Tissue.

scientific article published on 7 August 2015

TSHB mRNA is linked to cholesterol metabolism in adipose tissue.

scientific article published on 23 June 2017

Targeting the association of calgranulin B (S100A9) with insulin resistance and type 2 diabetes

scientific article published on 4 December 2012

Targeting the circulating microRNA signature of obesity.

scientific article

Telomere length of subcutaneous adipose tissue cells is shorter in obese and formerly obese subjects.

scientific article published on 16 March 2010

The MRC1/CD68 ratio is positively associated with adipose tissue lipogenesis and with muscle mitochondrial gene expression in humans

scientific article

The Trp64Arg β3-adrenergic receptor gene polymorphism is associated with endothelium-dependent vasodilatation

scientific article published on 27 March 2014

The alarm secretory leukocyte protease inhibitor increases with progressive metabolic dysfunction

scientific article published on 04 March 2011

The gene expression of the main lipogenic enzymes is downregulated in visceral adipose tissue of obese subjects.

scientific article published on 18 June 2009

The lung innate immune gene surfactant protein-D is expressed in adipose tissue and linked to obesity status.

scientific article published on 12 March 2013

The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training

scientific article published on 14 October 2008

Thyroid Hormone Receptors Are Differentially Expressed in Granulosa and Cervical Cells of Infertile Women.

scientific article published on 30 December 2015

Thyroid hormone receptor alpha gene variants increase the risk of developing obesity and show gene-diet interactions

scientific article published on 12 February 2013

Thyroid hormone responsive Spot 14 increases during differentiation of human adipocytes and its expression is down-regulated in obese subjects

scientific article published on 22 December 2009

Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression

scientific article published on 25 September 2014

Transferrin receptor-1 gene polymorphisms are associated with type 2 diabetes

scientific article published on 23 May 2010

Type I iodothyronine 5'-deiodinase mRNA and activity is increased in adipose tissue of obese subjects.

scientific article published on 24 May 2011

Val1483Ile in FASN gene is linked to central obesity and insulin sensitivity in adult white men.

scientific article published on 19 March 2009

miRNAs in cerebrospinal fluid identify patients with MS and specifically those with lipid-specific oligoclonal IgM bands

scientific article published in January 2017

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