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List of works by Violeta Serra

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

scientific article

A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation

scientific article published on 01 December 2018

A decade of clinical development of PARP inhibitors in perspective

scientific article published on 01 September 2019

AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

scientific article

Accelerated telomere shortening in Fanconi anemia fibroblasts--a longitudinal study

scientific article

Activity of HSP90 Inhibiton in a Metastatic Lung Cancer Patient With a Germline BRCA1 Mutation

scientific article published on 26 February 2018

Analysis of gene expression profiles in melanoma cells with acquired resistance against antineoplastic drugs

scientific article published on April 2006

Antitumor activity of the Hsp90 inhibitor IPI-504 in HER2-positive trastuzumab-resistant breast cancer

scientific article published on 7 March 2011

BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance

scientific article published on 11 December 2019

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

scientific article published on 25 July 2016

CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer

scientific article published in November 2016

Cancer network activity associated with therapeutic response and synergism

scientific article published on 24 August 2016

Chromosome 12p Amplification in Triple-Negative/BRCA1-Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity

scientific article published on 18 June 2019

Clinical consequences of BRCA2 hypomorphism

publication published on 09 September 2021

Clinical impact of aortic regurgitation after transcatheter aortic valve replacement: insights into the degree and acuteness of presentation

scientific article published in September 2014

Clinical response to a lapatinib-based therapy for a Li-Fraumeni syndrome patient with a novel HER2V659E mutation.

scientific article

Coamplification of miR-4728 protects HER2-amplified breast cancers from targeted therapy.

scientific article published on 23 February 2018

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

scientific article published on 07 January 2021

Controversies in oncology: are genomic tests quantifying homologous recombination repair deficiency (HRD) useful for treatment decision making?

scientific article

Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients

scientific article

Development of PI3K inhibitors: lessons learned from early clinical trials

scientific article published on 12 February 2013

Direct CDKN2 Modulation of CDK4 Alters Target Engagement of CDK4 Inhibitor Drugs

scientific article published on 05 March 2019

Dual mTORC1/2 and HER2 blockade results in antitumor activity in preclinical models of breast cancer resistant to anti-HER2 therapy

scientific article

Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor-Positive Breast Cancer

scientific article

Effect of p95HER2/611CTF on the response to trastuzumab and chemotherapy.

scientific article

Evaluation and clinical analyses of downstream targets of the Akt inhibitor GDC-0068.

scientific article published on 18 October 2013

Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening

scientific article

Functional transcriptomics: an experimental basis for understanding the systems biology for cancer cells.

scientific article published on March 2007

Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity

scientific article

Genetic alterations in the PI3K/AKT pathway and baseline AKT activity define AKT inhibitor sensitivity in breast cancer patient-derived xenografts

scientific article published on 27 March 2020

High HER2 expression correlates with response to the combination of lapatinib and trastuzumab.

scientific article published on 2 December 2014

Homologous Recombination Repair Deficiency and the Immune Response in Breast Cancer: A Literature Review

scientific article published on 02 January 2020

Human fibroblasts in vitro senesce with a donor-specific telomere length

scientific article published in April 2002

In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer

scientific article published in Nature Communications

Interrogating open issues in cancer medicine with patient-derived xenografts

scientific article published on 15 September 2017

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

scientific article published on 20 January 2017

Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

scientific article published on 31 March 2021

Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies.

scientific article

MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer.

scientific article published on 13 August 2015

MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer

scientific article

Methodological aspects of the molecular and histological study of prostate cancer: focus on PTEN

scientific article

Modulation of telomere protection by the PI3K/AKT pathway

scientific article published on 2 November 2017

Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy

scientific article published on 03 May 2019

Multicenter Phase II Study of Lurbinectedin in BRCA-Mutated and Unselected Metastatic Advanced Breast Cancer and Biomarker Assessment Substudy

scientific article published on 21 September 2018

NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

scientific article

PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition

scientific article published on 22 August 2012

PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

scientific article

PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer

scientific article published on April 2015

PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.

scientific article published on 24 October 2016

Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.

scientific article published on November 2008

Picking the point of inhibition: a comparative review of PI3K/AKT/mTOR pathway inhibitors

scientific article published on 18 April 2014

Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival.

scientific article

RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA mutated breast cancer.

scientific article published on 4 April 2018

RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer

scientific article published on May 2013

RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer.

scientific article published on 3 March 2014

Resistance to Taxanes in Triple-Negative Breast Cancer Associates with the Dynamics of a CD49f+ Tumor-Initiating Population

scientific article

Sensitizing HR-proficient cancers to PARP inhibitors

scientific article published on 3 March 2017

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells ⬇️

scientific article published on 18 July 2018

Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?

scientific article published in November 2000

Stratification and therapeutic potential of PML in metastatic breast cancer

scientific article

TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence

scientific article published on 06 August 2018

Targeting a cell state common to triple-negative breast cancers

scientific article

Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells.

scientific article

Targeting the fibroblast growth factor receptor 2 in gastric cancer: promise or pitfall?

scientific article published on 07 March 2017

Targeting the fibroblast growth factor receptor 2 in gastric cancer: promise or pitfall?

scientific article published on 2 January 2018

Telomere length as a marker of oxidative stress in primary human fibroblast cultures

article

Telomere shortening in human fibroblasts is not dependent on the size of the telomeric-3'-overhang

scientific article published in June 2004

The Altered Transcriptome and DNA Methylation Profiles of Docetaxel Resistance in Breast Cancer PDX Models

scientific article published on 18 July 2019

The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

scientific article published on May 2016

The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP1.

scientific article published on March 2006

Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors

scientific article published on 13 May 2020

mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer

scientific article published on July 2013

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.

scientific article published on 28 June 2017

p95HER2-T cell bispecific antibody for breast cancer treatment

scientific article published on 01 October 2018

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