List of works - Gauri J Sabnis

A nude mouse model of obesity to study the mechanisms of resistance to aromatase inhibitors

scientific article

Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole

scientific article published on June 2005

Adaptive changes result in activation of alternate signaling pathways and acquisition of resistance to aromatase inhibitors

scientific article

Adaptive changes results in activation of alternate signaling pathways and resistance to aromatase inhibitor resistance

scientific article published on 16 September 2010

Advances in mechanisms of resistance to aromatase inhibitors

scientific article published on 22 February 2014

Aromatase and breast cancer

scientific article published in 2006

Aromatase inhibitors and breast cancer

Aromatase inhibitors and xenograft studies

scientific article

Aromatase resistance mechanisms in model systems in vivo

scientific article

Aromatase, aromatase inhibitors, and breast cancer

scientific article published in 2011

Combination of anastrozole with fulvestrant in the intratumoral aromatase xenograft model

scientific article published in May 2008

Combined cancer therapy: strategies to overcome acquired aromatase inhibitor resistance

scientific article

Design, synthesis, and evaluation of novel mutual prodrugs (hybrid drugs) of all-trans-retinoic acid and histone deacetylase inhibitors with enhanced anticancer activities in breast and prostate cancer cells in vitro.

scientific article

Effect of selumetinib on the growth of anastrozole-resistant tumors

scientific article published on 19 March 2013

Extending aromatase inhibitor sensitivity in hormone resistant breast cancer

scientific article published on 01 March 2011

Functional activation of the estrogen receptor-α and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letrozole

scientific article

GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells

scientific article

HDAC inhibitor entinostat restores responsiveness of letrozole-resistant MCF-7Ca xenografts to aromatase inhibitors through modulation of Her-2

scientific article published on 03 October 2013

Histone Deacetylase Inhibitor Entinostat Inhibits Tumor-Initiating Cells in Triple-Negative Breast Cancer Cells

scientific article published on 2 June 2015

Histone deacetylase inhibitor entinostat in combination with a retinoid downregulates HER2 and reduces the tumor initiating cell population in aromatase inhibitor-resistant breast cancer

scientific article

Histone deacetylase inhibitor entinostat reverses epithelial to mesenchymal transition of breast cancer cells by reversing the repression of E-cadherin

scientific article published on 5 December 2013

Inhibition of the phosphatidylinositol 3-kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens

scientific article published on May 2007

Intrauterine growth retardation associated with precocious puberty and sertoli cell hyperplasia

scientific article

Model systems: mechanisms involved in the loss of sensitivity to letrozole

scientific article published in May 2005

Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer

scientific article published on 29 January 2014

Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth.

scientific article

Preclinical modeling of endocrine response and resistance: focus on aromatase inhibitors

scientific article published in February 2008

Prepubertal gynaecomastia caused by medication or the aromatase excess syndrome

scientific article published on 01 December 2004

Progress in aromatase research and identification of key future directions

scientific article

Prolonging hormone sensitivity in prostate cancer xenografts through dual inhibition of AR and mTOR.

scientific article

Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole

scientific article published on August 2006

Sensitivity to the aromatase inhibitor letrozole is prolonged after a "break" in treatment

scientific article

Seribantumab, an Anti-ERBB3 Antibody, Delays the Onset of Resistance and Restores Sensitivity to Letrozole in an Estrogen Receptor-Positive Breast Cancer Model

scientific article published on 26 August 2015

Stopping treatment can reverse acquired resistance to letrozole

scientific article published on June 2008

Synergistic effect of a novel antiandrogen, VN/124-1, and signal transduction inhibitors in prostate cancer progression to hormone independence in vitro.

scientific article published on January 2008

Synthesis and in vitro Characterization of Semitelechelic Poly[N-(2-hydroxypropyl)methacrylamide]-Trastuzumab Conjugates Targeted to Breast Cancer

scientific article published on 25 August 2011

The Coffey Lecture: steroidogenic enzyme inhibitors and hormone dependent cancer

scientific article

The importance of HER2 signaling in the tumor-initiating cell population in aromatase inhibitor-resistant breast cancer

scientific article

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

scientific article

The role of growth factor receptor pathways in human breast cancer cells adapted to long-term estrogen deprivation

scientific article

Therapeutic observations in MCF-7 aromatase xenografts.

scientific article

Toremifene-atamestane; alone or in combination: predictions from the preclinical intratumoral aromatase model

scientific article

Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen

scientific article published on 03 February 2009

Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery

scientific article

Understanding resistance to endocrine agents: molecular mechanisms and potential for intervention

scientific article

Upregulation of AIB1, aromatase and ERα provides long-term estrogen-deprived human breast cancer cells with a mechanistic growth advantage for survival

scientific article

Xenograft models for aromatase inhibitor studies

scientific article

mTOR inhibitors: changing landscape of endocrine-resistant breast cancer

scientific article published on February 2014

List of works by Gauri J Sabnis

A nude mouse model of obesity to study the mechanisms of resistance to aromatase inhibitors

Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole

Adaptive changes result in activation of alternate signaling pathways and acquisition of resistance to aromatase inhibitors

Adaptive changes results in activation of alternate signaling pathways and resistance to aromatase inhibitor resistance

Advances in mechanisms of resistance to aromatase inhibitors

Aromatase and breast cancer

Aromatase inhibitors and breast cancer

Aromatase inhibitors and xenograft studies

Aromatase resistance mechanisms in model systems in vivo

Aromatase, aromatase inhibitors, and breast cancer

Combination of anastrozole with fulvestrant in the intratumoral aromatase xenograft model

Combined cancer therapy: strategies to overcome acquired aromatase inhibitor resistance

Design, synthesis, and evaluation of novel mutual prodrugs (hybrid drugs) of all-trans-retinoic acid and histone deacetylase inhibitors with enhanced anticancer activities in breast and prostate cancer cells in vitro.

Effect of selumetinib on the growth of anastrozole-resistant tumors

Extending aromatase inhibitor sensitivity in hormone resistant breast cancer

Functional activation of the estrogen receptor-α and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letrozole

GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells

HDAC inhibitor entinostat restores responsiveness of letrozole-resistant MCF-7Ca xenografts to aromatase inhibitors through modulation of Her-2

Histone Deacetylase Inhibitor Entinostat Inhibits Tumor-Initiating Cells in Triple-Negative Breast Cancer Cells

Histone deacetylase inhibitor entinostat in combination with a retinoid downregulates HER2 and reduces the tumor initiating cell population in aromatase inhibitor-resistant breast cancer

Histone deacetylase inhibitor entinostat reverses epithelial to mesenchymal transition of breast cancer cells by reversing the repression of E-cadherin

Inhibition of the phosphatidylinositol 3-kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens

Intrauterine growth retardation associated with precocious puberty and sertoli cell hyperplasia

Model systems: mechanisms involved in the loss of sensitivity to letrozole

Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer

Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth.

Preclinical modeling of endocrine response and resistance: focus on aromatase inhibitors

Prepubertal gynaecomastia caused by medication or the aromatase excess syndrome

Progress in aromatase research and identification of key future directions

Prolonging hormone sensitivity in prostate cancer xenografts through dual inhibition of AR and mTOR.

Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole

Sensitivity to the aromatase inhibitor letrozole is prolonged after a "break" in treatment

Seribantumab, an Anti-ERBB3 Antibody, Delays the Onset of Resistance and Restores Sensitivity to Letrozole in an Estrogen Receptor-Positive Breast Cancer Model

Stopping treatment can reverse acquired resistance to letrozole

Synergistic effect of a novel antiandrogen, VN/124-1, and signal transduction inhibitors in prostate cancer progression to hormone independence in vitro.

Synthesis and in vitro Characterization of Semitelechelic Poly[N-(2-hydroxypropyl)methacrylamide]-Trastuzumab Conjugates Targeted to Breast Cancer

The Coffey Lecture: steroidogenic enzyme inhibitors and hormone dependent cancer

The importance of HER2 signaling in the tumor-initiating cell population in aromatase inhibitor-resistant breast cancer

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

The role of growth factor receptor pathways in human breast cancer cells adapted to long-term estrogen deprivation

Therapeutic observations in MCF-7 aromatase xenografts.

Toremifene-atamestane; alone or in combination: predictions from the preclinical intratumoral aromatase model

Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen

Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery

Understanding resistance to endocrine agents: molecular mechanisms and potential for intervention

Upregulation of AIB1, aromatase and ERα provides long-term estrogen-deprived human breast cancer cells with a mechanistic growth advantage for survival

Xenograft models for aromatase inhibitor studies

mTOR inhibitors: changing landscape of endocrine-resistant breast cancer