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List of works by Patricia H Janak

A causal link between prediction errors, dopamine neurons and learning

scientific article

A microdialysis study of extracellular levels of acamprosate and naltrexone in the rat brain following acute and repeated administration

scientific article

A quantitative reward prediction error signal in the ventral pallidum

scientific article published on 10 August 2020

Acamprosate attenuates cocaine- and cue-induced reinstatement of cocaine-seeking behavior in rats.

scientific article

Activity patterns in mesolimbic regions in rats during operant tasks for reward.

scientific article

Alcohol seeking in C57BL/6 mice induced by conditioned cues and contexts in the extinction-reinstatement model.

scientific article published in February 2006

Alcohol-Seeking Triggered by Discrete Pavlovian Cues is Invigorated by Alcohol Contexts and Mediated by Glutamate Signaling in the Basolateral Amygdala

scientific article published on 8 May 2015

Alpha4 subunit-containing GABAA receptors in the accumbens shell contribute to the reinforcing effects of alcohol

scientific article published on 20 April 2011

Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol

scientific article published on January 2009

Amygdala neural encoding of the absence of reward during extinction.

scientific article published in January 2010

Amygdala neurons differentially encode motivation and reinforcement

scientific article

Anxiogenic and aversive effects of corticotropin-releasing factor (CRF) in the bed nucleus of the stria terminalis in the rat: role of CRF receptor subtypes.

scientific article

BIG news in alcohol addiction: new findings on growth factor pathways BDNF, insulin, and GDNF.

scientific article published in February 2006

Behavioral assessment of forgetting in aged rodents and its relationship to peripheral sympathetic function

scientific article published on September 1988

Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H.

scientific article published on August 2009

Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor.

scientific article

Cocaine and amphetamine facilitate retention of jump-up responding in rats

scientific article published in April 1992

Cocaine enhances one-way avoidance responding in mice

scientific article published in April 1992

Cocaine enhances retention of avoidance conditioning in rats

scientific article published in January 1992

Cocaine impairs acquisition of an autoshaped lever-touch response

scientific article published in April 1997

Comparison of mesocorticolimbic neuronal responses during cocaine and heroin self-administration in freely moving rats.

scientific article published in April 1998

Comparison of reinstatement of ethanol- and sucrose-seeking by conditioned stimuli and priming injections of allopregnanolone after extinction in rats

scientific article published on 29 April 2003

Comparison of the effects of allopregnanolone with direct GABAergic agonists on ethanol self-administration with and without concurrently available sucrose

scientific article published in May 2003

Compound stimulus presentation and the norepinephrine reuptake inhibitor atomoxetine enhance long-term extinction of cocaine-seeking behavior.

scientific article published on 16 November 2011

Context is a trigger for relapse to alcohol.

scientific article published on 26 October 2005

Context-induced relapse of conditioned behavioral responding to ethanol cues in rats.

scientific article

Deepened extinction following compound stimulus presentation: noradrenergic modulation.

scientific article

Dissociable roles of the medial prefrontal cortex and nucleus accumbens core in goal-directed actions for differential reward magnitude

scientific article published on 22 March 2010

Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training

scientific article published on 17 October 2019

Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties

scientific article published on 23 July 2018

Downregulation of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice

scientific article

Dynamics of neural coding in the accumbens during extinction and reinstatement of rewarded behavior

scientific article

Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake

scientific article

Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice

scientific article published on July 2004

Enkephalin influences on behavioral and neural plasticity: mechanisms of action.

scientific article published on January 1990

Escalating ethanol intake is associated with altered corticostriatal BDNF expression

scientific article

Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons

scientific article

Establishing causality for dopamine in neural function and behavior with optogenetics ⬇️

scientific article published on September 29, 2012

Ethanol action on neural networks studied with multineuron recording in freely moving animals

scientific article published on February 1998

Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior.

scientific article published in March 2007

Ethanol operant self-administration in rats is regulated by adenosine A2 receptors

scientific article published in September 2004

Ethanol seeking triggered by environmental context is attenuated by blocking dopamine D1 receptors in the nucleus accumbens core and shell in rats.

scientific article published on 25 September 2009

Ethanol-associated cues produce general pavlovian-instrumental transfer

scientific article published on 22 March 2007

Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake.

scientific article

From circuits to behaviour in the amygdala

scientific article

Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward

scientific article

GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse

scientific article

GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinence

scientific article published on 19 March 2009

General and outcome-specific forms of Pavlovian-instrumental transfer: the effect of shifts in motivational state and inactivation of the ventral tegmental area.

scientific article published on 14 November 2007

Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption

scientific article

Habitual alcohol seeking: time course and the contribution of subregions of the dorsal striatum

scientific article

Habitual responding for alcohol depends upon both AMPA and D2 receptor signaling in the dorsolateral striatum

scientific article

In vivo extracellular recording of striatal neurons in the awake rat following unilateral 6-hydroxydopamine lesions

scientific article published in September 2001

Inactivation of the lateral but not medial dorsal striatum eliminates the excitatory impact of Pavlovian stimuli on instrumental responding.

scientific article published in December 2007

Long-lasting contribution of dopamine in the nucleus accumbens core, but not dorsal lateral striatum, to sign-tracking.

scientific article published on 12 July 2017

Methylphenidate facilitates learning-induced amygdala plasticity

scientific article published on 7 March 2010

Microdialysis measurement of striatal dopamine levels in freely moving rats after cocaine or amphetamine treatment

scientific article published in January 1992

Microinjection of glycine into the ventral tegmental area selectively decreases ethanol consumption.

scientific article published on 11 January 2012

Neuroactive steroids and ethanol

scientific article published in July 2005

Neuronal and behavioral correlations in the medial prefrontal cortex and nucleus accumbens during cocaine self-administration by rats

scientific article published in January 2000

Neuronal responses in prefrontal cortex and nucleus accumbens during heroin self-administration in freely moving rats

scientific article published in April 1997

Neuronal spike activity in the nucleus accumbens of behaving rats during ethanol self-administration

scientific article

Neurosteroids mediate pharmacological effects of ethanol: a new mechanism of ethanol action?

scientific article published in December 1999

Nucleus Accumbens and Posterior Amygdala Mediate Cue-Triggered Alcohol Seeking and Suppress Behavior During the Omission of Alcohol-Predictive Cues.

scientific article

Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma

scholarly article

Nucleus accumbens plasticity underlies multifaceted behavioral changes associated with addiction.

scientific article

Occasion setters attain incentive motivational value: implications for contextual influences on reward-seeking

scientific article published on 15 July 2019

Only tyrosine-containing metabolites of [Leu]enkephalin impair active avoidance conditioning in mice

scientific article published on December 1990

Pavlovian-conditioned alcohol-seeking behavior in rats is invigorated by the interaction between discrete and contextual alcohol cues: implications for relapse.

scientific article published on 06 February 2014

Positive reinforcement mediated by midbrain dopamine neurons requires D1 and D2 receptor activation in the nucleus accumbens

scientific article

Positive relationship between activity in a novel environment and operant ethanol self-administration in rats.

scientific article published in May 2002

Posterior dorsomedial striatum is critical for both selective instrumental and Pavlovian reward learning

scientific article

RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction.

scientific article published in November 2004

Rapid decay of cocaine-induced behavioral sensitization of locomotor behavior

scientific article

Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning

scientific article published on 11 May 2008

Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement

scientific article

Recruitment and disruption of value encoding during alcohol seeking

Recruitment and disruption of ventral pallidal cue encoding during alcohol seeking

scientific article published on 19 August 2019

Reinstated ethanol-seeking in rats is modulated by environmental context and requires the nucleus accumbens core

scientific article

Responses to ethanol in C57BL/6 versus C57BL/6 × 129 hybrid mice.

scientific article published on January 2012

Reward activity in ventral pallidum tracks satiety-sensitive preference and drives choice behavior

scientific article published on 04 November 2020

Safety encoding in the basal amygdala

scientific article published on February 2013

Separable roles of the nucleus accumbens core and shell in context- and cue-induced alcohol-seeking.

scientific article

Similar neural activity during fear and disgust in the rat basolateral amygdala

scientific article

Stressing the other paraventricular nucleus

scientific article published on 01 July 2018

Substantial similarity in amygdala neuronal activity during conditioned appetitive and aversive emotional arousal.

scientific article

The Potent Effect of Environmental Context on Relapse to Alcohol-Seeking After Extinction

scientific article published on January 2010

The Small G Protein H-Ras in the Mesolimbic System Is a Molecular Gateway to Alcohol-Seeking and Excessive Drinking Behaviors ⬇️

scientific article published on November 7, 2012

The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption.

scientific article published in February 2006

The ethanol self-administration context as a reinstatement cue: acute effects of naltrexone.

scientific article published on 3 March 2006

The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism

scientific article published on 17 November 2004

The nucleus accumbens core and shell are critical for the expression, but not the consolidation, of Pavlovian conditioned approach.

scientific article

The orbitofrontal cortex as part of a hierarchical neural system mediating choice between two good options.

scientific article published in October 2013

The reinforcing effects of ethanol are altered by the endogenous neurosteroid, allopregnanolone

scientific article published in August 1998

Unilateral inactivation of the basolateral amygdala attenuates context-induced renewal of Pavlovian-conditioned alcohol-seeking

scientific article

Uptake and metabolism of [3H]-Leu-enkephalin following either its intraperitoneal or subcutaneous administration to mice

scientific article published in May 1992

Ventral pallidal encoding of reward-seeking behavior depends on the underlying associative structure

scientific article published on 22 March 2018

Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens

scientific article published in Nature Communications

[Leu]enkephalin enhances active avoidance conditioning in rats and mice

scientific article published in February 1994

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