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List of works by Edward L. LeCluyse

A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes

scientific article

A map of the PPARα transcription regulatory network for primary human hepatocytes

scientific article published on 22 November 2013

A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression

scientific article

Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel.

scientific article

Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol

scientific article (publication date: December 2006)

Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China

scientific article

Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor

scientific article published on 23 May 2003

Bioactivation and toxicity of acetaminophen in a rat hepatocyte micropatterned coculture system

scientific article published on 5 August 2013

CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans

scientific article

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

scientific article

Cloning, tissue expression, and regulation of beagle dog CYP4A genes

scientific article published on 4 May 2006

Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition

scientific article published in April 2003

Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells

article

Concurrent induction and mechanism-based inactivation of CYP3A4 by an L-valinamide derivative

scientific article published in September 2003

Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

scientific article

Differential UGT1A1 induction by chrysin in primary human hepatocytes and HepG2 Cells

scientific article published on 31 August 2005

Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor

scientific article published on 2 March 2006

Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers

scientific article published in November 1999

Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).

scientific article published on 06 September 2013

Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo

scientific article

Enhanced bioavailability of cefoxitin using palmitoylcarnitine. II. Use of directly compressed tablet formulations in the rat and dog

scientific article published on 01 October 1993

Evaluation of the effect of culture configuration on morphology, survival time, antioxidant status and metabolic capacities of cultured rat hepatocytes

scientific article published in February 2002

Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes.

scientific article published on 17 July 2008

Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes

scientific article published in May 2003

Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro

scientific article

Hepatic stem cells and hepatoblasts: identification, isolation, and ex vivo maintenance

scientific article

Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha

scientific article

Human PXR forms a tryptophan zipper-mediated homodimer

scientific article published on July 2006

Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran.

scientific article published on 12 August 2010

Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin

scientific article

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

scientific article published in July 2001

In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone

scientific article published on 01 October 2000

Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing

scientific article

Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.

scientific article published on 16 July 2010

Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes

scientific article published on December 2004

Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice.

scientific article published on 13 July 2013

Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes

scientific article (publication date: March 2004)

Long-term stability of primary rat hepatocytes in micropatterned cocultures

scientific article

Metabolism of arsenic in primary cultures of human and rat hepatocytes

scientific article published on 01 July 1999

Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers

scientific article published in March 2005

Organotypic liver culture models: meeting current challenges in toxicity testing

scientific article

P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide.

scientific article published in July 2004

Partial maintenance of taurocholate uptake by adult rat hepatocytes cultured in a collagen sandwich configuration

scientific article published on 01 October 1998

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

scientific article published on January 2007

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

scientific article published on 23 August 2013

Regeneration and maintenance of bile canalicular networks in collagen-sandwiched hepatocytes

scientific article published in April 2000

Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers

scientific article published on March 2004

Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions

scientific article

Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes

scientific article published on January 2009

Relationship between drug absorption enhancing activity and membrane perturbing effects of acylcarnitines

scientific article published on 01 January 1991

Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers

scientific article published on 13 October 2006

Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes.

scientific article published on January 2003

Selenium compounds modulate the activity of recombinant rat AsIII-methyltransferase and the methylation of arsenite by rat and human hepatocytes

scientific article published in March 2003

Sulfotransferase gene expression in primary cultures of rat hepatocytes

scientific article published in November 1996

Temporal kinetics and concentration-response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes.

scientific article

The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes

scientific article

The human sulfotransferase SULT1A1 gene is regulated in a synergistic manner by Sp1 and GA binding protein

scientific article

Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals

scientific article published on February 2010

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