List of works by David M. Ornitz

A combined series of Fgf9 and Fgf18 mutant alleles identifies unique and redundant roles in skeletal development

scientific article published on 16 January 2016

A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3.

scholarly article

A high-resolution radiation hybrid map of the proximal portion of mouse chromosome 5

scientific article published on 01 May 2000

A model for the pharmacological treatment of crouzon syndrome

scientific article published in July 2006

A twist code determines the onset of osteoblast differentiation

scientific journal article

Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse

scientific article published on 23 June 2005

Achondroplasia: Development, pathogenesis, and therapy.

scientific article published on 17 December 2016

An FGF-WNT gene regulatory network controls lung mesenchyme development

scientific journal article

An S116R Phosphorylation Site Mutation in Human Fibroblast Growth Factor-1 Differentially Affects Mitogenic and Glucose-Lowering Activities

scientific article

Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification

scientific article published on 03 June 2020

Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate.

scientific article

Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23

scientific article

Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14.

scientific article

BK1: an FGF-responsive central nervous system-derived cell line

scientific article published on January 1995

Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1.

scientific article

Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements.

scientific article published on February 1991

Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation.

scientific article

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

scientific article (publication date: 22 February 1991)

Characterization of the cell of origin and propagation potential of the fibroblast growth factor 9-induced mouse model of lung adenocarcinoma

scientific article published on 17 December 2014

Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival

scientific article published on 18 March 2016

Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling

scientific article

Conserved roles for Slit and Robo proteins in midline commissural axon guidance

scientific journal article

Crystal Structure of a Fibroblast Growth Factor Homologous Factor (FHF) Defines a Conserved Surface on FHFs for Binding and Modulation of Voltage-gated Sodium Channels

scientific article

Defective bone mineralization and osteopenia in young adult FGFR3-/- mice

scientific article published on 17 December 2003

Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments

scientific article published on 16 June 2021

Delineating a conserved genetic cassette promoting outgrowth of body appendages

scientific article (publication date: 2013)

Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal

scientific journal article

Digenic Variants in the FGF21 Signaling Pathway Associated with Severe Insulin Resistance and Pseudoacromegaly ⬇️

scientific article published on 22 September 2020

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

scientific article

Dual transgene expression in murine cerebellar Purkinje neurons by viral transduction in vivo

scientific article

Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty

scientific article

Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice

scientific article

Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo

scientific journal article

Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis.

scientific article

Endothelial fibroblast growth factor receptor signaling is required for vascular remodeling following cardiac ischemia-reperfusion injury

scientific article published on 8 January 2016

Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application

scientific article

Expression and biological activity of mouse fibroblast growth factor-9

scientific article

Expression and function of FGF10 in mammalian inner ear development

scientific article published on June 2003

FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin

scientific article published on 19 September 2012

FGF receptors 1 and 2 control chemically induced injury and compound detoxification in regenerating livers of mice

scientific article

FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands

scientific journal article

FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth.

scientific article published on 06 April 2016

FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis.

scientific article published on 19 December 2007

FGF signalling generates ventral telencephalic cells independently of SHH.

scientific article published on 3 July 2006

FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium

scientific article

FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons

scientific article published on October 2008

FGF20-FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti

scientific article published on 31 July 2020

FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms

scientific article published on April 2017

FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain

scientific article

FGF9 and FGF10 activate distinct signaling pathways to direct lung epithelial specification and branching

scientific article published on 03 March 2020

FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.

scientific article

FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network

scientific article published on 19 September 2007

FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion

scientific article published on 15 February 2009

FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod

scientific journal article

FGFs, heparan sulfate and FGFRs: complex interactions essential for development

scientific article

Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding

scientific article

Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination

scientific journal article

Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions

scientific journal article

Fgf9 signaling regulates small intestinal elongation and mesenchymal development.

scientific article published on 24 July 2008

Fgfr3 expression by astrocytes and their precursors: evidence that astrocytes and oligodendrocytes originate in distinct neuroepithelial domains

scientific article published in January 2003

Fibroblast Growth Factor 9 Regulation by MicroRNAs Controls Lung Development and Links DICER1 Loss to the Pathogenesis of Pleuropulmonary Blastoma.

scientific article published on 15 May 2015

Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs

scientific article

Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels ⬇️

scientific article

Fibroblast growth factor 2 is an essential cardioprotective factor in a closed-chest model of cardiac ischemia-reperfusion injury

scientific article

Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin

scientific article

Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels

scientific article

Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy

scientific article

Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation

scientific article

Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis

scientific journal article

Fibroblast growth factor receptor 3 gene transcription is suppressed by cyclic adenosine 3',5'-monophosphate. Identification of a chondrocytic regulatory element

scientific article

Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis

scientific article

Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain

scientific journal article

Fibroblast growth factor signaling in skeletal development and disease

scientific article (publication date: 15 July 2015)

Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development

scientific journal article

Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease ⬇️

scientific article published on October 12, 2010

Generation and validation of novel conditional flox and inducible Cre alleles targeting fibroblast growth factor 18 (Fgf18)

scientific article published on 22 July 2019

Genomic landscape of non-small cell lung cancer in smokers and never-smokers

scientific article published on September 2012

Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene

scientific article published in September 1999

Genomic structure, mapping, activity and expression of fibroblast growth factor 17

scientific article (publication date: May 1999)

Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia

scientific article published on June 1996

Healing of non-displaced fractures produced by fatigue loading of the mouse ulna.

scientific article

Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development

scientific article published in September 2008

Heparan and chondroitin sulfate on growth plate perlecan mediate binding and delivery of FGF-2 to FGF receptors

scientific article published on 06 November 2006

Heparin-induced self-association of fibroblast growth factor-2. Evidence for two oligomerization processes

scientific article published on 01 June 1997

High-resolution mapping of tlt, a mouse mutant lacking otoconia

scientific article published on 01 June 1999

Histomorphological study of palatal shelf elevation during murine secondary palate formation.

scientific article published on 26 May 2011

Homodimerization Controls the Fibroblast Growth Factor 9 Subfamily's Receptor Binding and Heparan Sulfate-Dependent Diffusion in the Extracellular Matrix

scientific article

Identification of a FGF18-expressing alveolar myofibroblast that is developmentally cleared during alveologenesis

scientific article published on 17 January 2020

Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members

scientific article

Impaired hippocampal synaptic transmission and plasticity in mice lacking fibroblast growth factor 14.

scientific article published on 8 January 2007

Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14

scientific article

In vitro calcite crystal morphology is modulated by otoconial proteins otolin-1 and otoconin-90.

scientific article

Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody.

scientific article published on 07 April 2016

Inhibition or activation of Apert syndrome FGFR2 (S252W) signaling by specific glycosaminoglycans

scientific article published on 22 December 2005

Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2.

scientific article published on 19 November 2015

Int-2, an autocrine and/or ultra-short-range effector in transgenic mammary tissue transplants.

scientific article published in June 1992

Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation

scientific article published in September 2002

Intracellular FGF14 (iFGF14) Is Required for Spontaneous and Evoked Firing in Cerebellar Purkinje Neurons and for Motor Coordination and Balance

scientific article published on April 2015

Lineage-specific evolution of the vertebrate Otopetrin gene family revealed by comparative genomic analyses

scientific article

Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome.

scientific article published in December 2000

Male-to-female sex reversal in mice lacking fibroblast growth factor 9

scientific article published on 01 March 2001

Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity

scientific article (publication date: 3 December 1999)

Mapping the mouse otoconin-90 (Oc90) gene to chromosome 15.

scientific article

Mesenchymal fibroblast growth factor receptor signaling regulates palatal shelf elevation during secondary palate formation

scientific article published on 6 August 2015

Mesothelial- and epithelial-derived FGF9 have distinct functions in the regulation of lung development.

scientific article

Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation.

scientific article published in November 2006

Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti

scientific article published on April 2006

Missense mutations in Otopetrin 1 affect subcellular localization and inhibition of purinergic signaling in vestibular supporting cells

scientific article

Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development

scientific article

Molecular mechanisms underlying ectopic otoconia-like particles in the endolymphatic sac of embryonic mice

scientific article published on 01 August 2004

Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation

scientific article

Novel tool to suppress cell proliferation in vivo demonstrates that myocardial and coronary vascular growth represent distinct developmental programs.

scientific article published in March 2008

OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1+, hematopoietic, and endothelial cells from embryonic stem cells.

scientific article

Osx-Cre targets multiple cell types besides osteoblast lineage in postnatal mice

scientific article published on 15 January 2014

Otoconial agenesis in tilted mutant mice

scientific article published in August 1998

Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium.

scholarly article

Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio.

scientific article

Overlapping expression and redundant activation of mesenchymal fibroblast growth factor (FGF) receptors by alternatively spliced FGF-8 ligands

scientific article published on 01 February 1997

Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice.

scientific article published in March 1987

Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development

scientific article published in October 2001

Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation.

scientific article

Proteomic analysis of native cerebellar iFGF14 complexes.

scientific article published on 18 February 2016

Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling.

scientific article published on 9 May 2017

Rapid induction of lung adenocarcinoma by fibroblast growth factor 9 signaling through FGF receptor 3.

scientific article published on 18 July 2013

Rebuilding the coronary vasculature: hedgehog as a new candidate for pharmacologic revascularization.

scientific article published on April 2007

Receptor binding and mitogenic properties of mouse fibroblast growth factor 3. Modulation of response by heparin

scientific article

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family

scientific article

Region-specific regulation of cell proliferation by FGF receptor signaling during the Wolffian duct development.

scientific article

Regulation of cellular calcium in vestibular supporting cells by otopetrin 1

scientific article

Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex

scientific article

Regulation of the fibroblast growth factor receptor 3 promoter and intron I enhancer by Sp1 family transcription factors

scientific article published on 01 February 1998

Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue.

scientific article published on 19 February 2008

Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium

scientific article

Sculpting the skull through neurosensory epithelial-mesenchymal signaling

scientific article published on 24 September 2018

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

scientific journal article

Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature

scientific article published on January 2009

Signaling networks regulating development of the lower respiratory tract

scientific article published on May 2012

Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation.

scientific article published in June 2005

Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development

scientific article published on 01 January 2004

Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3.

scientific article published in April 1996

Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner

scientific article published on 05 July 2019

Specific expression of an elastase–human growth hormone fusion gene in pancreatic acinar cells of transgenic mice

scientific article published in Nature

Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts

scientific article published on 8 April 2004

Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development.

scientific article

Subcellular and developmental expression of alternatively spliced forms of fibroblast growth factor 14.

scientific article published on February 2000

Sulfated hydrogel matrices direct mitogenicity and maintenance of chondrocyte phenotype through activation of FGF signaling.

scientific article published on 23 March 2016

The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability

scientific article published in October 2007

The Fibroblast Growth Factor signaling pathway

scientific article

The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance

scientific article (publication date: 15 August 1999)

Tissue-specific expression of pancreatic genes in transgenic mice

scientific article

Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity

scientific article

Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis

scientific article

Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer

scientific article published on 20 May 2016

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