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List of works by Andrew Copp

A cell-type-specific abnormality of cell proliferation in mutant (curly tail) mouse embryos developing spinal neural tube defects

scientific article published on 01 October 1988

A curly-tail modifier locus, mct1, on mouse chromosome 17

scientific article published on 01 October 1995

A gene for autosomal dominant sacral agenesis maps to the holoprosencephaly region at 7q36.

scientific article

A genetic risk factor for mouse neural tube defects: defining the embryonic basis

scientific article published on 01 March 2000

Abnormal folate metabolism in foetuses affected by neural tube defects

scientific article published on April 2007

Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects.

scientific article published on April 1998

Accumulation of basement membrane-associated hyaluronate is reduced in the posterior neuropore region of mutant (curly tail) mouse embryos developing spinal neural tube defects

scientific article published in December 1988

Amniotic fluid brain-specific proteins are biomarkers for spinal cord injury in experimental myelomeningocele

scientific article published in October 2005

An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs)

scientific article published on 23 September 2020

Analysis of neural tube defects in a mouse mutant using whole embryo culture.

scientific article

Analysis of the planar cell polarity gene Vangl2 and its co-expressed paralogue Vangl1 in neural tube defect patients.

scientific article published in July 2005

Apoptosis is not required for mammalian neural tube closure.

scholarly article

Bending of the neural plate during mouse spinal neurulation is independent of actin microfilaments

scientific article

Biomechanical coupling facilitates spinal neural tube closure in mouse embryos

scientific article

Birth defects: from molecules to mechanisms

scientific article published on 01 July 1994

Blocking endogenous FGF-2 activity prevents cranial osteogenesis

scientific article published in March 2002

Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening

scientific article

Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening

CLN-1 and CLN-5, genes for infantile and variant late infantile neuronal ceroid lipofuscinoses, are expressed in the embryonic human brain

scientific article

Cardiac neural crest of the mouse embryo: axial level of origin, migratory pathway and cell autonomy of the splotch (Sp2H) mutant effect

scientific article published in July 2004

Cardiovascular defects associated with abnormalities in midline development in the Loop-tail mouse mutant

scientific journal article

Cell lineages

scientific article published on 01 March 1997

Cellular basis of neuroepithelial bending during mouse spinal neural tube closure.

scientific article published on 12 June 2015

Cellular mechanisms underlying Pax3-related neural tube defects and their prevention by folic acid

scientific article published on 22 November 2019

Chimaerism of primordial germ cells in the early postimplantation mouse embryo following microsurgical grafting of posterior primitive streak cells in vitro

scientific article published in June 1986

Circletail, a new mouse mutant with severe neural tube defects: chromosomal localization and interaction with the loop-tail mutation

scientific article published on 01 November 2001

Cloning and characterization of Igsf9 in mouse and human: a new member of the immunoglobulin superfamily expressed in the developing nervous system.

scientific article

Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23.

scientific article published in March 2001

Convergent extension analysis in mouse whole embryo culture

scientific article published on January 2012

Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure

scientific journal article

Cordon-bleu is a conserved gene involved in neural tube formation

scientific article (publication date: October 2003)

Could microRNAs be biomarkers for neural tube defects?

scientific article published on August 2012

Curly tail: a 50-year history of the mouse spina bifida model

scientific article published in April 2001

Curvature of the caudal region is responsible for failure of neural tube closure in the curly tail (ct) mouse embryo

scientific article published in October 1991

D-chiro-inositol is more effective than myo-inositol in preventing folate-resistant mouse neural tube defects.

scientific article published in September 2002

Death before birth: clues from gene knockouts and mutations

scientific article published on March 1995

Deceleration and acceleration in the rate of posterior neuropore closure during neurulation in the curly tail (ct) mouse embryo

scientific article published in January 1992

Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice

scientific article published on 18 March 2013

Defining a PARticular pathway of neural tube closure

scientific article published in January 2010

Development of a lethal congenital heart defect in the splotch (Pax3) mutant mouse.

scientific article published in November 1997

Development of the vertebrate central nervous system: formation of the neural tube.

scientific article published on April 2009

Developmental basis of severe neural tube defects in the loop-tail (Lp) mutant mouse: use of microsatellite DNA markers to identify embryonic genotype

scientific article published in September 1994

Differential protein expression at the stage of neural tube closure in the mouse embryo.

scientific article published on 27 August 2002

Diffusion microscopic MRI of the mouse embryo: Protocol and practical implementation in the splotch mouse model

scientific article published on 13 March 2014

Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates

scientific journal article

Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization

scientific article

Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse

scientific article (publication date: 15 January 2003)

Do cells become homeless during neural tube closure?

scientific article published on 12 August 2009

Dorsoventral patterning in oesophageal atresia with tracheo-oesophageal fistula: Evidence from a new mouse model.

scientific article published in February 2002

Dynamic acetylation profile during mammalian neurulation

scientific article published on 23 November 2019

Effect of implantation delay on transfer of rat embryos to mice

scientific article published on 01 January 1978

Effect of implantational delay on cellular proliferation in the mouse blastocyst

scientific article published on 01 November 1982

Embryology of oesophageal atresia

scientific article published on February 2009

Embryonic Folate Metabolism and Mouse Neural Tube Defects ⬇️

scientific article published on June 26, 1998

Enabling research with human embryonic and fetal tissue resources.

scientific article

EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion.

scientific article published in January 2009

Epithelial fusion during neural tube morphogenesis.

scientific article published on 03 September 2012

Etiology and pathogenesis of human neural tube defects: insights from mouse models.

scientific article published on December 1994

Evaluation of folate metabolism gene polymorphisms as risk factors for open and closed neural tube defects

article

Excess methionine suppresses the methylation cycle and inhibits neural tube closure in mouse embryos

scientific article published on 21 April 2006

Exogenous transferrin is taken up and localized by the neurulation-stage mouse embryo in vitro

scientific article published on 01 October 1992

Expression of PACAP, and PACAP type 1 (PAC1) receptor mRNA during development of the mouse embryo ⬇️

scientific article published on August 8, 1998

Expression pattern of glypican-4 suggests multiple roles during mouse development.

scientific article published in July 2005

FGF2 promotes skeletogenic differentiation of cranial neural crest cells

scientific article published in June 2001

FOXP2 and the neuroanatomy of speech and language

scientific article

FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder

scientific article published on 22 July 2003

Failure of neural tube closure in the loop-tail (Lp) mutant mouse: analysis of the embryonic mechanism

scientific article

Female predisposition to cranial neural tube defects is not because of a difference between the sexes in the rate of embryonic growth or development during neurulation.

scientific article

Fetal spina bifida in a mouse model: loss of neural function in utero

scientific article published on March 2007

Folate metabolite profiling of different cell types and embryos suggests variation in folate one-carbon metabolism, including developmental changes in human embryonic brain

scientific article published on 13 March 2013

Foregut separation and tracheo-oesophageal malformations: the role of tracheal outgrowth, dorso-ventral patterning and programmed cell death

scientific article

Formate supplementation enhances folate-dependent nucleotide biosynthesis and prevents spina bifida in a mouse model of folic acid-resistant neural tube defects

scientific article published on 23 February 2016

Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function.

scientific article published on 26 August 2008

Genesis and prevention of spinal neural tube defects in the curly tail mutant mouse: involvement of retinoic acid and its nuclear receptors RAR-beta and RAR-gamma.

scientific article published in March 1995

Genetic basis of neural tube defects: the mouse gene loop-tail maps to a region of chromosome 1 syntenic with human 1q21-q23

scientific article published on 01 April 1995

Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice

scientific article

Genetic models of mammalian neural tube defects.

scientific article published on January 1994

Genetics and development of neural tube defects.

scientific article

Genetics of human neural tube defects

scientific article

Genomic organization and embryonic expression of Igsf8, an immunoglobulin superfamily member implicated in development of the nervous system and organ epithelia

scientific article published in January 2003

Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice

scientific article

Glycosaminoglycans vary in accumulation along the neuraxis during spinal neurulation in the mouse embryo

scientific article published on 01 December 1988

Grainyhead genes and mammalian neural tube closure.

scientific article published on October 2008

Heparan sulphate proteoglycans and spinal neurulation in the mouse embryo

scientific article published in May 2002

Homocysteine is embryotoxic but does not cause neural tube defects in mouse embryos

scientific article published on 24 January 2003

Hyperglycaemia potentiates the teratogenicity of retinoic acid in diabetic pregnancy in mice.

scientific article published on 14 February 2004

Immunochemical detection of arylamine N-acetyltransferase during mouse embryonic development and in adult mouse brain

scientific article published in November 1998

In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A.

scientific article published on November 2005

Increased expression of Grainyhead-like-3 rescues spina bifida in a folate-resistant mouse model

scientific article published on 24 August 2007

Induction of chondrogenesis in neural crest cells by mutant fibroblast growth factor receptors

scientific article published in June 2002

Inositol and folate resistant neural tube defects

scientific article published in February 2002

Inositol deficiency increases the susceptibility to neural tube defects of genetically predisposed (curly tail) mouse embryos in vitro

scientific article published on 01 February 1992

Inositol for prevention of neural tube defects: a pilot randomised controlled trial - CORRIGENDUM

scientific article published on 26 February 2016

Inositol for the prevention of neural tube defects: a pilot randomised controlled trial

scientific article published on 5 February 2016

Inositol prevents folate-resistant neural tube defects in the mouse.

scientific article published in January 1997

Inositol, neural tube closure and the prevention of neural tube defects.

scientific article

Integrity of the methylation cycle is essential for mammalian neural tube closure.

scientific article

Interaction between inner cell mass and trophectoderm of the mouse blastocyst. I. A study of cellular proliferation

scientific article published on December 1, 1978

Interaction between inner cell mass and trophectoderm of the mouse blastocyst. II. The fate of the polar trophectoderm

scientific article published on 01 June 1979

Interaction between splotch (Sp) and curly tail (ct) mouse mutants in the embryonic development of neural tube defects.

scientific article published in September 1993

Intrinsic and extrinsic factors in the mechanism of neurulation: effect of curvature of the body axis on closure of the posterior neuropore

scientific article published on 01 March 1993

Is LMNB1 a susceptibility gene for neural tube defects in humans?

scientific article

Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

scientific article published on 6 January 2016

Knowledge and periconceptional use of folic acid for the prevention of neural tube defects in ethnic communities in the United Kingdom: systematic review and meta-analysis

scientific article published on July 2013

Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube

scientific article published on 19 October 2010

Lamin b1 polymorphism influences morphology of the nuclear envelope, cell cycle progression, and risk of neural tube defects in mice

scientific journal article

Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: implications for regulation of BMP signalling.

scientific article published on 4 September 2012

Linkage mapping of Lims1l, the murine homolog of the human LIM domain gene PINCH, to mouse chromosome 10

scientific article published on 01 January 1998

Localization of the mouse gene encoding tyrosine kinase receptor type 10 on distal chromosome 1

scientific article published on 01 December 1997

MRC-Wellcome Trust Human Developmental Biology Resource: enabling studies of human developmental gene expression.

scientific article

Maternal diabetes increases the risk of caudal regression caused by retinoic acid.

scientific article published in September 2002

Mechanisms of normal and abnormal neurulation: evidence from embryo culture studies

scientific article published on April 1997

Microtubules, polarity and vertebrate neural tube morphogenesis.

scientific article published on 29 March 2016

Mouse models of neural tube defects: investigating preventive mechanisms.

scientific article

Mouse whole embryo culture: Evaluating the requirement for rat serum as culture medium

scientific article published on 24 June 2019

Multifactorial inheritance of neural tube defects: localization of the major gene and recognition of modifiers in ct mutant mice

scientific article published on 01 April 1994

Multiple coexistent dysraphic pathologies ⬇️

scientific article published on April 12, 2003

Multiple developmental roles of Ahnak are suggested by localization to sites of placentation and neural plate fusion in the mouse conceptus

scientific article published in December 2002

Multiple developmental roles of Ahnak are suggested by localization to sites of placentation and neural plate fusion in the mouse conceptus

scientific article published in November 2002

Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse

scientific article (publication date: July 2003)

Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans

scientific article published on 13 December 2011

Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis

scientific article

Neural crest is involved in development of abnormal myocardial function.

scientific article

Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling.

scientific article published in September 2007

Neural tube closure in the chick embryo is multiphasic

scientific article published on November 1996

Neural tube closure: cellular, molecular and biomechanical mechanisms

scientific article published on February 2017

Neural tube defects

scientific article published on 01 October 1993

Neural tube defects

scientific article published on 01 January 2014

Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation

scientific article published on August 2010

Neural tube defects--disorders of neurulation and related embryonic processes

scientific article

Neural tube defects: prevention by folic acid and other vitamins.

scientific article

Neural tube defects: recent advances, unsolved questions, and controversies

scientific article

Neural tube development in mutant (curly tail) and normal mouse embryos: the timing of posterior neuropore closure in vivo and in vitro.

scientific article published in June 1982

Neuronal migration defects in the Dreher (Lmx1a) mutant mouse: role of disorders of the glial limiting membrane

scientific article

Neurulation and neural tube closure defects.

scientific article

Neurulation in the cranial region--normal and abnormal

scientific article

Novel exomphalos genetic mouse model: the importance of accurate phenotypic classification

scientific article

Novel mouse model of encephalocele: post-neurulation origin and relationship to open neural tube defects

scientific article published on 14 November 2019

Nucleotide precursors prevent folic acid-resistant neural tube defects in the mouse.

scientific article published on 08 August 2013

Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse

scientific journal article

Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (splotch).

scientific article published in December 1997

Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and 9: further evidence for a paralogous relationship

scientific article published in July 1998

Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes

scientific article published on 13 January 2017

Peter Thorogood (1947-1998).

scientific article published in December 1998

Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp).

scientific article

Planar cell polarity aligns osteoblast division in response to substrate strain

scientific article

Planar cell polarity and the kidney

scientific article

Prevention of neural tube defects: vitamins, enzymes and genes ⬇️

scientific article published on April 1, 1998

Prevention of spinal neural tube defects in the curly tail mouse mutant by a specific effect of retinoic acid

scientific article published in February 1994

Prevention of spinal neural tube defects in the mouse embryo by growth retardation during neurulation

scientific article published on October 1988

Quantitative analysis of myo-inositol in urine, blood and nutritional supplements by high-performance liquid chromatography tandem mass spectrometry.

scientific article

Quantitative analysis of s-adenosylmethionine and s-adenosylhomocysteine in neurulation-stage mouse embryos by liquid chromatography tandem mass spectrometry

scientific article published on 04 August 2006

Refinement of inducible gene deletion in embryos of pregnant mice

scientific article published on 03 December 2019

Regional differences in morphogenesis of the neuroepithelium suggest multiple mechanisms of spinal neurulation in the mouse

scientific article

Regional differences in the expression of laminin isoforms during mouse neural tube development.

scientific article published on 16 April 2011

Regulation of cell protrusions by small GTPases during fusion of the neural folds.

scientific article published on 26 April 2016

Relationship between altered axial curvature and neural tube closure in normal and mutant (curly tail) mouse embryos

scientific article published in February 1996

Relationship between timing of posterior neuropore closure and development of spinal neural tube defects in mutant (curly tail) and normal mouse embryos in culture

scientific article published in August 1985

Retinal axon misrouting at the optic chiasm in mice with neural tube closure defects

scientific article published on 01 May 2000

Retinoic acid induces down-regulation of Wnt-3a, apoptosis and diversion of tail bud cells to a neural fate in the mouse embryo

scientific article published on 01 June 1999

Rho GTPases in mammalian spinal neural tube closure.

scientific article published on 21 October 2016

Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.

scientific article published on 3 June 2015

RhoB is expressed in migrating neural crest and endocardial cushions of the developing mouse embryo.

scientific article

Rib truncations and fusions in the Sp2H mouse reveal a role for Pax3 in specification of the ventro-lateral and posterior parts of the somite

scientific article published in May 1999

Role of Sonic hedgehog in the development of the trachea and oesophagus

scientific article published in January 2003

Role of the extracellular matrix in neural crest cell migration.

scientific article

Role of the polar trophectoderm in determining the pattern of early post-implantation morphogenesis in mammals: evidence from development of the short-tailed field vole, Microtus agrestis

scientific article

Sequence and expression analysis of Nhlh1: a basic helix-loop-helix gene implicated in neurogenesis

scientific article published in January 1999

Sonic hedgehog and the molecular regulation of mouse neural tube closure

scientific article published in May 2002

Spatiotemporal analysis of programmed cell death during mouse cardiac septation.

scientific article published in April 2004

Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol ⬇️

scientific article published on November 12, 2003

Spina bifida

scientific article

Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.

scientific article published on 20 February 2018

Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2.

scientific article published on 6 June 2019

Split cervical spinal cord with Klippel-Feil syndrome: seven cases

scientific article published in December 1996

Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity

scientific journal article

Tethering of the spinal cord in mouse fetuses and neonates with spina bifida

scientific article published on September 2003

The Meckel-Gruber Syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation

scientific article

The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration

scientific article

The development of field vole (Microtus agrestis) and mouse blastocysts in vitro: a study of trophoblast cell migration

scientific article published on 01 January 1980

The embryonic development of mammalian neural tube defects.

scientific article published on January 1990

The genetic background of the curly tail strain confers susceptibility to folate-deficiency-induced exencephaly

scientific article

The genetic basis of mammalian neurulation.

scientific article

The mechanism of mouse egg-cylinder morphogenesis in vitro

scientific article published on 01 February 1981

The relationship between sonic Hedgehog signaling, cilia, and neural tube defects

scientific article published on August 2010

Transferrin and its receptor in the development of genetically determined neural tube defects in the mouse embryo

scientific article published in September 1996

Understanding the causes and prevention of neural tube defects: Insights from the splotch mouse model.

scientific article published on April 2009

Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc-deficient mice

scientific article published on 05 January 2017

Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals.

scientific article

Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract

scientific journal article

Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos.

scientific article published on 21 March 2018

Versican expression is associated with chamber specification, septation, and valvulogenesis in the developing mouse heart.

scientific article

Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system.

scientific article published in July 2005

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