List of works - Dora Brites

A link between hyperbilirubinemia, oxidative stress and injury to neocortical synaptosomes

scientific article published in November 2004

A look at tricellulin and its role in tight junction formation and maintenance

scientific article published on 24 August 2011

Aging confers different sensitivity to the neurotoxic properties of unconjugated bilirubin.

scientific article

Alterations of erythrocyte morphology and lipid composition by hyperbilirubinemia

article

Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation

scientific article published on 6 November 2014

Apoptosis and impairment of neurite network by short exposure of immature rat cortical neurons to unconjugated bilirubin increase with cell differentiation and are additionally enhanced by an inflammatory stimulus

scientific article published in May 2007

Apoptotic cell death does not parallel other indicators of liver damage in chronic hepatitis C patients.

scientific article published in May 2000

Assessment of bilirubin toxicity to erythrocytes. Implication in neonatal jaundice management

article

Astrocyte reactivity to unconjugated bilirubin requires TNF-α and IL-1β receptor signaling pathways

scientific journal article

Automated analysis of NeuronJ tracing data

scientific article

Axonal elongation and dendritic branching is enhanced by adenosine A2A receptors activation in cerebral cortical neurons

scientific article published on 12 June 2015

Beneficial effect of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta.

scientific article

Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment

scientific article

Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis

scientific article published on August 2009

Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order, and redox status in rat mitochondria.

scientific article published in March 2002

Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons.

scientific article

Bilirubin induces loss of membrane lipids and exposure of phosphatidylserine in human erythrocytes

scientific article published in January 2002

Bilirubin injury to neurons and glial cells: new players, novel targets, and newer insights

scientific article published on June 2011

Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid

scientific article published on 19 November 2007

Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid.

scientific article published on 10 October 2009

Bilirubin toxicity to human erythrocytes: a review

scientific article published on 17 June 2006

Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid.

scientific article published in March 2001

Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state

scientific article

Bilirubin-induced inflammatory response, glutamate release, and cell death in rat cortical astrocytes are enhanced in younger cells

scientific article published in November 2005

Bilirubin-induced neural impairment: a special focus on myelination, age-related windows of susceptibility and associated co-morbidities

scientific article published on 19 December 2014

Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation

scientific article published on 28 July 2016

Biological risks for neurological abnormalities associated with hyperbilirubinemia.

scientific article published on February 2009

Blood-brain barrier and bilirubin: clinical aspects and experimental data

scientific article

Blood-brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study

scientific article published on 18 November 2017

Cerebellar axon/myelin loss, angiogenic sprouting, and neuronal increase of vascular endothelial growth factor in a preterm infant with kernicterus

scientific article published on 21 December 2011

Contribution of inflammatory processes to nerve cell toxicity by bilirubin and efficacy of potential therapeutic agents

scientific article published on January 2009

Correction of maternal serum bile acid profile during ursodeoxycholic acid therapy in cholestasis of pregnancy

scientific article

Corrigendum to “A look at tricellulin and its role in tight junction formation and maintenance” [Eur. J. Cell Biol. 90 (2011) 787–796]

scholarly article published in European Journal of Cell Biology

Cortical Neurotoxic Astrocytes with Early ALS Pathology and miR-146a Deficit Replicate Gliosis Markers of Symptomatic SOD1G93A Mouse Model

scientific article published on 11 July 2018

Cross-talk between neurons and astrocytes in response to bilirubin: adverse secondary impacts

scientific article published in July 2014

Cross-talk between neurons and astrocytes in response to bilirubin: early beneficial effects

scientific article

Cytokine production, glutamate release and cell death in rat cultured astrocytes treated with unconjugated bilirubin and LPS.

scientific article

Development of a high throughput methodology to screen cathinones' toxicological impact

scientific article published on 23 February 2019

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation.

scientific article published on 31 October 2016

Directing mouse embryonic neurosphere differentiation toward an enriched neuronal population

scientific article

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

scientific article published on 13 June 2017

Dynamics of neuron-glia interplay upon exposure to unconjugated bilirubin

scientific article published on 23 March 2011

ER stress, mitochondrial dysfunction and calpain/JNK activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin

scientific article published on 17 June 2012

Effect of acidosis on bilirubin-induced toxicity to human erythrocytes

scientific article published on May 2003

Effect of bilirubin on erythrocyte shape and haemolysis, under hypotonic, aggregating or non-aggregating conditions, and correlation with cell age ⬇️

scientific article published on July 1, 1997

Effect of bilirubin on toxicity induced by trifluoperazine, dibucaine and praziquantel to erythrocytes

scientific article published in July 2001

Effects of bilirubin molecular species on membrane dynamic properties of human erythrocyte membranes: a spin label electron paramagnetic resonance spectroscopy study

scientific article published in March 2001

Elevated levels of bile acids in colostrum of patients with cholestasis of pregnancy are decreased following ursodeoxycholic acid therapy

scientific article published on 01 November 1998

Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity

scientific article published on May 2011

Endocytosis in rat cultured astrocytes is inhibited by unconjugated bilirubin

scientific article published in July 2001

Erythropoietin reduces acute lung injury and multiple organ failure/dysfunction associated to a scald-burn inflammatory injury in the rat.

scientific article published in February 2015

Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier

scientific article

Evidence of tricellulin expression by immune cells, particularly microglia

article

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype.

scientific article published on 17 May 2017

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization

scientific article published on 21 December 2016

Exposure to lipopolysaccharide and/or unconjugated bilirubin impair the integrity and function of brain microvascular endothelial cells

scientific article

Features of bilirubin-induced reactive microglia: from phagocytosis to inflammation.

scientific article

Frailty in mouse ageing: A conceptual approach

scientific article

Glio-vascular changes during ageing in wild-type and Alzheimer's disease-like APP/PS1 mice.

scientific article

Glycoursodeoxycholic Acid and Interleukin-10 Modulate the Reactivity of Rat Cortical Astrocytes to Unconjugated Bilirubin

scientific article published on 01 September 2007

Glycoursodeoxycholic acid reduces matrix metalloproteinase-9 and caspase-9 activation in a cellular model of superoxide dismutase-1 neurodegeneration

scientific article published on 22 May 2014

Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study

scientific article

Identification of a novel deletion in UDP-glucuronosyltransferase gene in a patient with Crigler-Najjar syndrome type I.

scientific article

Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment

scientific article published on 7 November 2017

Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin

scientific article published on 10 February 2006

Influence of hypoxia and ischemia preconditioning on bilirubin damage to astrocytes

scientific article published on 24 February 2007

Inhibition of Glutamate Uptake by Unconjugated Bilirubin in Cultured Cortical Rat Astrocytes: Role of Concentration and pH

scientific article published on 01 November 1999

Inhibition of glycogen synthase kinase-3β attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat.

scientific article published in April 2015

Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches ⬇️

scientific article published on May 26, 2010

MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes

scientific article

Membrane effects of trifluoperazine, dibucaine and praziquantel on human erythrocytes

scientific article published in May 2000

Membrane structural changes support the involvement of mitochondria in the bile salt-induced apoptosis of rat hepatocytes.

scientific article published in November 2002

Microglia centered pathogenesis in ALS: insights in cell interconnectivity

scientific article

Microglia change from a reactive to an age-like phenotype with the time in culture

scientific article

Molecular basis of bilirubin-induced neurotoxicity

scientific article published on February 2004

N-methyl-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity

scientific article

Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10.

scientific article published on 13 February 2012

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

scientific article

Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion

scientific article

Neurotoxic Astrocytes Directly Converted from Sporadic and Familial ALS Patient Fibroblasts Reveal Signature Diversities and miR-146a Theragnostic Potential in Specific Subtypes

scientific article published on 01 April 2022

Neurovascular unit: a focus on pericytes

scientific article published on 28 February 2012

New autopsy findings in different brain regions of a preterm neonate with kernicterus: neurovascular alterations and up-regulation of efflux transporters

scientific article published on 15 October 2013

Oligodendrocyte Development and Myelination in Neurodevelopment: Molecular Mechanisms in Health and Disease

scientific article published on 03 December 2015

Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions

scientific article published on 09 April 2019

Polyphenols journey through blood-brain barrier towards neuronal protection.

scientific article published on 13 September 2017

Potential for brain accessibility and analysis of stability of selected flavonoids in relation to neuroprotection in vitro.

scientific article

Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin

scientific article published on 16 March 2011

Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat.

scientific article

Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis

article

Rat cerebellar slice cultures exposed to bilirubin evidence reactive gliosis, excitotoxicity and impaired myelinogenesis that is prevented by AMPA and TNF-α inhibitors

scientific journal article

Rat cultured neuronal and glial cells respond differently to toxicity of unconjugated bilirubin

scientific article published in April 2002

Recovery of Depleted miR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons

scientific article published on 23 April 2021

Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia

scientific article

Regulatory function of microRNAs in microglia

scientific article published on 28 May 2020

Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in an high incidence area: Portugal

scientific article published in September 1998

Response to the Letter to the Editor by Mamdouha Ahdab-Barmada and Jon F. Watchko

scientific article published on 17 February 2014

Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin

scientific journal article

S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis

scientific article published on 17 July 2015

Secretome from SH-SY5Y APP Swe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling

article by Adelaide Fernandes et al published May 2018 in Biochimie

Selective vulnerability of rat brain regions to unconjugated bilirubin

scientific article published on 25 June 2011

Synthesis and friedländer reactions of 5-amino-4-cyano-1,3-oxazoles

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects

scientific article published on 29 April 2015

Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference?

scientific article published on 26 September 2016

Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability

scientific article published on 22 March 2019

The Evolving Landscape of Neurotoxicity by Unconjugated Bilirubin: Role of Glial Cells and Inflammation ⬇️

scientific article published on May 29, 2012

The Sedentary Lifestyle and Masticatory Dysfunction: Time to Review the Contribution to Age-Associated Cognitive Decline and Astrocyte Morphotypes in the Dentate Gyrus

scientific article published in 2022

Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining

scientific article

Tricellulin expression in brain endothelial and neural cells

scientific article published on 19 December 2012

Unconjugated bilirubin activates and damages microglia

scientific article

Unconjugated bilirubin differentially affects the redox status of neuronal and astroglial cells

scientific article published on 01 August 2007

Unconjugated bilirubin restricts oligodendrocyte differentiation and axonal myelination

scientific article

Unusual case of severe cholestasis of pregnancy with early onset, improved by ursodeoxycholic acid administration

scientific article published on 01 February 1998

List of works by Dora Brites

A link between hyperbilirubinemia, oxidative stress and injury to neocortical synaptosomes

A look at tricellulin and its role in tight junction formation and maintenance

Aging confers different sensitivity to the neurotoxic properties of unconjugated bilirubin.

Alterations of erythrocyte morphology and lipid composition by hyperbilirubinemia

Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation

Apoptosis and impairment of neurite network by short exposure of immature rat cortical neurons to unconjugated bilirubin increase with cell differentiation and are additionally enhanced by an inflammatory stimulus

Apoptotic cell death does not parallel other indicators of liver damage in chronic hepatitis C patients.

Assessment of bilirubin toxicity to erythrocytes. Implication in neonatal jaundice management

Astrocyte reactivity to unconjugated bilirubin requires TNF-α and IL-1β receptor signaling pathways

Automated analysis of NeuronJ tracing data

Axonal elongation and dendritic branching is enhanced by adenosine A2A receptors activation in cerebral cortical neurons

Beneficial effect of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta.

Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment

Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis

Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order, and redox status in rat mitochondria.

Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons.

Bilirubin induces loss of membrane lipids and exposure of phosphatidylserine in human erythrocytes

Bilirubin injury to neurons and glial cells: new players, novel targets, and newer insights

Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid

Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid.

Bilirubin toxicity to human erythrocytes: a review

Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid.

Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state

Bilirubin-induced inflammatory response, glutamate release, and cell death in rat cortical astrocytes are enhanced in younger cells

Bilirubin-induced neural impairment: a special focus on myelination, age-related windows of susceptibility and associated co-morbidities

Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation

Biological risks for neurological abnormalities associated with hyperbilirubinemia.

Blood-brain barrier and bilirubin: clinical aspects and experimental data

Blood-brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study

Cerebellar axon/myelin loss, angiogenic sprouting, and neuronal increase of vascular endothelial growth factor in a preterm infant with kernicterus

Contribution of inflammatory processes to nerve cell toxicity by bilirubin and efficacy of potential therapeutic agents

Correction of maternal serum bile acid profile during ursodeoxycholic acid therapy in cholestasis of pregnancy

Corrigendum to “A look at tricellulin and its role in tight junction formation and maintenance” [Eur. J. Cell Biol. 90 (2011) 787–796]

Cortical Neurotoxic Astrocytes with Early ALS Pathology and miR-146a Deficit Replicate Gliosis Markers of Symptomatic SOD1G93A Mouse Model

Cross-talk between neurons and astrocytes in response to bilirubin: adverse secondary impacts

Cross-talk between neurons and astrocytes in response to bilirubin: early beneficial effects

Cytokine production, glutamate release and cell death in rat cultured astrocytes treated with unconjugated bilirubin and LPS.

Development of a high throughput methodology to screen cathinones' toxicological impact

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation.

Directing mouse embryonic neurosphere differentiation toward an enriched neuronal population

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

Dynamics of neuron-glia interplay upon exposure to unconjugated bilirubin

ER stress, mitochondrial dysfunction and calpain/JNK activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin

Effect of acidosis on bilirubin-induced toxicity to human erythrocytes

Effect of bilirubin on erythrocyte shape and haemolysis, under hypotonic, aggregating or non-aggregating conditions, and correlation with cell age ⬇️

Effect of bilirubin on toxicity induced by trifluoperazine, dibucaine and praziquantel to erythrocytes

Effects of bilirubin molecular species on membrane dynamic properties of human erythrocyte membranes: a spin label electron paramagnetic resonance spectroscopy study

Elevated levels of bile acids in colostrum of patients with cholestasis of pregnancy are decreased following ursodeoxycholic acid therapy

Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity

Endocytosis in rat cultured astrocytes is inhibited by unconjugated bilirubin

Erythropoietin reduces acute lung injury and multiple organ failure/dysfunction associated to a scald-burn inflammatory injury in the rat.

Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier

Evidence of tricellulin expression by immune cells, particularly microglia

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype.

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization

Exposure to lipopolysaccharide and/or unconjugated bilirubin impair the integrity and function of brain microvascular endothelial cells

Features of bilirubin-induced reactive microglia: from phagocytosis to inflammation.

Frailty in mouse ageing: A conceptual approach

Glio-vascular changes during ageing in wild-type and Alzheimer's disease-like APP/PS1 mice.

Glycoursodeoxycholic Acid and Interleukin-10 Modulate the Reactivity of Rat Cortical Astrocytes to Unconjugated Bilirubin

Glycoursodeoxycholic acid reduces matrix metalloproteinase-9 and caspase-9 activation in a cellular model of superoxide dismutase-1 neurodegeneration

Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study

Identification of a novel deletion in UDP-glucuronosyltransferase gene in a patient with Crigler-Najjar syndrome type I.

Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment

Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin

Influence of hypoxia and ischemia preconditioning on bilirubin damage to astrocytes

Inhibition of Glutamate Uptake by Unconjugated Bilirubin in Cultured Cortical Rat Astrocytes: Role of Concentration and pH

Inhibition of glycogen synthase kinase-3β attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat.

Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches ⬇️

MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes

Membrane effects of trifluoperazine, dibucaine and praziquantel on human erythrocytes

Membrane structural changes support the involvement of mitochondria in the bile salt-induced apoptosis of rat hepatocytes.

Microglia centered pathogenesis in ALS: insights in cell interconnectivity

Microglia change from a reactive to an age-like phenotype with the time in culture

Molecular basis of bilirubin-induced neurotoxicity

N-methyl-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity

Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10.

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion