List of works - Randall J. Brezski

9th annual European Antibody Congress, November 11-13, 2013, Geneva, Switzerland

scientific article published on 17 January 2014

A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo

scientific article published on 30 October 2014

A novel therapeutic strategy to rescue the immune effector function of proteolytically inactivated cancer therapeutic antibodies

scientific article

A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy ⬇️

scientific article published on 08 August 2012

An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions

scientific article published on January 2015

An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations

scientific article

Avidity confers FcγR binding and immune effector function to aglycosylated immunoglobulin G1

scientific article published on 01 March 2012

Cleavage of IgGs by proteases associated with invasive diseases: an evasion tactic against host immunity?

scientific article published on 23 May 2010

Engineered protease-resistant antibodies with selectable cell-killing functions

scientific article published on 28 August 2013

Human anti-IgG1 hinge autoantibodies reconstitute the effector functions of proteolytically inactivated IgGs

scientific article

IgG Fc engineering to modulate antibody effector functions

scientific article published on 6 October 2017

Membrane cholesterol content accounts for developmental differences in surface B cell receptor compartmentalization and signaling

scientific article published on 5 May 2005

Structure and specificity of an antibody targeting a proteolytically cleaved IgG hinge

scientific article

The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge

scientific article

The origins, specificity, and potential biological relevance of human anti-IgG hinge autoantibodies.

scientific article

Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling.

scientific article

Trastuzumab triggers phagocytic killing of high HER2 cancer cells in vitro and in vivo by interaction with Fcγ receptors on macrophages

scientific article

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

scientific article published on 07 October 2009

Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor function.

scientific article published on 26 October 2012

List of works by Randall J. Brezski

9th annual European Antibody Congress, November 11-13, 2013, Geneva, Switzerland

A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo

A novel therapeutic strategy to rescue the immune effector function of proteolytically inactivated cancer therapeutic antibodies

A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy ⬇️

An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions

An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations

Avidity confers FcγR binding and immune effector function to aglycosylated immunoglobulin G1

Cleavage of IgGs by proteases associated with invasive diseases: an evasion tactic against host immunity?

Engineered protease-resistant antibodies with selectable cell-killing functions

Human anti-IgG1 hinge autoantibodies reconstitute the effector functions of proteolytically inactivated IgGs

IgG Fc engineering to modulate antibody effector functions

Membrane cholesterol content accounts for developmental differences in surface B cell receptor compartmentalization and signaling

Structure and specificity of an antibody targeting a proteolytically cleaved IgG hinge

The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge

The origins, specificity, and potential biological relevance of human anti-IgG hinge autoantibodies.

Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling.

Trastuzumab triggers phagocytic killing of high HER2 cancer cells in vitro and in vivo by interaction with Fcγ receptors on macrophages

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor function.