List of works - David Robert Mole

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase

scientific article published in August 2003

Altered regulation of DPF3, a member of the SWI/SNF complexes, underlies the 14q24 renal cancer susceptibility locus

scientific article published on 13 August 2021

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases

scientific article published in April 2003

Archean komatiite volcanism controlled by the evolution of early continents

scientific article

Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters

scientific article published on 8 August 2016

Case report of oxalate nephropathy in a patient with pancreatic metastases from renal carcinoma

scientific article published on 17 October 2019

Cellular oxygen sensing in health and disease

scientific article published on 23 October 2007

Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation

scientific article published on July 2006

Clinical features of the pathogenic m.5540G>A mitochondrial transfer RNA tryptophan gene mutation.

scientific article published on 17 August 2016

Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer

scientific article published on 10 December 2019

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.

scientific article

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

scientific article

Destruction of a distal hypoxia response element abolishes trans-activation of the PAG1 gene mediated by HIF-independent chromatin looping.

scientific article published on 24 May 2015

Determination and comparison of specific activity of the HIF-prolyl hydroxylases

scientific article

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

scientific article

Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression

scientific article published on 19 December 2019

Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2.

scientific article published on 21 December 2013

Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis

scientific article published on 4 November 2014

Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

scientific article published on 24 October 2016

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts

scientific article published on 21 April 2009

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

scientific article (publication date: August 2005)

Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer

scientific article published in 2015

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.

scientific article

Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)

scientific article

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI

scientific article published on 05 November 2019

Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer

scientific article published on 19 August 2015

Hypoxia-inducible factors: where, when and why?

scientific article published in January 2006

Hypoxic Regulation of Gene Transcription and Chromatin: Cause and Effect

scientific article published on 06 November 2020

Hypoxic microenvironment shapes HIV-1 replication and latency

scientific article published on 14 July 2020

Hypoxic regulation of the noncoding genome and NEAT1.

scientific article

Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin

scientific article published on 14 November 2018

Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia

scientific article published on 11 February 2014

Iron homeostasis and its interaction with prolyl hydroxylases

scientific article published on April 2010

MITF controls the TCA cycle to modulate the melanoma hypoxia response

scientific article published on 08 July 2019

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.

scientific article

No evidence for high-pressure melting of Earth's crust in the Archean

scientific article published on 05 December 2019

Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1

scientific article

Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases

scientific article

Pan-genomic binding of hypoxia-inducible transcription factors

scientific article published on April 2013

Postprandial alkaline tide: does it exist?

scientific article published in January 1995

Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.

scientific article

Regulation of HIF: prolyl hydroxylases.

scientific article

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha

scientific article

Regulation of growth differentiation factor 15 expression by intracellular iron.

scientific article

Regulation of hepcidin expression at high altitude

scientific article published on 30 November 2011

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex

scientific article

Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis

scientific article published on 21 October 2010

Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status

scientific article published on 17 December 2015

Sites of deposition of aqueous aerosols: a study of efficiency of delivery systems for lung ventilation imaging in man

scientific article published on 01 March 1989

Software management practice and metrics in the European community and Japan: Some results of a survey

scientific article published in 1994

Suppression of plasma hepcidin by venesection during steady-state hypoxia

scientific article published on 15 January 2016

The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia

scientific article published on 20 October 2017

The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1

scientific article

Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression

article

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival

scientific article published in August 2015

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.

scientific article published on 24 November 2014

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

scientific article published on 8 August 2016

Unlocking the complexity of hypoxia non-coding transcriptome landscape of breast cancer

scientific article

Unlocking the complexity of hypoxia non-coding transcriptome landscape of breast cancer

miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis.

scientific article published on 28 February 2013

List of works by David Robert Mole

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase

Altered regulation of DPF3, a member of the SWI/SNF complexes, underlies the 14q24 renal cancer susceptibility locus

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases

Archean komatiite volcanism controlled by the evolution of early continents

Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters

Case report of oxalate nephropathy in a patient with pancreatic metastases from renal carcinoma

Cellular oxygen sensing in health and disease

Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation

Clinical features of the pathogenic m.5540G>A mitochondrial transfer RNA tryptophan gene mutation.

Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

Destruction of a distal hypoxia response element abolishes trans-activation of the PAG1 gene mediated by HIF-independent chromatin looping.

Determination and comparison of specific activity of the HIF-prolyl hydroxylases

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression

Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2.

Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis

Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.

Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI

Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer

Hypoxia-inducible factors: where, when and why?

Hypoxic Regulation of Gene Transcription and Chromatin: Cause and Effect

Hypoxic microenvironment shapes HIV-1 replication and latency

Hypoxic regulation of the noncoding genome and NEAT1.

Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin

Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia

Iron homeostasis and its interaction with prolyl hydroxylases

MITF controls the TCA cycle to modulate the melanoma hypoxia response

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.

No evidence for high-pressure melting of Earth's crust in the Archean

Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1

Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases

Pan-genomic binding of hypoxia-inducible transcription factors

Postprandial alkaline tide: does it exist?

Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.

Regulation of HIF: prolyl hydroxylases.

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha

Regulation of growth differentiation factor 15 expression by intracellular iron.

Regulation of hepcidin expression at high altitude

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex

Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis

Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status

Sites of deposition of aqueous aerosols: a study of efficiency of delivery systems for lung ventilation imaging in man

Software management practice and metrics in the European community and Japan: Some results of a survey

Suppression of plasma hepcidin by venesection during steady-state hypoxia

The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia

The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1

Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

Unlocking the complexity of hypoxia non-coding transcriptome landscape of breast cancer

Unlocking the complexity of hypoxia non-coding transcriptome landscape of breast cancer

miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis.