List of works - Adrian Liston

A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction.

scientific article

A new role for interleukin-10 in immune regulation

scientific article published on 17 August 2010

A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling.

scientific article published in March 2014

Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism

scientific article published on 06 December 2012

Aire regulates negative selection of organ-specific T cells

scientific article (publication date: April 2003)

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance.

scientific article published on 19 April 2011

An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression

scientific article published on 17 May 2013

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

scientific article

Antigen recognition by autoreactive CD4⁺ thymocytes drives homeostasis of the thymic medulla

scientific article (publication date: 2012)

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

scientific article published on 26 May 2022

AutoSpill is a principled framework that simplifies the analysis of multichromatic flow cytometry data

scientific article published on 17 May 2021

Autoimmunity: beyond the immune system

scientific article published on 26 February 2008

Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis.

scientific article published on 10 December 2013

Crucial Role of Transient Receptor Potential Ankyrin 1 and Mast Cells in Induction of Nonallergic Airway Hyperreactivity in Mice

scientific article published on 21 December 2012

Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3–positive regulatory versus TH2 effector cells to cause allergy ⬇️

scientific article published on February 12, 2011

Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells.

scientific article published on 8 August 2006

Developmental plasticity of murine and human Foxp3(+) regulatory T cells

scientific article published in January 2013

Dicer-dependent microRNA pathway safeguards regulatory T cell function

scientific article

Dominant mutations in ITPR3 cause Charcot-Marie-Tooth disease

scientific article published on 19 September 2020

Foxp3+ follicular regulatory T cells control the germinal center response.

scientific article

Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.

scientific article

Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.

scientific article

Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

scientific article published in December 2004

Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice

scientific article

Genetic lesions in T-cell tolerance and thresholds for autoimmunity.

scientific article

Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity.

scientific article published in January 2005

Homeostatic control of regulatory T cell diversity.

scientific article published on 31 January 2014

IL-2 coordinates IL-2-producing and regulatory T cell interplay.

scientific article

Immune tolerance: are regulatory T cell subsets needed to explain suppression of autoimmunity?

scientific article published on 15 March 2012

Immunological tolerance 50 years after the Burnet Nobel Prize ⬇️

scientific article published on January 1, 2011

Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling

scientific article published on January 2007

Increased IL-10-producing regulatory T cells are characteristic of severe cases of COVID-19

scientific article published on 13 November 2020

Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice

scientific article

Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response

scientific article published in March 2009

Insufficient IL-10 Production as a Mechanism Underlying the Pathogenesis of Systemic Juvenile Idiopathic Arthritis

scientific article published on 28 September 2018

Is foxp3 the master regulator of regulatory T cells?

scientific article published on 01 January 2010

Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice.

scientific article published on 4 January 2012

Machine learning identifies an immunological pattern associated with multiple juvenile idiopathic arthritis subtypes

scientific article published on 12 March 2019

Macrophages have no lineage history of Foxp3 expression.

scientific article published in February 2012

Mast cells play no role in the pathogenesis of postoperative ileus induced by intestinal manipulation

scientific article published on 9 January 2014

MicroRNA in the adaptive immune system, in sickness and in health.

scientific article published on 27 February 2010

MicroRNA in the immune system, microRNA as an immune system

scientific article published on July 2009

MicroRNA regulation of T-cell development.

scientific article published on May 2013

MicroRNA-29 in the adaptive immune system: setting the threshold.

scientific article published on 13 September 2012

MicroRNAs Control the Maintenance of Thymic Epithelia and Their Competence for T Lineage Commitment and Thymocyte Selection ⬇️

scientific article published on September 12, 2012

Models of aire-dependent gene regulation for thymic negative selection.

scientific article published on 09 May 2011

Molecular control over thymic involution: from cytokines and microRNA to aging and adipose tissue

scientific article

Murine myeloproliferative disorder as a consequence of impaired collaboration between dendritic cells and CD4 T cells

scientific article published on 17 October 2018

No evidence for a role of rareCYP27B1functional variations in multiple sclerosis

scientific article published on 11 March 2013

Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

scientific article

Phenotype molding of stromal cells in the lung tumor microenvironment

scientific article published on 09 July 2018

Rapamycin increases survival in ALS mice lacking mature lymphocytes.

scientific article published on 11 September 2013

Regulatory T cells fulfil their promise?

scientific article published on 24 May 2011

Research priorities for neuroimmunology: identifying the key research questions to be addressed by 2030

scientific article published on 29 July 2021

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

scientific article published on 01 May 2019

Short-circuiting regulatory T-cell proliferation during chronic infection

scientific article published on 28 April 2009

Starting Your Independent Research Laboratory ⬇️

scientific article published in August 2021

Subversion of the chemokine world by microbial pathogens ⬇️

scientific article published on May 1, 2003

Systemic juvenile idiopathic arthritis-like syndrome in mice following stimulation of the immune system with Freund's complete adjuvant: regulation by interferon-γ

scientific article published on 01 May 2014

T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells.

scientific article published on May 2012

The Development of T-Cell Immunity

scientific article published on 01 January 2010

The Immunogenetic Architecture of Autoimmune Disease ⬇️

scientific article published on March 1, 2012

The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release.

scientific article published in September 2013

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor

scientific article published on 18 December 2011

The thymic niche does not limit development of the naturally diverse population of mouse regulatory T lymphocytes

scientific article published on 17 September 2012

Thymic development and peripheral homeostasis of regulatory T cells.

scientific article published on 15 February 2007

Tracing the action of IL-2 in tolerance to islet-specific antigen

scientific article published on 20 March 2007

Understanding the genetic regulation of IgE production

scientific article published on 15 July 2010

Unusual selection and peripheral homeostasis for immunoregulatory CD4(-) CD8(-) T cells.

scientific article

List of works by Adrian Liston

A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction.

A new role for interleukin-10 in immune regulation

A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling.

Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism

Aire regulates negative selection of organ-specific T cells

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance.

An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

Antigen recognition by autoreactive CD4⁺ thymocytes drives homeostasis of the thymic medulla

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

AutoSpill is a principled framework that simplifies the analysis of multichromatic flow cytometry data

Autoimmunity: beyond the immune system

Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis.

Crucial Role of Transient Receptor Potential Ankyrin 1 and Mast Cells in Induction of Nonallergic Airway Hyperreactivity in Mice

Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3–positive regulatory versus TH2 effector cells to cause allergy ⬇️

Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells.

Developmental plasticity of murine and human Foxp3(+) regulatory T cells

Dicer-dependent microRNA pathway safeguards regulatory T cell function

Dominant mutations in ITPR3 cause Charcot-Marie-Tooth disease

Foxp3+ follicular regulatory T cells control the germinal center response.

Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.

Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.

Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice

Genetic lesions in T-cell tolerance and thresholds for autoimmunity.

Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity.

Homeostatic control of regulatory T cell diversity.

IL-2 coordinates IL-2-producing and regulatory T cell interplay.

Immune tolerance: are regulatory T cell subsets needed to explain suppression of autoimmunity?

Immunological tolerance 50 years after the Burnet Nobel Prize ⬇️

Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling

Increased IL-10-producing regulatory T cells are characteristic of severe cases of COVID-19

Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice

Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response

Insufficient IL-10 Production as a Mechanism Underlying the Pathogenesis of Systemic Juvenile Idiopathic Arthritis

Is foxp3 the master regulator of regulatory T cells?

Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice.

Machine learning identifies an immunological pattern associated with multiple juvenile idiopathic arthritis subtypes

Macrophages have no lineage history of Foxp3 expression.

Mast cells play no role in the pathogenesis of postoperative ileus induced by intestinal manipulation

MicroRNA in the adaptive immune system, in sickness and in health.

MicroRNA in the immune system, microRNA as an immune system

MicroRNA regulation of T-cell development.

MicroRNA-29 in the adaptive immune system: setting the threshold.

MicroRNAs Control the Maintenance of Thymic Epithelia and Their Competence for T Lineage Commitment and Thymocyte Selection ⬇️

Models of aire-dependent gene regulation for thymic negative selection.

Molecular control over thymic involution: from cytokines and microRNA to aging and adipose tissue

Murine myeloproliferative disorder as a consequence of impaired collaboration between dendritic cells and CD4 T cells

No evidence for a role of rareCYP27B1functional variations in multiple sclerosis

Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

Phenotype molding of stromal cells in the lung tumor microenvironment

Rapamycin increases survival in ALS mice lacking mature lymphocytes.

Regulatory T cells fulfil their promise?

Research priorities for neuroimmunology: identifying the key research questions to be addressed by 2030

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

Short-circuiting regulatory T-cell proliferation during chronic infection

Starting Your Independent Research Laboratory ⬇️

Subversion of the chemokine world by microbial pathogens ⬇️

Systemic juvenile idiopathic arthritis-like syndrome in mice following stimulation of the immune system with Freund's complete adjuvant: regulation by interferon-γ

T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells.

The Development of T-Cell Immunity

The Immunogenetic Architecture of Autoimmune Disease ⬇️

The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release.

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor

The thymic niche does not limit development of the naturally diverse population of mouse regulatory T lymphocytes

Thymic development and peripheral homeostasis of regulatory T cells.

Tracing the action of IL-2 in tolerance to islet-specific antigen

Understanding the genetic regulation of IgE production

Unusual selection and peripheral homeostasis for immunoregulatory CD4(-) CD8(-) T cells.