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List of works by Omer Dushek

A THEMIS:SHP1 complex promotes T-cell survival

scientific article

A cell topography-based mechanism for ligand discrimination by the T cell receptor

scientific article published on 20 June 2019

A role for rebinding in rapid and reliable T cell responses to antigen

scientific article

A tissue-like platform for studying engineered quiescent human T-cells' interactions with dendritic cells

scientific article published on 25 September 2019

A tissue-like platform for studying engineered quiescent human T-cells’ interactions with dendritic cells

article published in 2019

An induced rebinding model of antigen discrimination

scientific article

Analysis of membrane-localized binding kinetics with FRAP.

scientific article published on 26 February 2008

Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters

scientific article published on 28 January 2008

Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation

scientific article

Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose

scientific article published on 04 October 2016

Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling

scientific article published on 14 November 2011

Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1.

scientific article published on 24 March 2017

Biosensor architectures for high-fidelity reporting of cellular signaling

scientific article

CD8 helps TCR catch slippery self pMHC

scientific article published on 01 December 2018

Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains

scientific article published on 29 December 2017

Constitutively active Lck kinase in T cells drives antigen receptor signal transduction

scientific article

Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand

scientific article published on 23 October 2015

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time

scientific article

Determination of the molecular reach of the protein tyrosine phosphatase SHP-1

scientific article published on 27 March 2021

Dynamic regulation of CD28 conformation and signaling by charged lipids and ions

scientific article

Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery

scientific article

Elementary Steps in T Cell Receptor Triggering ⬇️

scientific article published on January 10, 2012

Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function

scientific article published on 20 August 2020

Human CD8+ T Cells Exhibit a Shared Antigen Threshold for Different Effector Responses

scientific article published on 17 August 2020

Improving parameter estimation for cell surface FRAP data

scientific article

Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands

scientific article

Mechanical modulation of receptor-ligand interactions at cell-cell interfaces

scientific article published on 20 March 2012

Mechanisms for T cell receptor triggering

scientific article

Membrane Ultrastructure and T Cell Activation

Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants

scientific article published on 02 March 2022

Molecular flexibility of DNA as a key determinant of RAD51 recruitment

scientific article published on 14 January 2020

Molecular flexibility of DNA as a major determinant of RAD51 recruitment

scientific article published on 16 August 2018

Molecular mechanisms of T cell sensitivity to antigen

scientific article published on 01 September 2018

Multisite Phosphorylation Modulates the T Cell Receptor ζ-Chain Potency but not the Switchlike Response

scientific article published on April 2016

Non-catalytic tyrosine-phosphorylated receptors

scientific article

PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy

scientific article published on 8 December 2016

Phenotypic models of T cell activation

scientific article published in September 2014

Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation

scientific article

Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions

scientific article published on 25 April 2016

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation

scientific article

SpyAvidin hubs enable precise and ultrastable orthogonal nanoassembly

scientific article

Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity

scientific article

TCR-pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding

scientific article published on 17 July 2019

The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions

The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions

scientific article published on 28 August 2019

The contribution of major histocompatibility complex contacts to the affinity and kinetics of T cell receptor binding

scientific article published on 13 October 2016

The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor

scientific article

Ultrasensitivity in multisite phosphorylation of membrane-anchored proteins

scientific article

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