Search filters

List of works by Gilles P van Wezel

A New Piece of an Old Jigsaw: Glucose Kinase Is Activated Posttranslationally in a Glucose Transport-Dependent Manner in Streptomyces coelicolor A3(2)

scientific article published on 01 January 2007

A Single Biosynthetic Gene Cluster Is Responsible for the Production of Bagremycin Antibiotics and Ferroverdin Iron Chelators

scientific article published on 13 August 2019

A community resource for paired genomic and metabolomic data mining

scientific article published in 2021

A comparative study of the ribosomal RNA operons of Streptomyces coelicolor A3(2) and sequence analysis of rrnA.

scientific article

A comparison of key aspects of gene regulation in Streptomyces coelicolor and Escherichia coli using nucleotide-resolution transcription maps produced in parallel by global and differential RNA sequencing ⬇️

scientific article

A microbial expression system for high-level production of scFv HIV-neutralizing antibody fragments in Escherichia coli

scientific article published on 22 October 2019

A novel function of Streptomyces integration host factor (sIHF) in the control of antibiotic production and sporulation in Streptomyces coelicolor ⬇️

scientific article published on 29 October 2011

A novel locus for mycelial aggregation forms a gateway to improved Streptomyces cell factories

scientific article

A novel plasmid vector that uses the glucose kinase gene (glkA) for the positive selection of stable gene disruptants in Streptomyces

scientific article published in December 1996

A novel taxonomic marker that discriminates between morphologically complex actinomycetes

scientific article published on 23 October 2013

ActinoBase: tools and protocols for researchers working on Streptomyces and other filamentous actinobacteria

scientific article published in 2022

Actinoalloteichus fjordicus sp. nov. isolated from marine sponges: phenotypic, chemotaxonomic and genomic characterisation

scientific article published on 2 August 2017

Adrenaline-mediated activation of antibiotic production in Streptomyces highlights catechol as elicitor of specialized metabolism ⬇️

Aggregation of germlings is a major contributing factor towards mycelial heterogeneity of Streptomyces

scientific article published on 31 May 2016

Altered desferrioxamine-mediated iron utilization is a common trait of bald mutants of Streptomyces coelicolor

scientific article published in August 2014

Analysis of novel kitasatosporae reveals significant evolutionary changes in conserved developmental genes between Kitasatospora and Streptomyces

scientific article published on 24 June 2014

Analysis of two distinct mycelial populations in liquid-grown Streptomyces cultures using a flow cytometry-based proteomics approach

article

Antibiotic production in Streptomyces is organized by a division of labor through terminal genomic differentiation

scientific article published on 15 January 2020

Aromatic Polyketide GTRI-02 is a Previously Unidentified Product of the act Gene Cluster in Streptomyces coelicolor A3(2). ⬇️

scientific article

Artificial intelligence for natural product drug discovery ⬇️

scientific article from 2023

Atypical Spirotetronate Polyketides Identified in the Under-explored Genus Streptacidiphilus ⬇️

scientific article published on 20 July 2020

Bacterial solutions to multicellularity: a tale of biofilms, filaments and fruiting bodies

scientific article published on 02 January 2014

Bagremycin Antibiotics and Ferroverdin iron-chelators are synthetized by the Same Gene Cluster ⬇️

article

Biosynthesis, evolution and ecology of microbial terpenoids

scientific article published in 2022

Cell division and DNA segregation inStreptomyces: how to build a septum in the middle of nowhere? ⬇️

scientific article published on June 11, 2012

Chapter 5 Applying the Genetics of Secondary Metabolism in Model Actinomycetes to the Discovery of New Antibiotics

article

Characterization of the sporulation control protein SsgA by use of an efficient method to create and screen random mutant libraries in streptomycetes

scientific article published on 9 February 2007

Chemical ecology of antibiotic production by actinomycetes

scientific article published in May 2017

Chemical, structural and biological studies of cis-[Pt(3-Acpy)(2)Cl(2)].

scientific article

Classification of the gifted natural product producer Streptomyces roseofaciens sp. nov. by polyphasic taxonomy

Cloning and sequencing of the tuf genes of Streptomyces coelicolor A3(2)

article

Complete Genome Sequence of Escherichia coli AS19, an Antibiotic-Sensitive Variant of E. coli Strain B REL606.

scientific article published on 3 May 2018

Complete Genome Sequence of Streptomyces lunaelactis MM109T, Isolated from Cave Moonmilk Deposits. ⬇️

scientific article

Conserved cis -Acting Elements Upstream of Genes Composing the Chitinolytic System of Streptomycetes Are DasR-Responsive Elements

article

Constitutive expression of ftsZ overrides the whi developmental genes to initiate sporulation of Streptomyces coelicolor

scientific journal article

Correction for Barka et al., Taxonomy, Physiology, and Natural Products of Actinobacteria

scientific article published on 9 November 2016

Correction: Structure of an MmyB-Like Regulator from C. aurantiacus, Member of a New Transcription Factor Family Linked to Antibiotic Metabolism in Actinomycetes

scientific article

Correlative cryo-fluorescence light microscopy and cryo-electron tomography of Streptomyces

scientific article

Cracking the Regulatory Code of Biosynthetic Gene Clusters as a Strategy for Natural Product Discovery.

scientific article published on 5 January 2018

Cross-membranes orchestrate compartmentalization and morphogenesis in Streptomyces

scientific article

DNA cleavage and antitumour activity of platinum(II) and copper(II) compounds derived from 4-methyl-2-N-(2-pyridylmethyl)aminophenol: spectroscopic, electrochemical and biological investigation

scientific article published on 13 October 2009

Detection and identification of antibacterial proteins in snake venoms using at-line nanofractionation coupled to LC-MS

scientific article published on 31 August 2018

Developmental regulation of the Streptomyces lividans ram genes: involvement of RamR in regulation of the ramCSAB operon

scientific article published on August 2002

Discovery of C-Glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a Combined NMR-Based Metabolomics and Bioinformatics Workflow ⬇️

scientific article published on 27 January 2017

Discovery of Novel Glycerolated Quinazolinones from Streptomyces sp. MBT27: Supplemental Information

Discovery of actinomycin L, a new member of the actinomycin family of antibiotics

scientific article published on 18 February 2022

Discovery of novel glycerolated quinazolinones from Streptomyces sp. MBT27 ⬇️

scientific article published on 07 February 2019

Dispatches from the land of the morning calm: special issue papers from the 18th International Symposium on the Biology of Actinomycetes

scientific article published on 01 May 2018

Dissecting Disease-Suppressive Rhizosphere Microbiomes by Functional Amplicon Sequencing and 10× Metagenomics

scientific article published on 08 June 2021

Distance-dependent danger responses in bacteria

scientific article published on March 2017

Diversity and functions of volatile organic compounds produced by Streptomyces from a disease-suppressive soil ⬇️

scientific article published on 9 October 2015

Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Aspergillus Secretomes Using Activity-Based Probes

scientific article published on 24 May 2019

Dynamic localization of Tat protein transport machinery components in Streptomyces coelicolor

scientific article

Ecology and genomics of Actinobacteria: new concepts for natural product discovery

scientific article published on 01 June 2020

Editorial overview: Antimicrobials

scientific article published on 31 August 2018

Effects of increased and deregulated expression of cell division genes on the morphology and on antibiotic production of streptomycetes

scientific article published on 01 December 2000

Eliciting antibiotics active against the ESKAPE pathogens in a collection of actinomycetes isolated from mountain soils

scientific article published on 2 May 2014

Elongation factor Tu3 (EF-Tu3) from the kirromycin producer Streptomyces ramocissimus Is resistant to three classes of EF-Tu-specific inhibitors

scientific article published on 2 March 2007

Engineering of N-acetylglucosamine metabolism for improved antibiotic production in Streptomyces coelicolor A3(2) and an unsuspected role of NagA in glucosamine metabolism ⬇️

scientific article published on 15 August 2012

Enzyme-Constrained Models and Omics Analysis of Streptomyces coelicolor Reveal Metabolic Changes that Enhance Heterologous Production

scientific article published on 03 September 2020

Expanding the chemical space for natural products by Aspergillus-Streptomyces co-cultivation and biotransformation

scientific article published on 4 June 2015

Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lantibiotics ⬇️

scientific article published on 22 December 2020

Exploring the Chemical Space of Paenibacillus NRPs and Discovery of Paenilipoheptin B

scientific article published on 14 March 2025

FERMO: a Dashboard for Streamlined Rationalized Prioritization of Molecular Features from Mass Spectrometry Data

scientific article published on 22 December 2022

Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces

scientific article published on 30 May 2008

From dormant to germinating spores of Streptomyces coelicolor A3(2): new perspectives from the crp null mutant

scientific article

Front Cover: Mining for Microbial Gems: Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline

scholarly article

Functional analysis of the N-acetylglucosamine metabolic genes of Streptomyces coelicolor and role in control of development and antibiotic production

scientific article published on 22 December 2011

Functional and structural insights into a novel promiscuous ketoreductase of the lugdunomycin biosynthetic pathway

scientific article published on 25 August 2020

Genome Sequence of the Filamentous Actinomycete Kitasatospora viridifaciens

scientific article

Genome rearrangements and megaplasmid loss in the filamentous bacterium Kitasatospora viridifaciens are associated with protoplast formation and regeneration

scientific article published on 14 February 2020

Genome-wide analysis of in vivo binding of the master regulator DasR in Streptomyces coelicolor identifies novel non-canonical targets

scientific article published on 15 April 2015

GlcP constitutes the major glucose uptake system of Streptomyces coelicolor A3(2).

scientific article published in January 2005

Glucose kinase of Streptomyces coelicolor A3(2): large-scale purification and biochemical analysis

scientific article published on 01 December 2000

Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases

scientific article published on 28 July 2020

Goodbye to brute force in antibiotic discovery?

scientific article published on 27 January 2016

Healthy scents: microbial volatiles as new frontier in antibiotic research?

scientific article published on 12 March 2018

High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor

article

Identification and isolation of lantibiotics from culture: a bioorthogonal chemistry approach

article

Identification of glucose kinase-dependent and -independent pathways for carbon control of primary metabolism, development and antibiotic production in Streptomyces coelicolor by quantitative proteomics

scientific article published on 5 November 2012

Identification of glucose kinase-dependent and -independent pathways for carbon control of primary metabolism, development and antibiotic production in Streptomyces coelicolor by quantitative proteomics

scientific article

Identification of novel endophenaside antibiotics produced by Kitasatospora sp. MBT66. ⬇️

scientific article published on 18 February 2015

Imaging of Streptomyces coelicolor A3(2) with reduced autofluorescence reveals a novel stage of FtsZ localization

scientific journal article

Inter- and intracellular colonization of Arabidopsis roots by endophytic actinobacteria and the impact of plant hormones on their antimicrobial activity

scientific article published on 15 January 2018

Inter- and intracellular colonization of Arabidopsis roots by endophytic actinobacteria and the impact of plant hormones on their antimicrobial activity

article

Intertwined Precursor Supply during Biosynthesis of the Catecholate-Hydroxamate Siderophores Qinichelins in Streptomyces sp. MBT76.

scientific article published on 25 September 2017

Intertwining nutrient-sensory networks and the control of antibiotic production in Streptomyces

scientific article

Introduction to the Special Issue: "Natural Product Discovery and Development in the Genomic Era".

scientific article published on 11 December 2015

Iso ‐maleimycin, a Constitutional Isomer of Maleimycin, from Streptomyces sp. QL37 ⬇️

scientific article

Lack of A-factor production induces the expression of nutrient scavenging and stress-related proteins in Streptomyces griseus

scientific article published on 22 July 2009

Leucanicidin and Endophenasides Result from Methyl-Rhamnosylation by the Same Tailoring Enzymes in Kitasatospora sp. MBT66.

scientific article published on 16 December 2015

LogoMotif: A Comprehensive Database of Transcription Factor Binding Site Profiles in Actinobacteria

scientific article published in 2024

Loss of the controlled localization of growth stage-specific cell-wall synthesis pleiotropically affects developmental gene expression in an ssgA mutant of Streptomyces coelicolor

scientific article published in June 2007

Lugdunomycin, an Angucycline-Derived Molecule with Unprecedented Chemical Architecture

article by Changsheng Wu et al published 25 February 2019 in Angewandte Chemie International Edition

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

scientific article published on 9 December 2024

Mammalian cell entry genes in Streptomyces may provide clues to the evolution of bacterial virulence

scientific article published on 23 January 2013

Metabolic profiling as a tool for prioritizing antimicrobial compounds

scientific article published on 3 September 2015

Metabolomics in the natural products field--a gateway to novel antibiotics

scientific article published on 14 February 2015

Metabolomics-Driven Discovery of a Prenylated Isatin Antibiotic Produced by Streptomyces Species MBT28. ⬇️

scientific article published on 6 October 2015

Metabolomics-guided analysis of isocoumarin production by Streptomyces species MBT76 and biotransformation of flavonoids and phenylpropanoids ⬇️

scientific article

Microbial and volatile profiling of soils suppressive to Fusarium culmorum of wheat

scientific article published on 19 February 2020

Microencapsulation extends mycelial viability of Streptomyces lividans 66 and increases enzyme production

scientific article published on 12 March 2018

Minimum Information about a Biosynthetic Gene cluster.

scientific article published on August 2015

Mining for Microbial Gems: Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline

Modestobacter caceresii sp. nov., novel actinobacteria with an insight into their adaptive mechanisms for survival in extreme hyper-arid Atacama Desert soils

scientific article

Morphogenesis of Streptomyces in submerged cultures

scientific article

Morphology-driven downscaling of Streptomyces lividans to micro-cultivation

scientific article published in November 2017

Morphology-driven downscaling of Streptomyces lividans to micro-cultivation

MreB of Streptomyces coelicolor is not essential for vegetative growth but is required for the integrity of aerial hyphae and spores

scientific article published in May 2006

Multidimensional view of the bacterial cytoskeleton

scientific article published on 15 February 2013

Multiple allosteric effectors control the affinity of DasR for its target sites.

scientific article published on 26 June 2015

Natural product proteomining, a quantitative proteomics platform, allows rapid discovery of biosynthetic gene clusters for different classes of natural products

scientific article published on 8 May 2014

New approaches to achieve high level enzyme production in Streptomyces lividans

scientific article published on 4 February 2016

New developments in RiPP discovery, enzymology and engineering

scientific article published on 16 September 2020

NgcE Acts as a Lower-Affinity Binding Protein of an ABC Transporter for the Uptake of N,N'-Diacetylchitobiose in Streptomyces coelicolor A3(2)

scholarly article by Chiharu Iinuma et al published 29 September 2018 in Microbes and environments / JSME

Novel aspects of signaling in Streptomyces development

scientific article

Objective comparison of particle tracking methods

scientific article

Off the wall

scientific article published on 26 November 2014

Omics-based strategies to discover novel classes of RiPP natural products

scientific article published on 28 December 2020

OsdR of Streptomyces coelicolor and the Dormancy Regulator DevR of Mycobacterium tuberculosis Control Overlapping Regulons

scientific article published on 3 May 2016

PREDetector: a new tool to identify regulatory elements in bacterial genomes

scientific article published on 12 April 2007

Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome

scientific article published on 01 November 2019

Phenanthroline derivatives with improved selectivity as DNA-targeting anticancer or antimicrobial drugs

scientific article

Phylogenomic analyses and distribution of terpene synthases among Streptomyces

scientific article published on 29 May 2019

Platinum(II) compounds with chelating ligands based on pyridine and pyrimidine: DNA and protein binding studies

scientific article published on 6 August 2009

Polyphasic classification of the gifted natural product producer Streptomyces roseifaciens sp. nov.

scientific article published in April 2019

Positive control of cell division: FtsZ is recruited by SsgB during sporulation of Streptomyces

scientific journal article

Prodiginines Postpone the Onset of Sporulation in <i>Streptomyces coelicolor</i>

scientific article published on 26 November 2020

Production of Prodiginines Is Part of a Programmed Cell Death Process in

article

Production of ammonia as a low-cost and long-distance antibiotic strategy by Streptomyces species

scientific article published on 07 November 2019

Production of glycine-derived ammonia as a low-cost and long-distance antibiotic strategy by Streptomyces

Production of poly-β-1,6-N-acetylglucosamine by MatAB is required for hyphal aggregation and hydrophilic surface adhesion by Streptomyces.

scientific article

RRE-Finder: a Genome-Mining Tool for Class-Independent RiPP Discovery

scientific article published on 01 September 2020

Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining α-l-Arabinofuranosidases

scientific article published on 26 February 2020

Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era. ⬇️

scientific article published on 3 May 2018

Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS.

scientific article published on 23 May 2013

Role for a Lytic Polysaccharide Monooxygenase in Cell Wall Remodeling in Streptomyces coelicolor

scientific article published on 31 March 2022

SParticle, an algorithm for the analysis of filamentous microorganisms in submerged cultures

article

SParticle, an algorithm for the analysis of filamentous microorganisms in submerged cultures.

scientific article

SepG coordinates sporulation-specific cell division and nucleoid organization in Streptomyces coelicolor

scientific article

Single particle tracking of dynamically localizing TatA complexes in Streptomyces coelicolor

scientific article published on 15 July 2013

Socially mediated induction and suppression of antibiosis during bacterial coexistence.

scientific article published on 27 July 2015

Spatial structure increases the benefits of antibiotic production in Streptomyces

scientific article published on 26 August 2019

Sporulation-specific cell division defects in ylmE mutants of Streptomyces coelicolor are rescued by additional deletion of ylmD.

scientific article

SsgA-like proteins determine the fate of peptidoglycan during sporulation of Streptomyces coelicolor

scientific journal article

Streptomyces coelicolor

scientific article published on 06 January 2019

Streptomyces leeuwenhoekii sp. nov., the producer of chaxalactins and chaxamycins, forms a distinct branch in Streptomyces gene trees

scientific article

Stress-induced formation of cell wall-deficient cells in filamentous actinomycetes

scientific article published in Nature Communications

Structural and Proteomic Changes in Viable but Non-culturable

article

Structural and functional characterization of the alanine racemase from Streptomyces coelicolor A3(2).

scientific article published on 29 December 2016

Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes

scientific article

Structure and DNA cleavage properties of two copper(ii) complexes of the pyridine-pyrazole-containing ligands mbpzbpy and Hmpzbpya

scientific article published on 05 July 2007

Structure of an MmyB-Like Regulator from C. aurantiacus, Member of a New Transcription Factor Family Linked to Antibiotic Metabolism in Actinomycetes

scientific article

Structure, cytotoxicity, and DNA-cleavage properties of the complex [Cu(II)(pbt)Br2].

scientific article

Structured morphological modeling as a framework for rational strain design of Streptomyces species

scientific article

Subcompartmentalization by cross-membranes during early growth of Streptomyces hyphae

scientific article

Substrate Inhibition of VanA by d-Alanine Reduces Vancomycin Resistance in a VanX-Dependent Manner

scientific article

Substrate induction and glucose repression of maltose utilization by Streptomyces coelicolor A3(2) is controlled by malR, a member of the lacl-galR family of regulatory genes

scientific article published in February 1997

Taxonomy, Physiology, and Natural Products of Actinobacteria

scientific article

Teichoic acids anchor distinct cell wall lamellae in an apically growing bacterium

scientific article published on 17 June 2020

The DyP-type peroxidase DtpA is a Tat-substrate required for GlxA maturation and morphogenesis in Streptomyces.

scientific article published on January 2016

The ROK family regulator Rok7B7 pleiotropically affects xylose utilization, carbon catabolite repression, and antibiotic production in streptomyces coelicolor ⬇️

scientific article

The ROK-family Regulator Rok7B7 Directly Controls Carbon Catabolite Repression, Antibiotic Biosynthesis, and Morphological Development in Streptomyces avermitilis

scientific article published on 25 May 2020

The Secreted Signaling Protein Factor C Triggers the A-factor Response Regulon inStreptomyces griseus

scientific article published on 20 March 2007

The SsgA-like proteins in actinomycetes: small proteins up to a big task

scientific article published on 14 February 2008

The Streptomyces coelicolor ssgB gene is required for early stages of sporulation

scientific journal article

The chitobiose-binding protein, DasA, acts as a link between chitin utilization and morphogenesis in Streptomyces coelicolor

scientific article published on February 2008

The evolution of actinomycetes: papers from the 16th International Symposium on the Biology of Actinomycetes

scientific article published in October 2012

The genome sequence of Streptomyces lividans 66 reveals a novel tRNA-dependent peptide biosynthetic system within a metal-related genomic island.

scientific article published on January 2013

The malEFG gene cluster of Streptomyces coelicolor A3(2): characterization, disruption and transcriptional analysis

scientific article published on May 1997

The permease gene nagE2 is the key to N-acetylglucosamine sensing and utilization in Streptomyces coelicolor and is subject to multi-level control ⬇️

scientific article published in March 2010

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances ⬇️

scientific article published on May 25, 2011

The square-planar cytotoxic [Cu(II)(pyrimol)Cl] complex acts as an efficient DNA cleaver without reductant

scientific article published on January 2006

The sugar phosphotransferase system of Streptomyces coelicolor is regulated by the GntR-family regulator DasR and links N-acetylglucosamine metabolism to the control of development

scientific article published in September 2006

The tmRNA-tagging mechanism and the control of gene expression: a review

scientific article

The tuf3 gene of Streptomyces coelicolor A3(2) encodes an inessential elongation factor Tu that is apparently subject to positive stringent control ⬇️

scientific article published on October 1, 1995

The tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA. ⬇️

scientific article

The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces

scientific article published in 2022

Three tuf-like genes in the kirromycin producer Streptomyces ramocissimus

scientific article published in April 1994

Transcription of the sporulation gene ssgA is activated by the IclR-type regulator SsgR in a whi-independent manner in Streptomyces coelicolor A3(2).

scientific article

Transcriptional analysis of the cell division-related ssg genes in Streptomyces coelicolor reveals direct control of ssgR by AtrA ⬇️

scientific journal article

Transcriptional and functional analysis of the gene for factor C, an extracellular signal protein involved in cytodifferentiation of Streptomyces griseus

scientific article published in December 2000

Transfer-messenger RNA controls the translation of cell-cycle and stress proteins in Streptomyces

scientific article published on 18 December 2009

Triggers and cues that activate antibiotic production by actinomycetes

scientific article published on 02 August 2013

Unique ligand-based oxidative DNA cleavage by zinc(II) complexes of hpyramol and hpyrimol

scientific article published in January 2007

Unlocking Streptomyces spp. for Use as Sustainable Industrial Production Platforms by Morphological Engineering

scientific article published in October 2006

Unlocking Streptomyces spp. for use as sustainable industrial production platforms by morphological engineering

scientific article published on August 2006

Unsuspected control of siderophore production by N-acetylglucosamine in streptomycetes

scientific article published on 18 May 2012

antiSMASH 6.0: improving cluster detection and comparison capabilities

scientific article published in 2021

ssgA is essential for sporulation of Streptomyces coelicolor A3(2) and affects hyphal development by stimulating septum formation

scientific article

Paulina is supported by:

About Paulina

Help