List of works - Simon P Robinson

31P-magnetic resonance spectroscopy and 2H-magnetic resonance imaging studies of a panel of early-generation transplanted murine tumour models.

scientific article

A Longitudinal Study of R2* and R2 Magnetic Resonance Imaging Relaxation Rate Measurements in Murine Liver After a Single Administration of 3 Different Iron Oxide-Based Contrast Agents

scientific article published on 01 December 2005

A multi-parametric imaging investigation of the response of C6 glioma xenografts to MLN0518 (tandutinib) treatment.

scientific article

Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomas.

scientific article

Acute tumor response to ZD6126 assessed by intrinsic susceptibility magnetic resonance imaging.

scientific article published in May 2005

Acute tumour response to a bispecific Ang-2-VEGF-A antibody: insights from multiparametric MRI and gene expression profiling.

scientific article

Acute tumour response to the MEK1/2 inhibitor selumetinib (AZD6244, ARRY-142886) evaluated by non-invasive diffusion-weighted MRI.

scientific article published on 13 August 2013

Assessment of the direct effects of DDAH I on tumour angiogenesis in vivo.

scientific article published on 2 May 2018

Assessment of tumor response to the vascular disrupting agents 5,6-dimethylxanthenone-4-acetic acid or combretastatin-A4-phosphate by intrinsic susceptibility magnetic resonance imaging

scientific article

Bayesian estimation of changes in transverse relaxation rates

scientific article published on September 2010

CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs.

scientific article published on 28 August 2012

Calmodulin discriminates between the two enantiomers of the receptor-operated calcium channel blocker SK&F 96365: a study using 1H-NMR and chiral HPLC

scientific article published on 01 January 1990

Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: a magnetic resonance study in vivo.

scientific article published in March 1998

Characterisation of fibrosis in chemically-induced rat mammary carcinomas using multi-modal endogenous contrast MRI on a 1.5T clinical platform.

scientific article

Characterization of a novel mouse model of multiple myeloma and its use in preclinical therapeutic assessment

scientific article

Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease

scientific article published on 12 January 2015

Correction: A Multi-Parametric Imaging Investigation of the Response of C6 Glioma Xenografts to MLN0518 (Tandutinib) Treatment

scientific article (publication date: 12 September 2013)

Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model

scientific article

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

scientific article published on October 2013

Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma

scientific article published on 22 July 2015

DIPG-25. GENETIC ALTERATIONS TARGETING THE MAPK PATHWAY CONFERS PRECLINICAL SENSITIVITY TO TRAMETINIB IN A CO-CLINICAL TRIAL IN DIPG

Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition.

scientific article

Detecting microvascular changes in the mouse spleen using optical computed tomography.

scientific article

Detection of the prodrug-activating enzyme carboxypeptidase G2 activity with chemical exchange saturation transfer magnetic resonance.

scientific article

Dichloroacetate induces autophagy in colorectal cancer cells and tumours.

scientific article

Diffusion-weighted MRI for imaging cell death after cytotoxic or apoptosis-inducing therapy.

scientific article published on 16 April 2015

Effect of Gd-DTPA-BMA on choline signals of HT29 tumors detected by in vivo 1H MRS.

scientific article

Effects of different levels of hypercapnic hyperoxia on tumour R(2)* and arterial blood gases

scientific article published on February 2001

Effects of overexpression of dimethylarginine dimethylaminohydrolase on tumor angiogenesis assessed by susceptibility magnetic resonance imaging.

scientific article published in August 2003

Enhanced uptake of ifosfamide into GH3 prolactinomas with hypercapnic hyperoxic gases monitored in vivo by (31)P MRS.

scientific article

Evaluating Imaging Biomarkers of Acquired Resistance to Targeted EGFR Therapy in Xenograft Models of Human Head and Neck Squamous Cell Carcinoma

scientific article published on 23 July 2018

Evaluation and immunohistochemical qualification of carbogen-induced ΔR₂ as a noninvasive imaging biomarker of improved tumor oxygenation.

scientific article

Evaluation of clinically translatable MR imaging biomarkers of therapeutic response in the TH-MYCN transgenic mouse model of neuroblastoma

scientific article published on 20 November 2012

Evaluation of novel combined carbogen USPIO (CUSPIO) imaging biomarkers in assessing the antiangiogenic effects of cediranib (AZD2171) in rat C6 gliomas.

scientific article

Evaluation of the Response of Intracranial Xenografts to VEGF Signaling Inhibition Using Multiparametric MRI

scientific article

Exploring the biomechanical properties of brain malignancies and their pathologic determinants in vivo with magnetic resonance elastography

scientific article

Exploring ΔR(2) * and ΔR(1) as imaging biomarkers of tumor oxygenation.

scientific article

False-negative MRI biomarkers of tumour response to targeted cancer therapeutics

scientific article

Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues.

scientific article

HG-99A PATIENT-DERIVED PAEDIATRIC HIGH GRADE GLIOMA AND DIPG CELL CULTURE PANEL RECAPITULATING THE GENOTYPIC AND PHENOTYPIC DIVERSITY OF THE DISEASE.

scientific article published on 30 May 2016

HGG-23. DRUG SCREENING LINKED TO MOLECULAR PROFILING IDENTIFIES NOVEL DEPENDENCIES IN PATIENT-DERIVED PRIMARY CULTURES OF PAEDIATRIC HIGH GRADE GLIOMA AND DIPG

article by Alan Mackay et al published 22 June 2018 in Neuro-Oncology

Hyperpolarized (13)C magnetic resonance detection of carboxypeptidase G2 activity

scientific article published in November 2009

Hypoxia and its therapeutic possibilities in paediatric cancers

scientific article published on 27 October 2020

Imaging biomarker roadmap for cancer studies ⬇️

scientific article

Imaging hypoxia in tumours with advanced MRI.

scientific article

Immunoassays for the quantification of ALK and phosphorylated ALK support the evaluation of on-target ALK inhibitors in neuroblastoma.

scientific article published on 22 April 2017

Immunohistochemical assessment of intrinsic and extrinsic markers of hypoxia in reproductive tissue: differential expression of HIF1α and HIF2α in rat oviduct and endometrium.

scientific article

Improving apparent diffusion coefficient estimates and elucidating tumor heterogeneity using Bayesian adaptive smoothing

scientific article published on 16 November 2010

In Vivo Modeling of Chemoresistant Neuroblastoma Provides New Insights into Chemorefractory Disease and Metastasis

scientific article published on 12 August 2019

In vivo determination of tumor oxygenation during growth and in response to carbogen breathing using 15C5-loaded alginate capsules as fluorine-19 magnetic resonance imaging oxygen sensors

scientific article published in November 2004

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

scientific article published on 01 April 2020

Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors

scientific article (publication date: 6 September 2016)

Intrinsic susceptibility MR imaging of chemically induced rat mammary tumors: relationship to histologic assessment of hypoxia and fibrosis

scientific article published on January 2010

Intrinsic susceptibility MRI identifies tumors with ALKF1174L mutation in genetically-engineered murine models of high-risk neuroblastoma

scientific article published on 25 March 2014

Investigating intracranial tumour growth patterns with multiparametric MRI incorporating Gd-DTPA and USPIO-enhanced imaging

scientific article

Investigating temporal fluctuations in tumor vasculature with combined carbogen and ultrasmall superparamagnetic iron oxide particle (CUSPIO) imaging.

scientific article

Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography

scientific article published on 11 October 2019

Investigating the Vascular Phenotype of Subcutaneously and Orthotopically Propagated PC3 Prostate Cancer Xenografts Using Combined Carbogen Ultrasmall Superparamagnetic Iron Oxide MRI.

scientific article published on October 2016

Investigating the role of tumour cell derived iNOS on tumour growth and vasculature in vivo using a tetracycline regulated expression system

scientific article published on 12 January 2016

Investigations in vivo of the effects of carbogen breathing on 5-fluorouracil pharmacokinetics and physiology of solid rodent tumours

scientific article published on 5 October 2004

Issues in GRE & SE magnetic resonance imaging to probe tumor oxygenation

scientific article

Issues in flow and oxygenation dependent contrast (FLOOD) imaging of tumours

scientific article published in November 2001

Longitudinal in vivo susceptibility contrast MRI measurements of LS174T colorectal liver metastasis in nude mice.

scientific article

MODL-20. A BIOBANK OF ~100 PATIENT-DERIVED MODELS REPRESENTING BIOLOGICAL HETEROGENEITY AND DISTINCT THERAPEUTIC DEPENDENCIES IN PAEDIATRIC HIGH GRADE GLIOMA AND DIPG

scientific article published in 2020

MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment

scientific article published on 15 March 2019

MRI measurements of vessel calibre in tumour xenografts: comparison with vascular corrosion casting

scientific article published on 18 August 2012

Magnetic resonance imaging techniques for monitoring changes in tumor oxygenation and blood flow.

scientific article published in July 1998

Magnetic resonance spectroscopy and imaging methods for measuring tumour and tissue oxygenation

scientific article

Mapping Hypoxia in Renal Carcinoma with Oxygen-enhanced MRI: Comparison with Intrinsic Susceptibility MRI and Pathology

scientific article published on 05 June 2018

Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma

scientific article published on 31 October 2018

Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): evidence of an anabolic role for the HIF-1 pathway

scientific article published in February 2002

Model free approach to kinetic analysis of real-time hyperpolarized 13C magnetic resonance spectroscopy data

scientific article (publication date: 2013)

Modification of Tumour Perfusion and Oxygenation Monitored by Gradient Recalled Echo MRI and31P MRS

scientific article published on 01 August 1996

Modulation of renal oxygenation and perfusion in rat kidney monitored by quantitative diffusion and blood oxygen level dependent magnetic resonance imaging on a clinical 1.5T platform.

scientific article

Monitoring the vascular response and resistance to sunitinib in renal cell carcinoma in vivo with susceptibility contrast MRI. ⬇️

scientific article

Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight

scientific article

Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)

scientific article

Non-invasive in vivo imaging of vessel calibre in orthotopic prostate tumour xenografts

scientific article

Noninvasive Imaging of Cycling Hypoxia in Head and Neck Cancer Using Intrinsic Susceptibility MRI.

scientific article

Noninvasive MRI native T1 mapping detects response to MYCN-targeted therapies in the Th-MYCN model of neuroblastoma

scientific article published on 28 June 2020

Noninvasive detection of carboxypeptidase G2 activity in vivo

scientific article published on 3 October 2010

Noninvasive monitoring of carbogen-induced changes in tumor blood flow and oxygenation by functional magnetic resonance imaging

scientific article published on 01 November 1995

Nuclear magnetic resonance spectroscopy of cancer

scientific article published on November 1997

Orally administered lenalidomide (CC-5013) is anti-angiogenic in vivo and inhibits endothelial cell migration and Akt phosphorylation in vitro

scientific article published in January 2005

Overexpression of dimethylarginine dimethylaminohydrolase enhances tumor hypoxia: an insight into the relationship of hypoxia and angiogenesis in vivo.

scientific article

Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models

scientific article published on 9 December 2015

Oxygen-enhanced MRI can accurately identify, quantify and map tumour hypoxia in preclinical models.

scientific article published on 2 October 2015

PCM-02A GENETICALLY ENGINEERED MOUSE MODEL RECAPITULATES RADIOLOGICAL FEATURES OF HUMAN ADAMANTINOMATOUS CRANIOPHARYNGIOMA.

scientific article

PCM-08IN VIVO MAGNETIC RESONANCE IMAGING IDENTIFIES CLINICAL PHENOTYPES OF PAEDIATRIC GLIOBLASTOMA IN AN ORTHOTOPIC MOUSE XENOGRAFT MODEL.

scientific article

PDTM-31. DRUG SCREENING LINKED TO MOLECULAR PROFILING IDENTIFIES NOVEL DEPENDENCIES IN PATIENT-DERIVED PRIMARY CULTURES OF PAEDIATRIC HIGH GRADE GLIOMA AND DIPG

article by Alan Mackay et al published 5 November 2018 in Neuro-Oncology

PDTM-33. ATRX LOSS CONFERS ENHANCED SENSITIVITY TO COMBINED PARP INHIBITION AND RADIOTHERAPY IN PAEDIATRIC GLIOBLASTOMA MODELS

article by Janat Fazal Salom et al published 5 November 2018 in Neuro-Oncology

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.

scientific article

Pattern recognition of 31P magnetic resonance spectroscopy tumour spectra obtained in vivo

scientific article

Pre-clinical imaging of transgenic mouse models of neuroblastoma using a dedicated 3-element solenoid coil on a clinical 3T platform.

scientific article published on 08 August 2017

Precipitation and 13C-NMR relaxation enhancement measurements of the interactions of bile acids with synthetic cationic bile acid derivatives, and with spin labelled fatty acids

scientific article published on 01 December 1991

Preclinical evaluation of imaging biomarkers for prostate cancer bone metastasis and response to cabozantinib.

scientific article published on 14 March 2014

Preclinical transgenic and patient-derived xenograft models recapitulate the radiological features of human adamantinomatous craniopharyngioma.

scientific article published on 8 May 2017

Rapid modification of the bone microenvironment following short-term treatment with Cabozantinib in vivo.

scientific article published on 13 August 2015

Reduced Warburg effect in cancer cells undergoing autophagy: steady- state 1H-MRS and real-time hyperpolarized 13C-MRS studies

scientific article

Repeatability and sensitivity of T2* measurements in patients with head and neck squamous cell carcinoma at 3T

scientific article published on 22 January 2016

Response of hepatoma 9618a and normal liver to host carbogen and carbon monoxide breathing

scientific article published on December 1999

Robust estimation of the apparent diffusion coefficient (ADC) in heterogeneous solid tumors

scientific article published in August 2009

Single dose of the antivascular agent, ZD6126 (N-acetylcolchinol-O-phosphate), reduces perfusion for at least 96 hours in the GH3 prolactinoma rat tumor model

scientific article published on March 2004

Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma

scientific article published on 08 August 2016

Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma

scientific article published on 8 July 2013

Susceptibility contrast magnetic resonance imaging determination of fractional tumor blood volume: a noninvasive imaging biomarker of response to the vascular disrupting agent ZD6126.

scientific article

The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and MYCN

scientific article published on 07 July 2016

The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma

scientific article published in July 2012

The C-neu mammary carcinoma in Oncomice; characterization and monitoring response to treatment with herceptin by magnetic resonance methods

scientific article

The Effects of Tumour Blood Flow and Oxygenation Modifiers on Subcutaneous Tumours as Determined by NIRS

scientific article published on 01 January 2005

The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function.

scientific article

The OxyLite: a fibre-optic oxygen sensor

scientific article published on 01 July 1999

The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo.

scientific article published in September 2011

The effects of tumor-derived platelet-derived growth factor on vascular morphology and function in vivo revealed by susceptibility MRI.

scientific article

The importance of tumor metabolism in cancer prognosis and therapy; pre-clinical studies on rodent tumors with agents that improve tumor oxygenation

scientific article

The response of RIF-1 fibrosarcomas to the vascular-disrupting agent ZD6126 assessed by in vivo and ex vivo 1H magnetic resonance spectroscopy

scientific article published on July 2006

The response of human tumors to carbogen breathing, monitored by gradient-recalled echo magnetic resonance imaging

scientific article published on 01 October 1997

The role of tumour-derived iNOS in tumour progression and angiogenesis

scientific article

Tumor R2* is a prognostic indicator of acute radiotherapeutic response in rodent tumors

scientific article

Tumor vascular architecture and function evaluated by non-invasive susceptibility MRI methods and immunohistochemistry.

scientific article published in April 2003

Tumour biomechanical response to the vascular disrupting agent ZD6126 in vivo assessed by magnetic resonance elastography

scientific article

Tumour overexpression of inducible nitric oxide synthase (iNOS) increases angiogenesis and may modulate the anti-tumour effects of the vascular disrupting agent ZD6126.

scientific article

Tumour response to hypercapnia and hyperoxia monitored by FLOOD magnetic resonance imaging

article

Vessel size index magnetic resonance imaging to monitor the effect of antivascular treatment in a rodent tumor model

scientific article published on 5 June 2008

p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance.

scientific article published on 29 March 2016

¹H NMR and hyperpolarized ¹³C NMR assays of pyruvate-lactate: a comparative study

scientific article published on 27 May 2013

List of works by Simon P Robinson

31P-magnetic resonance spectroscopy and 2H-magnetic resonance imaging studies of a panel of early-generation transplanted murine tumour models.

A Longitudinal Study of R2* and R2 Magnetic Resonance Imaging Relaxation Rate Measurements in Murine Liver After a Single Administration of 3 Different Iron Oxide-Based Contrast Agents

A multi-parametric imaging investigation of the response of C6 glioma xenografts to MLN0518 (tandutinib) treatment.

Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomas.

Acute tumor response to ZD6126 assessed by intrinsic susceptibility magnetic resonance imaging.

Acute tumour response to a bispecific Ang-2-VEGF-A antibody: insights from multiparametric MRI and gene expression profiling.

Acute tumour response to the MEK1/2 inhibitor selumetinib (AZD6244, ARRY-142886) evaluated by non-invasive diffusion-weighted MRI.

Assessment of the direct effects of DDAH I on tumour angiogenesis in vivo.

Assessment of tumor response to the vascular disrupting agents 5,6-dimethylxanthenone-4-acetic acid or combretastatin-A4-phosphate by intrinsic susceptibility magnetic resonance imaging

Bayesian estimation of changes in transverse relaxation rates

CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs.

Calmodulin discriminates between the two enantiomers of the receptor-operated calcium channel blocker SK&F 96365: a study using 1H-NMR and chiral HPLC

Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: a magnetic resonance study in vivo.

Characterisation of fibrosis in chemically-induced rat mammary carcinomas using multi-modal endogenous contrast MRI on a 1.5T clinical platform.

Characterization of a novel mouse model of multiple myeloma and its use in preclinical therapeutic assessment

Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease

Correction: A Multi-Parametric Imaging Investigation of the Response of C6 Glioma Xenografts to MLN0518 (Tandutinib) Treatment

Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma

DIPG-25. GENETIC ALTERATIONS TARGETING THE MAPK PATHWAY CONFERS PRECLINICAL SENSITIVITY TO TRAMETINIB IN A CO-CLINICAL TRIAL IN DIPG

Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition.

Detecting microvascular changes in the mouse spleen using optical computed tomography.

Detection of the prodrug-activating enzyme carboxypeptidase G2 activity with chemical exchange saturation transfer magnetic resonance.

Dichloroacetate induces autophagy in colorectal cancer cells and tumours.

Diffusion-weighted MRI for imaging cell death after cytotoxic or apoptosis-inducing therapy.

Effect of Gd-DTPA-BMA on choline signals of HT29 tumors detected by in vivo 1H MRS.

Effects of different levels of hypercapnic hyperoxia on tumour R(2)* and arterial blood gases

Effects of overexpression of dimethylarginine dimethylaminohydrolase on tumor angiogenesis assessed by susceptibility magnetic resonance imaging.

Enhanced uptake of ifosfamide into GH3 prolactinomas with hypercapnic hyperoxic gases monitored in vivo by (31)P MRS.

Evaluating Imaging Biomarkers of Acquired Resistance to Targeted EGFR Therapy in Xenograft Models of Human Head and Neck Squamous Cell Carcinoma

Evaluation and immunohistochemical qualification of carbogen-induced ΔR₂ as a noninvasive imaging biomarker of improved tumor oxygenation.

Evaluation of clinically translatable MR imaging biomarkers of therapeutic response in the TH-MYCN transgenic mouse model of neuroblastoma

Evaluation of novel combined carbogen USPIO (CUSPIO) imaging biomarkers in assessing the antiangiogenic effects of cediranib (AZD2171) in rat C6 gliomas.

Evaluation of the Response of Intracranial Xenografts to VEGF Signaling Inhibition Using Multiparametric MRI

Exploring the biomechanical properties of brain malignancies and their pathologic determinants in vivo with magnetic resonance elastography

Exploring ΔR(2) * and ΔR(1) as imaging biomarkers of tumor oxygenation.

False-negative MRI biomarkers of tumour response to targeted cancer therapeutics

Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues.

HG-99A PATIENT-DERIVED PAEDIATRIC HIGH GRADE GLIOMA AND DIPG CELL CULTURE PANEL RECAPITULATING THE GENOTYPIC AND PHENOTYPIC DIVERSITY OF THE DISEASE.

HGG-23. DRUG SCREENING LINKED TO MOLECULAR PROFILING IDENTIFIES NOVEL DEPENDENCIES IN PATIENT-DERIVED PRIMARY CULTURES OF PAEDIATRIC HIGH GRADE GLIOMA AND DIPG

Hyperpolarized (13)C magnetic resonance detection of carboxypeptidase G2 activity

Hypoxia and its therapeutic possibilities in paediatric cancers

Imaging biomarker roadmap for cancer studies ⬇️

Imaging hypoxia in tumours with advanced MRI.

Immunoassays for the quantification of ALK and phosphorylated ALK support the evaluation of on-target ALK inhibitors in neuroblastoma.

Immunohistochemical assessment of intrinsic and extrinsic markers of hypoxia in reproductive tissue: differential expression of HIF1α and HIF2α in rat oviduct and endometrium.

Improving apparent diffusion coefficient estimates and elucidating tumor heterogeneity using Bayesian adaptive smoothing

In Vivo Modeling of Chemoresistant Neuroblastoma Provides New Insights into Chemorefractory Disease and Metastasis

In vivo determination of tumor oxygenation during growth and in response to carbogen breathing using 15C5-loaded alginate capsules as fluorine-19 magnetic resonance imaging oxygen sensors

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors

Intrinsic susceptibility MR imaging of chemically induced rat mammary tumors: relationship to histologic assessment of hypoxia and fibrosis

Intrinsic susceptibility MRI identifies tumors with ALKF1174L mutation in genetically-engineered murine models of high-risk neuroblastoma

Investigating intracranial tumour growth patterns with multiparametric MRI incorporating Gd-DTPA and USPIO-enhanced imaging

Investigating temporal fluctuations in tumor vasculature with combined carbogen and ultrasmall superparamagnetic iron oxide particle (CUSPIO) imaging.

Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography

Investigating the Vascular Phenotype of Subcutaneously and Orthotopically Propagated PC3 Prostate Cancer Xenografts Using Combined Carbogen Ultrasmall Superparamagnetic Iron Oxide MRI.

Investigating the role of tumour cell derived iNOS on tumour growth and vasculature in vivo using a tetracycline regulated expression system

Investigations in vivo of the effects of carbogen breathing on 5-fluorouracil pharmacokinetics and physiology of solid rodent tumours

Issues in GRE & SE magnetic resonance imaging to probe tumor oxygenation

Issues in flow and oxygenation dependent contrast (FLOOD) imaging of tumours

Longitudinal in vivo susceptibility contrast MRI measurements of LS174T colorectal liver metastasis in nude mice.

MODL-20. A BIOBANK OF ~100 PATIENT-DERIVED MODELS REPRESENTING BIOLOGICAL HETEROGENEITY AND DISTINCT THERAPEUTIC DEPENDENCIES IN PAEDIATRIC HIGH GRADE GLIOMA AND DIPG

MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment

MRI measurements of vessel calibre in tumour xenografts: comparison with vascular corrosion casting

Magnetic resonance imaging techniques for monitoring changes in tumor oxygenation and blood flow.

Magnetic resonance spectroscopy and imaging methods for measuring tumour and tissue oxygenation

Mapping Hypoxia in Renal Carcinoma with Oxygen-enhanced MRI: Comparison with Intrinsic Susceptibility MRI and Pathology

Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma

Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): evidence of an anabolic role for the HIF-1 pathway

Model free approach to kinetic analysis of real-time hyperpolarized 13C magnetic resonance spectroscopy data

Modification of Tumour Perfusion and Oxygenation Monitored by Gradient Recalled Echo MRI and31P MRS

Modulation of renal oxygenation and perfusion in rat kidney monitored by quantitative diffusion and blood oxygen level dependent magnetic resonance imaging on a clinical 1.5T platform.

Monitoring the vascular response and resistance to sunitinib in renal cell carcinoma in vivo with susceptibility contrast MRI. ⬇️

Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight

Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)

Non-invasive in vivo imaging of vessel calibre in orthotopic prostate tumour xenografts

Noninvasive Imaging of Cycling Hypoxia in Head and Neck Cancer Using Intrinsic Susceptibility MRI.