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List of works by Martin Eilers

A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer

scientific article published on December 2015

A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer

scientific article published on 23 May 2016

A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.

scientific article

A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth

scientific journal article

Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Euro

scientific article published on 12 June 2017

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.

scientific article

Activation of c-Myc uncouples DNA replication from activation of G1-cyclin-dependent kinases

scientific article published on 01 August 1997

Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis

scientific article (publication date: 17 June 1996)

Addicted to Myc--but why?

scientific article published on May 2011

Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage

scientific article published on 5 December 2004

All-trans retinoic acid treatment of Wilms tumor cells reverses expression of genes associated with high risk and relapse in vivo

scientific article

An alternative pathway for gene regulation by Myc

scientific article

An unsteady scaffold for Myc.

scientific article published in March 2009

An unsteady scaffold for Myc.

scientific article published in May 2009

Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival

scientific article published on 09 March 2020

Association of Myc with the Zinc-finger Protein Miz-1 Defines a Novel Pathway for Gene Regulation by Myc ⬇️

scientific article published on January 1, 1997

BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues

scientific article

Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms.

scientific article

Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria.

scientific article

Binding of a tightly folded artificial mitochondrial precursor protein to the mitochondrial outer membrane involves a lipid-mediated conformational change

scientific article published on 01 February 1989

C-myc activation impairs the NF-kappaB and the interferon response: implications for the pathogenesis of Burkitt's lymphoma

scientific article published on April 2007

CIP2A influences survival in colon cancer and is critical for maintaining Myc expression

scientific article

Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes

scientific article published on 01 November 1997

Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter.

scientific article published on July 1996

Cell growth: downstream of Myc - to grow or to cycle?

scientific article

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

scientific article published in Nature

Combined inhibition of Aurora-A and ATR kinase results in regression of <i>MYCN</i>-amplified neuroblastoma

scientific article published on 11 February 2021

Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: sustained regression before and after allogeneic stem cell transplantation

scientific article (publication date: 25 June 2009)

Contributions of Myc to tumorigenesis

scientific article

Control of cell proliferation and growth by Myc proteins.

scientific article published on January 2006

Control of cell proliferation by Myc proteins.

scientific article published in January 1998

Control of cell proliferation by Myc.

scientific article

Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60.

scientific article published on May 2000

Cystathionase mediates senescence evasion in melanocytes and melanoma cells

scientific article

DNA binding cooperativity of p53 modulates the decision between cell-cycle arrest and apoptosis.

scientific article published in May 2010

DNA binding of USF is required for specific E-box dependent gene activation in vivo

scientific article published on December 1999

DeltaNp73 can modulate the expression of various genes in a p53-independent fashion

scientific article

Deregulated MYC expression induces dependence upon AMPK-related kinase 5.

scientific article

Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

scientific article

Discrimination between different E-box-binding proteins at an endogenous target gene of c-myc

scientific article

Drugging MYCN through an allosteric transition in Aurora kinase A

scientific article

Dual regulation of Fbw7 function and oncogenic transformation by Usp28.

scientific article published on 30 October 2014

Expression of P27KIP1 is prognostic and independent ofMYCN amplification in human neuroblastoma

scientific article published on 01 May 2001

Expression of cyclin D1 mRNA is not upregulated by Myc in rat fibroblasts

scientific article published on 01 November 1995

Expression profiling of Wilms tumors reveals new candidate genes for different clinical parameters

scientific article

Facilitating replication under stress: an oncogenic function of MYC?

scientific article published on June 2009

Fbw7 and Usp28 regulate myc protein stability in response to DNA damage

scientific article

FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.

scientific article published on November 2007

Gene expression analysis after receptor tyrosine kinase activation reveals new potential melanoma proteins

scientific article

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

scientific article

HCT116 cells deficient in p21(Waf1) are hypersensitive to tyrosine kinase inhibitors and adriamycin through a mechanism unrelated to p21 and dependent on p53.

scientific article published on 15 January 2009

Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes.

scientific article published on October 1995

Identification of a novel Krüppel-associated box domain protein, Krim-1, that interacts with c-Myc and inhibits its oncogenic activity

scientific article published on 13 May 2003

Import of Proteins into Mitochondria

scientific article published on 01 May 1988

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.

scientific article

Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events

scientific article

Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.

scientific article published on 2 April 2014

Inhibition of retinoic acid receptor signaling by Ski in acute myeloid leukemia

scientific article published in March 2006

Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes

scientific article (publication date: 30 June 2005)

Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR/ABL and down-regulates bcl-2.

scientific article published on 4 December 2003

Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma

scientific article published on 01 November 2002

Loss of caspase-8 expression does not correlate with MYCN amplification, aggressive disease, or prognosis in neuroblastoma

scientific article published on October 2006

MYB and MYC in the cell cycle

scientific article published in January 1991

MYC and tumor metabolism: chicken and egg.

scientific article published on 10 November 2017

MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling

scientific article published in 2022

MYC regulates the antitumor immune response through CD47 and PD-L1

scientific article published on 10 March 2016

MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures

scientific article published on February 2016

MYCN regulates oncogenic MicroRNAs in neuroblastoma

scientific article

Mad1 function in cell proliferation and transcriptional repression is antagonized by cyclin E/CDK2.

scientific article published on 18 February 2005

Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells

scientific article published on 04 March 2020

Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes

scientific article

Mechanisms of transcriptional repression by Myc.

scientific article

MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer

scientific article published on 20 August 2021

Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

scientific article

Miz1 deficiency in the mammary gland causes a lactation defect by attenuated Stat5 expression and phosphorylation

scientific article (publication date: 2014)

Miz1 is a critical repressor of cdkn1a during skin tumorigenesis

scientific article

Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation

scientific article published on 07 October 2009

Miz1 is required for early embryonic development during gastrulation

scientific journal article

Miz1 is required for hair follicle structure and hair morphogenesis

scientific article

Miz1 is required to maintain autophagic flux.

scientific article published in January 2013

Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation.

scientific article published on April 1994

Multiple myeloma is affected by multiple and heterogeneous somatic mutations in adhesion- and receptor tyrosine kinase signaling molecules

scientific article published on 8 February 2013

Mutual requirement of CDK4 and Myc in malignant transformation: evidence for cyclin D1/CDK4 and p16INK4A as upstream regulators of Myc.

scientific article published on July 1997

Myc coordinates transcription and translation to enhance transformation and suppress invasiveness

scientific article

Myc increases self-renewal in neural progenitor cells through Miz-1.

scientific article published on 11 November 2008

Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1

scientific article

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

scientific article (publication date: 23 January 2003)

Myc's broad reach

scientific article published on October 2008

Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins

scientific article

Myc: a single gene controls both proliferation and apoptosis in mammalian cells

scientific article

Negative regulation of the mammalian UV response by Myc through association with Miz-1

scientific article (publication date: September 2002)

Nramp1-mediated innate resistance to intraphagosomal pathogens is regulated by IRF-8, PU.1, and Miz-1.

scientific article published on 6 August 2003

OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors

scientific article

Oncogenic RAS enables DNA damage- and p53-dependent differentiation of acute myeloid leukemia cells in response to chemotherapy

scientific article

PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity

scientific article

PIM1 and MYC: a changing relationship?

scientific article published on 01 August 2007

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

scientific article published in Nature Communications

Pluripotency without Max

scientific article published on 01 July 2011

Pontin and Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1.

scientific article published on 22 January 2005

Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity

scientific article published on 02 November 2018

Protein unfolding and the energetics of protein translocation across biological membranes

scientific article published on February 1988

Publisher Correction: Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

scientific article published on 20 February 2019

Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter.

scientific article

Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells

scientific article published on 20 April 2015

Repression of cyclin D1: a novel function of MYC

scientific article published on June 1994

Repression of p15INK4b expression by Myc through association with Miz-1

scientific article (publication date: April 2001)

Selective ablation of retinoblastoma protein function by the RET finger protein

scientific article

Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation

scientific article

Silencing of the meiotic genes SMC1beta and STAG3 in somatic cells by E2F6.

scientific article

Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma

scientific article published on 8 July 2013

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma

scientific article

Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ.

scientific article published on 24 March 2013

TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

scientific article published in April 2001

TGFβ-dependent gene expression shows that senescence correlates with abortive differentiation along several lineages in Myc-induced lymphomas

scientific article published in December 2010

Taming of the beast: shaping Myc-dependent amplification

scientific article

Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors

scientific journal article

Target gene-independent functions of MYC oncoproteins

scientific article published on 18 February 2020

Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

scientific article published on 06 July 2021

Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer

scientific article published on May 2015

The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis

scientific article published on March 2010

The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity

scientific journal article

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

scientific article

The MYC mRNA 3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.

scientific article

The MYC protein activates transcription of the alpha-prothymosin gene.

scientific article

The adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation

scientific article published on 05 March 2020

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

scientific article

The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer

scientific article

The functions of Myc in cell cycle progression and apoptosis.

scientific article published on January 1996

The functions of Myc proteins

scientific article published on December 1992

The human papillomavirus type 16 E7 oncoprotein targets Myc-interacting zinc-finger protein-1.

scientific article

The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance

scientific article

The role of MIZ-1 in MYC-dependent tumorigenesis

scientific article

The role of p53 in coordinated regulation of cyclin D1 and p21 gene expression by the adenovirus E1A and E1B oncogenes.

scientific article

The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

scientific article

The ubiquitin-specific protease USP28 is required for MYC stability

scientific article

Transactivation of prothymosin alpha and c-myc promoters by human papillomavirus type 16 E6 protein

scientific article published on May 1997

Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation

scientific article published in December 2010

Transcriptional regulation and transformation by Myc proteins

scientific article

Transcriptional repression by Myc.

scientific article

Transcriptional repression: the dark side of myc.

scientific article published on June 2010

Transport of proteins into yeast mitochondria

scientific article published on January 1988

Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase

scientific article

Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation.

scientific article published on 10 December 2015

Ubiquitination of Myc: proteasomal degradation and beyond

scientific article published on 01 January 2008

Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover

scientific article published on 19 September 2010

Unfolding and refolding of a purified precursor protein during import into isolated mitochondria.

scientific article

Usp28 counteracts Fbw7 in intestinal homeostasis and cancer

scientific article

ZBTB17 ( MIZ1 ) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure

article

Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation

scientific article

c-Myc antagonizes the effect of p53 on apoptosis and p21WAF1 transactivation in K562 leukemia cells

scientific article

c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha

scientific article

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication

scientific journal article

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