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List of works by Takashi Saito

A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation

scientific article published in Science

A Heat-Stable Extract From Mucuna Stimulates the Differentiation of Bone Marrow Cells Into Dendritic Cells and Induces Apoptosis in Cancer Cells

article published in 2010

A Lysosomal Protein Negatively Regulates Surface T Cell Antigen Receptor Expression by Promoting CD3ζ-Chain Degradation

article by Rika Ouchida et al published July 2008 in Immunity

A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28

scientific article

Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor

scientific journal article

Activation-induced accumulation of B and T lymphocyte attenuator at the immunological synapse in CD4+ T cells

scientific article

Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells

scientific article published on 17 May 2019

Amyloidogenicity and pathogenicity of Abeta43 in Alzheimer's disease

scientific article published in July 2013

An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells

scientific article published on 7 May 2014

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

scientific article

Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility

scientific article published on 24 February 2014

Autophagy-related protein 7 deficiency in amyloid β (Aβ) precursor protein transgenic mice decreases Aβ in the multivesicular bodies and induces Aβ accumulation in the Golgi

scientific article published on 26 November 2014

Bach2 maintains T cells in a naive state by suppressing effector memory-related genes

scientific article published on 10 June 2013

C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia

scientific journal article

CARD9 versus CARMA1 in innate and adaptive immunity

scientific article published on 07 April 2009

CD25(+)CD4(+) regulatory T cells exert in vitro suppressive activity independent of CTLA-4

CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway

scientific article published on 27 June 2011

CRTAM Confers Late-Stage Activation of CD8+ T Cells to Regulate Retention within Lymph Node

Calnexin suppresses GD3 synthase-induced apoptosis

scientific article

Carminerin contributes to chondrocyte calcification during endochondral ossification

scientific article published on 07 May 2006

Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function

scientific article

Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-κB signalling

scientific article published on 20 January 2015

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis

scientific article published on 28 July 2018

Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression

scientific article published on 20 May 2013

DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes

scientific article

Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans

scientific journal article

Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor.

scientific article

Deregulated Mucosal Immune Surveillance through Gut-Associated Regulatory T Cells and PD-1+ T Cells in Human Colorectal Cancer.

scientific article published on 26 March 2018

Differential display analysis reveals the expression of glutathione S-transferase omega and novel genes through an ITAM-containing receptor in ascidian immunocytes

scientific article published on 7 July 2005

Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain

scientific article

Diverging signaling events control the pathway of GPVI down-regulation in vivo

scientific article

Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β.

scientific article published on 20 June 2013

Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters

scientific article

Dynamic regulation of T-cell costimulation through TCR-CD28 microclusters

scientific article published on May 2009

Dynein-Driven Transport of T Cell Receptor Microclusters Regulates Immune Synapse Formation and T Cell Activation

Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34 + cells

scientific article published on 28 November 2008

Essential role of Rap signal in pre-TCR-mediated beta-selection checkpoint in alphabeta T-cell development

scientific article published on 18 September 2008

Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils

scientific article published on 21 December 2008

Fc receptor-independent development of autoimmune glomerulonephritis in lupus-prone MRL/lpr mice

scientific article

GPVI levels in platelets: relationship to platelet function at high shear

scientific article

Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells

scientific article

Genetic analysis reveals an intrinsic property of the germinal center B cells to generate A:T mutations

scientific article published on 17 June 2008

Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation

scientific article

Heterotypic interaction of CRTAM with Necl2 induces cell adhesion on activated NK cells and CD8+ T cells

scientific article published on 9 August 2005

Hsp-antigen fusion and their use for immunization

scientific article published in January 2004

Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation

scientific article published on 04 July 2019

IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid

scientific article published on 3 December 2010

IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-alpha production in mast cells.

scientific article

IRAK-4--a shared NF-kappaB activator in innate and acquired immunity

scientific article published on December 2006

Identification of Pathogenic Cardiac CD11c+ Macrophages in Nod1-Mediated Acute Coronary Arteritis

scientific article published on 2 April 2015

Identification of a novel isoform of ZAP-70, truncated ZAP kinase

scientific article published on March 2004

Identification of distinct ligands for the C-type lectin receptors Mincle and Dectin-2 in the pathogenic fungus Malassezia

scientific article published in April 2013

Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses.

scientific article published on 17 June 2002

Immunological synapse and microclusters: the site for recognition and activation of T cells

scientific article

Impact of Hyperhomocysteinemia and Different Dietary Interventions on Cognitive Performance in a Knock-in Mouse Model for Alzheimer's Disease

scientific article published on 23 October 2020

In vivo overexpression of CTLA-4 suppresses lymphoproliferative diseases and thymic negative selection

scientific article published in February 2005

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species ⬇️

scientific article (publication date: 21 January 2011)

Inhibition of T cell activation and function by the adaptor protein CIN85

scientific article published on 05 February 2019

Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner

scientific article

Inhibitory adaptors in lymphocytes

scientific article

Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR).

scientific article published on 7 June 2004

Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal

scientific article

LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival

scientific article published on 9 April 2007

LFA-1 decreases the antigen dose for T cell activation in vivo

scientific article published on 21 July 2008

Looking beyond the standard version of the Morris water task in the assessment of mouse models of cognitive deficits

scientific article published on 11 November 2018

Mechanistic basis of pre–T cell receptor–mediated autonomous signaling critical for thymocyte development

article

Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation

scientific article published on 25 January 2012

Micro-adhesion rings surrounding TCR microclusters are essential for T cell activation

scientific article

Mincle is an ITAM-coupled activating receptor that senses damaged cells

scientific journal article

Molecular basis for pre-TCR-mediated autonomous signaling

scientific article published on 28 November 2006

Nanocluster Formation: More with Memory ⬇️

scientific article published on September 23, 2011

Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease

scientific article published on 19 February 2009

Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance

scientific article published on 24 May 2005

Neuronal Cell Cycle Re-Entry Enhances Neuropathological Features in AppNLF Knock-In Mice

scientific article published on 01 January 2021

Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease.

scientific article

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

scientific article published on 6 November 2005

Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.

scientific article published on 24 August 2008

Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization

scientific article published on 23 February 2009

Nucleic acid sensing by T cells initiates Th2 cell differentiation

scientific article published on 10 April 2014

Overexpression of human acyl-CoA thioesterase upregulates peroxisome biogenesis

scientific article

Predominant role of T cell receptor (TCR)-alpha chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system

scientific article

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.

scientific article

Progress in allergy signal research on mast cells: signal regulation of multiple mast cell responses through FcepsilonRI.

scientific article published on March 2008

Protein kinase C-η controls CTLA-4-mediated regulatory T cell function

scientific article

Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals

scientific article published on 09 December 2020

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub

scientific journal article

RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor

scientific article

Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function

scientific article published on 25 January 2019

Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice

scientific article published on 21 December 2017

Reduction of glycosphingolipid levels in lipid rafts affects the expression state and function of glycosylphosphatidylinositol-anchored proteins but does not impair signal transduction via the T cell receptor

scientific article published on 23 September 2003

Regulation of NF-kappaB-dependent T cell activation and development by MEKK3.

scientific article published on 17 February 2009

Selective impairment of Fc RI-mediated allergic reaction in Gads-deficient mice

article published in 2008

Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD

scientific article published on 17 August 2019

Single App knock-in mouse models of Alzheimer's disease.

scientific article published on 13 April 2014

Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation

scientific article published on 20 March 2005

Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation

Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation

scientific article

T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

scientific article

T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clustering

scientific article

Tau binding protein CAPON induces tau aggregation and neurodegeneration

scientific article published on 03 June 2019

Temporal progression of Alzheimer's disease in brains and intestines of transgenic mice

scientific article published on 13 June 2019

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

scientific article published on 10 March 2017

The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation

scientific article published on 14 September 2006

The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors

article by Hiromitsu Hara et al published 7 May 2007 in Nature Immunology

The immunological synapse, TCR microclusters, and T cell activation

scientific article published on January 2010

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

scientific journal article

The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse

scientific article published on November 2004

The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model

scientific article published on 11 October 2004

Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma

scientific article

Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules

scientific article published on 18 January 2013

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