List of works - Hong-Gang Wang

A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex

scientific article (publication date: 12 July 2002)

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

scientific article published on 8 April 2013

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

scientific article

Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2.

scientific article

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

scientific article published in Nature Communications

Androgen receptor-dependent regulation of Bcl-xL expression: Implication in prostate cancer progression

scientific article published on March 2008

Arsenic trioxide (As(2)O(3)) induces apoptosis through activation of Bax in hematopoietic cells

scientific article published in May 2005

Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model

scientific article published on 08 September 2016

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

scientific article published on 23 February 2012

Bax interacting factor-1 promotes survival and mitochondrial elongation in neurons

scientific journal article

Bax-interacting factor-1 expression in prostate cancer

scientific article published on September 2008

Bc1-2, Raf-1 and mitochondrial regulation of apoptosis

scientific article published on January 1998

Bcl-2 acts upstream of the PARP protease and prevents its activation

scientific article published in January 1997

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1

scientific article

Bcl-2 targets the protein kinase Raf-1 to mitochondria

scientific article

Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides

scientific article

Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance

scientific article published on 9 February 2016

Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy

scientific article published on 3 January 2013

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

scientific article

Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy

scientific article

Bif-1 suppresses breast cancer cell migration by promoting EGFR endocytic degradation

scientific article

C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia

scientific article

CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells

scientific article

Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy

scientific article

Caspase-3-mediated cleavage of Rad9 during apoptosis

scientific article published on September 2003

Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia

scientific article published on 19 November 2019

Chemotherapy-Induced Small Extracellular Vesicles Prime the Pre-Metastatic Niche to Accelerate Neuroblastoma Metastasis

scientific article published in 2023

Chemotherapy-Induced Upregulation of Small Extracellular Vesicle-Associated PTX3 Accelerates Breast Cancer Metastasis

scientific article published on 28 October 2020

Computational Identification of Gene Networks as a Biomarker of Neuroblastoma Risk

scientific article published on 28 July 2020

Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics

scientific article published on 30 September 2016

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

scientific article published on 6 February 2012

Down-regulation of Bax-interacting factor 1 in human pancreatic ductal adenocarcinoma

scientific article

Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma

scientific article

Dysfunction of nucleus accumbens-1 activates cellular senescence and inhibits tumor cell proliferation and oncogenesis

scientific article published on 4 June 2012

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis

scientific article published in May 2002

Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements

scientific article

Expression of multiple apoptosis-regulatory genes in human breast cancer cell lines and primary tumors

article

FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia

scientific article published on 07 November 2019

GSK-3beta promotes cell survival by modulating Bif-1-dependent autophagy and cell death

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains

scientific article

HTLV-2 Tax immortalizes human CD4+ memory T lymphocytes by oncogenic activation and dysregulation of autophagy

scientific article

HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells

scientific article published on 11 August 2009

Human hRad1 but not hRad9 protects hHus1 from ubiquitin-proteasomal degradation

scientific article published on July 2004

Identification and Sequence of Seventy-nine New Transcripts Expressed in Hemocytes of Ciona intestinalis, Three of Which May Be Involved in Characteristic Cell-cell Communication

scientific article published on 01 October 2003

Identification of a novel negative role of flagellin in regulating IL-10 production

scientific article

Identification of candidate genes encoding the core components of the cell death machinery in the Ciona intestinalis genome

article

Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression

scientific article published on 16 September 2011

Insig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosis

scientific article

Integrin activation by R-ras.

scientific article published in April 1996

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

scientific article published on September 1994

Lipidic pore formation by the concerted action of proapoptotic BAX and tBID.

scientific article

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis

scientific article

Loss of endophilin-B1 exacerbates Alzheimer's disease pathology

scientific article published on 16 May 2015

Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression

scientific article

Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax

scientific article (publication date: 8 June 2001)

Molecular determinants of epothilone B derivative (BMS 247550) and Apo-2L/TRAIL-induced apoptosis of human ovarian cancer cells

scientific article published in April 2003

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

scientific article

Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells

scientific article (publication date: 2013)

PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex

scientific article

Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells.

scientific article

R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism.

scientific article

Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

scientific article

Regulation of 17-AAG-induced apoptosis: role of Bcl-2, Bcl-XL, and Bax downstream of 17-AAG-mediated down-regulation of Akt, Raf-1, and Src kinases

scientific article published on 6 March 2003

Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways

scientific article published on 19 July 2004

Regulation of the mitogen-activated protein kinase signaling pathway by SHP2.

scientific article published on 4 January 2002

SNAPping off Golgi membranes for autophagosome formation

scientific article

SRC directly phosphorylates Bif-1 and prevents its interaction with Bax and the initiation of anoikis

scientific article published on 12 May 2008

Schizosaccharomyces pombe Rad9 contains a BH3-like region and interacts with the anti-apoptotic protein Bcl-2.

scientific article published on September 2000

Screening of protein-protein interaction modulators via sulfo-click kinetic target-guided synthesis

scientific article

Selective Reversible Inhibition of Autophagy in Hypoxic Breast Cancer Cells Promotes Pulmonary Metastasis

scientific article published on 15 November 2016

Sh3glb1/Bif-1 and mitophagy: acquisition of apoptosis resistance during Myc-driven lymphomagenesis

scientific article published on 29 April 2013

Shp2E76K mutant confers cytokine-independent survival of TF-1 myeloid cells by up-regulating Bcl-XL.

scientific article

Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia

scientific article published on 01 September 2019

Sphingolipids: regulators of crosstalk between apoptosis and autophagy

scientific article

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

scientific article

Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia

scientific article

Survival-factor-induced phosphorylation of Bad results in its dissociation from Bcl-x(L) but not Bcl-2

scientific article

Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction

scientific article

Synthesis of cell-permeable stapled BH3 peptide-based Mcl-1 inhibitors containing simple aryl and vinylaryl cross-linkers

scientific article

Targeted delivery of ubiquitin-conjugated BH3 peptide-based Mcl-1 inhibitors into cancer cells

scientific article published on 22 January 2014

Targeting the ESCRT-III component CHMP2A for noncanonical Caspase-8 activation on autophagosomal membranes

scientific article published on 17 August 2020

Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction

scientific article

The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner

scientific article

The Draft Genome of Ciona intestinalis: Insights into Chordate and Vertebrate Origins

scientific article

The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

scientific article

The association of AMPK with ULK1 regulates autophagy

scientific article

The cell death machinery controlled by Bax and Bcl-XL is evolutionarily conserved in Ciona intestinalis

scientific article published on December 2005

The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change

scientific article

The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.

scientific article

Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia

scientific article

Therapeutic targeting of FLT3 and associated drug resistance in acute myeloid leukemia

scientific article published on 19 November 2020

Time-resolved FRET and NMR analyses reveal selective binding of peptides containing the LC3-interacting region to ATG8 family proteins

scientific article published on 30 July 2019

VPS37A directs ESCRT recruitment for phagophore closure

scientific article published on 13 September 2019

c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage

scientific article

miR-200b restoration and DNA methyltransferase inhibitor block lung metastasis of mesenchymal-phenotype hepatocellular carcinoma ⬇️

scientific article published on June 11, 2012

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

scientific article (publication date: 2000)

p53 acetylation is crucial for its transcription-independent proapoptotic functions

scientific article

List of works by Hong-Gang Wang

A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2.

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

Androgen receptor-dependent regulation of Bcl-xL expression: Implication in prostate cancer progression

Arsenic trioxide (As(2)O(3)) induces apoptosis through activation of Bax in hematopoietic cells

Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Bax interacting factor-1 promotes survival and mitochondrial elongation in neurons

Bax-interacting factor-1 expression in prostate cancer

Bc1-2, Raf-1 and mitochondrial regulation of apoptosis

Bcl-2 acts upstream of the PARP protease and prevents its activation

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1

Bcl-2 targets the protein kinase Raf-1 to mitochondria

Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides

Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance

Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy

Bif-1 suppresses breast cancer cell migration by promoting EGFR endocytic degradation

C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia

CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells

Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy

Caspase-3-mediated cleavage of Rad9 during apoptosis

Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia

Chemotherapy-Induced Small Extracellular Vesicles Prime the Pre-Metastatic Niche to Accelerate Neuroblastoma Metastasis

Chemotherapy-Induced Upregulation of Small Extracellular Vesicle-Associated PTX3 Accelerates Breast Cancer Metastasis

Computational Identification of Gene Networks as a Biomarker of Neuroblastoma Risk

Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

Down-regulation of Bax-interacting factor 1 in human pancreatic ductal adenocarcinoma

Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma

Dysfunction of nucleus accumbens-1 activates cellular senescence and inhibits tumor cell proliferation and oncogenesis

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis

Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements

Expression of multiple apoptosis-regulatory genes in human breast cancer cell lines and primary tumors

FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia

GSK-3beta promotes cell survival by modulating Bif-1-dependent autophagy and cell death

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains

HTLV-2 Tax immortalizes human CD4+ memory T lymphocytes by oncogenic activation and dysregulation of autophagy

HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells

Human hRad1 but not hRad9 protects hHus1 from ubiquitin-proteasomal degradation

Identification and Sequence of Seventy-nine New Transcripts Expressed in Hemocytes of Ciona intestinalis, Three of Which May Be Involved in Characteristic Cell-cell Communication

Identification of a novel negative role of flagellin in regulating IL-10 production

Identification of candidate genes encoding the core components of the cell death machinery in the Ciona intestinalis genome

Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression

Insig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosis

Integrin activation by R-ras.

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

Lipidic pore formation by the concerted action of proapoptotic BAX and tBID.

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis

Loss of endophilin-B1 exacerbates Alzheimer's disease pathology

Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression

Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax

Molecular determinants of epothilone B derivative (BMS 247550) and Apo-2L/TRAIL-induced apoptosis of human ovarian cancer cells

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells

PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex

Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells.

R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism.

Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

Regulation of 17-AAG-induced apoptosis: role of Bcl-2, Bcl-XL, and Bax downstream of 17-AAG-mediated down-regulation of Akt, Raf-1, and Src kinases

Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways

Regulation of the mitogen-activated protein kinase signaling pathway by SHP2.

SNAPping off Golgi membranes for autophagosome formation

SRC directly phosphorylates Bif-1 and prevents its interaction with Bax and the initiation of anoikis

Schizosaccharomyces pombe Rad9 contains a BH3-like region and interacts with the anti-apoptotic protein Bcl-2.

Screening of protein-protein interaction modulators via sulfo-click kinetic target-guided synthesis

Selective Reversible Inhibition of Autophagy in Hypoxic Breast Cancer Cells Promotes Pulmonary Metastasis

Sh3glb1/Bif-1 and mitophagy: acquisition of apoptosis resistance during Myc-driven lymphomagenesis

Shp2E76K mutant confers cytokine-independent survival of TF-1 myeloid cells by up-regulating Bcl-XL.

Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia

Sphingolipids: regulators of crosstalk between apoptosis and autophagy

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia

Survival-factor-induced phosphorylation of Bad results in its dissociation from Bcl-x(L) but not Bcl-2