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List of works by William A Coetzee

A homozygous SCN5A mutation associated with atrial standstill and sudden death

scientific article published on 21 May 2018

A potential role of calcium ions in early ischemic and reperfusion arrhythmias

scientific article published on January 1988

AMP-activated protein kinase connects cellular energy metabolism to KATP channel function

scientific article published on 24 August 2011

ATP-sensitive potassium channels and myocardial ischemia: why do they open?

scientific article

Alpha1-adrenoceptor-mediated breakdown of phosphatidylinositol 4,5-bisphosphate inhibits pinacidil-activated ATP-sensitive K+ currents in rat ventricular myocytes

scientific article published in August 2002

Amiodarone inhibits cardiac ATP-sensitive potassium channels.

scientific article

Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc

scientific article published on 14 January 2020

Anti-arrhythmic effects of levcromakalim in the ischaemic rat heart: a dual mechanism of action?

scientific article published on 01 August 2000

Applying High-Resolution Variant Classification to Cardiac Arrhythmogenic Gene Testing in a Demographically Diverse Cohort of Sudden Unexplained Deaths.

scientific article published in December 2017

Calcium channel blockers and early ischemic ventricular arrhythmias: electrophysiological versus anti-ischemic effects

scientific article published on May 1987

Calmodulin kinase II inhibition prevents arrhythmias in RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia.

scientific article

Cardiovascular KATP channels and advanced aging

scientific article

Channel-mediated calcium current in the heart

scientific article published on January 1988

Characterization of NGP 1-01, an aromatic polycyclic amine, as a calcium antagonist

scientific article published in May 1986

Cloning of components of a novel subthreshold-activating K(+) channel with a unique pattern of expression in the cerebral cortex.

scientific article published on December 1999

Comparative proteomic analysis of the ATP-sensitive K+ channel complex in different tissue types

scientific article published on 03 January 2013

Consequences of cardiac myocyte-specific ablation of KATP channels in transgenic mice expressing dominant negative Kir6 subunits.

scientific article

Decreased connexin43 expression in the mouse heart potentiates pacing-induced remodeling of repolarizing currents

scientific article published on 29 August 2008

Developmental expression of NCS-1 (frequenin), a regulator of Kv4 K+ channels, in mouse heart

scientific article published on 20 February 2003

Developmental programming resulting from maternal obesity in mice: effects on myocardial ischaemia-reperfusion injury

scientific article

Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1.

scientific article

Disruption of ATP-sensitive potassium channel function in skeletal muscles promotes production and secretion of musclin

scientific article published on 29 January 2016

Effects of R-56865 on transient inward current, Na(+)-Ca2+ exchange, and Ca2+ release from SR in cardiac myocytes

scientific article published on 01 February 1994

Effects of components of ischemia and metabolic inhibition on delayed afterdepolarizations in guinea pig papillary muscle

scientific article published in August 1987

Effects of coronary flow, pacing rate, isoprenaline and diltiazem on ischemic ventricular arrhythmias in guinea pig hearts.

scientific article published in January 1989

Effects of oxygen free radicals on isolated cardiac myocytes from guinea-pig ventricle: electrophysiological studies

scientific article published on 01 June 1992

Effects of proton buffering and of amiloride derivatives on reperfusion arrhythmias in isolated rat hearts. Possible evidence for an arrhythmogenic role of Na(+)-H+ exchange

scientific article published on April 1990

Effects of the ACE inhibitor, perindoprilat, and of angiotensin II on the transient inward current of guinea pig ventricular myocytes.

scientific article published in January 1992

Effects of thiol-modifying agents on KATP channels in guinea pig ventricular cells

scientific article published in November 1995

Effects of thyroid hormone on action potential and repolarizing currents in rat ventricular myocytes

scientific article published on 01 February 2000

Endosomal KATP channels as a reservoir after myocardial ischemia: a role for SUR2 subunits ⬇️

scientific article published on October 22, 2010

Exercise-induced expression of cardiac ATP-sensitive potassium channels promotes action potential shortening and energy conservation

scientific article

Expression of a sorcin missense mutation in the heart modulates excitation-contraction coupling

scientific article

Eye on ion channels in immune cells

scientific article published on 12 March 2019

Functional and pharmacological characterization of a Shal-related K+ channel subunit in Zebrafish

scientific article

Functional characterization of ABCC9 variants identified in sudden unexpected natural death

scientific article published on 27 February 2019

Functional characterization of SCN10A variants in several cases of sudden unexplained death

scientific article published on 29 May 2019

Functional characterization of TRPM4 variants identified in sudden unexpected natural death

article

Functional reclassification of variants of uncertain significance in the HCN4 gene identified in sudden unexpected death

scientific article published on 04 January 2019

Functional significance of channelopathy gene variants in unexplained death

scientific article published on 13 December 2018

Heterogeneity of ATP-sensitive K+ channels in cardiac myocytes: enrichment at the intercalated disk

scientific article

Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells.

scientific article published in December 2006

Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit.

scientific article

Infant sudden death: Mutations responsible for impaired Nav1.5 channel trafficking and function

scientific article

Influence of postnatal changes in action potential duration on Na-Ca exchange in rabbit ventricular myocytes

scientific article published on 01 May 1998

Inhibition by simulated ischemia or hypoxia of delayed afterdepolarizations provoked by cyclic AMP: significance for ischemic and reperfusion arrhythmias

scientific article published on 01 February 1988

Inhibition of rat ventricular IK1 with antisense oligonucleotides targeted to Kir2.1 mRNA.

scientific article published in March 1998

Is the molecular composition of K(ATP) channels more complex than originally thought?

scientific article published in August 2001

K ATP channels of primary human coronary artery endothelial cells consist of a heteromultimeric complex of Kir6.1, Kir6.2, and SUR2B subunits

scientific article published in October 2004

KATP Channels in the Cardiovascular System

scientific article

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

scientific article published on 19 September 2006

Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis

scientific article

Measuring and evaluating the role of ATP-sensitive K+ channels in cardiac muscle.

scientific article published on 3 January 2012

Modulation of Kv4 channels, key components of rat ventricular transient outward K+ current, by PKC.

scientific article published in October 1997

Modulation of human cardiovascular outward rectifying chloride channel by intra- and extracellular ATP.

scientific article published on 12 October 2007

Molecular autopsy: using the discovery of a novel de novo pathogenic variant in the KCNH2 gene to inform healthcare of surviving family

article

Na+/Ca2+ exchange current and contractions measured under Cl(-)-free conditions in developing rabbit hearts

scientific article published on 01 August 1997

Na+/Ca2+ exchange current density in cardiac myocytes from rabbits and guinea pigs during postnatal development

scientific article published in April 1995

Negative inotropic effect of nifedipine in the immature rabbit heart is due to shortening of the action potential

scientific article published on 20 December 2004

Novel insights into hydrogen sulfide--mediated cytoprotection.

scientific article

Ontogeny and hormonal regulation of cardiac Na(+)-Ca2+ exchanger expression in rabbits

scientific article published on 01 April 1996

Oxidant stress inhibits Na-Ca-exchange current in cardiac myocytes: mediation by sulfhydryl groups?

scientific article published in March 1994

Palmitoylation of the KATP channel Kir6.2 subunit promotes channel opening by regulating PIP2 sensitivity

scientific article published on 24 April 2020

Paradoxical effect of dofetilide on action potential duration and calcium transient amplitude in newborn rabbit ventricular myocytes

scientific article published in February 2005

Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1.

scientific article

Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.

scientific article published on 24 July 2017

Plasticity of sarcolemmal KATP channel surface expression: relevance during ischemia and ischemic preconditioning.

scientific article published on April 2016

Proposed role of energy supply in the genesis of delayed afterdepolarizations--implications for ischemic or reperfusion arrhythmias

scientific article

Reduction in number of sarcolemmal KATP channels slows cardiac action potential duration shortening under hypoxia.

scientific article published on 3 November 2011

Reduction of ischemic K+ loss and arrhythmias in rat hearts. Effect of glibenclamide, a sulfonylurea

scientific article published in February 1990

Regulation of ATP sensitive potassium channel of isolated guinea pig ventricular myocytes by sarcolemmal monocarboxylate transport ⬇️

scientific article published on November 1, 1992

Regulation of KATP Channel Trafficking in Pancreatic β Cells by Protein Histidine Phosphorylation.

scientific article published on 12 February 2018

Reperfusion damage: free radicals mediate delayed membrane changes rather than early ventricular arrhythmias

scientific article

Role of calcium ions in reperfusion arrhythmias: relevance to pharmacologic intervention

scientific article published on December 1988

Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury

scientific article published on 3 March 2008

Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells

scientific article

Role of the sarcoplasmic reticulum in contraction and relaxation of immature rabbit ventricular myocytes

scientific article published on 01 October 1997

Sarcolemmal ATP-sensitive K(+) channels control energy expenditure determining body weight

scientific article

Sarcolemmal ATP-sensitive potassium channels modulate skeletal muscle function under low-intensity workloads.

scientific article published on 16 December 2013

Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts

scientific article published on 17 September 2014

Short communication: flecainide exerts an antiarrhythmic effect in a mouse model of catecholaminergic polymorphic ventricular tachycardia by increasing the threshold for triggered activity.

scientific article

Sorcin regulates excitation-contraction coupling in the heart

scientific article

Specificity of the myotubularin family of phosphatidylinositol-3-phosphatase is determined by the PH/GRAM domain

scientific article published on 16 August 2006

Stretch-activated cation channels in skeletal muscle myotubes from sarcoglycan-deficient hamsters

scientific article

Subcellular [Ca2+]i gradients during excitation-contraction coupling in newborn rabbit ventricular myocytes.

scientific article

Subsecond regulation of striatal dopamine release by pre-synaptic KATP channels

scientific article

Sulfonylurea receptor 1 subunits of ATP-sensitive potassium channels and myocardial ischemia/reperfusion injury.

scientific article published on February 2009

Targeting Piezo1 unleashes innate immunity against cancer and infectious disease

scientific article published on 01 August 2020

The effect of inhibition of mitochondrial energy metabolism on the transient inward current of isolated guinea-pig ventricular myocytes

scientific article published in March 1988

The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its function

scientific journal article

The phosphatidylinositol 3-phosphate phosphatase myotubularin- related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1

scientific article

The role of Kir2.1 in the genesis of native cardiac inward-rectifier K+ currents during pre- and postnatal development

scientific article published on April 1999

The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation-coupled calcium release and response to hemodynamic load

scientific article

The trafficking protein, EHD2, positively regulates cardiac sarcolemmal KATP channel surface expression: role in cardioprotection

scientific article published on 13 November 2017

Thyroid hormone increases pacemaker activity in rat neonatal atrial myocytes

scientific article

Transcriptional remodeling of ion channel subunits by flow adaptation in human coronary artery endothelial cells.

scientific article

Transgenic expression of a dominant negative K(ATP) channel subunit in the mouse endothelium: effects on coronary flow and endothelin-1 secretion

scientific article

Trimetazidine: effects on delayed afterdepolarizations (DADs) and upstroke velocity of the action potential

scientific article published on 01 August 1990

Unique properties of the ATP-sensitive K⁺ channel in the mouse ventricular cardiac conduction system

scientific article published on 9 October 2011

β2-Adrenergic receptor agonists stimulate L-type calcium current independent of PKA in newborn rabbit ventricular myocytes

article

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