List of works - Gregers R. Andersen

A C3 specific nanobody that blocks all three activation pathways in the human and murine complement system

scientific article published on 06 May 2020

A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity

scientific article published on 16 September 2020

A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein

scientific article published on 29 November 2018

A noncoding expansion in EIF4A3 causes Richieri-Costa-Pereira syndrome, a craniofacial disorder associated with limb defects

scientific article

A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement

scientific article published in March 2018

An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase

scientific article published on 07 August 2020

Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes

scientific article

Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family

scientific article published on 31 May 2022

Crystal structure of human S100A8 in complex with zinc and calcium.

scientific article

Crystallisation and preliminary X-ray analysis of the receptor-binding domain of human and bovine alpha 2-macroglobulin

scientific article published on 01 September 1995

Crystallization and X-ray analysis of monodisperse human properdin

scientific article published on 23 January 2019

Crystallization and preliminary X-ray analysis of methylamine-treated alpha 2-macroglobulin and 3 alpha 2-macroglobulin-proteinase complexes

scientific article published on 01 November 1991

Crystallization of human methylamine-treated complement C3 and C3b

scientific article published on 01 September 1994

Crystallization of proteins of the alpha 2-macroglobulin superfamily

scientific article published on 01 September 1994

Expression in Escherichia coli: purification and characterization of cyclin H, a subunit of the human general transcription/DNA repair factor TFIIH

scientific article

Functional and structural insight into properdin control of complement alternative pathway amplification.

scientific article published on 6 March 2017

Interacting with the Human Insulin Receptor.

scientific article

Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures

scientific article published on 27 September 2017

Low resolution X-ray structure of human methylamine-treated alpha 2-macroglobulin.

scientific article

Low-resolution X-ray diffraction data obtained from hexagonal crystals of methylamine-treated alpha2-macroglobulin.

scientific article published in May 1994

Maximizing Sequence Coverage in Top-Down Proteomics By Automated Multimodal Gas-Phase Protein Fragmentation

scientific article published on 10 October 2018

Mimer: an automated spreadsheet-based crystallization screening system

scientific article published on 29 June 2013

Models of the complement C1 complex

scientific article published on 13 April 2018

Multiple low-affinity interactions support binding of human osteopontin to integrin αXβ2

scientific article published on 01 April 2015

Mutations in complement C3 from aHUS patients

scientific article

Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A.

scientific article published on 11 August 2017

Purification of human complement protein C5.

scientific article

Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4

scientific article

Recent cryogenic electron microscopy structures of human A2M may not be representative of the native protein

scientific article published in 2022

Reply to Arlaud et al.: Structure of the C1 complex and the unbound C1r2s2 tetramer

scientific article published on 12 July 2017

Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4

scientific article published on 22 January 2020

Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

scientific article published on 10 September 2020

Solution Structures of Complement C2 and Its C4 Complexes Propose Pathway-specific Mechanisms for Control and Activation of the Complement Proconvertases.

scientific article published on June 2016

Structural Basis for Eculizumab-Mediated Inhibition of the Complement Terminal Pathway

scientific article

Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System

scientific article published on 22 August 2019

Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3.

scientific article published on 23 June 2016

Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement

scientific article

Structural analysis of RNA helicases with small-angle X-ray scattering.

scientific article

Structural and functional characterization of human and murine C5a anaphylatoxins

scientific article

Structural basis for activation of the complement system by component C4 cleavage

scientific article

Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes

scientific article

Structural basis for the function of DEAH helicases

scientific article (publication date: March 2010)

Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer

scientific article published on 22 April 2015

Structural insight into proteolytic activation and regulation of the complement system

scientific article

Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3

scientific article

Structural insights into the initiating complex of the lectin pathway of complement activation.

scientific article

Structural insights into the oligomerization mode of the human receptor for advanced glycation end-products

scientific article

Structure and activation of C1, the complex initiating the classical pathway of the complement cascade

scientific article published on 19 January 2017

Structure and function of a family of tick-derived complement inhibitors targeting properdin

scientific article published on 14 January 2022

Structure of and influence of a tick complement inhibitor on human complement component 5

scientific article

Structure of intact IgE and the mechanism of ligelizumab revealed by electron microscopy

scientific article published on 09 February 2020

Structure of the DEAH/RHA ATPase Prp43p bound to RNA implicates a pair of hairpins and motif Va in translocation along RNA.

scientific article published on 17 April 2017

Structure of the haptoglobin-haemoglobin complex

scientific article

Structure of the omalizumab Fab.

scientific article

Structure, function and control of complement C5 and its proteolytic fragments.

scientific article published on September 2012

Substituting the Thiol Ester of Human A2M or C3 with a Disulfide Produces Native Proteins with Altered Proteolysis-Induced Conformational Changes

scientific article published on 10 December 2020

Synergistic activation of eIF4A by eIF4B and eIF4G.

scientific article

The Structure of the RAGE:S100A6 Complex Reveals a Unique Mode of Homodimerization for S100 Proteins.

scientific article published on 28 October 2016

The cationic peptide LL-37 binds Mac-1 (CD11b/CD18) with a low dissociation rate and promotes phagocytosis

scientific article published on 11 February 2016

The crystal structure of human α2-macroglobulin reveals a unique molecular cage

scientific article

The specificity of DNA recognition by the RAGE receptor

scientific article

The structure of bovine complement component 3 reveals the basis for thioester function

scientific article

Toward a structure-based comprehension of the lectin pathway of complement

scientific article published on 27 June 2013

Toward a structure-based comprehension of the lectin pathway of complement

scientific article published on August 2013

Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction.

scientific article published on 2 January 2018

α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes

scientific article published on 2 July 2015

List of works by Gregers R. Andersen

A C3 specific nanobody that blocks all three activation pathways in the human and murine complement system

A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity

A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein

A noncoding expansion in EIF4A3 causes Richieri-Costa-Pereira syndrome, a craniofacial disorder associated with limb defects

A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement

An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase

Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes

Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family

Crystal structure of human S100A8 in complex with zinc and calcium.

Crystallisation and preliminary X-ray analysis of the receptor-binding domain of human and bovine alpha 2-macroglobulin

Crystallization and X-ray analysis of monodisperse human properdin

Crystallization and preliminary X-ray analysis of methylamine-treated alpha 2-macroglobulin and 3 alpha 2-macroglobulin-proteinase complexes

Crystallization of human methylamine-treated complement C3 and C3b

Crystallization of proteins of the alpha 2-macroglobulin superfamily

Expression in Escherichia coli: purification and characterization of cyclin H, a subunit of the human general transcription/DNA repair factor TFIIH

Functional and structural insight into properdin control of complement alternative pathway amplification.

Interacting with the Human Insulin Receptor.

Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures

Low resolution X-ray structure of human methylamine-treated alpha 2-macroglobulin.

Low-resolution X-ray diffraction data obtained from hexagonal crystals of methylamine-treated alpha2-macroglobulin.

Maximizing Sequence Coverage in Top-Down Proteomics By Automated Multimodal Gas-Phase Protein Fragmentation

Mimer: an automated spreadsheet-based crystallization screening system

Models of the complement C1 complex

Multiple low-affinity interactions support binding of human osteopontin to integrin αXβ2

Mutations in complement C3 from aHUS patients

Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A.

Purification of human complement protein C5.

Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4

Recent cryogenic electron microscopy structures of human A2M may not be representative of the native protein

Reply to Arlaud et al.: Structure of the C1 complex and the unbound C1r2s2 tetramer

Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4

Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

Solution Structures of Complement C2 and Its C4 Complexes Propose Pathway-specific Mechanisms for Control and Activation of the Complement Proconvertases.

Structural Basis for Eculizumab-Mediated Inhibition of the Complement Terminal Pathway

Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System

Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3.

Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement

Structural analysis of RNA helicases with small-angle X-ray scattering.

Structural and functional characterization of human and murine C5a anaphylatoxins

Structural basis for activation of the complement system by component C4 cleavage

Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes

Structural basis for the function of DEAH helicases

Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer

Structural insight into proteolytic activation and regulation of the complement system

Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3

Structural insights into the initiating complex of the lectin pathway of complement activation.

Structural insights into the oligomerization mode of the human receptor for advanced glycation end-products

Structure and activation of C1, the complex initiating the classical pathway of the complement cascade

Structure and function of a family of tick-derived complement inhibitors targeting properdin

Structure of and influence of a tick complement inhibitor on human complement component 5

Structure of intact IgE and the mechanism of ligelizumab revealed by electron microscopy

Structure of the DEAH/RHA ATPase Prp43p bound to RNA implicates a pair of hairpins and motif Va in translocation along RNA.

Structure of the haptoglobin-haemoglobin complex

Structure of the omalizumab Fab.

Structure, function and control of complement C5 and its proteolytic fragments.

Substituting the Thiol Ester of Human A2M or C3 with a Disulfide Produces Native Proteins with Altered Proteolysis-Induced Conformational Changes

Synergistic activation of eIF4A by eIF4B and eIF4G.

The Structure of the RAGE:S100A6 Complex Reveals a Unique Mode of Homodimerization for S100 Proteins.

The cationic peptide LL-37 binds Mac-1 (CD11b/CD18) with a low dissociation rate and promotes phagocytosis

The crystal structure of human α2-macroglobulin reveals a unique molecular cage

The specificity of DNA recognition by the RAGE receptor

The structure of bovine complement component 3 reveals the basis for thioester function

Toward a structure-based comprehension of the lectin pathway of complement

Toward a structure-based comprehension of the lectin pathway of complement

Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction.

α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes