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List of works by Steve P. Watson

1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis

scientific article published on May 1985

1,2-Diacylglycerols do not potentiate the action of phospholipases A2 and C in human platelets

scientific article published on 01 May 1984

1,4-dithiothreitol non-specifically potentiates spasmogen actions on the guinea-pig ileum

scientific article

3H-substance P binding to guinea-pig ileum longitudinal smooth muscle membranes.

scientific article

50th anniversary of the discovery of ibuprofen: an interview with Dr Stewart Adams

scientific article

A Critical Role for Phospholipase Cγ2 in αIIbβ3-mediated Platelet Spreading

scientific article published on 27 June 2003

A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1

scientific journal article

A collagen-related peptide regulates phospholipase Cgamma2 via phosphatidylinositol 3-kinase in human platelets

scientific article published on August 1999

A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein

scientific article

A diacylglycerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets

scientific article published on May 1987

A germline mutation in BLOC1S3/reduced pigmentation causes a novel variant of Hermansky-Pudlak syndrome (HPS8)

scientific article

A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter.

scientific article published on October 2006

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

scientific article

A novel inhibitory action of wheat germ agglutinin on phospholipase C in HEL and MEG-01 cell lines

scientific article published on March 1997

A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function

scientific journal article

A novel mutation in the P2Y12 receptor and a function-reducing polymorphism in protease-activated receptor 1 in a patient with chronic bleeding

scientific article published on May 2014

A novel role for PECAM-1 (CD31) in regulating haematopoietic progenitor cell compartmentalization between the peripheral blood and bone marrow ⬇️

scientific article

A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice

scientific article

A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis

scientific article published on 14 October 2009

A novel thromboxane A2 receptor N42S variant results in reduced surface expression and platelet dysfunction

scientific article published on 23 January 2014

A novel viper venom metalloproteinase, alborhagin, is an agonist at the platelet collagen receptor GPVI.

scientific article published on 8 May 2001

A product of their environment: do megakaryocytes rely on extracellular cues for proplatelet formation?

scientific article published on November 2006

A review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO.

scientific article published on December 2006

A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen.

scientific article published in October 1998

A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1)

scientific article published in February 2012

ADP-induced platelet shape change: an investigation of the signalling pathways involved and their dependence on the method of platelet preparation

scientific article published on 01 August 2000

Accessible Synthetic Probes for Staining Actin inside Platelets and Megakaryocytes by Employing Lifeact Peptide.

scientific article

Activation of GPVI by collagen is regulated by alpha2beta1 and secondary mediators

scientific article published in June 2003

Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands

scientific article

Activation of human platelets by peroxovanadate is associated with tyrosine phosphorylation of phospholipase C gamma and formation of inositol phosphates

scientific article published on March 1993

Adhesion of human and mouse platelets to collagen under shear: a unifying model

scientific article

Agreement Between Temporal Artery, Oral, and Axillary Temperature Measurements in the Perioperative Period

scientific article published on 01 June 2011

Akt and mitogen-activated protein kinase enhance C-type lectin-like receptor 2-mediated platelet activation by inhibition of glycogen synthase kinase 3α/β.

scientific article published on 9 May 2015

Amplification of bacteria-induced platelet activation is triggered by FcγRIIA, integrin αIIbβ3, and platelet factor 4.

scientific article published on 18 March 2014

An atypical IgM class platelet cold agglutinin induces GPVI-dependent aggregation of human platelets.

scientific article

An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets.

scientific article published on 21 September 2011

Anagrelide is an anti-megakaryocytic and not an anti-platelet agent

scientific article published on 07 November 2018

Analysis of Solid-Phase Reactions: Product Identification and Quantification by Use of UV-Chromophore-Containing Dual-Linker Analytical Constructs We thank Dr. P. Marshall for the provision of analytical data.

scientific article

Analyzing the platelet proteome.

scientific article published in August 2004

Application of high-throughput screening techniques to drug discovery.

scientific article

Applying proteomics technology to platelet research.

scientific article

Are the proposed substance P receptor sub-types, substance P receptors?

scientific article

Are there subtypes of the inositol 1,4,5-trisphosphate receptor?

scientific article published on July 1990

Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling

scientific article (publication date: 14 June 2002)

Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures

scientific article published on 29 July 2016

Biochemistry and physiology of preterm labour and delivery

scientific article published in September 1993

C-terminal peptide of thrombospondin-1 induces platelet aggregation through the Fc receptor gamma-chain-associated signaling pathway and by agglutination

scientific article published in December 2001

CD31 is required on CD4+ T cells to promote T cell survival during Salmonella infection

scientific article

CLEC-2 activates Syk through dimerization

scientific article published on 12 February 2010

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

scientific article

CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice.

scientific article published on 23 August 2017

CLEC-2 expression is maintained on activated platelets and on platelet microparticles.

scientific article

CLEC-2 is not required for platelet aggregation at arteriolar shear

scientific article published on October 2010

CLEC-2 is required for development and maintenance of lymph nodes.

scientific article published on 14 February 2014

CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP

scientific article

Cellular pathology of atherosclerosis: smooth muscle cells promote adhesion of platelets to cocultured endothelial cells

scientific article published in December 2005

Ceramide does not mediate the effect of tumour necrosis factor alpha on superoxide generation in human neutrophils

scientific article published on March 1994

Characterisation of [3H]-senktide binding to NK3 tachykinin receptors in guinea-pig ileum and cerebral cortex.

scientific article published in December 1989

Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking

scientific article

Characterization of a novel protein from Proatheris superciliaris venom: proatherocytin, a 34-kDa platelet receptor PAR1 agonist

scientific article published on October 2005

Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay

scientific article published on 09 January 2014

Characterization of the major superoxide dismutase of Staphylococcus aureus and its role in starvation survival, stress resistance, and pathogenicity

scientific article

Characterization of the starvation-survival response of Staphylococcus aureus.

scientific article published on April 1998

Chronic lithium treatment inhibits basal and agonist-stimulated responses in rat cerebral cortex and GH3 pituitary cells

scientific article published on October 1992

Clinical and molecular markers of long-term survival after oligometastasis-directed stereotactic body radiotherapy (SBRT).

scientific article

Collagen or collagen-related peptide cause (Ca2+)i elevation and increased tyrosine phosphorylation in human megakaryocytes

scientific article published on 01 September 1999

Collagen promotes sustained glycoprotein VI signaling in platelets and cell lines.

scientific article published on 22 August 2007

Collagen receptor signalling in platelets: extending the role of the ITAM.

scientific article published in June 1998

Collagen stimulates [3H]inositol trisphosphate formation in indomethacin-treated human platelets

scientific article published on March 1985

Collagen stimulates tyrosine phosphorylation of phospholipase C-γ2 but not phospholipase C-γ1 in human platelets

scientific article published on 01 October 1994

Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice.

scientific article published on 28 February 2013

Comparison of Ins(1,4,5)P3 receptors from rat cerebellum and bovine adrenal cortex

scientific article published in February 1993

Comparison of multiple electrode aggregometry with lumi-aggregometry for the diagnosis of patients with mild bleeding disorders.

scientific article published in August 2017

Comparison of the GPVI inhibitors losartan and honokiol ⬇️

scientific article published on 08 March 2019

Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood

scientific article

Correction: Lineage Tracing of Pf4-Cre Marks Hematopoietic Stem Cells and Their Progeny.

scientific article published on 31 May 2013

Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).

scientific article

Critical redundant functions of the adapters Grb2 and Gads in platelet (hem)ITAM signaling in mice

scientific article published on 16 January 2020

Critical role for ERK1/2 in bone marrow and fetal liver-derived primary megakaryocyte differentiation, motility, and proplatelet formation

scientific article published on 18 July 2009

Critical role of FcR gamma-chain, LAT, PLCgamma2 and thrombin in arteriolar thrombus formation upon mild, laser-induced endothelial injury in vivo

scientific article

Critical role of Src-Syk-PLC{gamma}2 signaling in megakaryocyte migration and thrombopoiesis.

scientific article

Critical role of the HDAC6-cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect.

scientific article published on 27 November 2017

CtaA of Staphylococcus aureus is required for starvation survival, recovery, and cytochrome biosynthesis

scientific article

Cyclic ADP-ribose-induced Ca2+ release from rat brain microsomes

scientific article published in March 1993

Cytosolic Phospholipase A2 Is Phosphorylated in Collagen- and Thrombin-stimulated Human Platelets Independent of Protein Kinase C and Mitogen-activated Protein Kinase

scientific article published on 01 October 1995

DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets

scientific article

Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation

scientific article

Decanoyl lysophosphatidic acid induces platelet aggregation through an extracellular action. Evidence against a second messenger role for lysophosphatidic acid

scientific article published on November 1985

Delineation of the region in the glycoprotein VI tail required for association with the Fc receptor gamma-chain

scientific article published on 7 July 2003

Deoxycholateinduces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C

scientific article published on 01 June 1985

Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets

scientific article published on 01 September 1999

Differential effects of reduced glycoprotein VI levels on activation of murine platelets by glycoprotein VI ligands

scientific article

Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins

scientific article (publication date: 15 March 2004)

Differential regulation of adapter proteins Dok2 and Dok1 in platelets, leading to an association of Dok2 with integrin alphaIIbbeta3.

scientific article

Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets

scientific article

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.

scientific article published on 27 September 2008

Differential roles of integrins alpha2beta1 and alphaIIbbeta3 in collagen and CRP-induced platelet activation

scientific article published in August 2004

Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets

scientific article

Direct Inhibition of Cyclooxygenase-1 and -2 by the Kinase Inhibitors SB 203580 and PD 98059

scientific article published on 01 October 1998

Distinct Contributions of Glycoprotein VI and α2β1 Integrin to the Induction of Platelet Protein Tyrosine Phosphorylation and Aggregation

scientific article published on 01 February 2000

Distinct but critical roles for integrin ?IIb?3in platelet lamellipodia formation on fibrinogen, collagen-related peptide and thrombin

scientific article published on 09 October 2006

Distinct roles of GPVI and integrin alpha(2)beta(1) in platelet shape change and aggregation induced by different collagens

scientific article published on September 2002

Diversity and impact of rare variants in genes encoding the platelet G protein-coupled receptors

scientific article published on 8 January 2015

Docking protein Gab2 positively regulates glycoprotein VI-mediated platelet activation

scientific article

Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all? ⬇️

scientific article published on 15 August 2018

Does the hydrolysis of inositol phospholipids lead to the opening of voltage operated Ca2+ channels in guinea-pig ileum? Studies with fluoride ions and caffeine.

scientific article

Dominant role of the protein-tyrosine phosphatase CD148 in regulating platelet activation relative to protein-tyrosine phosphatase-1B.

scientific article

Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification.

scientific article published on 14 June 2009

Down-regulation of G alpha s in human myometrium in term and preterm labor: a mechanism for parturition

scientific article published on 01 December 1994

Dual role of collagen in factor XII-dependent thrombus formation

scientific article published on 16 April 2009

Dynamic tyrosine kinase-regulated signaling and actin polymerisation mediate aggregate stability under shear

scientific article published on 5 June 2008

Editorial Platelets 2021: toward a brighter year

scientific article published on 01 December 2020

Editorial policy during the lockdown

scientific article published on 25 April 2020

Effect of anti-podoplanin antibody administration during lipopolysaccharide-induced lung injury in mice.

scientific article published on 8 November 2017

Endothelial cell-borne platelet bridges selectively recruit monocytes in human and mouse models of vascular inflammation

scientific article published on 01 February 2011

Enrichment of FLI1 and RUNX1 mutations in families with excessive bleeding and platelet dense granule secretion defects

scientific article

Ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA) and the tyrphostin ST271 inhibit phospholipase C in human platelets by preventing Ca2+ entry

scientific article published on 01 April 1995

Evaluation of a whole blood remote platelet function test for the diagnosis of mild bleeding disorders

scientific article published on May 2014

Evaluation of participants with suspected heritable platelet function disorders including recommendation and validation of a streamlined agonist panel

scientific article published on 21 September 2012

Evaluation of the role of platelet integrins in fibronectin-dependent spreading and adhesion

scientific article published in October 2004

Evidence against a direct role of the integrin α2β1 in collagen-induced tyrosine phosphorylation in human platelets

scientific article published on 01 April 2000

Evidence for a decrease in sympathetic control of intestinal function in the aged rat.

scientific article published in July 1991

Evidence for neurokinin-3 receptor-mediated tachykinin release in the guinea-pig ileum.

scientific article published in December 1987

Evidence for the involvement of p59fyn and p53/56lyn in collagen receptor signalling in human platelets

scientific article published on February 1999

Evidence for two types of tachykinin receptors on cholinergic neurons of the guinea pig ileum myenteric plexus

scientific article published on January 1991

Evidence of a Role for SHP-1 in Platelet Activation by the Collagen Receptor Glycoprotein VI

scientific article published on 01 September 2000

Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets

scientific article (publication date: August 1999)

Expression of the collagen receptor glycoprotein VI during megakaryocyte differentiation

scientific article

Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry

scientific article published on March 2004

Factors to consider in the naming of a G protein-coupled receptor subtype

scientific article published on January 1995

Fcγ receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor

scientific article published on 01 March 1994

Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.

scientific article

Fibrin activates GPVI in human and mouse platelets

scientific article

Fibrin and D-dimer bind to monomeric GPVI

scientific article published on 15 August 2017

Fire in the operating room during tracheostomy.

scientific article published on March 1998

Fluorescence Approaches Unravel Spatial and Temporal Aspects of GPCR Organisation, Location, and Intracellular Signalling.

scientific article published on 21 December 2017

Fluoride inhibits agonist-induced formation of inositol phosphates in rat cortex

scientific article published on 01 September 1988

Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2)

scientific article published on 22 January 2013

G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho Kinase in platelets

scientific article published in August 2011

G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2

scientific article

GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase

scientific article published on 18 December 2003

GPVI and CLEC-2 in hemostasis and vascular integrity

scientific article published on 25 March 2010

GPVI levels in platelets: relationship to platelet function at high shear

scientific article

GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.

scientific article

Genetic and pharmacological analyses of involvement of Src-family, Syk and Btk tyrosine kinases in platelet shape change. Src-kinases mediate integrin alphaIIb beta3 inside-out signalling during shape change.

scientific article

Genotyping and phenotyping of platelet function disorders

scientific article

Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex

scientific article published on 16 April 2008

Glycoprotein IIb-IIIa-dependent aggregation by glycoprotein Ibα is reinforced by a Src family kinase inhibitor (PP1)-sensitive signalling pathway ⬇️

scientific article published on January 15, 2002

Glycoprotein Ibα and FcγRIIa play key roles in platelet activation by the colonizing bacterium, Streptococcus oralis

scientific article

Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor γ‐chain ⬇️

scientific article published on August 18, 1997

Glycoprotein VI oligomerization in cell lines and platelets

scientific article published on 15 March 2007

Glycoprotein VI/Fc receptor gamma chain-independent tyrosine phosphorylation and activation of murine platelets by collagen

scientific article

Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites

scientific article

Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets

scientific article published on 21 November 2013

Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3.

scientific article

Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease

scientific article published on 2 December 2015

Identification and characterization of a novel P2Y 12 variant in a patient diagnosed with type 1 von Willebrand disease in the European MCMDM-1VWD study

scientific article published on 23 February 2009

Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy

scientific article

Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains

scientific article

Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading

scientific article published in November 2008

Identification of novel glycine sulfonamide antagonists for the EP1 receptor

scientific article published on 22 December 2006

Identification of novel pyrazole acid antagonists for the EP1 receptor

scientific article

Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells

scientific article

Immobilized fibrinogen activates human platelets through glycoprotein VI. ⬇️

scientific article published on 22 February 2018

Impact of the PI3-kinase/Akt pathway on ITAM and hemITAM receptors: haemostasis, platelet activation and antithrombotic therapy

scientific article

In celebration of Professor Gus Born's life, 29 July 1921 - 16 April 2018

article

In vivo activity of an azole series of CCR2 antagonists

article published in 2012

In vivo evidence for platelet-induced physiological angiogenesis by a COX driven mechanism ⬇️

scientific article

Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets

scientific article

Influence of Mg2+ and pH on n.m.r. spectra and radioligand binding of inositol 1,4,5-trisphosphate

scientific article published on September 1991

Inherited platelet disorders: Insight from platelet genomics using next-generation sequencing

scientific article published on 27 June 2016

Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation to GPVI

scholarly article by Phillip L R Nicolson et al published 19 July 2018 in Haematologica

Inhibition of mitogen-activated protein kinase kinase does not impair primary activation of human platelets

scientific article published on August 1996

Inositol 1,4,5-Trisphosphate and Oxytocin Binding in Human Myometrium*

scientific article published on 01 July 1990

Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2.

scientific article published on March 2003

Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI

scientific article (publication date: June 2002)

International Union of Pharmacology. XXXI. Recommendations for the nomenclature of multimeric G protein-coupled receptors.

scientific article

Introducing high-throughput sequencing into mainstream genetic diagnosis practice in inherited platelet disorders.

scientific article published on 5 October 2017

Investigation of the contribution of an underlying platelet defect in women with unexplained heavy menstrual bleeding

scientific article published on 06 December 2018

Involvement of Src kinases and PLCgamma2 in clot retraction

scientific article published on 19 October 2006

Ionophore A23187 stimulates phosphorylation of the 40, 000dalton protein in human platelets without phospholipase C activation

scientific article published on 01 August 1986

Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara

scientific article published on 7 April 2006

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia

scientific article

JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia

scientific article published on October 2013

K+-stimulation of the phosphoinositide pathway in guinea-pig ileum longitudinal smooth muscle is predominantly neuronal in origin and mediated by the entry of extracellular Ca2+ ⬇️

scientific article published on January 1, 1990

LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.

scientific article

Lack of association of epidermal growth factor-, insulin-, and serum-induced mitogenesis with stimulation of phosphoinositide degradation in BALB/c 3T3 fibroblasts

scientific article published on January 1986

Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI.

scientific article published on 11 October 2005

Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny

scientific article

Lithium potentiates agonist formation of [3H]CDP-diacylglycerol in human platelets

scientific article published in April 1990

Lithium-induced decrease in spontaneous Ca2+ oscillations in single GH3 rat pituitary cells

scientific article published on June 1994

Low angle light scattering analysis: a novel quantitative method for functional characterization of human and murine platelet receptors

scientific article published on 01 July 2012

Lowering of the extracellular Na+ concentration enhances high-K+-induced formation of inositol phosphates in the guinea-pig ileum

scientific article published on June 1988

Lymphatic blood filling in CLEC-2-deficient mouse models

scientific article published on 04 March 2020

Manipulation of Mouse Hematopoietic Progenitors by Specific Retroviral Infection

scientific article published on 18 August 2003

Mapping the platelet proteome: a report of the ISTH Platelet Physiology Subcommittee

scientific article published on 01 September 2005

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

scientific article

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane

scientific article published on 10 January 2013

Mice Deficient in T-bet Form Inducible NO Synthase-Positive Granulomas That Fail to Constrain Salmonella

scientific article published on 26 June 2020

Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function

scientific journal article

Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis

scientific article published on 19 January 2017

Microsatellite markers as a rapid approach for autozygosity mapping in Hermansky-Pudlak syndrome: identification of the second HPS7 mutation in a patient presenting late in life

article by Gillian C Lowe et al published April 2013 in Thrombosis and Haemostasis

Minimal regulation of platelet activity by PECAM-1.

scientific article published on February 2007

Molecular basis of platelet activation by an alphaIIbbeta3-CHAMPS peptide

scientific article published on 20 November 2008

Monomeric (glycine-proline-hydroxyproline)10 repeat sequence is a partial agonist of the platelet collagen receptor glycoprotein VI.

scientific article published on April 1999

Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: A novel mechanism of haemostasis

scientific article published in November 2017

Mucor circinelloides induces platelet aggregation through integrin αIIbβ3 and FcγRIIA.

scientific article published on 3 January 2018

Murine GPVI stimulates weak integrin activation in PLCgamma2-/- platelets: involvement of PLCgamma1 and PI3-kinase

scientific article published in May 2003

Mutation in is associated with severe congenital thrombocytopenia

Mutations in TTC37 cause trichohepatoenteric syndrome (phenotypic diarrhea of infancy)

scientific article

Natriuretic peptides induce weak VASP phosphorylation at Serine 239 in platelets

scientific article published on 7 March 2013

Neomycin cannot be used as a selective inhibitor of inositol phospholipid hydrolysis in intact or semi-permeabilized human platelets. Aminoglycosides activate semi-permeabilized platelets

scientific article published on May 1987

Neurokinin3-receptors are linked to inositol phospholipid hydrolysis in the guinea-pig ileum longitudinal muscle-myenteric plexus preparation.

scientific article published on May 1988

Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation

scientific article published on 12 April 2018

Nitrite is a cGMP generator in isolated platelets.

scientific article published on 2 September 2015

Non-peptide antagonists, CP-96,345 and RP 67580, distinguish species variants in tachykinin NK1 receptors.

scientific article published in January 1993

Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry

article

Novel diagnostic assays for heparin-induced thrombocytopenia

scientific article

Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction

scientific article published on 27 May 2016

Okadaic acid inhibits activation of phospholipase C in human platelets by mimicking the actions of protein kinases A and C.

scientific article published on March 1992

Origin-Specific Adhesive Interactions of Mesenchymal Stem Cells with Platelets Influence Their Behavior After Infusion

scientific article published on 28 February 2018

Oxytocin-stimulated phosphoinositide hydrolysis in human myometrial cells: involvement of pertussis toxin-sensitive and -insensitive G-proteins

scientific article

P2X1 Receptors Amplify FcγRIIa-Induced Ca2+ Increases and Functional Responses in Human Platelets.

scientific article published on 29 January 2018

PCR and the cloning of receptor subtype genes.

scientific article published on September 1989

PKCalpha regulates platelet granule secretion and thrombus formation in mice

scientific article

PKD: a new protein kinase C-dependent pathway in platelets

scientific article published on 10 October 2002

Pharmacological analysis of [3H]-senktide binding to NK3 tachykinin receptors in guinea-pig ileum longitudinal muscle-myenteric plexus and cerebral cortex membranes ⬇️

scientific article published on April 1, 1990

Pharmacological characterization of a substance P antagonist, [D-Arg1, D-Pro2, D-Trp79, Leu11]-substance P ⬇️

scientific article published on September 1, 1983

Phenylarsine oxide inhibits tyrosine phosphorylation of phospholipase C gamma 2 in human platelets and phospholipase C gamma 1 in NIH-3T3 fibroblasts

scientific article published on July 1995

Phorbol esters inhibit smooth muscle contractions through activation of Na+ -K+ -ATPase ⬇️

scientific article published on February 1, 1990

Phosphatidylinositol-3,4,5-trisphosphate stimulates Ca(2+) elevation and Akt phosphorylation to constitute a major mechanism of thromboxane A2 formation in human platelets

scientific article published on 19 March 2015

Phosphorylation and activation of cytosolic phospholipase A2 by 38-kDa mitogen-activated protein kinase in collagen-stimulated human platelets

scientific article published on May 1997

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac.

scientific article published on 12 February 2010

Phosphorylation of JAK2 in thrombin-stimulated human platelets

scientific article published on 01 October 1994

Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways

scientific article published on 01 October 1999

Phosphorylation-dependent and -independent pathways of platelet aggregation

scientific article published on March 1989

Platelet CLEC-2 and podoplanin in cancer metastasis

scientific article published on 01 April 2012

Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse.

scientific article published on 24 August 2017

Platelet GPVI repairs its own damage.

scientific article

Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.

scientific article

Platelet activation by extracellular matrix proteins in haemostasis and thrombosis

scientific article published on January 2009

Platelet activation via the collagen receptor GPVI is not altered in platelets from chronic myeloid leukaemia patients despite the presence of the constitutively phosphorylated adapter protein CrkL.

scientific article published in March 2001

Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling

scientific article

Platelet aggregation induced by polystyrene and platinum nanoparticles is dependent on surface area

scientific article published on 01 November 2018

Platelet lipidomics: modern day perspective on lipid discovery and characterization in platelets

scientific article

Platelet-collagen interaction: is GPVI the central receptor?

scientific article (publication date: 15 July 2003)

Platelets - the second growth cycle

scientific article published on 04 December 2018

Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation

scientific article published on June 2011

Platelets in lymph vessel development and integrity

scientific article published on January 2014

Platelets-Joining the 400 club

scientific article

Platelets: No longer bystanders in liver disease

scientific article

Platelets: the end of an era, start of a new beginning

scientific article published in January 2015

Platelets– maintaining the flow

scientific article published on 22 December 2015

Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development

scientific article

Podoplanin negatively regulates CD4+ effector T cell responses

scientific article

Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2.

scientific article published on March 2012

Postnatal Deletion of Podoplanin in Lymphatic Endothelium Results in Blood Filling of the Lymphatic System and Impairs Dendritic Cell Migration to Lymph Nodes

scientific article

Preterm labour: a pharmacological challenge

scientific article

Prostaglandin endoperoxide analogues stimulate formation of 1,2-diacylglycerol and myo-inositol 1,4,5-triphosphate in human platelets

scientific article published on 01 January 1985

Protein kinase C mediates delayed inhibitory feedback regulation of human neurokinin type 1 receptor activation of phospholipase C in UC11 astrocytoma cells

scientific article published on 01 August 1994

Protein kinase Cε and protein kinase Cθ double-deficient mice have a bleeding diathesis.

scientific article

Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions

scientific article published on 11 August 2009

RECAPRetrosynthetic Combinatorial Analysis Procedure: A Powerful New Technique for Identifying Privileged Molecular Fragments with Useful Applications in Combinatorial Chemistry ⬇️

scientific article published on May 1, 1998

Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.

scientific article

Rapid degradation of [3H]-substance p in guinea-pig ileum and rat vas deferens in vitro

scientific article published on June 1983

Rapid genetic diagnosis of heritable platelet function disorders with next-generation sequencing: proof-of-principle with Hermansky-Pudlak syndrome.

scientific article

Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia.

scientific article

Receptor subtypes or species homologues: relevance to drug discovery

scientific article published on October 1993

Recommendations for the Standardization of Light Transmission Aggregometry: A Consensus of the Working Party from the Platelet Physiology Subcommittee of SSC/ISTH.

scientific article published on 10 April 2013

Reference curves for aggregation and ATP secretion to aid diagnose of platelet-based bleeding disorders: effect of inhibition of ADP and thromboxane A(2) pathways

scientific article published in August 2007

Regulation and function of WASp in platelets by the collagen receptor, glycoprotein VI.

scientific article

Regulation of RAS in human platelets

scientific article published on 01 March 2002

Regulation of cytosolic calcium by collagen in single human platelets

scientific article published on May 1995

Regulation of proplatelet formation and platelet release by integrin alpha IIb beta3.

scientific article

Renal cells activate the platelet receptor CLEC-2 through podoplanin

scientific article

Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets

scientific article published on May 2005

SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis

scientific article

SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase

scientific article

SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice

scientific article

SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects

scientific journal article

Salmonella-induced thrombi in mice develop asynchronously in the spleen and liver and are not effective bacterial traps

scientific article published on 06 November 2018

Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation

scientific article

Selective impairment of platelet activation to collagen in the absence of GATA1

scientific article

Sequential adhesion of platelets and leukocytes from flowing whole blood onto a collagen-coated surface: requirement for a GpVI-binding site in collagen

scientific article published on 01 May 2007

Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases

scientific article (publication date: December 2000)

Signalling components underlying platelet aggregation to a Ca2+ ionophore and a phorbol ester.

scientific article published in December 2001

Signalling events underlying platelet aggregation induced by the glycoprotein VI agonist convulxin

scientific article

Signalling through Src family kinase isoforms is not redundant in models of thrombo-inflammatory vascular disease

scientific article published on 04 July 2018

Simultaneous measurement of ATP release and LTA does not potentiate platelet aggregation to epinephrine

Single bead characterization using analytical constructs: application to quality control of libraries

scientific article published in March 2001

Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor

scientific article published on 4 January 2007

Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI

article

Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear

scientific article

Special issue of Platelets in celebration of Stan Heptinstall, founder and Editor-in-Chief (1990-2015).

scientific article published on 28 May 2015

Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P).

scientific article

Src family kinases are essential for primary aggregation by G(i) -coupled receptors

scientific article published on October 2010

Stimulatory and inhibitory actions of excitatory amino acids on inositol phospholipid metabolism in rat cerebral cortex

scientific article published on September 1988

Stress stimuli increase calcium-induced arachidonic acid release through phosphorylation of cytosolic phospholipase A2.

scientific article published on December 1999

Studies on the mechanism of the peroxyoxalate chemiluminescence reaction: part 2. Further identification of intermediates using 2D EXSY 13C nuclear magnetic resonance spectroscopy

scientific article published on 13 March 2008

Submaximal inhibition of protein kinase C restores ADP-induced dense granule secretion in platelets in the presence of Ca2+.

scientific article published on 13 April 2011

Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions

scientific article

Substance P induced hydrolysis of inositol phospholipids in guinea-pig ileum and rat hypothalamus

scientific article published in September 1983

Substance P receptors in the nervous system and possible receptor subtypes

scientific article

Syk and Fyn Are Required by Mouse Megakaryocytes for the Rise in Intracellular Calcium Induced by a Collagen-related Peptide

scientific article published on 01 October 1997

Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells

scientific article

Syk interacts with tyrosine-phosphorylated proteins in human platelets activated by collagen and cross-linking of the Fc gamma-IIA receptor

scientific article published on October 1995

Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling

scientific article published on 22 November 2010

Synergy between Ca2+ and protein kinase C is the major factor in determining the level of secretion from human platelets

scientific journal article

Synthesis and metabolic stability of a tritium-labelled substance P analogue

scientific article published on 01 January 1982

Tachykinin receptor types: Classification and membrane signalling mechanisms

scientific article published on January 1991

Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization

scientific article

Tec regulates platelet activation by GPVI in the absence of Btk.

scientific article published on 3 July 2003

Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation.

scientific article published on 29 December 2016

The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade

scientific article

The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

scientific journal article

The Fc receptor gamma-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin

scientific article published on June 2002

The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets

scientific article

The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression

scientific article

The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation

scientific article published on 25 October 2016

The action of substance P on contraction, inositol phospholipids and adenylate cyclase in rat small intestine

scientific article published on 01 December 1984

The action of the protein kinase C inhibitor, staurosporine, on human platelets. Evidence against a regulatory role for protein kinase C in the formation of inositol trisphosphate by thrombin

scientific article

The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid

scientific article published on 04 August 2020

The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent.

scientific article

The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors

scientific article published in August 2017

The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists

scientific article published on 30 July 2010

The dual role of platelet-innate immune cell interactions in thrombo-inflammation

scientific article published on 17 October 2019

The effect of sodium bisulphite on nicotinic cholinoceptors in the frog rectus abdominis muscle

scientific article published on 01 February 1981

The expression of mouse CLEC-2 on leucocyte subsets varies according to their anatomical location and inflammatory state

scientific article

The formation of [3H]inositol phosphates in human platelets by palmitoyl lysophosphatidic acid is blocked by indomethacin

scientific article published on 01 October 1985

The heptapeptide LSARLAF mediates platelet activation through phospholipase Cgamma2 independently of glycoprotein IIb-IIIa

scientific article published on February 2004

The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist.

scientific article

The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists.

scientific article

The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function

scientific article published on 2 October 2014

The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure

scientific article

The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors

scientific article

The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets.

scientific article published on 24 April 2009

The p85 Subunit of Phosphatidylinositol 3-Kinase Associates with the Fc Receptor γ-Chain and Linker for Activitor of T Cells (LAT) in Platelets Stimulated by Collagen and Convulxin

scientific article published on 01 December 1998

The physiological and pathophysiological roles of platelet CLEC-2

The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure

scientific article published on 22 April 2020

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

scientific article published on 21 December 2017

The presence of NK3 tachykinin receptors on rat uterus

scientific article published on 01 October 1991

The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin

scientific article published on 01 November 1984

The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen

scientific article published on 01 July 2001

The role of receptor-stimulated inositol phospholipid hydrolysis in the autonomic nervous system

scientific article published on January 1988

The snake venom toxin alboaggregin-A activates glycoprotein VI.

scientific article published in June 2001

The transmembrane adapter LAT plays a central role in immune receptor signalling.

scientific article

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis

scientific journal article

The use of inhibitors of protein kinases and protein phosphatases to investigate the role of protein phosphorylation in platelet activation.

scientific article

The use of reflection as an assessment of practice. Can you mark learning contracts?

scientific article published in September 2002

The use of snake venom toxins as tools to study platelet receptors for collagen and von Willebrand factor.

scientific article

Thrombin-induced conversion of fibrinogen to fibrin results in rapid platelet trapping which is not dependent on platelet activation or GPIb

scientific article published on February 2003

Thrombopoietin potentiates activation of human platelets in association with JAK2 and TYK2 phosphorylation

scientific article

Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo

scientific article

Tissue selectivity of substance P alkyl esters: suggesting multiple receptors

scientific article published on January 1983

Tityus discrepans scorpion venom activates platelets through GPVI and a novel Src-dependent signaling pathway.

scientific article

Towards complete analysis of the platelet proteome

scientific article (publication date: March 2002)

Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells

scientific article published on 20 December 2018

Tumor necrosis factor alpha stimulates sphingomyelinase through the 55 kDa receptor in HL-60 cells

scientific article published on December 1992

Tyrosine Phosphorylation of the Fc Receptor γ-Chain in Collagen-stimulated Platelets

scientific article published on 01 July 1996

Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets

scientific article (publication date: 26 February 1999)

Up-Regulation of p21- and RhoA-Activated Protein Kinases in Human Pregnant Myometrium

scientific article published on 01 March 2000

Use of next-generation sequencing and candidate gene analysis to identify underlying defects in patients with inherited platelet function disorders

scientific article published on 27 January 2015

Utility of the ISTH bleeding assessment tool in predicting platelet defects in participants with suspected inherited platelet function disorders.

scientific article published on September 2013

VPS33B regulates protein sorting into and maturation of α-granule progenitor organelles in mouse megakaryocytes

scientific journal article

Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3.

scientific article published on February 2007

Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.

scientific article

Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C.

scientific article published in November 2002

What can proteomics tell us about platelets?

scientific article published on March 2014

What is the role of genetic testing in the investigation of patients with suspected platelet function disorders?

scientific article published on 30 January 2014

Whole exome sequencing identifies genetic variants in inherited thrombocytopenia with secondary qualitative function defects

scientific article

c-Cbl negatively regulates platelet activation by glycoprotein VI.

scientific article published in November 2003

cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis

scientific article published in Nature

myo-Inositol 1,4,5-trisphosphate stimulates protein phosphorylation in saponin-permeabilized human platelets

scientific article published on December 1984

pH-controlled delivery of luminescent europium coated nanoparticles into platelets.

scientific article published on 20 January 2012

von Willebrand factor mediates platelet spreading through glycoprotein Ib and alphaIIbbeta3 in the presence of botrocetin and ristocetin, respectively

scientific article published on 01 June 2006

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